AiPD: Autoinhibited Protein Database

Gene name	Ddx46 (Kiaa0801)
Protein name	Probable ATP-dependent RNA helicase DDX46
Names	DEAD box protein 46
Species	Mus musculus (Mouse)
KEGG Pathway	mmu:212880
EC number	3.6.4.13: Acting on ATP; involved in cellular and subcellular movement
Protein Class

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

57-152 (Predicted disordered autoinhibitory region) PR

57-152 (Predicted disordered autoinhibitory region)

cis-regPred

No accessory elements

Entry ID	Method	Resolution	Chain	Position	Source
AF-Q569Z5-F1	Predicted				AlphaFoldDB

Variant ID(s)	Position	Change	Diseaes Association	Provenance
rs3389301846	18	S>C	No	EVA
rs222476673	41	R>W	No	EVA
rs3389284692	134	K>N	No	EVA
rs3413055857	148	A>V	No	EVA
rs3403978879	164	K>N	No	EVA
rs3389282612	194	Q>H	No	EVA
rs3389286716	221	E>K	No	EVA
rs3389286786	222	D>H	No	EVA
rs3389278263	241	K>R	No	EVA
rs3389286775	243	N>D	No	EVA
rs3389278203	247	V>M	No	EVA
rs3389293804	266	T>N	No	EVA
rs3389282571	281	K>T	No	EVA
rs3389284522	294	Y>*	No	EVA
rs3389301841	338	E>*	No	EVA
rs3389287682	338	E>V	No	EVA
rs3404188393	372	K>*	No	EVA
rs3389293743	396	T>K	No	EVA
rs3389301902	400	T>I	No	EVA
rs3389244325	414	G>S	No	EVA
rs3389284542	424	I>N	No	EVA
rs3404273203	575	L>R	No	EVA
rs3389268849	625	F>C	No	EVA
rs3389287869	640	M>L	No	EVA
rs3389301876	739	E>*	No	EVA
rs3389301909	752	L>R	No	EVA
rs3389296554	761	K>I	No	EVA
rs3403766097	764	G>A	No	EVA
rs3389296571	874	M>I	No	EVA
rs3389215108	884	G>C	No	EVA
rs3389215109	884	G>D	No	EVA
rs3389287727	912	V>M	No	EVA
rs3389268806	925	G>R	No	EVA
rs3389260534	965	A>T	No	EVA
rs3389268866	973	Y>N	No	EVA
rs3389215132	979	E>K	No	EVA
rs3389282579	989	L>M	No	EVA

Type	Name	Position	InterPro Accession
conserved_site	Heat shock protein 70, conserved site	11 - 18	IPR018181-1
conserved_site	Heat shock protein 70, conserved site	202 - 215	IPR018181-2
conserved_site	Heat shock protein 70, conserved site	339 - 353	IPR018181-3

		Description
EC Number	3.6.4.13	Acting on ATP; involved in cellular and subcellular movement
Subcellular Localization	Nucleus speckle Nucleus, Cajal body	Present in Cajal bodies (CBs) and nuclear speckles
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category	No pathway information available

Name	Definition
Cajal body	A class of nuclear body, first seen after silver staining by Ramon y Cajal in 1903, enriched in small nuclear ribonucleoproteins, and certain general RNA polymerase II transcription factors; ultrastructurally, they appear as a tangle of coiled, electron-dense threads roughly 0.5 micrometers in diameter; involved in aspects of snRNP biogenesis; the protein coilin serves as a marker for Cajal bodies. Some argue that Cajal bodies are the sites for preassembly of transcriptosomes, unitary particles involved in transcription and processing of RNA.
fibrillar center	A structure found most metazoan nucleoli, but not usually found in lower eukaryotes; surrounded by the dense fibrillar component; the zone of transcription from multiple copies of the pre-rRNA genes is in the border region between these two structures.
membrane	A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it.
nuclear speck	A discrete extra-nucleolar subnuclear domain, 20-50 in number, in which splicing factors are seen to be localized by immunofluorescence microscopy.
nucleus	A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.

Name	Definition
ATP binding	Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
ATP hydrolysis activity	Catalysis of the reaction: ATP + H2O = ADP + H+ phosphate. ATP hydrolysis is used in some reactions as an energy source, for example to catalyze a reaction or drive transport against a concentration gradient.
RNA binding	Binding to an RNA molecule or a portion thereof.
RNA helicase activity	Unwinding of an RNA helix, driven by ATP hydrolysis.

Name	Definition
mRNA splicing, via spliceosome	The joining together of exons from one or more primary transcripts of messenger RNA (mRNA) and the excision of intron sequences, via a spliceosomal mechanism, so that mRNA consisting only of the joined exons is produced.

UniProt AC	Gene Name	Protein Name	Species	Evidence Code
P21372	PRP5	Pre-mRNA-processing ATP-dependent RNA helicase PRP5	Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)	EV
Q9VNP5	BoYb	Putative ATP-dependent RNA helicase BoYb	Drosophila melanogaster (Fruit fly)	PR
Q9VL52	SoYb	Putative ATP-dependent RNA helicase SoYb	Drosophila melanogaster (Fruit fly)	PR
Q7L014	DDX46	Probable ATP-dependent RNA helicase DDX46	Homo sapiens (Human)	PR
Q6ZPL9	Ddx55	ATP-dependent RNA helicase DDX55	Mus musculus (Mouse)	PR
P60843	Eif4a1	Eukaryotic initiation factor 4A-I	Mus musculus (Mouse)	PR
P10630	Eif4a2	Eukaryotic initiation factor 4A-II	Mus musculus (Mouse)	PR
Q4FZF3	Ddx49	Probable ATP-dependent RNA helicase DDX49	Mus musculus (Mouse)	PR
Q8K363	Ddx18	ATP-dependent RNA helicase DDX18	Mus musculus (Mouse)	PR
Q9CWX9	Ddx47	Probable ATP-dependent RNA helicase DDX47	Mus musculus (Mouse)	PR
Q8K4L0	Ddx54	ATP-dependent RNA helicase DDX54	Mus musculus (Mouse)	PR
Q9ESV0	Ddx24	ATP-dependent RNA helicase DDX24	Mus musculus (Mouse)	PR
Q91VR5	Ddx1	ATP-dependent RNA helicase DDX1	Mus musculus (Mouse)	PR
Q9CWT6	Ddx28	Probable ATP-dependent RNA helicase DDX28	Mus musculus (Mouse)	PR
Q62780	Ddx46	Probable ATP-dependent RNA helicase DDX46	Rattus norvegicus (Rat)	PR
Q8H0U8	RH42	DEAD-box ATP-dependent RNA helicase 42	Arabidopsis thaliana (Mouse-ear cress)	SS