Q54KF1

SS
Gene name
forC
Protein name
Formin-C
Names
Species
Dictyostelium discoideum (Slime mold)
KEGG Pathway
ddi:DDB_G0287295
EC number
Protein Class

Descriptions

Formins are conserved actin nucleators responsible for the assembly of diverse actin structures. In a study with Formin-3, the autoinhibition mechanism involves the intramolecular interaction between N-terminal DID domain and C-terminal DAD domain. This interaction is disrupted by Rho GTPase that is able to bind to the DID domain.

Autoinhibitory domains (AIDs)

257-306 (DID domain) SS

Target domain

601-1077 (FH2 domain)

Relief mechanism

Partner binding

Assay

1134-1158 (DAD domain) SS

Target domain

601-1077 (FH2 domain)

Relief mechanism

Partner binding

Assay

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

2 structures for Q54KF1

Entry ID Method Resolution Chain Position Source
2L1A NMR - A 1-100 PDB
AF-Q54KF1-F1 Predicted AlphaFoldDB

No variants for Q54KF1

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for Q54KF1

No associated diseases with Q54KF1

3 regional properties for Q54KF1

Type Name Position InterPro Accession
domain Rho GTPase-binding/formin homology 3 (GBD/FH3) domain 20 - 388 IPR014768
domain Formin, FH2 domain 601 - 1077 IPR015425
domain ELMO, armadillo-like helical domain 131 - 280 IPR024574

Functions

Description
EC Number
Subcellular Localization
  • Cytoplasm, cytosol
  • Cytoplasm, cytoskeleton
  • Found localized to the crowns, which are macropinocytotic cups rich in F-actin
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

5 GO annotations of cellular component

Name Definition
cell-cell junction A cell junction that forms a connection between two or more cells of an organism; excludes direct cytoplasmic intercellular bridges, such as ring canals in insects.
cytoplasm The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
cytoskeleton A cellular structure that forms the internal framework of eukaryotic and prokaryotic cells. The cytoskeleton includes intermediate filaments, microfilaments, microtubules, the microtrabecular lattice, and other structures characterized by a polymeric filamentous nature and long-range order within the cell. The various elements of the cytoskeleton not only serve in the maintenance of cellular shape but also have roles in other cellular functions, including cellular movement, cell division, endocytosis, and movement of organelles.
cytosol The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
macropinosome A membrane-bounded, uncoated intracellular vesicle formed by the process of macropinocytosis.

1 GO annotations of molecular function

Name Definition
actin filament binding Binding to an actin filament, also known as F-actin, a helical filamentous polymer of globular G-actin subunits.

6 GO annotations of biological process

Name Definition
actin filament bundle assembly The assembly of actin filament bundles; actin filaments are on the same axis but may be oriented with the same or opposite polarities and may be packed with different levels of tightness.
actin filament network formation The assembly of a network of actin filaments; actin filaments on different axes and with differing orientations are crosslinked together to form a mesh of filaments.
cortical actin cytoskeleton organization A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of actin-based cytoskeletal structures in the cell cortex, i.e. just beneath the plasma membrane.
culmination involved in sorocarp development The process whose specific outcome is the progression of the culminant over time, from its formation to the mature structure. Culmination begins with a morphogenetic change of the finger-like or migratory slug giving rise to an organized structure containing a stalk and a sorus. This process is the final stage of sorocarp development.
gene expression The process in which a gene's sequence is converted into a mature gene product (protein or RNA). This includes the production of an RNA transcript and its processing, translation and maturation for protein-coding genes.
sorocarp spore cell differentiation The process in which a relatively unspecialized cell acquires specialized features of a sorocarp spore cell, a cell of the sorocarp sorus. A sorocarp is the fruiting body characteristic of certain cellular slime moulds (e.g., Dictyosteliida) and consists of both stalk and a sorus (spore mass).

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MKIRVELING NEHRTSSTPQ QPQQNPSVSH IFDGETAVKD HIKVLLTHFK IPVDKVSSYA
70 80 90 100 110 120
LQNPFTLAYV EDSFLTPERL VEAEKSYFIL RMKPHAIADR VVDQLTKIEP TSPHIKDTIF
130 140 150 160 170 180
NIRYQMKDVE YVEEFIIKGG INQLLAVIIK SRGNTQSYAL TALRCFMGYN SGLEEVMSRP
190 200 210 220 230 240
QLIDKLYSLV CSVGVLPSVC RQAIELLFCV CNFDGFQLVH RSAKNHAQET STPAYSNLIT
250 260 270 280 290 300
LLSSGDMETQ LNTLTLFNCL LDNAPNPRKS EKLLSRWQQL GIIKILKSQE HVTHSDFRTQ
310 320 330 340 350 360
IARFQANSGF GIDGSGRKRT LTRQLSTQEL EFQLHQFREQ QPLISLLTSE LKFLRNAIKS
370 380 390 400 410 420
AIENGSYINY RAPTERYDEY SQRKLEMIGD SPTNLQFLKR NDKFTNAFRK SMYVRSPNTS
430 440 450 460 470 480
DLFDSSTLED TYDGNNDTNS CTSISTSSTP IHISQPTTLI VPSTTPNHPP QQSQQTPPLQ
490 500 510 520 530 540
LQKEKEKEKE KEKEKEKEKE KEQQQQQQQS NKQSTPKPNL SCLLSPITIS NTLNNNNNNN
550 560 570 580 590 600
NNTNNNIIKS NNNNNNNNCT IKDLSPIVKS EKSNEDEIHE ISLNGASSNH EEPIKYKLQP
610 620 630 640 650 660
TKSPITPSKR MKPLHWTRIL NSQFEGKKTI WNSYLPEVTF EEELFVDLFS LYTERIVSFS
670 680 690 700 710 720
GSPVGSGTSI SGGGPIKSKP IQKVISVLSQ KRSNAIIVMC GKLPSDDILI RAIRNLDSNK
730 740 750 760 770 780
LSLDGVSSII SNFPTSEELA SIHELHSNEV ILDKPERWCL MIDGFPMIKH RLRCWEFMLK
790 800 810 820 830 840
IEDSLKSIIE SIDTVLLACK ELRTSITINC LFSLLLQLGN YLNGGHLYRG QSDGFNLESL
850 860 870 880 890 900
SKMIEIKDNS NSGSLLDFAI KTLYQQSPMK GNSNTSIHLE LAHVPNASLI NFTDVGTSVS
910 920 930 940 950 960
KLLQDYSEIV LMSDEIQQTT DKDDPFLDIV PKFMGTILLI LKNLQTKFLE TEKYLFETID
970 980 990 1000 1010 1020
YFNPTNQTLQ QYQQQQYQQY QQQQFQQNII NNNNNNNNNN SNNNNNNISG NTTTTTTTTT
1030 1040 1050 1060 1070 1080
TTTTGSIINN NNNNNNNNNN SNNNIINNNN SQSNLQSLLH PQYYLSNSSS SSSSSYKITP
1090 1100 1110 1120 1130 1140
PLSSSLSITS QEWNQQKFTC EKFFTLFSTI TTAFKKSPSK RLSQKGFGLK ISNSDDPMAV
1150
IIEALKTGSP NDMVKRAF