Q53B87

SS
Gene name
NOD2 (CARD15)
Protein name
Nucleotide-binding oligomerization domain-containing protein 2
Names
Caspase recruitment domain-containing protein 15
Species
Pan troglodytes (Chimpanzee)
KEGG Pathway
EC number
Protein Class

Descriptions

NOD2, a NOD-like receptor (NLR), is an intracellular sensor of bacterial muramyl dipeptide (MDP) that promotes secretion of the proinflammatory cytokine IL-1β. NOT2 through its N-terminal caspase recruitment domain directly binds and activates caspase-1 to trigger IL-1β processing and secretion in MDP-stimulated macrophages, wherease the C-terminal leucine-rich repeats (LRR) of NOD2 prevent caspase-1 activation in non-stimulated cells. Removal of the LRR rendered NOD2 a constitutive activator of pro-IL-1β processing and caspase-1. The autoinhibitory region was inferred by sequence similarity with the human NOD2 (Q9HC29).

Autoinhibitory domains (AIDs)

791-1032 (Leucine-rich repeats) SS

Target domain

26-218 (CARD domains)

Relief mechanism

Partner binding

Assay

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for Q53B87

Entry ID Method Resolution Chain Position Source
AF-Q53B87-F1 Predicted AlphaFoldDB

No variants for Q53B87

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for Q53B87

No associated diseases with Q53B87

8 regional properties for Q53B87

Type Name Position InterPro Accession
domain CARD domain 26 - 120 IPR001315-1
domain CARD domain 134 - 218 IPR001315-2
repeat Leucine-rich repeat 898 - 920 IPR001611-1
repeat Leucine-rich repeat 927 - 948 IPR001611-2
repeat Leucine-rich repeat 981 - 1005 IPR001611-3
domain NACHT nucleoside triphosphatase 293 - 462 IPR007111
domain NOD2, winged helix domain 546 - 587 IPR041075
domain NACHT, LRR and PYD domains-containing protein, helical domain HD2 603 - 757 IPR041267

Functions

Description
EC Number
Subcellular Localization
  • Cell membrane ; Lipid-anchor
  • Basolateral cell membrane
  • Cytoplasm
  • Mitochondrion
  • Palmitoylation promotes localization to the cell membrane, where it detects bacterial invasion at the point of entry
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

5 GO annotations of cellular component

Name Definition
basolateral plasma membrane The region of the plasma membrane that includes the basal end and sides of the cell. Often used in reference to animal polarized epithelial membranes, where the basal membrane is the part attached to the extracellular matrix, or in plant cells, where the basal membrane is defined with respect to the zygotic axis.
cytoplasm The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
cytoskeleton A cellular structure that forms the internal framework of eukaryotic and prokaryotic cells. The cytoskeleton includes intermediate filaments, microfilaments, microtubules, the microtrabecular lattice, and other structures characterized by a polymeric filamentous nature and long-range order within the cell. The various elements of the cytoskeleton not only serve in the maintenance of cellular shape but also have roles in other cellular functions, including cellular movement, cell division, endocytosis, and movement of organelles.
protein-containing complex A stable assembly of two or more macromolecules, i.e. proteins, nucleic acids, carbohydrates or lipids, in which at least one component is a protein and the constituent parts function together.
vesicle Any small, fluid-filled, spherical organelle enclosed by membrane.

1 GO annotations of molecular function

Name Definition
ATP binding Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.

7 GO annotations of biological process

Name Definition
cellular response to lipopolysaccharide Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a lipopolysaccharide stimulus; lipopolysaccharide is a major component of the cell wall of gram-negative bacteria.
cellular response to muramyl dipeptide Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a muramyl dipeptide stimulus. Muramyl dipeptide is derived from peptidoglycan.
innate immune response Innate immune responses are defense responses mediated by germline encoded components that directly recognize components of potential pathogens.
nucleotide-binding oligomerization domain containing 2 signaling pathway The series of molecular signals initiated by the binding of a ligand (such as a bacterial peptidoglycan) to a cytoplasmic nucleotide-binding oligomerization domain containing 2 (NOD2) protein receptor, and ending with regulation of a downstream cellular process.
positive regulation of NF-kappaB transcription factor activity Any process that activates or increases the frequency, rate or extent of activity of the transcription factor NF-kappaB.
positive regulation of transcription by RNA polymerase II Any process that activates or increases the frequency, rate or extent of transcription from an RNA polymerase II promoter.
regulation of apoptotic process Any process that modulates the occurrence or rate of cell death by apoptotic process.

3 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
Q6E804 NOD2 Nucleotide-binding oligomerization domain-containing protein 2 Bos taurus (Bovine) SS
Q9HC29 NOD2 Nucleotide-binding oligomerization domain-containing protein 2 Homo sapiens (Human) EV
Q8K3Z0 Nod2 Nucleotide-binding oligomerization domain-containing protein 2 Mus musculus (Mouse) EV
10 20 30 40 50 60
MGEEGGSVSH DEEERASVLL GHSLGCEMCS QEAFQAQRSQ LVELLVSGSL EGFESVLDWL
70 80 90 100 110 120
LSWEVLSWED YEGFHLLGQP LSHLARRLLD TVWNKGTWAC QKLIAAAQEA QADSQSPKLH
130 140 150 160 170 180
GCWDPHSLHP ARDLQSHRPA IVRRLHNHVE NMLDLAWERG FVSQYECDEI RLPIFTPSQR
190 200 210 220 230 240
ARRLLDLATV KANGLAAFLL QHVQELPVPL ALPLEAATCK KYMAKLRTTV SAQSRFLSTY
250 260 270 280 290 300
DGAETLCLED IYTENVLEVW ADVGMAGPPQ KSPATLGLEE LFSTPGHLND DADTVLVVGE
310 320 330 340 350 360
AGSGKSTLLQ RLHLLWAAGR DFQEFLFVFP FSCRQLQCMA KPLSVRTLLF EHCCWPDVGQ
370 380 390 400 410 420
EDIFQLLLDH PDRVLLTFDG FDEFKFRFTD RERHCSPTDP TSVQTLLFNL LQGNLLKNAR
430 440 450 460 470 480
KVVTSRPAAV SAFLRKYIRT EFNLKGFSEQ GIELYLRKRH REPGVADRLI RLLQATSALH
490 500 510 520 530 540
GLCHLPVFSW MVSKCHQELL LQEGGSPKTT TDMYLLILQH FLLHATPPDS ASQGLGPSLL
550 560 570 580 590 600
RGRLPTLLHL GRLALWGLGM CCYVFSAQQL QAAQVSPDDI SLGFLVRAKG VVPGSTAPLE
610 620 630 640 650 660
FLHITFQCFF AAFYLALSAD VPPALLRHLF NCGRPGNSPM ARLLPTMCIQ GSEGKDSSVA
670 680 690 700 710 720
ALLQKAEPHN LQITAAFLAG LLSREHWGLL AECQTSEKAL LRRQACARWC LARSLRKHFH
730 740 750 760 770 780
SIPPAAPGEA KSVHAMPGFI WLIRSLYEMQ EERLARKAAR GLNVGHLKLT FCSVGPAECA
790 800 810 820 830 840
ALAFVLQHLR RPVALQLDYN SVGDIGVEQL LPCLGVCKAL YLRDNNISDR GICKLIECAL
850 860 870 880 890 900
HCEQLQKLAL FNNKLTDGCA HSMAKLLACR QNFLALRLGN NYITAAGAQV LAQGLRGNTS
910 920 930 940 950 960
LQFLGFWGNR VGDEGAQALA EALGDHQSLR WLSLVGNNIG SVGAQALALM LAKNVMLEEL
970 980 990 1000 1010 1020
CLEENHLQDE GVCSLAEGLK KNSSLKILKL SNNCITYLGA EALLQALERN DTILEVWLRG
1030
NTFSLEEVDK LGCRDTRLLL