Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

Autoinhibited structure

Activated structure

1 structures for Q503D6

Entry ID Method Resolution Chain Position Source
AF-Q503D6-F1 Predicted AlphaFoldDB

No variants for Q503D6

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for Q503D6

No associated diseases with Q503D6

3 regional properties for Q503D6

Type Name Position InterPro Accession
domain Cyclin, N-terminal 31 - 138 IPR006671
domain Cyclin-like domain 34 - 132 IPR013763-1
domain Cyclin-like domain 152 - 238 IPR013763-2

Functions

Description
EC Number
Subcellular Localization
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

1 GO annotations of cellular component

Name Definition
nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.

1 GO annotations of molecular function

Name Definition
cyclin-dependent protein serine/threonine kinase regulator activity Modulates the activity of a cyclin-dependent protein serine/threonine kinase, enzymes of the protein kinase family that are regulated through association with cyclins and other proteins.

1 GO annotations of biological process

Name Definition
regulation of transcription by RNA polymerase II Any process that modulates the frequency, rate or extent of transcription mediated by RNA polymerase II.

11 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
Q6T8E9 CCNT1 Cyclin-T1 Bos taurus (Bovine) SS
Q8HXN7 CCNT1 Cyclin-T1 Pan troglodytes (Chimpanzee) SS
O60563 CCNT1 Cyclin-T1 Homo sapiens (Human) EV
O75909 CCNK Cyclin-K Homo sapiens (Human) PR
Q8N1B3 CCNQ Cyclin-Q Homo sapiens (Human) PR
O88874 Ccnk Cyclin-K Mus musculus (Mouse) PR
Q9QWV9 Ccnt1 Cyclin-T1 Mus musculus (Mouse) SS
Q6Z7H3 CYCT1_2 Cyclin-T1-2 Oryza sativa subsp japonica (Rice) PR
Q2RAC5 CYCT1-3 Cyclin-T1-3 Oryza sativa subsp japonica (Rice) PR
Q2QQS5 CYCT1-1 Cyclin-T1-4 Oryza sativa subsp japonica (Rice) PR
Q8GYM6 CYCT1-4 Cyclin-T1-4 Arabidopsis thaliana (Mouse-ear cress) PR
10 20 30 40 50 60
MSAHASTSAA ANEARGRRSA EDVEYSKTHF RVCRFITETG VKLGMRSVPM ATACVLYHRF
70 80 90 100 110 120
FQSASLQIYE PYLVAMSAIH LAGKVEEQHL RTRDIINVCH RYFHPDSEPL ELNGKFWELR
130 140 150 160 170 180
DSIVQCELLI LRQLNFQVTF EHPHKYLLHY LLSVRSLLNR HAWSRTPIAE TALAVLKDSY
190 200 210 220 230 240
HGSVCVRHRP QHLALTALYL ALQTYGVQLP RGELEWWQVV CADITKAQIE TIMSELLQLY
DMEAKCT