Q501J6
PR
Gene name |
Ddx17 |
Protein name |
Probable ATP-dependent RNA helicase DDX17 |
Names |
DEAD box protein 17 |
Species |
Mus musculus (Mouse) |
KEGG Pathway |
mmu:67040 |
EC number |
3.6.4.13: Acting on ATP; involved in cellular and subcellular movement |
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for Q501J6
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-Q501J6-F1 | Predicted | AlphaFoldDB |
32 variants for Q501J6
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| rs3389367278 | 48 | L>V | No | EVA | |
| rs3404754372 | 102 | Y>* | No | EVA | |
| rs3406497108 | 102 | Y>* | No | EVA | |
| rs3405781812 | 105 | D>V | No | EVA | |
| rs3411650090 | 106 | V>L | No | EVA | |
| rs3406283334 | 112 | F>I | No | EVA | |
| rs3389384109 | 171 | L>Q | No | EVA | |
| rs3389335545 | 176 | E>* | No | EVA | |
| rs3389380495 | 197 | T>M | No | EVA | |
| rs3389380554 | 198 | C>R | No | EVA | |
| rs3389371156 | 230 | L>M | No | EVA | |
| rs3389384121 | 243 | L>R | No | EVA | |
| rs3389367340 | 247 | E>K | No | EVA | |
| rs3389368406 | 286 | Q>H | No | EVA | |
| rs3389367300 | 340 | N>D | No | EVA | |
| rs3389368493 | 356 | T>I | No | EVA | |
| rs864304989 | 360 | R>C | No | EVA | |
| rs3389372763 | 362 | D>Y | No | EVA | |
| rs3389377292 | 368 | C>Y | No | EVA | |
| rs3389335533 | 373 | K>N | No | EVA | |
| rs3389384094 | 394 | I>F | No | EVA | |
| rs3389377336 | 396 | T>M | No | EVA | |
| rs3413036337 | 406 | E>A | No | EVA | |
| rs3389379196 | 409 | K>Q | No | EVA | |
| rs3389379164 | 418 | N>H | No | EVA | |
| rs3389372781 | 491 | T>S | No | EVA | |
| rs3389384088 | 500 | M>L | No | EVA | |
| rs3389374756 | 505 | C>Y | No | EVA | |
| rs3389390091 | 550 | Q>R | No | EVA | |
| rs3389372811 | 593 | S>Y | No | EVA | |
| rs3406268223 | 594 | Q>E | No | EVA | |
| rs3406293064 | 629 | G>V | No | EVA |
No associated diseases with Q501J6
7 regional properties for Q501J6
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| domain | EF-hand domain | 182 - 233 | IPR002048 |
| domain | FAD-binding 8 | 562 - 678 | IPR013112 |
| domain | Ferric reductase, NAD binding domain | 685 - 849 | IPR013121 |
| domain | Ferric reductase transmembrane component-like domain | 363 - 518 | IPR013130 |
| domain | NADPH oxidase Respiratory burst | 103 - 201 | IPR013623 |
| domain | FAD-binding domain, ferredoxin reductase-type | 558 - 681 | IPR017927 |
| binding_site | EF-Hand 1, calcium-binding site | 211 - 223 | IPR018247 |
Functions
| Description | ||
|---|---|---|
| EC Number | 3.6.4.13 | Acting on ATP; involved in cellular and subcellular movement |
| Subcellular Localization |
|
|
| PANTHER Family | ||
| PANTHER Subfamily | ||
| PANTHER Protein Class | ||
| PANTHER Pathway Category | No pathway information available | |
5 GO annotations of cellular component
| Name | Definition |
|---|---|
| cytosol | The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. |
| nuclear speck | A discrete extra-nucleolar subnuclear domain, 20-50 in number, in which splicing factors are seen to be localized by immunofluorescence microscopy. |
| nucleolus | A small, dense body one or more of which are present in the nucleus of eukaryotic cells. It is rich in RNA and protein, is not bounded by a limiting membrane, and is not seen during mitosis. Its prime function is the transcription of the nucleolar DNA into 45S ribosomal-precursor RNA, the processing of this RNA into 5.8S, 18S, and 28S components of ribosomal RNA, and the association of these components with 5S RNA and proteins synthesized outside the nucleolus. This association results in the formation of ribonucleoprotein precursors; these pass into the cytoplasm and mature into the 40S and 60S subunits of the ribosome. |
| nucleus | A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. |
| ribonucleoprotein complex | A macromolecular complex that contains both RNA and protein molecules. |
7 GO annotations of molecular function
| Name | Definition |
|---|---|
| ATP binding | Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. |
| ATP hydrolysis activity | Catalysis of the reaction: ATP + H2O = ADP + H+ phosphate. ATP hydrolysis is used in some reactions as an energy source, for example to catalyze a reaction or drive transport against a concentration gradient. |
| chromatin DNA binding | Binding to DNA that is assembled into chromatin. |
| lncRNA binding | Binding to a long noncoding RNA (lncRNA). |
| RNA binding | Binding to an RNA molecule or a portion thereof. |
| RNA helicase activity | Unwinding of an RNA helix, driven by ATP hydrolysis. |
| transcription coactivator activity | A transcription coregulator activity that activates or increases the transcription of specific gene sets via binding to a DNA-bound DNA-binding transcription factor, either on its own or as part of a complex. Coactivators often act by altering chromatin structure and modifications. For example, one class of transcription coactivators modifies chromatin structure through covalent modification of histones. A second class remodels the conformation of chromatin in an ATP-dependent fashion. A third class modulates interactions of DNA-bound DNA-binding transcription factors with other transcription coregulators. A fourth class of coactivator activity is the bridging of a DNA-binding transcription factor to the general (basal) transcription machinery. The Mediator complex, which bridges sequence-specific DNA binding transcription factors and RNA polymerase, is also a transcription coactivator. |
16 GO annotations of biological process
| Name | Definition |
|---|---|
| alternative mRNA splicing, via spliceosome | The process of generating multiple mRNA molecules from a given set of exons by differential use of exons from the primary transcript(s) to form multiple mature mRNAs that vary in their exon composition. |
| androgen receptor signaling pathway | The series of molecular signals initiated by androgen binding to its receptor, and ending with the regulation of a downstream cellular process, e.g. transcription. |
| defense response to virus | Reactions triggered in response to the presence of a virus that act to protect the cell or organism. |
| epithelial to mesenchymal transition | A transition where an epithelial cell loses apical/basolateral polarity, severs intercellular adhesive junctions, degrades basement membrane components and becomes a migratory mesenchymal cell. |
| gene expression | The process in which a gene's sequence is converted into a mature gene product (protein or RNA). This includes the production of an RNA transcript and its processing, translation and maturation for protein-coding genes. |
| gene silencing by RNA | A process in which an RNA molecule reduces expression of target genes. This can occur pre-transcriptionally by assembly of heterochromatin and prevention of transcription or co- or post-transcriptionally by targeting RNAs for degradation or by interfering with splicing or translation. This process starts once the inhibitory RNA molecule has been transcribed, and includes processing of the RNA such as cleavage, modifications, transport from the nucleus to the cytoplasm, loading onto the RISC complex, and the effect on transcription or translation. |
| immune system process | Any process involved in the development or functioning of the immune system, an organismal system for calibrated responses to potential internal or invasive threats. |
| intracellular estrogen receptor signaling pathway | The series of molecular signals initiated by estrogen binding to an intracellular receptor, and ending with the regulation of a downstream cellular process, e.g. transcription. |
| miRNA metabolic process | The chemical reactions and pathways involving miRNA, microRNA, a class of single-stranded RNA molecules of about 21-23 nucleotides in length, which regulates gene expression. |
| miRNA transcription | The cellular synthesis of microRNA (miRNA) transcripts. MicroRNA genes are synthesized as primary (pri) miRNA transcripts and subsequently processed to produce the ~22nt miRNAs that function in gene regulation. |
| myoblast differentiation | The process in which a relatively unspecialized cell acquires specialized features of a myoblast. A myoblast is a mononucleate cell type that, by fusion with other myoblasts, gives rise to the myotubes that eventually develop into striated muscle fibers. |
| positive regulation of transcription by RNA polymerase II | Any process that activates or increases the frequency, rate or extent of transcription from an RNA polymerase II promoter. |
| regulation of alternative mRNA splicing, via spliceosome | Any process that modulates the frequency, rate or extent of alternative splicing of nuclear mRNAs. |
| regulation of skeletal muscle cell differentiation | Any process that modulates the frequency, rate or extent of skeletal muscle cell differentiation. |
| regulation of transcription by RNA polymerase II | Any process that modulates the frequency, rate or extent of transcription mediated by RNA polymerase II. |
| rRNA processing | Any process involved in the conversion of a primary ribosomal RNA (rRNA) transcript into one or more mature rRNA molecules. |
23 homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| Q2NL08 | DDX55 | ATP-dependent RNA helicase DDX55 | Bos taurus (Bovine) | PR |
| P17844 | DDX5 | Probable ATP-dependent RNA helicase DDX5 | Homo sapiens (Human) | PR |
| Q8NHQ9 | DDX55 | ATP-dependent RNA helicase DDX55 | Homo sapiens (Human) | PR |
| Q6ZPL9 | Ddx55 | ATP-dependent RNA helicase DDX55 | Mus musculus (Mouse) | PR |
| Q91VC3 | Eif4a3 | Eukaryotic initiation factor 4A-III | Mus musculus (Mouse) | PR |
| Q61496 | Ddx4 | ATP-dependent RNA helicase DDX4 | Mus musculus (Mouse) | SS |
| Q62095 | Ddx3y | ATP-dependent RNA helicase DDX3Y | Mus musculus (Mouse) | SS |
| P16381 | D1Pas1 | Putative ATP-dependent RNA helicase Pl10 | Mus musculus (Mouse) | SS |
| Q62167 | Ddx3x | ATP-dependent RNA helicase DDX3X | Mus musculus (Mouse) | SS |
| Q9QY15 | Ddx25 | ATP-dependent RNA helicase DDX25 | Mus musculus (Mouse) | PR |
| Q61655 | Ddx19a | ATP-dependent RNA helicase DDX19A | Mus musculus (Mouse) | SS |
| Q8VDW0 | Ddx39a | ATP-dependent RNA helicase DDX39A | Mus musculus (Mouse) | PR |
| Q9Z1N5 | Ddx39b | Spliceosome RNA helicase Ddx39b | Mus musculus (Mouse) | PR |
| Q91VN6 | Ddx41 | Probable ATP-dependent RNA helicase DDX41 | Mus musculus (Mouse) | PR |
| Q99MJ9 | Ddx50 | ATP-dependent RNA helicase DDX50 | Mus musculus (Mouse) | PR |
| Q61656 | Ddx5 | Probable ATP-dependent RNA helicase DDX5 | Mus musculus (Mouse) | PR |
| Q0E2Z7 | Os02g0201900 | DEAD-box ATP-dependent RNA helicase 41 | Oryza sativa subsp japonica (Rice) | PR |
| Q5QMN3 | Os01g0197200 | DEAD-box ATP-dependent RNA helicase 20 | Oryza sativa subsp japonica (Rice) | PR |
| Q5N7W4 | Os01g0911100 | DEAD-box ATP-dependent RNA helicase 30 | Oryza sativa subsp japonica (Rice) | PR |
| Q56X76 | RH39 | DEAD-box ATP-dependent RNA helicase 39 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q9C718 | RH20 | DEAD-box ATP-dependent RNA helicase 20 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q8W4R3 | RH30 | DEAD-box ATP-dependent RNA helicase 30 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q8H136 | RH14 | DEAD-box ATP-dependent RNA helicase 14 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| 10 | 20 | 30 | 40 | 50 | 60 |
| MRGGGFGDRD | RDRDRGGFGA | RGGSGLPPKK | FGNPGERLRK | KKWDLSELPK | FEKNFYVEHP |
| 70 | 80 | 90 | 100 | 110 | 120 |
| EVARLTPYEV | DELRRKKEIT | VRGGDVCPKP | VFAFHHANFP | QYVMDVLMDQ | HFTEPTPIQC |
| 130 | 140 | 150 | 160 | 170 | 180 |
| QGFPLALSGR | DMVGIAQTGS | GKTLAYLLPA | IVHINHQPYL | ERGDGPICLV | LAPTRELAQQ |
| 190 | 200 | 210 | 220 | 230 | 240 |
| VQQVADDYGK | CSRLKSTCIY | GGAPKGPQIR | DLERGVEICI | ATPGRLIDFL | ESGKTNLRRC |
| 250 | 260 | 270 | 280 | 290 | 300 |
| TYLVLDEADR | MLDMGFEPQI | RKIVDQIRPD | RQTLMWSATW | PKEVRQLAED | FLRDYTQINV |
| 310 | 320 | 330 | 340 | 350 | 360 |
| GNLELSANHN | ILQIVDVCME | SEKDHKLIQL | MEEIMAEKEN | KTIIFVETKR | RCDDLTRRMR |
| 370 | 380 | 390 | 400 | 410 | 420 |
| RDGWPAMCIH | GDKSQPERDW | VLNEFRSGKA | PILIATDVAS | RGLDVEDVKF | VINYDYPNSS |
| 430 | 440 | 450 | 460 | 470 | 480 |
| EDYVHRIGRT | ARSTNKGTAY | TFFTPGNLKQ | ARELIKVLEE | ANQAINPKLM | QLVDHRGGGG |
| 490 | 500 | 510 | 520 | 530 | 540 |
| GGGGRSRYRT | TSSANNPNLM | YQDECDRRLR | GVKDGGRRDS | TSYRDRSETD | RASYANGSGY |
| 550 | 560 | 570 | 580 | 590 | 600 |
| GSPNSAFGAQ | AGQYTYAQGT | YGAAAYGTSG | YTAQEYAAGT | YGASSTASAG | RSSQSSSQQF |
| 610 | 620 | 630 | 640 | ||
| SGIGRSGQQP | QPLMSQQFAQ | PPGATNMIGY | MGQTAYQYPP | PPPPPPPSRK |