Q4W5Z4

SS
Gene name
DNMT3A
Protein name
DNA
Names
cytosine-5-methyltransferase 3A , Dnmt3a , EC 2.1.1.37 , Cysteine methyltransferase DNMT3A , EC 2.1.1.-
Species
Gallus gallus (Chicken)
KEGG Pathway
gga:421991
EC number
2.1.1.37: Methyltransferases
Protein Class

Descriptions

DNMT3A is required for genome-wide de novo methylation and is essential for the establishment of DNA methylation patterns during development. The ADD domain of DNMT3A inhibits the enzymatic activity of its catalytic domain (CD) by blocking DNA-binding. Both the ADD domain (476-609) and the ADD-linker (476-626) show comparable binding affinity to the CD domain, but only the ADD-linker (476-626) retains its inhibitory function. Therefore, both the ADD domain and linker are important for the autoinhibition of DNMT3A.

Autoinhibitory domains (AIDs)

441-591 (ADD-linker) SS

Target domain

592-877 (Catalytic domain)

Relief mechanism

Partner binding

Assay

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for Q4W5Z4

Entry ID Method Resolution Chain Position Source
AF-Q4W5Z4-F1 Predicted AlphaFoldDB

No variants for Q4W5Z4

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for Q4W5Z4

No associated diseases with Q4W5Z4

3 regional properties for Q4W5Z4

Type Name Position InterPro Accession
domain Protein kinase domain 102 - 367 IPR000719
active_site Serine/threonine-protein kinase, active site 225 - 237 IPR008271
binding_site Protein kinase, ATP binding site 108 - 131 IPR017441

Functions

Description
EC Number 2.1.1.37 Methyltransferases
Subcellular Localization
  • Nucleus
  • Chromosome
  • Cytoplasm
  • Accumulates in the major satellite repeats at pericentric heterochromatin
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

4 GO annotations of cellular component

Name Definition
cytoplasm The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
euchromatin A dispersed and relatively uncompacted form of chromatin that is in a transcription-competent conformation.
nuclear matrix The dense fibrillar network lying on the inner side of the nuclear membrane.
nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.

4 GO annotations of molecular function

Name Definition
core promoter sequence-specific DNA binding Binding to a sequence of DNA that is part of a core promoter region. The core promoter is composed of the transcription start site and binding sites for the RNA polymerase and the basal transcription machinery. The transcribed region might be described as a gene, cistron, or operon.
DNA (cytosine-5-)-methyltransferase activity Catalysis of the reaction
metal ion binding Binding to a metal ion.
protein-cysteine methyltransferase activity Catalysis of the reaction

5 GO annotations of biological process

Name Definition
methylation The process in which a methyl group is covalently attached to a molecule.
negative regulation of DNA-templated transcription Any process that stops, prevents, or reduces the frequency, rate or extent of cellular DNA-templated transcription.
negative regulation of gene expression via chromosomal CpG dinucleotide methylation An epigenetic gene regulation mechanism that negatively regulates gene expression by methylation of cytosine residues in chromosomal CpG islands. CpG islands are genomic regions that contain a high frequency of the CG dinucleotide and are often associated with the transcription start site of genes.
response to fibroblast growth factor Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a fibroblast growth factor stimulus.
response to heat Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a heat stimulus, a temperature stimulus above the optimal temperature for that organism.

5 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
Q9UBC3 DNMT3B DNA Homo sapiens (Human) EV
Q9Y6K1 DNMT3A DNA (cytosine-5)-methyltransferase 3A Homo sapiens (Human) EV
O88509 Dnmt3b DNA Mus musculus (Mouse) SS
O88508 Dnmt3a DNA Mus musculus (Mouse) EV
Q1LZ53 Dnmt3a DNA Rattus norvegicus (Rat) SS
10 20 30 40 50 60
MVESSDTPKD TAAVPKCPPP CPEASPAEPL PNGDLEADGA QWKGTEEGGA SPKSGRPEED
70 80 90 100 110 120
ETESLADGET GRALENGRCT PKEGLDAPAD EGELAPSDPQ KKRGRRKLLE ATEKSKEEKE
130 140 150 160 170 180
ENNFDSLKME GSRGRLRGGL GWESSLRQRP MQRHTFQAGD PYYISKRKRD EWLARWKREA
190 200 210 220 230 240
EKKAKVIAVM NVVEETPRAE PQKEEEASPP ASQQPTDPAS PNVATTPEPV VADAVDKNTS
250 260 270 280 290 300
KSADDEPEYE DGRGLGIGEL VWGKLRGFSW WPGRIVSWWM TGRSRAAEGT RWVMWFGDGK
310 320 330 340 350 360
FSVVCVEKLL PLSSFSSAFH QATYNKQPMY RKAIYEVLQV ASSRAGKIFP ACPENDETDT
370 380 390 400 410 420
SKVVEIQNKQ MIEWALGGFQ PSGPKGLEPP EEERNPYKEV YTEMWVEPEA AAYAPPPPAK
430 440 450 460 470 480
KPRKSTTEKP KVKEIIDERT RERLVYEVRQ KCRNIEDICI SCGSLNVTLE HPLFIGGMCQ
490 500 510 520 530 540
NCKNCFLECA YQYDDDGYQS YCTICCGGRE VLMCGNNNCC RCFCVECVDL LVGPGAAQAA
550 560 570 580 590 600
IKEDPWNCYM CGHKGVYGLL RRREDWPSRL QMFFANNHDQ EFDPPKVYPP VPAEKRKPIR
610 620 630 640 650 660
VLSLFDGIAT GLLVLKDLGI QVDRYIASEV CEDSITVGMV RHQGKIMYVG DVRNVTQKHI
670 680 690 700 710 720
QEWGPFDLVI GGSPCNDLSI VNPARKGLYE GTGRLFFEFY RLLHEARPKE GDDRPFFWLF
730 740 750 760 770 780
ENVVAMGVSD KRDISRFLES NPVMIDAKEV SAAHRARYFW GNLPGMNRPL ASTVNDKLEL
790 800 810 820 830 840
QECLEHGRIA KFSKVRTITT RSNSIKQGKD QHFPVFMNEK EDILWCTEME RVFGFPVHYT
850 860 870
DVSNMSRLAR QRLLGRSWSV PVIRHLFAPL KEYFACV