Q4V8G0
Gene name |
Lrrc63 |
Protein name |
Leucine-rich repeat-containing protein 63 |
Names |
|
Species |
Rattus norvegicus (Rat) |
KEGG Pathway |
rno:364427 |
EC number |
|
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for Q4V8G0
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-Q4V8G0-F1 | Predicted | AlphaFoldDB |
3 variants for Q4V8G0
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| rs106661058 | 115 | G>R | No | EVA | |
| rs106045589 | 115 | G>V | No | EVA | |
| rs3322641712 | 150 | E>D | No | EVA |
No associated diseases with Q4V8G0
6 regional properties for Q4V8G0
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| repeat | Leucine-rich repeat | 380 - 401 | IPR001611-1 |
| repeat | Leucine-rich repeat | 404 - 460 | IPR001611-2 |
| repeat | Leucine-rich repeat, typical subtype | 378 - 400 | IPR003591-1 |
| repeat | Leucine-rich repeat, typical subtype | 401 - 424 | IPR003591-2 |
| repeat | Leucine-rich repeat, typical subtype | 427 - 446 | IPR003591-3 |
| repeat | Leucine-rich repeat, typical subtype | 447 - 470 | IPR003591-4 |
No GO annotations of cellular component
| Name | Definition |
|---|---|
| No GO annotations for cellular component |
No GO annotations of molecular function
| Name | Definition |
|---|---|
| No GO annotations for molecular function |
No GO annotations of biological process
| Name | Definition |
|---|---|
| No GO annotations for biological process |
37 homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| Q3MHH9 | ECM2 | Extracellular matrix protein 2 | Bos taurus (Bovine) | PR |
| P58874 | OPTC | Opticin | Bos taurus (Bovine) | PR |
| Q24K06 | LRRC10 | Leucine-rich repeat-containing protein 10 | Bos taurus (Bovine) | PR |
| Q9V780 | Lap1 | Protein lap1 | Drosophila melanogaster (Fruit fly) | PR |
| Q96NW7 | LRRC7 | Leucine-rich repeat-containing protein 7 | Homo sapiens (Human) | PR |
| Q8IWT6 | LRRC8A | Volume-regulated anion channel subunit LRRC8A | Homo sapiens (Human) | PR |
| Q9HCJ2 | LRRC4C | Leucine-rich repeat-containing protein 4C | Homo sapiens (Human) | PR |
| Q9UFC0 | LRWD1 | Leucine-rich repeat and WD repeat-containing protein 1 | Homo sapiens (Human) | PR |
| Q96L50 | LRR1 | Leucine-rich repeat protein 1 | Homo sapiens (Human) | PR |
| Q86UN2 | RTN4RL1 | Reticulon-4 receptor-like 1 | Homo sapiens (Human) | PR |
| Q8IWK6 | ADGRA3 | Adhesion G protein-coupled receptor A3 | Homo sapiens (Human) | PR |
| Q7L1W4 | LRRC8D | Volume-regulated anion channel subunit LRRC8D | Homo sapiens (Human) | PR |
| Q96FE5 | LINGO1 | Leucine-rich repeat and immunoglobulin-like domain-containing nogo receptor-interacting protein 1 | Homo sapiens (Human) | PR |
| Q8TDW0 | LRRC8C | Volume-regulated anion channel subunit LRRC8C | Homo sapiens (Human) | PR |
| Q38SD2 | LRRK1 | Leucine-rich repeat serine/threonine-protein kinase 1 | Homo sapiens (Human) | EV |
| Q9D9Q0 | Lrrc69 | Leucine-rich repeat-containing protein 69 | Mus musculus (Mouse) | PR |
| Q8BGI7 | Lrrc39 | Leucine-rich repeat-containing protein 39 | Mus musculus (Mouse) | PR |
| Q7TT36 | Adgra3 | Adhesion G protein-coupled receptor A3 | Mus musculus (Mouse) | PR |
| P59383 | Lrrn4 | Leucine-rich repeat neuronal protein 4 | Mus musculus (Mouse) | PR |
| Q9D1T0 | Lingo1 | Leucine-rich repeat and immunoglobulin-like domain-containing nogo receptor-interacting protein 1 | Mus musculus (Mouse) | PR |
| Q8R502 | Lrrc8c | Volume-regulated anion channel subunit LRRC8C | Mus musculus (Mouse) | PR |
| Q80WG5 | Lrrc8a | Volume-regulated anion channel subunit LRRC8A | Mus musculus (Mouse) | PR |
| Q8K0S5 | Rtn4rl1 | Reticulon-4 receptor-like 1 | Mus musculus (Mouse) | PR |
| Q80TE7 | Lrrc7 | Leucine-rich repeat-containing protein 7 | Mus musculus (Mouse) | PR |
| Q5DU41 | Lrrc8b | Volume-regulated anion channel subunit LRRC8B | Mus musculus (Mouse) | PR |
| Q5RKR3 | Islr2 | Immunoglobulin superfamily containing leucine-rich repeat protein 2 | Mus musculus (Mouse) | PR |
| Q8C031 | Lrrc4c | Leucine-rich repeat-containing protein 4C | Mus musculus (Mouse) | PR |
| A6H694 | Lrrc63 | Leucine-rich repeat-containing protein 63 | Mus musculus (Mouse) | PR |
| P70587 | Lrrc7 | Leucine-rich repeat-containing protein 7 | Rattus norvegicus (Rat) | PR |
| Q80WD0 | Rtn4rl1 | Reticulon-4 receptor-like 1 | Rattus norvegicus (Rat) | PR |
| Q9TZM3 | lrk-1 | Leucine-rich repeat serine/threonine-protein kinase 1 | Caenorhabditis elegans | SS |
| Q9SHI4 | RLP3 | Receptor-like protein 3 | Arabidopsis thaliana (Mouse-ear cress) | SS |
| Q5G5E0 | PIRL5 | Plant intracellular Ras-group-related LRR protein 5 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| B0JZ65 | lrwd1 | Leucine-rich repeat and WD repeat-containing protein 1 | Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) | PR |
| Q68F79 | lrrc8e | Volume-regulated anion channel subunit LRRC8E | Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) | PR |
| B0R160 | lrwd1 | Leucine-rich repeat and WD repeat-containing protein 1 | Danio rerio (Zebrafish) (Brachydanio rerio) | PR |
| Q7SXW3 | lrrc40 | Leucine-rich repeat-containing protein 40 | Danio rerio (Zebrafish) (Brachydanio rerio) | PR |
| 10 | 20 | 30 | 40 | 50 | 60 |
| MRKRIYHSFK | TQQHPLLLRR | PLPPKLPKLP | LVKKKVRIVQ | TGSAREPQEA | RRKFDTEESA |
| 70 | 80 | 90 | 100 | 110 | 120 |
| LVKIDQSVSQ | PQKPASVQNV | CLDYEHDEPE | RVVNIFPHPH | GVRRLHWKVP | KSAAGSMFIP |
| 130 | 140 | 150 | 160 | 170 | 180 |
| RCLSASSRVF | RKTLSQIKRA | RKSLKSKQDE | DLTKKPFSNT | LVISEELSKP | LPPSYSRLIA |
| 190 | 200 | 210 | 220 | 230 | 240 |
| SRFKHSGTKF | RPAPKISHYI | QELPLLKDVK | ETVLSPISSA | SSAIPEPEWS | ERPLPKTTIG |
| 250 | 260 | 270 | 280 | 290 | 300 |
| KVIQLNTGSL | PPAHSLPTPA | LPRKPPRQIM | IENAVMTRKT | ETQKPVEITL | RPTRRLDPDA |
| 310 | 320 | 330 | 340 | 350 | 360 |
| HVLRGDGFKA | VGATRSETIL | ALTTLAIINC | QIYGRNALNF | KGFFLAQCPD | LTSVAFQLVY |
| 370 | 380 | 390 | 400 | 410 | 420 |
| LNLSYNDLHQ | FPGEVLYLQN | LQVLKLRNNP | IREIPSEIQQ | LKYLRKFTIA | FNFITSLPAG |
| 430 | 440 | 450 | 460 | 470 | 480 |
| LFCLNYLEEL | DVSYNEIENI | PNEIQKLRSL | EKLTVDGTNI | TAFPPGILKL | NLVKLEFENT |
| 490 | 500 | 510 | 520 | 530 | 540 |
| FTIPPFWLEN | SCNNPPRLTH | ICSLFIVKNN | LHKILDYDPV | VVQKYLISTS | DCDWCHGPKF |
| 550 | 560 | 570 | 580 | 590 | 600 |
| GEGFGIIRSC | NIFGLSHVPI | KFHVCSLSCY | LEIRESSFVL | EGFPSRRIAL | NMDWVKERKV |
| SNVSFYL |