Q4V8G0

PR
Gene name
Lrrc63
Protein name
Leucine-rich repeat-containing protein 63
Names
Species
Rattus norvegicus (Rat)
KEGG Pathway
rno:364427
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

1-317 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for Q4V8G0

Entry ID Method Resolution Chain Position Source
AF-Q4V8G0-F1 Predicted AlphaFoldDB

3 variants for Q4V8G0

Variant ID(s) Position Change Description Diseaes Association Provenance
rs106661058 115 G>R No EVA
rs106045589 115 G>V No EVA
rs3322641712 150 E>D No EVA

No associated diseases with Q4V8G0

3 regional properties for Q4V8G0

Type Name Position InterPro Accession
domain Protein kinase domain 83 - 340 IPR000719
active_site Serine/threonine-protein kinase, active site 200 - 212 IPR008271
binding_site Protein kinase, ATP binding site 89 - 116 IPR017441

Functions

Description
EC Number
Subcellular Localization
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

No GO annotations of cellular component

Name Definition
No GO annotations for cellular component

No GO annotations of molecular function

Name Definition
No GO annotations for molecular function

No GO annotations of biological process

Name Definition
No GO annotations for biological process

37 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
Q3MHH9 ECM2 Extracellular matrix protein 2 Bos taurus (Bovine) PR
P58874 OPTC Opticin Bos taurus (Bovine) PR
Q24K06 LRRC10 Leucine-rich repeat-containing protein 10 Bos taurus (Bovine) PR
Q9V780 Lap1 Protein lap1 Drosophila melanogaster (Fruit fly) PR
Q96NW7 LRRC7 Leucine-rich repeat-containing protein 7 Homo sapiens (Human) PR
Q8IWT6 LRRC8A Volume-regulated anion channel subunit LRRC8A Homo sapiens (Human) PR
Q9HCJ2 LRRC4C Leucine-rich repeat-containing protein 4C Homo sapiens (Human) PR
Q9UFC0 LRWD1 Leucine-rich repeat and WD repeat-containing protein 1 Homo sapiens (Human) PR
Q96L50 LRR1 Leucine-rich repeat protein 1 Homo sapiens (Human) PR
Q86UN2 RTN4RL1 Reticulon-4 receptor-like 1 Homo sapiens (Human) PR
Q8IWK6 ADGRA3 Adhesion G protein-coupled receptor A3 Homo sapiens (Human) PR
Q7L1W4 LRRC8D Volume-regulated anion channel subunit LRRC8D Homo sapiens (Human) PR
Q96FE5 LINGO1 Leucine-rich repeat and immunoglobulin-like domain-containing nogo receptor-interacting protein 1 Homo sapiens (Human) PR
Q8TDW0 LRRC8C Volume-regulated anion channel subunit LRRC8C Homo sapiens (Human) PR
Q38SD2 LRRK1 Leucine-rich repeat serine/threonine-protein kinase 1 Homo sapiens (Human) EV
Q9D9Q0 Lrrc69 Leucine-rich repeat-containing protein 69 Mus musculus (Mouse) PR
Q8BGI7 Lrrc39 Leucine-rich repeat-containing protein 39 Mus musculus (Mouse) PR
Q7TT36 Adgra3 Adhesion G protein-coupled receptor A3 Mus musculus (Mouse) PR
P59383 Lrrn4 Leucine-rich repeat neuronal protein 4 Mus musculus (Mouse) PR
Q9D1T0 Lingo1 Leucine-rich repeat and immunoglobulin-like domain-containing nogo receptor-interacting protein 1 Mus musculus (Mouse) PR
Q8R502 Lrrc8c Volume-regulated anion channel subunit LRRC8C Mus musculus (Mouse) PR
Q80WG5 Lrrc8a Volume-regulated anion channel subunit LRRC8A Mus musculus (Mouse) PR
Q8K0S5 Rtn4rl1 Reticulon-4 receptor-like 1 Mus musculus (Mouse) PR
Q80TE7 Lrrc7 Leucine-rich repeat-containing protein 7 Mus musculus (Mouse) PR
Q5DU41 Lrrc8b Volume-regulated anion channel subunit LRRC8B Mus musculus (Mouse) PR
Q5RKR3 Islr2 Immunoglobulin superfamily containing leucine-rich repeat protein 2 Mus musculus (Mouse) PR
Q8C031 Lrrc4c Leucine-rich repeat-containing protein 4C Mus musculus (Mouse) PR
A6H694 Lrrc63 Leucine-rich repeat-containing protein 63 Mus musculus (Mouse) PR
P70587 Lrrc7 Leucine-rich repeat-containing protein 7 Rattus norvegicus (Rat) PR
Q80WD0 Rtn4rl1 Reticulon-4 receptor-like 1 Rattus norvegicus (Rat) PR
Q9TZM3 lrk-1 Leucine-rich repeat serine/threonine-protein kinase 1 Caenorhabditis elegans SS
Q9SHI4 RLP3 Receptor-like protein 3 Arabidopsis thaliana (Mouse-ear cress) SS
Q5G5E0 PIRL5 Plant intracellular Ras-group-related LRR protein 5 Arabidopsis thaliana (Mouse-ear cress) PR
B0JZ65 lrwd1 Leucine-rich repeat and WD repeat-containing protein 1 Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) PR
Q68F79 lrrc8e Volume-regulated anion channel subunit LRRC8E Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) PR
B0R160 lrwd1 Leucine-rich repeat and WD repeat-containing protein 1 Danio rerio (Zebrafish) (Brachydanio rerio) PR
Q7SXW3 lrrc40 Leucine-rich repeat-containing protein 40 Danio rerio (Zebrafish) (Brachydanio rerio) PR
10 20 30 40 50 60
MRKRIYHSFK TQQHPLLLRR PLPPKLPKLP LVKKKVRIVQ TGSAREPQEA RRKFDTEESA
70 80 90 100 110 120
LVKIDQSVSQ PQKPASVQNV CLDYEHDEPE RVVNIFPHPH GVRRLHWKVP KSAAGSMFIP
130 140 150 160 170 180
RCLSASSRVF RKTLSQIKRA RKSLKSKQDE DLTKKPFSNT LVISEELSKP LPPSYSRLIA
190 200 210 220 230 240
SRFKHSGTKF RPAPKISHYI QELPLLKDVK ETVLSPISSA SSAIPEPEWS ERPLPKTTIG
250 260 270 280 290 300
KVIQLNTGSL PPAHSLPTPA LPRKPPRQIM IENAVMTRKT ETQKPVEITL RPTRRLDPDA
310 320 330 340 350 360
HVLRGDGFKA VGATRSETIL ALTTLAIINC QIYGRNALNF KGFFLAQCPD LTSVAFQLVY
370 380 390 400 410 420
LNLSYNDLHQ FPGEVLYLQN LQVLKLRNNP IREIPSEIQQ LKYLRKFTIA FNFITSLPAG
430 440 450 460 470 480
LFCLNYLEEL DVSYNEIENI PNEIQKLRSL EKLTVDGTNI TAFPPGILKL NLVKLEFENT
490 500 510 520 530 540
FTIPPFWLEN SCNNPPRLTH ICSLFIVKNN LHKILDYDPV VVQKYLISTS DCDWCHGPKF
550 560 570 580 590 600
GEGFGIIRSC NIFGLSHVPI KFHVCSLSCY LEIRESSFVL EGFPSRRIAL NMDWVKERKV
SNVSFYL