Q4V793

PR
Gene name
Hipk4
Protein name
Homeodomain-interacting protein kinase 4
Names
Species
Rattus norvegicus (Rat)
KEGG Pathway
rno:308449
EC number
2.7.11.1: Protein-serine/threonine kinases
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

313-616 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for Q4V793

Entry ID Method Resolution Chain Position Source
AF-Q4V793-F1 Predicted AlphaFoldDB

No variants for Q4V793

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for Q4V793

No associated diseases with Q4V793

5 regional properties for Q4V793

Type Name Position InterPro Accession
domain Helicase, C-terminal 407 - 567 IPR001650
domain DEAD/DEAH box helicase domain 205 - 384 IPR011545
domain Helicase superfamily 1/2, ATP-binding domain 200 - 411 IPR014001
domain RNA helicase, DEAD-box type, Q motif 181 - 209 IPR014014
domain DDX41, DEAD-box helicase domain 192 - 397 IPR044113

Functions

Description
EC Number 2.7.11.1 Protein-serine/threonine kinases
Subcellular Localization
  • Cytoplasm
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

2 GO annotations of cellular component

Name Definition
cytoplasm The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.

6 GO annotations of molecular function

Name Definition
ATP binding Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
histone kinase activity Catalysis of the transfer of a phosphate group to a histone.
protein kinase activity Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP.
protein serine kinase activity Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate.
protein serine/threonine kinase activity Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate, and ATP + protein threonine = ADP + protein threonine phosphate.
protein tyrosine kinase activity Catalysis of the reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate.

6 GO annotations of biological process

Name Definition
histone modification The covalent alteration of one or more amino acid residues within a histone protein.
peptidyl-serine phosphorylation The phosphorylation of peptidyl-serine to form peptidyl-O-phospho-L-serine.
peptidyl-threonine phosphorylation The phosphorylation of peptidyl-threonine to form peptidyl-O-phospho-L-threonine.
protein autophosphorylation The phosphorylation by a protein of one or more of its own amino acid residues (cis-autophosphorylation), or residues on an identical protein (trans-autophosphorylation).
protein phosphorylation The process of introducing a phosphate group on to a protein.
regulation of signal transduction by p53 class mediator Any process that modulates the frequency, rate or extent of signal transduction by p53 class mediator.

10 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
Q92630 DYRK2 Dual specificity tyrosine-phosphorylation-regulated kinase 2 Homo sapiens (Human) PR
Q13627 DYRK1A Dual specificity tyrosine-phosphorylation-regulated kinase 1A Homo sapiens (Human) PR
Q9NR20 DYRK4 Dual specificity tyrosine-phosphorylation-regulated kinase 4 Homo sapiens (Human) PR
Q9H2X6 HIPK2 Homeodomain-interacting protein kinase 2 Homo sapiens (Human) EV
Q9H422 HIPK3 Homeodomain-interacting protein kinase 3 Homo sapiens (Human) SS
Q8NE63 HIPK4 Homeodomain-interacting protein kinase 4 Homo sapiens (Human) PR
Q8BI55 Dyrk4 Dual specificity tyrosine-phosphorylation-regulated kinase 4 Mus musculus (Mouse) PR
Q61214 Dyrk1a Dual specificity tyrosine-phosphorylation-regulated kinase 1A Mus musculus (Mouse) PR
Q9QZR5 Hipk2 Homeodomain-interacting protein kinase 2 Mus musculus (Mouse) SS
Q3V016 Hipk4 Homeodomain-interacting protein kinase 4 Mus musculus (Mouse) PR
10 20 30 40 50 60
MATIQSETDC YDIIEVLGKG TFGEVAKGWR RSTGEMVAIK ILKNDAYRSR IIKNELKLLR
70 80 90 100 110 120
CVRGLDPDEA HVIRFLEFFH DALKFYLVFE LLEQNLFEFQ KENNFAPLPA RHIRTVTLQV
130 140 150 160 170 180
LRALARLKEL AIIHADLKPE NIMLVDQTRC PFRVKVIDFG SASIFSEVRY VKEPYIQSRF
190 200 210 220 230 240
YRAPEILLGL PFCEKVDVWS LGCVMAELHL GWPLYPGNNE YDQVRYICET QGLPKPHLLH
250 260 270 280 290 300
AARKAHHFFK RNPHPDATNP WQLKSSADYL AETKVRPLER RKYMLKSLDQ IETVNGGGAV
310 320 330 340 350 360
NRLSFPDREA LAEHADLKSM VELIKRMLTW ESHERISPSA ALRHPFVSMQ QLRSAHEATR
370 380 390 400 410 420
YYQLSLRGCR LSLQVDGKPP PPVIANAEDG PPYYRLAEEE ETAGLGGVTG SGSFFREDKA
430 440 450 460 470 480
PGMQRAIDQL DDLSLQEARR GLWSDTRADM VSDMLAPLKV ATTSHRVPDS GPEPILAFYG
490 500 510 520 530 540
SRLTGRHKAR KAPAGSKSDS NFSNLIRLSQ ASPEDAGSCR GSGWEEGEGH TTSTEPSAIP
550 560 570 580 590 600
QREGDGPSIK DRPMDAERSG PELFDPSGCP GEWLNEPEWT LEGIRGSRAQ GLPARHPHPH
610
GPPRTTSFLQ HVGGHH