Q4V3C8

PR
Gene name
PDPK2 (PDK2, At3g10540, F13M14.18, F18K10.12)
Protein name
3-phosphoinositide-dependent protein kinase 2
Names
AtPDK2
Species
Arabidopsis thaliana (Mouse-ear cress)
KEGG Pathway
ath:AT3G10540
EC number
2.7.11.1: Protein-serine/threonine kinases
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

1-62 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

185-195 (Activation loop from InterPro)

Target domain

45-312 (Protein kinase domain)

Relief mechanism

Assay

210-218 (Activation loop from InterPro)

Target domain

45-312 (Protein kinase domain)

Relief mechanism

Assay

References

Autoinhibited structure

Activated structure

1 structures for Q4V3C8

Entry ID Method Resolution Chain Position Source
AF-Q4V3C8-F1 Predicted AlphaFoldDB

17 variants for Q4V3C8

Variant ID(s) Position Change Description Diseaes Association Provenance
ENSVATH00315356 5 D>E No 1000Genomes
ENSVATH10587937 9 D>Y No 1000Genomes
ENSVATH10587938 16 G>R No 1000Genomes
ENSVATH05804446 24 T>I No 1000Genomes
tmp_3_3290315_A_G 75 I>V No 1000Genomes
ENSVATH00315359 178 L>S No 1000Genomes
ENSVATH10587968 204 A>T No 1000Genomes
ENSVATH05804464 205 A>T No 1000Genomes
ENSVATH13893593 232 F>S No 1000Genomes
ENSVATH05804470 279 A>T No 1000Genomes
tmp_3_3291471_G_A 286 R>Q No 1000Genomes
tmp_3_3291908_G_C 374 R>P No 1000Genomes
ENSVATH05804487 401 V>M No 1000Genomes
tmp_3_3292154_G_A 425 V>I No 1000Genomes
tmp_3_3292203_A_G 441 N>S No 1000Genomes
ENSVATH05804488 442 S>Y No 1000Genomes
ENSVATH10588014 475 Q>E No 1000Genomes

No associated diseases with Q4V3C8

3 regional properties for Q4V3C8

Type Name Position InterPro Accession
domain Protein kinase domain 45 - 312 IPR000719
active_site Serine/threonine-protein kinase, active site 164 - 176 IPR008271
domain PDK1-type, PH domain 383 - 485 IPR033931

Functions

Description
EC Number 2.7.11.1 Protein-serine/threonine kinases
Subcellular Localization
  • Cytoplasm
  • Membrane ; Peripheral membrane protein
  • Membrane-associated after cell stimulation leading to its translocation
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

2 GO annotations of cellular component

Name Definition
cytoplasm The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
membrane A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it.

4 GO annotations of molecular function

Name Definition
ATP binding Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
kinase activity Catalysis of the transfer of a phosphate group, usually from ATP, to a substrate molecule.
protein serine kinase activity Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate.
protein serine/threonine kinase activity Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate, and ATP + protein threonine = ADP + protein threonine phosphate.

2 GO annotations of biological process

Name Definition
intracellular signal transduction The process in which a signal is passed on to downstream components within the cell, which become activated themselves to further propagate the signal and finally trigger a change in the function or state of the cell.
peptidyl-serine phosphorylation The phosphorylation of peptidyl-serine to form peptidyl-O-phospho-L-serine.

8 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
Q03407 PKH1 Serine/threonine-protein kinase PKH1 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) PR
Q9W0V1 Pdk1 3-phosphoinositide-dependent protein kinase 1 Drosophila melanogaster (Fruit fly) SS
O15530 PDPK1 3-phosphoinositide-dependent protein kinase 1 Homo sapiens (Human) EV
Q6A1A2 PDPK2P Putative 3-phosphoinositide-dependent protein kinase 2 Homo sapiens (Human) PR
Q9Z2A0 Pdpk1 3-phosphoinositide-dependent protein kinase 1 Mus musculus (Mouse) SS
O55173 Pdpk1 3-phosphoinositide-dependent protein kinase 1 Rattus norvegicus (Rat) SS
Q9Y1J3 pdk-1 3-phosphoinositide-dependent protein kinase 1 Caenorhabditis elegans SS
F4HPN2 IRE4 Probable serine/threonine protein kinase IRE4 Arabidopsis thaliana (Mouse-ear cress) PR
10 20 30 40 50 60
MLTMDKEFDS KLTLQGNSSS NGETISRSKS FAFKAPQENF TYHDFELGKI YGVGSYSKVV
70 80 90 100 110 120
RAKKKDNGTV YALKIMDKKF ITKENKTAYV KLERIVLDQL EHPGIVKLFF TFQDTQSLYM
130 140 150 160 170 180
ALESCEGGEL FDQITRKGRL SEDEARFYSA EVVDALEYIH NMGLIHRDIK PENLLLTLDG
190 200 210 220 230 240
HIKIADFGSV KPMQDSQITV LPNAASDDKA CTFVGTAAYV PPEVLNSSPA TFGNDLWALG
250 260 270 280 290 300
CTLYQMLSGT SPFKDASEWL IFQRIIARDI KFPNHFSEAA RDLIDRLLDT DPSRRPGAGS
310 320 330 340 350 360
EGYDSLKRHP FFKGVDWKNL RSQTPPKLAP DPASQSASPE RDGSPWNPTH VGDTSVLQND
370 380 390 400 410 420
GHNGLSESSG SITRLASIDS FDSRWQQFLE PGESVLMISA VKKLQKITSK KVQLILTNKP
430 440 450 460 470 480
RLIYVDPSKL VVKGNIIWSD NSNDLNVQVS SPSHFKICTP KKVLSFEDAK QRALQWKKAI
ETLQNR