Q4TVR5

PR
Gene name
DSTYK (RIPK5)
Protein name
Dual serine/threonine and tyrosine protein kinase
Names
Endocytic receptor 180, Macrophage mannose receptor 2, Dusty protein kinase, Dusty PK, Receptor-interacting serine/threonine-protein kinase 5
Species
Bos taurus (Bovine)
KEGG Pathway
bta:534684
EC number
2.7.12.1: Dual-specificity kinases (those acting on Ser/Thr and Tyr residues)
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

27-102 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

793-813 (Activation loop from InterPro)

Target domain

651-905 (Protein kinase domain)

Relief mechanism

Assay

References

Autoinhibited structure

Activated structure

1 structures for Q4TVR5

Entry ID Method Resolution Chain Position Source
AF-Q4TVR5-F1 Predicted AlphaFoldDB

170 variants for Q4TVR5

Variant ID(s) Position Change Description Diseaes Association Provenance
rs464676155 11 E>D No EVA
rs454183859 18 P>R No EVA
rs465963713 23 V>G No EVA
rs480533603 48 T>P No EVA
rs132878835 69 E>G No EVA
rs1117224127 80 D>E No EVA
rs459335560 90 Q>H No EVA
rs442520353 91 L>P No EVA
rs480371838 92 S>G No EVA
rs463387466 94 I>L No EVA
rs451937225 98 P>A No EVA
rs451937225 98 P>S No EVA
rs441457901 100 E>V No EVA
rs472611377 101 E>K No EVA
rs455695998 102 K>T No EVA
rs435550429 103 R>G No EVA
rs470312432 105 Q>K No EVA
rs456583307 107 M>V No EVA
rs437038498 108 V>A No EVA
rs437038498 108 V>G No EVA
rs434957518 110 C>R No EVA
rs465156631 112 P>H No EVA
rs445193182 121 C>G No EVA
rs479735932 127 L>R No EVA
rs465997880 130 L>M No EVA
rs448883792 134 V>G No EVA
rs463467477 136 V>E No EVA
rs463467477 136 V>G No EVA
rs443280553 137 L>V No EVA
rs478249636 139 T>A No EVA
rs478249636 139 T>P No EVA
rs441492524 144 G>D No EVA
rs455927631 145 E>G No EVA
rs442014578 146 N>T No EVA
rs476622149 155 T>A No EVA
rs456671267 156 Y>* No EVA
rs433243121 157 G>A No EVA
rs466420206 158 T>A No EVA
rs451541576 164 L>Q No EVA
rs434545925 167 P>H No EVA
rs449036099 173 V>G No EVA
rs435220480 175 T>P No EVA
rs449726782 187 P>R No EVA
rs477681401 192 E>Q No EVA
rs457647778 194 R>G No EVA
rs519308055 199 D>N No EVA
rs447808707 200 A>D No EVA
rs479208921 201 A>D No EVA
rs1114243979 203 V>I No EVA
rs462498354 204 L>V No EVA
rs442284527 205 A>G No EVA
rs462934209 209 V>A No EVA
rs439603970 210 T>S No EVA
rs471104299 211 M>V No EVA
rs454183737 213 H>P No EVA
rs468918069 219 V>A No EVA
rs448791141 220 D>E No EVA
rs483052520 224 A>E No EVA
rs462934164 229 L>V No EVA
rs460617106 231 P>L No EVA
rs440993956 234 D>E No EVA
rs472423504 237 S>R No EVA
rs455512626 243 F>S No EVA
rs476040902 244 L>* No EVA
rs455995024 244 L>F No EVA
rs441849322 244 L>V No EVA
rs432733050 245 P>L No EVA
rs715018585 247 I>V No EVA
rs464227568 248 T>A No EVA
rs453789273 252 H>D No EVA
rs434218467 267 I>N No EVA
rs458832277 272 S>A No EVA
rs468756290 273 F>C No EVA
rs448831964 316 L>H No EVA
rs438806212 319 C>Y No EVA
rs876048217 355 V>G No EVA
rs876572091 365 H>P No EVA
rs1116536815 367 R>C No EVA
rs800794281 461 R>Q No EVA
rs517740751 475 V>G No EVA
rs444014319 490 F>L No EVA
rs460919785 490 F>Y No EVA
rs481982892 491 V>I No EVA
rs458535522 497 C>G No EVA
rs438990347 507 V>G No EVA
rs473591316 510 H>P No EVA
rs453515674 513 S>R No EVA
rs447975417 552 T>I No EVA
rs479040039 555 S>T No EVA
rs481118753 650 K>N No EVA
rs446420861 650 K>T No EVA
rs460959270 655 Q>H No EVA
rs444676375 656 E>D No EVA
rs475999465 657 L>P No EVA
rs459284591 658 G>R No EVA
rs439041864 660 G>R No EVA
rs453202347 665 V>L No EVA
rs436312453 670 S>G No EVA
rs457360541 671 W>G No EVA
rs437825319 672 G>V No EVA
rs469130037 678 A>V No EVA
rs445793590 682 V>F No EVA
rs445793590 682 V>L No EVA
rs432260052 683 V>G No EVA
rs446463736 687 E>Q No EVA
rs481012580 688 K>* No EVA
rs461094392 691 N>H No EVA
rs450485361 692 D>A No EVA
rs482501881 693 L>V No EVA
rs459103458 694 A>P No EVA
rs438927504 698 H>L No EVA
rs436812458 712 L>R No EVA
rs464773938 715 S>Y No EVA
rs451168427 716 V>G No EVA
rs465656599 717 I>F No EVA
rs449398196 717 I>T No EVA
rs799493663 718 D>N No EVA
rs470508915 724 G>S No EVA
rs450351168 725 S>P No EVA
rs479117454 732 I>F No EVA
rs462196155 733 M>I No EVA
rs442640388 734 E>D No EVA
rs474009660 736 L>R No EVA
rs463647111 737 H>D No EVA
rs443534060 737 H>P No EVA
rs451205265 738 R>P No EVA
rs471474135 738 R>W No EVA
rs472148400 739 D>A No EVA
rs455411784 739 D>E No EVA
rs472148400 739 D>G No EVA
rs435820174 740 L>I No EVA
rs470379891 740 L>P No EVA
rs450174030 744 L>Q No EVA
rs450174030 744 L>R No EVA
rs478967281 746 A>S No EVA
rs454646045 790 A>T No EVA
rs437794103 804 M>I No EVA
rs463474744 846 K>E No EVA
rs443217511 846 K>N No EVA
rs451166517 859 H>Y No EVA
rs440903599 863 N>I No EVA
rs472233167 864 V>L No EVA
rs797444718 872 R>C No EVA
rs445782176 872 R>L No EVA
rs477103043 874 P>T No EVA
rs460706761 875 V>L No EVA
rs440541521 880 C>G No EVA
rs481821339 883 L>V No EVA
rs444432444 887 C>F No EVA
rs461469052 887 C>R No EVA
rs452363149 888 W>* No EVA
rs475588613 888 W>R No EVA
rs438901133 889 D>E No EVA
rs473488060 890 G>A No EVA
rs468487369 891 D>G No EVA
rs433767931 891 D>Y No EVA
rs454809129 893 S>P No EVA
rs468983514 894 Q>P No EVA
rs466681794 895 R>S No EVA
rs477146771 895 R>T No EVA
rs461507878 897 L>H No EVA
rs481649153 897 L>I No EVA
rs481649153 897 L>V No EVA
rs444722567 900 I>N No EVA
rs458787769 903 P>A No EVA
rs458787769 903 P>S No EVA
rs438738986 910 D>E No EVA
rs137020569 913 C>S No EVA
rs473543882 913 C>W No EVA
rs453373691 915 S>* No EVA

No associated diseases with Q4TVR5

4 regional properties for Q4TVR5

Type Name Position InterPro Accession
domain Protein kinase domain 651 - 905 IPR000719
domain Serine-threonine/tyrosine-protein kinase, catalytic domain 653 - 898 IPR001245
active_site Serine/threonine-protein kinase, active site 772 - 784 IPR008271
binding_site Protein kinase, ATP binding site 657 - 680 IPR017441

Functions

Description
EC Number 2.7.12.1 Dual-specificity kinases (those acting on Ser/Thr and Tyr residues)
Subcellular Localization
  • Cytoplasm
  • Cell membrane
  • Apical cell membrane
  • Basolateral cell membrane
  • Cell junction
  • Detected in basolateral and apical membranes of all tubular epithelia
  • Detected at apical cell-cell junctions
  • Colocalized with FGF receptors to the cell membrane
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

4 GO annotations of cellular component

Name Definition
anchoring junction A cell junction that mechanically attaches a cell (and its cytoskeleton) to neighboring cells or to the extracellular matrix.
apical plasma membrane The region of the plasma membrane located at the apical end of the cell.
basolateral plasma membrane The region of the plasma membrane that includes the basal end and sides of the cell. Often used in reference to animal polarized epithelial membranes, where the basal membrane is the part attached to the extracellular matrix, or in plant cells, where the basal membrane is defined with respect to the zygotic axis.
cytoplasm The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.

5 GO annotations of molecular function

Name Definition
ATP binding Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
protein serine kinase activity Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate.
protein serine/threonine kinase activity Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate, and ATP + protein threonine = ADP + protein threonine phosphate.
protein serine/threonine/tyrosine kinase activity Catalysis of the reactions: ATP + a protein serine = ADP + protein serine phosphate; ATP + a protein threonine = ADP + protein threonine phosphate; and ATP + a protein tyrosine = ADP + protein tyrosine phosphate.
protein tyrosine kinase activity Catalysis of the reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate.

5 GO annotations of biological process

Name Definition
cellular response to fibroblast growth factor stimulus Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an fibroblast growth factor stimulus.
negative regulation of apoptotic process Any process that stops, prevents, or reduces the frequency, rate or extent of cell death by apoptotic process.
positive regulation of ERK1 and ERK2 cascade Any process that activates or increases the frequency, rate or extent of signal transduction mediated by the ERK1 and ERK2 cascade.
positive regulation of fibroblast growth factor receptor signaling pathway Any process that activates or increases the frequency, rate or extent of fibroblast growth factor receptor signaling pathway activity.
positive regulation of kinase activity Any process that activates or increases the frequency, rate or extent of kinase activity, the catalysis of the transfer of a phosphate group, usually from ATP, to a substrate molecule.

37 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
A2VDU3 MAP3K7 Mitogen-activated protein kinase kinase kinase 7 Bos taurus (Bovine) SS
Q3SZJ2 RIPK2 Receptor-interacting serine/threonine-protein kinase 2 Bos taurus (Bovine) PR
Q6XUX0 DSTYK Dual serine/threonine and tyrosine protein kinase Gallus gallus (Chicken) PR
P83104 Takl1 Putative mitogen-activated protein kinase kinase kinase 7-like Drosophila melanogaster (Fruit fly) PR
Q95UN8 slpr Mitogen-activated protein kinase kinase kinase Drosophila melanogaster (Fruit fly) EV
O43353 RIPK2 Receptor-interacting serine/threonine-protein kinase 2 Homo sapiens (Human) PR
Q02779 MAP3K10 Mitogen-activated protein kinase kinase kinase 10 Homo sapiens (Human) SS
Q8NB16 MLKL Mixed lineage kinase domain-like protein Homo sapiens (Human) EV
Q16584 MAP3K11 Mitogen-activated protein kinase kinase kinase 11 Homo sapiens (Human) EV
P00540 MOS Proto-oncogene serine/threonine-protein kinase mos Homo sapiens (Human) PR
Q5TCX8 MAP3K21 Mitogen-activated protein kinase kinase kinase 21 Homo sapiens (Human) PR
O43318 MAP3K7 Mitogen-activated protein kinase kinase kinase 7 Homo sapiens (Human) SS
Q9NYL2 MAP3K20 Mitogen-activated protein kinase kinase kinase 20 Homo sapiens (Human) PR
Q38SD2 LRRK1 Leucine-rich repeat serine/threonine-protein kinase 1 Homo sapiens (Human) EV
P80192 MAP3K9 Mitogen-activated protein kinase kinase kinase 9 Homo sapiens (Human) SS
Q6XUX3 DSTYK Dual serine/threonine and tyrosine protein kinase Homo sapiens (Human) PR
Q80XI6 Map3k11 Mitogen-activated protein kinase kinase kinase 11 Mus musculus (Mouse) PR
Q8VDG6 Map3k21 Mitogen-activated protein kinase kinase kinase 21 Mus musculus (Mouse) PR
P58801 Ripk2 Receptor-interacting serine/threonine-protein kinase 2 Mus musculus (Mouse) PR
Q62073 Map3k7 Mitogen-activated protein kinase kinase kinase 7 Mus musculus (Mouse) EV
Q3U1V8 Map3k9 Mitogen-activated protein kinase kinase kinase 9 Mus musculus (Mouse) SS
Q9D2Y4 Mlkl Mixed lineage kinase domain-like protein Mus musculus (Mouse) SS
Q9ESL4 Map3k20 Mitogen-activated protein kinase kinase kinase 20 Mus musculus (Mouse) PR
P00536 Mos Proto-oncogene serine/threonine-protein kinase mos Mus musculus (Mouse) PR
Q66L42 Map3k10 Mitogen-activated protein kinase kinase kinase 10 Mus musculus (Mouse) SS
P0C8E4 Map3k7 Mitogen-activated protein kinase kinase kinase 7 Rattus norvegicus (Rat) SS
Q66HA1 Map3k11 Mitogen-activated protein kinase kinase kinase 11 Rattus norvegicus (Rat) PR
D3ZG83 Map3k10 Mitogen-activated protein kinase kinase kinase 10 Rattus norvegicus (Rat) SS
P00539 Mos Proto-oncogene serine/threonine-protein kinase mos Rattus norvegicus (Rat) PR
Q9TZM3 lrk-1 Leucine-rich repeat serine/threonine-protein kinase 1 Caenorhabditis elegans SS
Q9FPR3 EDR1 Serine/threonine-protein kinase EDR1 Arabidopsis thaliana (Mouse-ear cress) PR
Q2MHE4 HT1 Serine/threonine/tyrosine-protein kinase HT1 Arabidopsis thaliana (Mouse-ear cress) PR
O22558 STY8 Serine/threonine-protein kinase STY8 Arabidopsis thaliana (Mouse-ear cress) PR
Q8RWL6 STY17 Serine/threonine-protein kinase STY17 Arabidopsis thaliana (Mouse-ear cress) PR
F4JTP5 STY46 Serine/threonine-protein kinase STY46 Arabidopsis thaliana (Mouse-ear cress) PR
Q05609 CTR1 Serine/threonine-protein kinase CTR1 Arabidopsis thaliana (Mouse-ear cress) PR
Q67E00 dstyk Dual serine/threonine and tyrosine protein kinase Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) PR
10 20 30 40 50 60
MEGDGVPWGS EPESGPGPGG GGVIRELCRG FGRYRRYLGR LRQNLRDTQK FFRDLRGSQP
70 80 90 100 110 120
RGCPSSPAEG GEAGRGPAGD VAATGLPAGQ LSCISFPPKE EKRLQQMVDC LPCILILGQD
130 140 150 160 170 180
CSVKCQLLNL LLGVQVLPTN KLGGENCKLR RLRFTYGTQT RVSLALPDRY ELVHTLAAHQ
190 200 210 220 230 240
GTWETVPEED LEAREDSEDA ARVLAELEVT MRHALLQEVD IVVAPCQGLR PTVDVLSDLV
250 260 270 280 290 300
NDFLPVITYA LHKDELSERD EQELQEIRKY FSFPIFFFKV PKLGSEIIDS STERMESERS
310 320 330 340 350 360
PLHRQLTDLG YLSSSLCNCG APGQDTKAQS MLVEQSEKLR HLNTFSHQVL QTRLVDAAKA
370 380 390 400 410 420
LNLVHCRCLD IFINQAFDMQ RDLQITPKRL EYTRKKENEL YESLMNIANR KQEEMKDMIV
430 440 450 460 470 480
ETLNTMKEEL LDDAANMEFK DVIVPENGEP VGTREIKCCI RQIQELIISR LNQAVANKLI
490 500 510 520 530 540
SSVDYLRESF VGTLERCLQS LEKSQDVSVH ITSNYLKQIL NAAYHVEVTF HSGSSVTRML
550 560 570 580 590 600
WEQIKQIIQR ITWVSPPAIT LEWKRKVAQE AIESLSASKL AKSICSQFRT RLNSSHEAFA
610 620 630 640 650 660
ASLRQLEAGH SGRLEKTEDL WLKVRKDHAP RLARLSLESR SLQDVLLHRK PKLGQELGRG
670 680 690 700 710 720
QYGVVYLCDS WGGHFPCALK SVVPPDEKHW NDLALEFHYM RSLPKHERLV DLHGSVIDYS
730 740 750 760 770 780
YGGGSSIAVL LIMERLHRDL YTGLKAGLAL ETRLQIALDV VEGIRFLHSQ GLVHRDVKLK
790 800 810 820 830 840
NVLLDKQNRA KITDLGFCKP EAMMSGSIVG TPIHMAPELF TGKYDNSVDV YAFGILFWYI
850 860 870 880 890 900
CSGSVKLPEA FERCASKDHL WNNVRRGARP ERLPVFDEEC WQLMEACWDG DPSQRPLLGI
910 920
VQPMLQGIMD RLCKSHSERP NRGLDDST