Q4R574

SS
Gene name
CHMP3 (VPS24)
Protein name
Charged multivesicular body protein 3
Names
Chromatin-modifying protein 3, Vacuolar protein sorting-associated protein 24
Species
Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey)
KEGG Pathway
EC number
Protein Class

Descriptions

CHMP3 is a core component of the endosomal sorting required for transport complex III (ESCRT-III), which is involved in multivesicular bodies (MVBs) formation and sorting of endosomal cargo proteins into MVBs. The autoinhibition of CHMP3 is regulated through the intramolecular interactions between N-terminal basic domain and C-terminal acidic domain. The binding of the endosome-associated ubiquitin isopeptidase (AMSH) to the acidic half relieves the autoinhibition of CHMP3. CHMP3 can be induced to block HIV-1 release (Anti-HIV-1 budding activity) by coexpressing AMSH or by truncating the acidic domain.

Autoinhibitory domains (AIDs)

151-222 (C-terminal autoinhibitory region) SS

Target domain

1-150 (N-terminal domain)

Relief mechanism

Partner binding

Assay

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for Q4R574

Entry ID Method Resolution Chain Position Source
AF-Q4R574-F1 Predicted AlphaFoldDB

No variants for Q4R574

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for Q4R574

No associated diseases with Q4R574

No regional properties for Q4R574

Type Name Position InterPro Accession
No domain, repeats, and functional sites for Q4R574

Functions

Description
EC Number
Subcellular Localization
  • Cytoplasm, cytosol
  • Membrane ; Lipid-anchor
  • Endosome
  • Late endosome membrane
  • Localizes to the midbody of dividing cells
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

2 GO annotations of cellular component

Name Definition
cytosol The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
late endosome membrane The lipid bilayer surrounding a late endosome.

No GO annotations of molecular function

Name Definition
No GO annotations for molecular function

4 GO annotations of biological process

Name Definition
cell cycle The progression of biochemical and morphological phases and events that occur in a cell during successive cell replication or nuclear replication events. Canonically, the cell cycle comprises the replication and segregation of genetic material followed by the division of the cell, but in endocycles or syncytial cells nuclear replication or nuclear division may not be followed by cell division.
cell division The process resulting in division and partitioning of components of a cell to form more cells; may or may not be accompanied by the physical separation of a cell into distinct, individually membrane-bounded daughter cells.
protein transport The directed movement of proteins into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.
vacuolar transport The directed movement of substances into, out of or within a vacuole.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MGLFGKTQEK PPKELVNEWS LKIRKEMRVV DRQIRDIQRE EEKVKRSVKD AAKKGQKDVC
70 80 90 100 110 120
VVLAKEMIRS RKAVSKLYAS KAHMNSVLMG MKNQLAVLRV AGSLQKSTEV MKAMQSLVKI
130 140 150 160 170 180
PEIRATMREL SKEMMKAGII EEMLEDTFES MDDQEEMEEA AEMEIDRILF EITAGALGKA
190 200 210 220
PSKVTDALPE PEPSGAMAAS DEEEEEEEAL EAMQSRLATL RS