AiPD: Autoinhibited Protein Database

Gene name	ADOMETC (LMJF_30_3110)
Protein name	S-adenosylmethionine decarboxylase proenzyme
Names	EC 4.1.1.50
Species	Leishmania major
KEGG Pathway	lma:LMJF_30_3110
EC number	4.1.1.-: Carboxy-lyases
Protein Class

31-34 (N-terminal autoinhibitory sequence) SS

Target domain	90-374 (S-adenosylmethionine decarboxylase alpha chain, specifically, 202-247 active site helices/strands)
Relief mechanism	Partner binding
Assay

31-34 (N-terminal autoinhibitory sequence)

90-374 (S-adenosylmethionine decarboxylase alpha chain, specifically, 202-247 active site helices/strands)

Partner binding (Binding of catalytically dead paralog)

No accessory elements

Entry ID	Method	Resolution	Chain	Position	Source
AF-Q4Q6X9-F1	Predicted				AlphaFoldDB

Variant ID(s)	Position	Change	Description	Diseaes Association	Provenance
No variants for Q4Q6X9

Type	Name	Position	InterPro Accession
conserved_site	S-adenosylmethionine decarboxylase, conserved site	84 - 94	IPR018166

		Description
EC Number	4.1.1.-	Carboxy-lyases
Subcellular Localization
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category	No pathway information available

Name	Definition
cytosol	The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.

Name	Definition
adenosylmethionine decarboxylase activity	Catalysis of the reaction

Name	Definition
spermidine biosynthetic process	The chemical reactions and pathways resulting in the formation of spermidine, N-(3-aminopropyl)-1,4-diaminobutane.
spermine biosynthetic process	The chemical reactions and pathways resulting in the formation of spermine, a polybasic amine found in human sperm, in ribosomes and in some viruses and involved in nucleic acid packaging.

UniProt AC	Gene Name	Protein Name	Species	Evidence Code
No homologous proteins