Q4KM47

PR
Gene name
Cdk10
Protein name
Cyclin-dependent kinase 10
Names
Cell division protein kinase 10
Species
Rattus norvegicus (Rat)
KEGG Pathway
rno:361434
EC number
2.7.11.22: Protein-serine/threonine kinases
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

299-358 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

178-201 (Activation loop from InterPro)

Target domain

29-337 (Catalytic domain of the Serine/Threonine Kinase, Cyclin-Dependent protein Kinase 10)

Relief mechanism

Assay

References

Autoinhibited structure

Activated structure

1 structures for Q4KM47

Entry ID Method Resolution Chain Position Source
AF-Q4KM47-F1 Predicted AlphaFoldDB

No variants for Q4KM47

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for Q4KM47

No associated diseases with Q4KM47

4 regional properties for Q4KM47

Type Name Position InterPro Accession
domain Protein kinase domain 37 - 321 IPR000719
active_site Serine/threonine-protein kinase, active site 157 - 169 IPR008271
binding_site Protein kinase, ATP binding site 43 - 66 IPR017441
domain Cyclin-dependent kinase 10, catalytic domain 29 - 337 IPR044093

Functions

Description
EC Number 2.7.11.22 Protein-serine/threonine kinases
Subcellular Localization
  • Cytoplasm, cytoskeleton, cilium basal body
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

3 GO annotations of cellular component

Name Definition
ciliary basal body A membrane-tethered, short cylindrical array of microtubules and associated proteins found at the base of a eukaryotic cilium (also called flagellum) that is similar in structure to a centriole and derives from it. The cilium basal body is the site of assembly and remodelling of the cilium and serves as a nucleation site for axoneme growth. As well as anchoring the cilium, it is thought to provide a selective gateway regulating the entry of ciliary proteins and vesicles by intraflagellar transport.
cytoplasm The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.

5 GO annotations of molecular function

Name Definition
ATP binding Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
cyclin-dependent protein kinase activity Cyclin-dependent catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP.
cyclin-dependent protein serine/threonine kinase activity Cyclin-dependent catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate, and ATP + protein threonine = ADP + protein threonine phosphate.
protein serine kinase activity Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate.
protein serine/threonine kinase activity Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate, and ATP + protein threonine = ADP + protein threonine phosphate.

8 GO annotations of biological process

Name Definition
cell projection organization A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a prolongation or process extending from a cell, e.g. a flagellum or axon.
negative regulation of cilium assembly Any process that stops, prevents or reduces the frequency, rate or extent of cilium assembly.
peptidyl-threonine phosphorylation The phosphorylation of peptidyl-threonine to form peptidyl-O-phospho-L-threonine.
positive regulation of MAPK cascade Any process that activates or increases the frequency, rate or extent of signal transduction mediated by the MAPK cascade.
protein phosphorylation The process of introducing a phosphate group on to a protein.
regulation of actin cytoskeleton organization Any process that modulates the frequency, rate or extent of the formation, arrangement of constituent parts, or disassembly of cytoskeletal structures comprising actin filaments and their associated proteins.
regulation of cell cycle Any process that modulates the rate or extent of progression through the cell cycle.
regulation of mitotic cell cycle Any process that modulates the rate or extent of progress through the mitotic cell cycle.

12 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
Q2TBL8 CDK10 Cyclin-dependent kinase 10 Bos taurus (Bovine) PR
P21127 CDK11B Cyclin-dependent kinase 11B Homo sapiens (Human) PR
Q15131 CDK10 Cyclin-dependent kinase 10 Homo sapiens (Human) PR
Q3UMM4 Cdk10 Cyclin-dependent kinase 10 Mus musculus (Mouse) PR
Q641Z4 Cdk9 Cyclin-dependent kinase 9 Rattus norvegicus (Rat) PR
Q66HE7 Cdkl1 Cyclin-dependent kinase-like 1 Rattus norvegicus (Rat) PR
Q5XIT0 Cdkl2 Cyclin-dependent kinase-like 2 Rattus norvegicus (Rat) PR
Q4KM34 Cdk20 Cyclin-dependent kinase 20 Rattus norvegicus (Rat) PR
O35831 Cdk17 Cyclin-dependent kinase 17 Rattus norvegicus (Rat) PR
Q9JM01 Cdkl3 Cyclin-dependent kinase-like 3 Rattus norvegicus (Rat) PR
Q09437 cdk-11.1 Cyclin-dependent kinase 11.1 Caenorhabditis elegans PR
Q9FGW5 CDKG1 Cyclin-dependent kinase G1 Arabidopsis thaliana (Mouse-ear cress) PR
10 20 30 40 50 60
MSQCQIWVRH HLCCSFQIPT LAASLFQLGR CRSVKEFEKL NRIGEGTYGI VYRARDTQTD
70 80 90 100 110 120
EIVALKKVRM DKEKDGIPIS SLREITLLLR LRHPNIVELK EVVVGNHLES IFLVMGYCEQ
130 140 150 160 170 180
DLASLLENMP TPFSEAQVKC ILLQVLRGLQ YLHRSFIIHR DLKVSNLLMT DKGCVKTADF
190 200 210 220 230 240
GLARAYGVPV KPMTPKVVTL WYRAPELLLG TTTQTTSIDM WAVGCILAEL LAHKPLLPGT
250 260 270 280 290 300
SEIHQIDLIV QLLGTPSENI WPGFSKLPLA GQYSLRKQPY NNLKHKFPWL SEAGLRLLNF
310 320 330 340 350
LFMYDPKKRA TAGDCLESSY FKEKPLPCEP ELMPTFPHHR NKRAAPAATE GQSKRCRP