Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

144-168 (Activation loop from InterPro)

Target domain

4-288 (Protein kinase domain)

Relief mechanism

Assay

Autoinhibited structure

Activated structure

1 structures for Q4KM34

Entry ID Method Resolution Chain Position Source
AF-Q4KM34-F1 Predicted AlphaFoldDB

No variants for Q4KM34

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for Q4KM34

No associated diseases with Q4KM34

4 regional properties for Q4KM34

Type Name Position InterPro Accession
domain Protein kinase domain 4 - 288 IPR000719
active_site Serine/threonine-protein kinase, active site 123 - 135 IPR008271
binding_site Protein kinase, ATP binding site 10 - 33 IPR017441
domain Cyclin-dependent kinase 20-like, catalytic domain 3 - 289 IPR048002

Functions

Description
EC Number 2.7.11.22 Protein-serine/threonine kinases
Subcellular Localization
  • Nucleus
  • Cytoplasm
  • Cell projection, cilium
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

3 GO annotations of cellular component

Name Definition
cilium A specialized eukaryotic organelle that consists of a filiform extrusion of the cell surface and of some cytoplasmic parts. Each cilium is largely bounded by an extrusion of the cytoplasmic (plasma) membrane, and contains a regular longitudinal array of microtubules, anchored to a basal body.
cytoplasm The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.

3 GO annotations of molecular function

Name Definition
ATP binding Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
cyclin-dependent protein serine/threonine kinase activity Cyclin-dependent catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate, and ATP + protein threonine = ADP + protein threonine phosphate.
protein serine kinase activity Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate.

13 GO annotations of biological process

Name Definition
cell cycle The progression of biochemical and morphological phases and events that occur in a cell during successive cell replication or nuclear replication events. Canonically, the cell cycle comprises the replication and segregation of genetic material followed by the division of the cell, but in endocycles or syncytial cells nuclear replication or nuclear division may not be followed by cell division.
cell division The process resulting in division and partitioning of components of a cell to form more cells; may or may not be accompanied by the physical separation of a cell into distinct, individually membrane-bounded daughter cells.
embryonic brain development The process occurring during the embryonic phase whose specific outcome is the progression of the brain over time, from its formation to the mature structure.
embryonic camera-type eye development The process occurring during the embryonic phase whose specific outcome is the progression of the eye over time, from its formation to the mature structure.
embryonic skeletal system development The process, occurring during the embryonic phase, whose specific outcome is the progression of the skeleton over time, from its formation to the mature structure.
floor plate formation The formation of a ventral region of glial cells in the neural tube that provides inductive signals for the specification of neuronal cell types. The floor plate is evident at the ventral midline by the neural fold stage.
negative regulation of smoothened signaling pathway involved in dorsal/ventral neural tube patterning Any process that stops, prevents or reduces the frequency, rate or extent of smoothened signaling pathway involved in dorsal/ventral neural tube patterning.
neural tube closure The last step in the formation of the neural tube, where the paired neural folds are brought together and fuse at the dorsal midline.
protein localization to cilium A process in which a protein is transported to, or maintained in, a location within a cilium.
protein phosphorylation The process of introducing a phosphate group on to a protein.
regulation of protein maturation Any process that modulates the frequency, rate or extent of protein maturation.
regulation of smoothened signaling pathway involved in dorsal/ventral neural tube patterning Any process that modulates the frequency, rate or extent of smoothened signaling pathway involved in dorsal/ventral neural tube patterning.
roof of mouth development The biological process whose specific outcome is the progression of the roof of the mouth from an initial condition to its mature state. This process begins with the formation of the structure and ends with the mature structure. The roof of the mouth is the partition that separates the nasal and oral cavities.

13 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
Q8IZL9 CDK20 Cyclin-dependent kinase 20 Homo sapiens (Human) PR
Q9JHU3 Cdk20 Cyclin-dependent kinase 20 Mus musculus (Mouse) PR
Q4KM47 Cdk10 Cyclin-dependent kinase 10 Rattus norvegicus (Rat) PR
Q641Z4 Cdk9 Cyclin-dependent kinase 9 Rattus norvegicus (Rat) PR
Q66HE7 Cdkl1 Cyclin-dependent kinase-like 1 Rattus norvegicus (Rat) PR
Q5XIT0 Cdkl2 Cyclin-dependent kinase-like 2 Rattus norvegicus (Rat) PR
O35831 Cdk17 Cyclin-dependent kinase 17 Rattus norvegicus (Rat) PR
Q9JM01 Cdkl3 Cyclin-dependent kinase-like 3 Rattus norvegicus (Rat) PR
P29620 CDKD-1 Cyclin-dependent kinase D-1 Oryza sativa subsp japonica (Rice) PR
Q5Z754 CDKF-1 Cyclin-dependent kinase F-1 Oryza sativa subsp japonica (Rice) PR
Q9LMT0 CDKD-3 Cyclin-dependent kinase D-3 Arabidopsis thaliana (Mouse-ear cress) PR
Q9C9U2 CDKD-1 Cyclin-dependent kinase D-1 Arabidopsis thaliana (Mouse-ear cress) PR
A8WIP6 cdk20 Cyclin-dependent kinase 20 Danio rerio (Zebrafish) (Brachydanio rerio) PR
10 20 30 40 50 60
MDQYCILGRI GEGAHGIVFK AKHVETGEIV ALKKVALRRL EDGIPNQALR EIKALQEIED
70 80 90 100 110 120
SQYVVQLKAV FPHGAGFVLA FEFMLSDLAE VVRHAQRPLA PAQVKSYLQM LLKGVAFCHA
130 140 150 160 170 180
NNIVHRDLKP ANLLISASGQ LKIADFGLAR VFSPDGGRLY THQVATRWYR APELLYGARQ
190 200 210 220 230 240
YDQGVDLWAV GCIMGELLNG SPLFPGENDI EQLCCVLRIL GTPSPRVWPE ITELPDYNKI
250 260 270 280 290 300
SFKEQAPVPL EEVLPDASHQ ALDLLGQFLL YPPRQRIAAS QALLHQYFFT APLPAHPSEL
310 320 330 340
PIPQRPGGPT PKAHPGPPHV HDFHVDRPLE ESLLNPELIR PFIPEG