Q4KM34
Gene name |
Cdk20 (Ccrk) |
Protein name |
Cyclin-dependent kinase 20 |
Names |
Cell cycle-related kinase, Cell division protein kinase 20 |
Species |
Rattus norvegicus (Rat) |
KEGG Pathway |
rno:364666 |
EC number |
2.7.11.22: Protein-serine/threonine kinases |
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
144-168 (Activation loop from InterPro)
Target domain |
4-288 (Protein kinase domain) |
Relief mechanism |
|
Assay |
|
Autoinhibited structure
Activated structure
1 structures for Q4KM34
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-Q4KM34-F1 | Predicted | AlphaFoldDB |
No variants for Q4KM34
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| No variants for Q4KM34 | |||||
No associated diseases with Q4KM34
4 regional properties for Q4KM34
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| domain | Protein kinase domain | 4 - 288 | IPR000719 |
| active_site | Serine/threonine-protein kinase, active site | 123 - 135 | IPR008271 |
| binding_site | Protein kinase, ATP binding site | 10 - 33 | IPR017441 |
| domain | Cyclin-dependent kinase 20-like, catalytic domain | 3 - 289 | IPR048002 |
Functions
| Description | ||
|---|---|---|
| EC Number | 2.7.11.22 | Protein-serine/threonine kinases |
| Subcellular Localization |
|
|
| PANTHER Family | ||
| PANTHER Subfamily | ||
| PANTHER Protein Class | ||
| PANTHER Pathway Category | No pathway information available | |
3 GO annotations of cellular component
| Name | Definition |
|---|---|
| cilium | A specialized eukaryotic organelle that consists of a filiform extrusion of the cell surface and of some cytoplasmic parts. Each cilium is largely bounded by an extrusion of the cytoplasmic (plasma) membrane, and contains a regular longitudinal array of microtubules, anchored to a basal body. |
| cytoplasm | The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. |
| nucleus | A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. |
3 GO annotations of molecular function
| Name | Definition |
|---|---|
| ATP binding | Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. |
| cyclin-dependent protein serine/threonine kinase activity | Cyclin-dependent catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate, and ATP + protein threonine = ADP + protein threonine phosphate. |
| protein serine kinase activity | Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate. |
13 GO annotations of biological process
| Name | Definition |
|---|---|
| cell cycle | The progression of biochemical and morphological phases and events that occur in a cell during successive cell replication or nuclear replication events. Canonically, the cell cycle comprises the replication and segregation of genetic material followed by the division of the cell, but in endocycles or syncytial cells nuclear replication or nuclear division may not be followed by cell division. |
| cell division | The process resulting in division and partitioning of components of a cell to form more cells; may or may not be accompanied by the physical separation of a cell into distinct, individually membrane-bounded daughter cells. |
| embryonic brain development | The process occurring during the embryonic phase whose specific outcome is the progression of the brain over time, from its formation to the mature structure. |
| embryonic camera-type eye development | The process occurring during the embryonic phase whose specific outcome is the progression of the eye over time, from its formation to the mature structure. |
| embryonic skeletal system development | The process, occurring during the embryonic phase, whose specific outcome is the progression of the skeleton over time, from its formation to the mature structure. |
| floor plate formation | The formation of a ventral region of glial cells in the neural tube that provides inductive signals for the specification of neuronal cell types. The floor plate is evident at the ventral midline by the neural fold stage. |
| negative regulation of smoothened signaling pathway involved in dorsal/ventral neural tube patterning | Any process that stops, prevents or reduces the frequency, rate or extent of smoothened signaling pathway involved in dorsal/ventral neural tube patterning. |
| neural tube closure | The last step in the formation of the neural tube, where the paired neural folds are brought together and fuse at the dorsal midline. |
| protein localization to cilium | A process in which a protein is transported to, or maintained in, a location within a cilium. |
| protein phosphorylation | The process of introducing a phosphate group on to a protein. |
| regulation of protein maturation | Any process that modulates the frequency, rate or extent of protein maturation. |
| regulation of smoothened signaling pathway involved in dorsal/ventral neural tube patterning | Any process that modulates the frequency, rate or extent of smoothened signaling pathway involved in dorsal/ventral neural tube patterning. |
| roof of mouth development | The biological process whose specific outcome is the progression of the roof of the mouth from an initial condition to its mature state. This process begins with the formation of the structure and ends with the mature structure. The roof of the mouth is the partition that separates the nasal and oral cavities. |
13 homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| Q8IZL9 | CDK20 | Cyclin-dependent kinase 20 | Homo sapiens (Human) | PR |
| Q9JHU3 | Cdk20 | Cyclin-dependent kinase 20 | Mus musculus (Mouse) | PR |
| Q4KM47 | Cdk10 | Cyclin-dependent kinase 10 | Rattus norvegicus (Rat) | PR |
| Q641Z4 | Cdk9 | Cyclin-dependent kinase 9 | Rattus norvegicus (Rat) | PR |
| Q66HE7 | Cdkl1 | Cyclin-dependent kinase-like 1 | Rattus norvegicus (Rat) | PR |
| Q5XIT0 | Cdkl2 | Cyclin-dependent kinase-like 2 | Rattus norvegicus (Rat) | PR |
| O35831 | Cdk17 | Cyclin-dependent kinase 17 | Rattus norvegicus (Rat) | PR |
| Q9JM01 | Cdkl3 | Cyclin-dependent kinase-like 3 | Rattus norvegicus (Rat) | PR |
| P29620 | CDKD-1 | Cyclin-dependent kinase D-1 | Oryza sativa subsp japonica (Rice) | PR |
| Q5Z754 | CDKF-1 | Cyclin-dependent kinase F-1 | Oryza sativa subsp japonica (Rice) | PR |
| Q9LMT0 | CDKD-3 | Cyclin-dependent kinase D-3 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q9C9U2 | CDKD-1 | Cyclin-dependent kinase D-1 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| A8WIP6 | cdk20 | Cyclin-dependent kinase 20 | Danio rerio (Zebrafish) (Brachydanio rerio) | PR |
| 10 | 20 | 30 | 40 | 50 | 60 |
| MDQYCILGRI | GEGAHGIVFK | AKHVETGEIV | ALKKVALRRL | EDGIPNQALR | EIKALQEIED |
| 70 | 80 | 90 | 100 | 110 | 120 |
| SQYVVQLKAV | FPHGAGFVLA | FEFMLSDLAE | VVRHAQRPLA | PAQVKSYLQM | LLKGVAFCHA |
| 130 | 140 | 150 | 160 | 170 | 180 |
| NNIVHRDLKP | ANLLISASGQ | LKIADFGLAR | VFSPDGGRLY | THQVATRWYR | APELLYGARQ |
| 190 | 200 | 210 | 220 | 230 | 240 |
| YDQGVDLWAV | GCIMGELLNG | SPLFPGENDI | EQLCCVLRIL | GTPSPRVWPE | ITELPDYNKI |
| 250 | 260 | 270 | 280 | 290 | 300 |
| SFKEQAPVPL | EEVLPDASHQ | ALDLLGQFLL | YPPRQRIAAS | QALLHQYFFT | APLPAHPSEL |
| 310 | 320 | 330 | 340 | ||
| PIPQRPGGPT | PKAHPGPPHV | HDFHVDRPLE | ESLLNPELIR | PFIPEG |