AiPD: Autoinhibited Protein Database

Gene name	Ddx49
Protein name	Probable ATP-dependent RNA helicase DDX49
Names	DEAD box protein 49
Species	Mus musculus (Mouse)
KEGG Pathway	mmu:234374
EC number	3.6.4.13: Acting on ATP; involved in cellular and subcellular movement
Protein Class

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

351-480 (Predicted disordered autoinhibitory region) PR

351-480 (Predicted disordered autoinhibitory region)

cis-regPred

No accessory elements

Entry ID	Method	Resolution	Chain	Position	Source
AF-Q4FZF3-F1	Predicted				AlphaFoldDB

Variant ID(s)	Position	Change	Diseaes Association	Provenance
rs3388991866	9	L>*	No	EVA
rs3388939771	24	Q>H	No	EVA
rs3388984466	26	T>A	No	EVA
rs3388939737	40	R>Q	No	EVA
rs3388991617	48	T>K	No	EVA
rs3388963179	55	A>V	No	EVA
rs3399231990	77	T>S	No	EVA
rs3388991668	89	Q>*	No	EVA
rs3388988198	99	L>V	No	EVA
rs3388975278	115	L>Q	No	EVA
rs3399309685	132	A>V	No	EVA
rs49343197	135	L>V	No	EVA
rs3388957114	148	F>I	No	EVA
rs3388984678	160	Q>*	No	EVA
rs248383026	176	V>I	No	EVA
rs3388988236	195	E>K	No	EVA
rs3388988277	206	F>V	No	EVA
rs3412117927	225	L>S	No	EVA
rs3388969275	235	L>P	No	EVA
rs3399222083	243	Q>K	No	EVA
rs3399209494	244	D>E	No	EVA
rs3388988084	346	G>E	No	EVA
rs260494366	452	R>L	No	EVA
rs3388963105	459	T>I	No	EVA

Type	Name	Position	InterPro Accession
conserved_site	ATP-dependent RNA helicase DEAD-box, conserved site	150 - 158	IPR000629
domain	Helicase, C-terminal	218 - 382	IPR001650
domain	DEAD/DEAH box helicase domain	26 - 196	IPR011545
domain	Helicase superfamily 1/2, ATP-binding domain	21 - 222	IPR014001
domain	RNA helicase, DEAD-box type, Q motif	2 - 30	IPR014014

		Description
EC Number	3.6.4.13	Acting on ATP; involved in cellular and subcellular movement
Subcellular Localization
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category	No pathway information available

Name	Definition
nucleus	A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.

Name	Definition
ATP binding	Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
ATP hydrolysis activity	Catalysis of the reaction: ATP + H2O = ADP + H+ phosphate. ATP hydrolysis is used in some reactions as an energy source, for example to catalyze a reaction or drive transport against a concentration gradient.
RNA binding	Binding to an RNA molecule or a portion thereof.
RNA helicase activity	Unwinding of an RNA helix, driven by ATP hydrolysis.

Name	Definition
positive regulation of cell growth	Any process that activates or increases the frequency, rate, extent or direction of cell growth.
regulation of rRNA stability	Any process that modulates the propensity of rRNA molecules to degradation. Includes processes that both stabilize and destabilize rRNAs.
rRNA processing	Any process involved in the conversion of a primary ribosomal RNA (rRNA) transcript into one or more mature rRNA molecules.

UniProt AC	Gene Name	Protein Name	Species	Evidence Code
Q9Y6V7	DDX49	Probable ATP-dependent RNA helicase DDX49	Homo sapiens (Human)	PR
Q8K363	Ddx18	ATP-dependent RNA helicase DDX18	Mus musculus (Mouse)	PR
Q8K4L0	Ddx54	ATP-dependent RNA helicase DDX54	Mus musculus (Mouse)	PR
Q9CWX9	Ddx47	Probable ATP-dependent RNA helicase DDX47	Mus musculus (Mouse)	PR
Q9CWT6	Ddx28	Probable ATP-dependent RNA helicase DDX28	Mus musculus (Mouse)	PR
Q91VR5	Ddx1	ATP-dependent RNA helicase DDX1	Mus musculus (Mouse)	PR
Q6ZPL9	Ddx55	ATP-dependent RNA helicase DDX55	Mus musculus (Mouse)	PR
Q9ESV0	Ddx24	ATP-dependent RNA helicase DDX24	Mus musculus (Mouse)	PR
P60843	Eif4a1	Eukaryotic initiation factor 4A-I	Mus musculus (Mouse)	PR
P10630	Eif4a2	Eukaryotic initiation factor 4A-II	Mus musculus (Mouse)	PR
Q569Z5	Ddx46	Probable ATP-dependent RNA helicase DDX46	Mus musculus (Mouse)	PR
Q8L4E9	Os07g0633500	DEAD-box ATP-dependent RNA helicase 36	Oryza sativa subsp japonica (Rice)	PR
Q9FZ92	RH44	Putative DEAD-box ATP-dependent RNA helicase 44	Arabidopsis thaliana (Mouse-ear cress)	PR
Q9SA27	RH36	DEAD-box ATP-dependent RNA helicase 36	Arabidopsis thaliana (Mouse-ear cress)	PR