Q4ACW4

PR
Gene name
CD1D
Protein name
Antigen-presenting glycoprotein CD1d
Names
Species
Pan troglodytes (Chimpanzee)
KEGG Pathway
ptr:469524
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

33-116 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for Q4ACW4

Entry ID Method Resolution Chain Position Source
AF-Q4ACW4-F1 Predicted AlphaFoldDB

No variants for Q4ACW4

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for Q4ACW4

No associated diseases with Q4ACW4

3 regional properties for Q4ACW4

Type Name Position InterPro Accession
domain Immunoglobulin C1-set 219 - 289 IPR003597
domain Immunoglobulin-like domain 185 - 285 IPR007110
domain MHC class I-like antigen recognition-like 1 - 198 IPR011161

Functions

Description
EC Number
Subcellular Localization
  • Cell membrane ; Single-pass type I membrane protein
  • Basolateral cell membrane ; Single-pass type I membrane protein
  • Endosome membrane ; Single-pass type I membrane protein
  • Lysosome membrane ; Single-pass type I membrane protein
  • Endoplasmic reticulum membrane ; Single-pass type I membrane protein
  • Subject to intracellular trafficking between the cell membrane, endosomes and lysosomes
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

8 GO annotations of cellular component

Name Definition
basolateral plasma membrane The region of the plasma membrane that includes the basal end and sides of the cell. Often used in reference to animal polarized epithelial membranes, where the basal membrane is the part attached to the extracellular matrix, or in plant cells, where the basal membrane is defined with respect to the zygotic axis.
endoplasmic reticulum membrane The lipid bilayer surrounding the endoplasmic reticulum.
endosome membrane The lipid bilayer surrounding an endosome.
external side of plasma membrane The leaflet of the plasma membrane that faces away from the cytoplasm and any proteins embedded or anchored in it or attached to its surface.
extracellular space That part of a multicellular organism outside the cells proper, usually taken to be outside the plasma membranes, and occupied by fluid.
integral component of membrane The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.
lysosomal membrane The lipid bilayer surrounding the lysosome and separating its contents from the cell cytoplasm.
lysosome A small lytic vacuole that has cell cycle-independent morphology found in most animal cells and that contains a variety of hydrolases, most of which have their maximal activities in the pH range 5-6. The contained enzymes display latency if properly isolated. About 40 different lysosomal hydrolases are known and lysosomes have a great variety of morphologies and functions.

4 GO annotations of molecular function

Name Definition
endogenous lipid antigen binding Binding to an endogenous cellular lipid antigen.
exogenous lipid antigen binding Binding to an exogenous lipid antigen (examples include microbial lipids and glycolipids).
lipid antigen binding Binding to a lipid antigen.
lipopeptide binding Binding to a lipopeptide, any of a group of organic compounds comprising two or more amino acids linked by peptide bonds and containing a nonprotein group consisting of a lipid or lipids.

4 GO annotations of biological process

Name Definition
antigen processing and presentation, endogenous lipid antigen via MHC class Ib The process in which an antigen-presenting cell expresses lipid antigen of endogenous origin in association with an MHC class Ib protein complex on its cell surface. Class Ib here refers to non-classical class I molecules, such as those of the CD1 family.
antigen processing and presentation, exogenous lipid antigen via MHC class Ib The process in which an antigen-presenting cell expresses lipid antigen of exogenous origin in association with an MHC class Ib protein complex on its cell surface. Class Ib here refers to non-classical class I molecules, such as those of the CD1 family.
innate immune response Innate immune responses are defense responses mediated by germline encoded components that directly recognize components of potential pathogens.
positive regulation of T cell mediated cytotoxicity Any process that activates or increases the frequency, rate or extent of T cell mediated cytotoxicity.

3 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
P29017 CD1C T-cell surface glycoprotein CD1c Homo sapiens (Human) PR
P15813 CD1D Antigen-presenting glycoprotein CD1d Homo sapiens (Human) PR
Q63493 Cd1d Antigen-presenting glycoprotein CD1d Rattus norvegicus (Rat) PR
10 20 30 40 50 60
MGCLLFLLLW ALLQAWGSAE VPQRLFPLRC LQISSFANSS WTRTDGLAWL GELQTHSWSN
70 80 90 100 110 120
DSDTVRSLKP WSQGTFSDQQ WETLQHIFRV YRSSFTRDVK EFAKMLRLSY PLELQVSAGC
130 140 150 160 170 180
EVHPGNASNN FFHVAFQGKD ILSFQGTSWE PTQEAPLWVN LAIQVLNQDK WTRETVQWLL
190 200 210 220 230 240
NGTCPQFVSG LLESGKSELE KQVKPKAWLS RGPSPGPGRL LLVCHVSGFY PKPVWVKWMR
250 260 270 280 290 300
GEQEQQDTQP GDILPNADET WYLRATLDVA AGEAAGLSCR VKHSSLEGQD IILYWGGSYT
310 320 330
SVGLIVLAVL ACLLFLLIVG FTSRFKRQTS YQGVL