Q45FX5

SS
Gene name
vav-1
Protein name
Protein vav-1
Names
Species
Caenorhabditis elegans
KEGG Pathway
EC number
Protein Class

Descriptions

The Vav family is a group of tyrosine phosphorylation-dependent guanine nucleotide exchange factors (GEFs) that activate members of the Rac and Rho families of guanosine triphosphatases (GTPases) downstream of protein tyrosine kinases. When the tyrosine residues within the acidic (Ac) region are non-phosphorylated, the CH domain and Ac region occlude the GTPase-binding site within DH domain. The interaction is stabilized by the interaction between the hydroxyl group of Tyr174 within Ac region and GTPase binding site as well as the interaction between CH domain and DH-PH domains. The Y174F mutant displays constitutive and phosphorylation-independent catalytic activity. In addition to the N-terminal autoinhibitory regions, the truncation of C-terminal SH3 domain also relives the autoinhibition. C-terminal SH3 domain interacts with DH-PH domains and the intramolecular interaction occludes the GTPase-binding site of DH domain. (Description from P27870)

Autoinhibitory domains (AIDs)

37-151 (CH domain) SS

Target domain

240-437 (DH domain)

Relief mechanism

PTM

Assay

151-239 (Acidic domain) SS

Target domain

240-437 (DH domain)

Relief mechanism

PTM

Assay

926-991 (C-terminal SH3) SS

Target domain

240-437 (DH domain)

Relief mechanism

Partner binding, PTM

Assay

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for Q45FX5

Entry ID Method Resolution Chain Position Source
AF-Q45FX5-F1 Predicted AlphaFoldDB

No variants for Q45FX5

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for Q45FX5

No associated diseases with Q45FX5

8 regional properties for Q45FX5

Type Name Position InterPro Accession
domain CDC48, N-terminal subdomain 5 - 86 IPR003338
domain AAA+ ATPase domain 252 - 399 IPR003593-1
domain AAA+ ATPase domain 535 - 671 IPR003593-2
domain ATPase, AAA-type, core 256 - 396 IPR003959-1
domain ATPase, AAA-type, core 539 - 668 IPR003959-2
conserved_site ATPase, AAA-type, conserved site 367 - 385 IPR003960
domain CDC48, domain 2 111 - 183 IPR004201
domain AAA ATPase, AAA+ lid domain 423 - 461 IPR041569

Functions

Description
EC Number
Subcellular Localization
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

No GO annotations of cellular component

Name Definition
No GO annotations for cellular component

2 GO annotations of molecular function

Name Definition
guanyl-nucleotide exchange factor activity Stimulates the exchange of GDP to GTP on a signaling GTPase, changing its conformation to its active form. Guanine nucleotide exchange factors (GEFs) act by stimulating the release of guanosine diphosphate (GDP) to allow binding of guanosine triphosphate (GTP), which is more abundant in the cell under normal cellular physiological conditions.
metal ion binding Binding to a metal ion.

5 GO annotations of biological process

Name Definition
intracellular signal transduction The process in which a signal is passed on to downstream components within the cell, which become activated themselves to further propagate the signal and finally trigger a change in the function or state of the cell.
negative regulation of Notch signaling pathway Any process that stops, prevents, or reduces the frequency, rate or extent of the Notch signaling pathway.
positive regulation of locomotion Any process that activates or increases the frequency, rate or extent of locomotion of a cell or organism.
positive regulation of nematode male tail tip morphogenesis Any process that activates or increases the frequency, rate or extent of nematode male tail tip morphogenesis.
regulation of vulval development Any process that modulates the frequency, rate or extent of development of the vulva. Vulval development is the process whose specific outcome is the progression of the egg-laying organ of female and hermaphrodite nematodes over time, from its formation to the mature structure. In nematodes, the vulva is formed from ventral epidermal cells during larval stages to give rise to a fully formed vulva in the adult.

9 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
Q08DN7 VAV1 Proto-oncogene vav Bos taurus (Bovine) SS
Q9NHV9 Vav Protein vav Drosophila melanogaster (Fruit fly) SS
Q9UKW4 VAV3 Guanine nucleotide exchange factor VAV3 Homo sapiens (Human) SS
P52735 VAV2 Guanine nucleotide exchange factor VAV2 Homo sapiens (Human) SS
P15498 VAV1 Proto-oncogene vav Homo sapiens (Human) EV SS
Q60992 Vav2 Guanine nucleotide exchange factor VAV2 Mus musculus (Mouse) SS
P27870 Vav1 Proto-oncogene vav Mus musculus (Mouse) EV
Q9R0C8 Vav3 Guanine nucleotide exchange factor VAV3 Mus musculus (Mouse) SS
P54100 Vav1 Proto-oncogene vav Rattus norvegicus (Rat) SS
10 20 30 40 50 60
MSRRSTTTST NFGLSWSLVD VISSSTAVFK VPMNGGCDLW IGCARWLRDM KVLTTDKNGT
70 80 90 100 110 120
MLEFASVLRD GILLCRLANT LVPNGIDQKK IMRTNQPSPF LCCNNINYFA MFCKTYFNLE
130 140 150 160 170 180
DADLFTAEDL YYMNGFQKVL KTLSFLSHTK ESLSRGVDPF PDTDNNQEGT SNGSEFEDDV
190 200 210 220 230 240
EIYQSLHDNI ENVDPNRTIY GPITSADPEE QQSEQLYDRI VTNRKPSMNE NDLQNTPTLK
250 260 270 280 290 300
RNRCIRELYD TEKNYVAQAL VTIIKTFYEP LKGIIPTSDY NIIFGNIEEI NVLHTALLAD
310 320 330 340 350 360
LEYPVKVALG LSDATPPRPI SLNECVPQTI GEVFIKYRDQ FLAYGKYCSN LPDSRKLSNE
370 380 390 400 410 420
LLKTNEFISR NINELTAQGN CKFGMNDLLC VPFQRLTKYP LLLKELQKKT DLASPDRKSL
430 440 450 460 470 480
EEAVEVMEDV CNYINEESRD TNAIKVIDEI EQSITDLSMP LNVKLHDYGR VNLDGEVKMA
490 500 510 520 530 540
ESTLTQAGKP KQRYIFLFDK VIVVCKAANK VMAAKTTGAS ARTNTFTYKN AYVMSELTID
550 560 570 580 590 600
KNASLDVKSG GTITRRTQYV IIMTRDRNEN NEITQLTFYF KNEATRNNWM TALLLSKSNV
610 620 630 640 650 660
SPTDYLRDTN HKVAFHSFRV DVKNPATCDV CDKLMKGLQY QGYKCESCNM SMHKECLGLK
670 680 690 700 710 720
KCEAVRKSTH ETRSSQSFNC NRPRFHIHEG DIVVANSNST PSDLSYLQFA KGDRIEVIKM
730 740 750 760 770 780
QGHNRFTGCL INNRNRTGLV HLDHVSQSRT TSMIGLSPID SPAGSIAPRV VRNESTVLPN
790 800 810 820 830 840
KLLSDGSSRS LSGPHGSRSS RNSSSSTING SMDSVPRQQD YVNTEISEFL WYMGEMERAK
850 860 870 880 890 900
AESTLKGTPN GTFLVRYSKN RKQTAISLSY KNDVKHMIIE QNSDGKVYLD EDYIFNSTVE
910 920 930 940 950 960
LVQYYRSNNL IEIFAALDTC LKNPYSQCKV FKAVHDYDAP SPNNEGKFLS FKTGDIVVLL
970 980 990 1000
DTVGEDRGWW KGQVNNKSGF FPLSYVKPYD PATEGSSSPV TPTSSSS