Q43867
SS
Gene name |
PME1 (ARATH65, At1g53840, T18A20.7) |
Protein name |
Pectinesterase 1 |
Names |
Virus-encoded semaphorin protein receptor, PE 1, Pectin methylesterase 1, AtPME1 |
Species |
Arabidopsis thaliana (Mouse-ear cress) |
KEGG Pathway |
ath:AT1G53840 |
EC number |
3.1.1.11: Carboxylic ester hydrolases |
Protein Class |
|
Descriptions
(Annotation from UniProt)
The PMEI region may act as an autoinhibitory domain.
Autoinhibitory domains (AIDs)
Target domain |
280-572 (Pectinesterase domain) |
Relief mechanism |
|
Assay |
|
Accessory elements
No accessory elements
References
Autoinhibited structure
Activated structure
1 structures for Q43867
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-Q43867-F1 | Predicted | AlphaFoldDB |
21 variants for Q43867
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| ENSVATH14311560 | 19 | L>S | No | 1000Genomes | |
| ENSVATH13561933 | 31 | L>I | No | 1000Genomes | |
| ENSVATH13561934 | 50 | T>I | No | 1000Genomes | |
| tmp_1_20101701_A_G | 57 | N>D | No | 1000Genomes | |
| tmp_1_20101706_G_C | 58 | E>D | No | 1000Genomes | |
| ENSVATH00096764 | 60 | T>K | No | 1000Genomes | |
| tmp_1_20101894_A_G | 121 | D>G | No | 1000Genomes | |
| tmp_1_20102068_C_A | 179 | T>N | No | 1000Genomes | |
| tmp_1_20102313_G_A | 261 | V>M | No | 1000Genomes | |
| tmp_1_20102323_A_C | 264 | E>A | No | 1000Genomes | |
| ENSVATH01367838 | 285 | G>S | No | 1000Genomes | |
| ENSVATH04956925 | 289 | G>A | No | 1000Genomes | |
| ENSVATH04956926 | 347 | K>N | No | 1000Genomes | |
| tmp_1_20102607_G_C,A | 359 | A>P | No | 1000Genomes | |
| tmp_1_20102607_G_C,A | 359 | A>T | No | 1000Genomes | |
| tmp_1_20102610_A_G | 360 | T>A | No | 1000Genomes | |
| ENSVATH04956930 | 378 | T>I | No | 1000Genomes | |
| ENSVATH13561959 | 399 | Y>C | No | 1000Genomes | |
| ENSVATH00096773 | 480 | A>T | No | 1000Genomes | |
| ENSVATH13561962 | 554 | P>Q | No | 1000Genomes | |
| tmp_1_20103360_G_A | 555 | V>I | No | 1000Genomes |
No associated diseases with Q43867
17 regional properties for Q43867
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| domain | Flavodoxin-like | 520 - 533 | IPR001094-1 |
| domain | Flavodoxin-like | 567 - 578 | IPR001094-2 |
| domain | Flavodoxin-like | 643 - 653 | IPR001094-3 |
| domain | Flavodoxin-like | 667 - 686 | IPR001094-4 |
| domain | Oxidoreductase FAD/NAD(P)-binding | 1010 - 1122 | IPR001433 |
| domain | Flavoprotein pyridine nucleotide cytochrome reductase | 792 - 802 | IPR001709-1 |
| domain | Flavoprotein pyridine nucleotide cytochrome reductase | 937 - 944 | IPR001709-2 |
| domain | Flavoprotein pyridine nucleotide cytochrome reductase | 973 - 982 | IPR001709-3 |
| domain | Flavoprotein pyridine nucleotide cytochrome reductase | 1009 - 1028 | IPR001709-4 |
| domain | Flavoprotein pyridine nucleotide cytochrome reductase | 1039 - 1048 | IPR001709-5 |
| domain | Flavoprotein pyridine nucleotide cytochrome reductase | 1052 - 1063 | IPR001709-6 |
| domain | Flavoprotein pyridine nucleotide cytochrome reductase | 1084 - 1100 | IPR001709-7 |
| domain | Flavoprotein pyridine nucleotide cytochrome reductase | 1109 - 1117 | IPR001709-8 |
| domain | Sulfite reductase [NADPH] flavoprotein alpha-component-like, FAD-binding | 751 - 978 | IPR003097 |
| domain | Nitric oxide synthase, N-terminal | 119 - 480 | IPR004030 |
| domain | Flavodoxin/nitric oxide synthase | 519 - 702 | IPR008254 |
| domain | FAD-binding domain, ferredoxin reductase-type | 755 - 1001 | IPR017927 |
Functions
| Description | ||
|---|---|---|
| EC Number | 3.1.1.11 | Carboxylic ester hydrolases |
| Subcellular Localization |
|
|
| PANTHER Family | ||
| PANTHER Subfamily | ||
| PANTHER Protein Class | ||
| PANTHER Pathway Category | No pathway information available | |
9 GO annotations of cellular component
| Name | Definition |
|---|---|
| endosome | A vacuole to which materials ingested by endocytosis are delivered. |
| extracellular region | The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite. |
| Golgi apparatus | A membrane-bound cytoplasmic organelle of the endomembrane system that further processes the core oligosaccharides (e.g. N-glycans) added to proteins in the endoplasmic reticulum and packages them into membrane-bound vesicles. The Golgi apparatus operates at the intersection of the secretory, lysosomal, and endocytic pathways. |
| Golgi membrane | The lipid bilayer surrounding any of the compartments of the Golgi apparatus. |
| nucleus | A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. |
| plant-type vacuole | A closed structure that is completely surrounded by a unit membrane, contains liquid, and retains the same shape regardless of cell cycle phase. An example of this structure is found in Arabidopsis thaliana. |
| plasma membrane | The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. |
| plasmodesma | A fine cytoplasmic channel, found in all higher plants, that connects the cytoplasm of one cell to that of an adjacent cell. |
| trans-Golgi network | The network of interconnected tubular and cisternal structures located within the Golgi apparatus on the side distal to the endoplasmic reticulum, from which secretory vesicles emerge. The trans-Golgi network is important in the later stages of protein secretion where it is thought to play a key role in the sorting and targeting of secreted proteins to the correct destination. |
4 GO annotations of molecular function
| Name | Definition |
|---|---|
| aspartyl esterase activity | Catalysis of the hydrolysis of an ester bond by a mechanism involving a catalytically active aspartic acid residue. |
| pectinesterase activity | Catalysis of the reaction: pectin + n H2O = n methanol + pectate. |
| pectinesterase inhibitor activity | Binds to and stops, prevents or reduces the activity of pectinesterase. |
| protein C-terminal methylesterase activity | Catalysis of the reaction: C-terminal protein amino acid methyl ester + H2O = protein amino acid + methanol. |
3 GO annotations of biological process
| Name | Definition |
|---|---|
| cell wall modification | The series of events leading to chemical and structural alterations of an existing cell wall that can result in loosening, increased extensibility or disassembly. |
| cellular response to hypoxia | Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating lowered oxygen tension. Hypoxia, defined as a decline in O2 levels below normoxic levels of 20.8 - 20.95%, results in metabolic adaptation at both the cellular and organismal level. |
| pectin catabolic process | The chemical reactions and pathways resulting in the breakdown of pectin, a polymer containing a backbone of alpha-1,4-linked D-galacturonic acid residues. |
42 homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| Q9SRX4 | PME7 | Probable pectinesterase/pectinesterase inhibitor 7 | Arabidopsis thaliana (Mouse-ear cress) | SS |
| Q1JPL7 | PME18 | Pectinesterase/pectinesterase inhibitor 18 | Arabidopsis thaliana (Mouse-ear cress) | SS |
| Q84JX1 | PME19 | Probable pectinesterase/pectinesterase inhibitor 19 | Arabidopsis thaliana (Mouse-ear cress) | SS |
| O49298 | PME6 | Probable pectinesterase/pectinesterase inhibitor 6 | Arabidopsis thaliana (Mouse-ear cress) | SS |
| Q42534 | PME2 | Pectinesterase 2 | Arabidopsis thaliana (Mouse-ear cress) | SS |
| O48711 | PME12 | Probable pectinesterase/pectinesterase inhibitor 12 | Arabidopsis thaliana (Mouse-ear cress) | SS |
| Q7Y201 | PME13 | Probable pectinesterase/pectinesterase inhibitor 13 | Arabidopsis thaliana (Mouse-ear cress) | SS |
| Q9SKX2 | PME16 | Probable pectinesterase/pectinesterase inhibitor 16 | Arabidopsis thaliana (Mouse-ear cress) | SS |
| O22149 | PME17 | Probable pectinesterase/pectinesterase inhibitor 17 | Arabidopsis thaliana (Mouse-ear cress) | SS |
| O80722 | PME4 | Pectinesterase 4 | Arabidopsis thaliana (Mouse-ear cress) | SS |
| Q5MFV8 | PME5 | Pectinesterase 5 | Arabidopsis thaliana (Mouse-ear cress) | SS |
| O22256 | PME20 | Probable pectinesterase/pectinesterase inhibitor 20 | Arabidopsis thaliana (Mouse-ear cress) | SS |
| Q8GX86 | PME21 | Probable pectinesterase/pectinesterase inhibitor 21 | Arabidopsis thaliana (Mouse-ear cress) | SS |
| Q9M9W7 | PME22 | Putative pectinesterase/pectinesterase inhibitor 22 | Arabidopsis thaliana (Mouse-ear cress) | SS |
| Q8GXA1 | PME23 | Probable pectinesterase/pectinesterase inhibitor 23 | Arabidopsis thaliana (Mouse-ear cress) | SS |
| Q9SG77 | PME24 | Putative pectinesterase/pectinesterase inhibitor 24 | Arabidopsis thaliana (Mouse-ear cress) | SS |
| O49006 | PME3 | Pectinesterase/pectinesterase inhibitor 3 | Arabidopsis thaliana (Mouse-ear cress) | SS |
| Q9STY3 | PME33 | Probable pectinesterase/pectinesterase inhibitor 33 | Arabidopsis thaliana (Mouse-ear cress) | SS |
| Q9LYT5 | PME35 | Probable pectinesterase/pectinesterase inhibitor 35 | Arabidopsis thaliana (Mouse-ear cress) | SS |
| Q84R10 | PME36 | Probable pectinesterase/pectinesterase inhibitor 36 | Arabidopsis thaliana (Mouse-ear cress) | SS |
| Q5MFV6 | VGDH2 | Probable pectinesterase/pectinesterase inhibitor VGDH2 | Arabidopsis thaliana (Mouse-ear cress) | SS |
| O81320 | PME38 | Putative pectinesterase/pectinesterase inhibitor 38 | Arabidopsis thaliana (Mouse-ear cress) | SS |
| O81415 | PME39 | Probable pectinesterase/pectinesterase inhibitor 39 | Arabidopsis thaliana (Mouse-ear cress) | SS |
| O81301 | PME40 | Probable pectinesterase/pectinesterase inhibitor 40 | Arabidopsis thaliana (Mouse-ear cress) | SS |
| Q8RXK7 | PME41 | Probable pectinesterase/pectinesterase inhibitor 41 | Arabidopsis thaliana (Mouse-ear cress) | SS |
| Q1PEC0 | PME42 | Probable pectinesterase/pectinesterase inhibitor 42 | Arabidopsis thaliana (Mouse-ear cress) | SS |
| O23447 | PME43 | Putative pectinesterase/pectinesterase inhibitor 43 | Arabidopsis thaliana (Mouse-ear cress) | SS |
| Q9SMY7 | PME44 | Probable pectinesterase/pectinesterase inhibitor 44 | Arabidopsis thaliana (Mouse-ear cress) | SS |
| Q9SMY6 | PME45 | Putative pectinesterase/pectinesterase inhibitor 45 | Arabidopsis thaliana (Mouse-ear cress) | SS |
| Q9FF78 | PME46 | Probable pectinesterase/pectinesterase inhibitor 46 | Arabidopsis thaliana (Mouse-ear cress) | SS |
| Q9FF77 | PME47 | Probable pectinesterase/pectinesterase inhibitor 47 | Arabidopsis thaliana (Mouse-ear cress) | SS |
| Q9LXD9 | PME51 | Probable pectinesterase/pectinesterase inhibitor 51 | Arabidopsis thaliana (Mouse-ear cress) | SS |
| Q3E989 | PME54 | Probable pectinesterase/pectinesterase inhibitor 54 | Arabidopsis thaliana (Mouse-ear cress) | SS |
| Q3E8Z8 | PME28 | Putative pectinesterase/pectinesterase inhibitor 28 | Arabidopsis thaliana (Mouse-ear cress) | SS |
| Q9FJ21 | PME58 | Probable pectinesterase/pectinesterase inhibitor 58 | Arabidopsis thaliana (Mouse-ear cress) | SS |
| Q9FHN5 | PME59 | Probable pectinesterase/pectinesterase inhibitor 59 | Arabidopsis thaliana (Mouse-ear cress) | SS |
| Q9FHN4 | PME60 | Probable pectinesterase/pectinesterase inhibitor 60 | Arabidopsis thaliana (Mouse-ear cress) | SS |
| Q9FK05 | PME61 | Probable pectinesterase/pectinesterase inhibitor 61 | Arabidopsis thaliana (Mouse-ear cress) | SS |
| Q8L7Q7 | PME64 | Probable pectinesterase/pectinesterase inhibitor 64 | Arabidopsis thaliana (Mouse-ear cress) | SS |
| Q94CB1 | PME25 | Probable pectinesterase/pectinesterase inhibitor 25 | Arabidopsis thaliana (Mouse-ear cress) | SS |
| Q9LXK7 | PME32 | Probable pectinesterase/pectinesterase inhibitor 32 | Arabidopsis thaliana (Mouse-ear cress) | SS |
| Q9M3B0 | PME34 | Probable pectinesterase/pectinesterase inhibitor 34 | Arabidopsis thaliana (Mouse-ear cress) | SS |
| 10 | 20 | 30 | 40 | 50 | 60 |
| MDSVNSFKGY | GKVDEAQDLA | LKKKTRKRLL | LLSISVVVLI | AVIIAAVVAT | VVHKNKNEST |
| 70 | 80 | 90 | 100 | 110 | 120 |
| PSPPPELTPS | TSLKAICSVT | RFPESCISSI | SKLPSSNTTD | PETLFKLSLK | VIIDELDSIS |
| 130 | 140 | 150 | 160 | 170 | 180 |
| DLPEKLSKET | EDERIKSALR | VCGDLIEDAL | DRLNDTVSAI | DDEEKKKTLS | SSKIEDLKTW |
| 190 | 200 | 210 | 220 | 230 | 240 |
| LSATVTDHET | CFDSLDELKQ | NKTEYANSTI | TQNLKSAMSR | STEFTSNSLA | IVSKILSALS |
| 250 | 260 | 270 | 280 | 290 | 300 |
| DLGIPIHRRR | RLMSHHHQQS | VDFEKWARRR | LLQTAGLKPD | VTVAGDGTGD | VLTVNEAVAK |
| 310 | 320 | 330 | 340 | 350 | 360 |
| VPKKSLKMFV | IYVKSGTYVE | NVVMDKSKWN | VMIYGDGKGK | TIISGSKNFV | DGTPTYETAT |
| 370 | 380 | 390 | 400 | 410 | 420 |
| FAIQGKGFIM | KDIGIINTAG | AAKHQAVAFR | SGSDFSVYYQ | CSFDGFQDTL | YPHSNRQFYR |
| 430 | 440 | 450 | 460 | 470 | 480 |
| DCDVTGTIDF | IFGSAAVVFQ | GCKIMPRQPL | SNQFNTITAQ | GKKDPNQSSG | MSIQRCTISA |
| 490 | 500 | 510 | 520 | 530 | 540 |
| NGNVIAPTYL | GRPWKEFSTT | VIMETVIGAV | VRPSGWMSWV | SGVDPPASIV | YGEYKNTGPG |
| 550 | 560 | 570 | 580 | ||
| SDVTQRVKWA | GYKPVMSDAE | AAKFTVATLL | HGADWIPATG | VINQLS |