Q42534
SS
Gene name |
PME2 (ARATH8, At1g53830, T18A20.6) |
Protein name |
Pectinesterase 2 |
Names |
PE 2, Pectin methylesterase 2, AtPME2 |
Species |
Arabidopsis thaliana (Mouse-ear cress) |
KEGG Pathway |
ath:AT1G53830 |
EC number |
3.1.1.11: Carboxylic ester hydrolases |
Protein Class |
|
Descriptions
(Annotation from UniProt)
The PMEI region may act as an autoinhibitory domain.
Autoinhibitory domains (AIDs)
Target domain |
276-572 (Pectinesterase domain) |
Relief mechanism |
|
Assay |
|
Accessory elements
No accessory elements
References
Autoinhibited structure
Activated structure
1 structures for Q42534
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-Q42534-F1 | Predicted | AlphaFoldDB |
57 variants for Q42534
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| ENSVATH01367809 | 6 | E>D | No | 1000Genomes | |
| ENSVATH04956861 | 12 | S>P | No | 1000Genomes | |
| ENSVATH01367811 | 17 | N>D | No | 1000Genomes | |
| ENSVATH04956863 | 26 | A>T | No | 1000Genomes | |
| tmp_1_20098657_G_C | 32 | L>F | No | 1000Genomes | |
| ENSVATH00096748 | 35 | I>V | No | 1000Genomes | |
| tmp_1_20098689_C_G | 43 | T>R | No | 1000Genomes | |
| ENSVATH04956866 | 49 | Q>K | No | 1000Genomes | |
| ENSVATH13561877 | 50 | K>I | No | 1000Genomes | |
| ENSVATH13561878 | 51 | I>S | No | 1000Genomes | |
| ENSVATH00096749 | 61 | I>V | No | 1000Genomes | |
| tmp_1_20098809_G_A | 83 | G>E | No | 1000Genomes | |
| ENSVATH13561879 | 90 | Q>K | No | 1000Genomes | |
| tmp_1_20098844_G_C | 95 | E>Q | No | 1000Genomes | |
| ENSVATH14311483 | 107 | H>Y | No | 1000Genomes | |
| ENSVATH14311484 | 117 | A>T | No | 1000Genomes | |
| ENSVATH14311535 | 130 | L>I | No | 1000Genomes | |
| tmp_1_20098985_G_A | 142 | D>N | No | 1000Genomes | |
| ENSVATH04956868 | 148 | V>A | No | 1000Genomes | |
| ENSVATH04956868 | 148 | V>G | No | 1000Genomes | |
| tmp_1_20099054_G_A | 165 | D>N | No | 1000Genomes | |
| tmp_1_20099067_C_T | 169 | T>I | No | 1000Genomes | |
| ENSVATH04956871 | 197 | A>E | No | 1000Genomes | |
| tmp_1_20099405_C_G | 214 | A>G | No | 1000Genomes | |
| ENSVATH04956875 | 215 | M>I | No | 1000Genomes | |
| tmp_1_20099452_A_G | 230 | R>G | No | 1000Genomes | |
| tmp_1_20099492_A_G | 243 | K>R | No | 1000Genomes | |
| ENSVATH04956877 | 253 | S>N | No | 1000Genomes | |
| tmp_1_20099527_G_A | 255 | G>R | No | 1000Genomes | |
| tmp_1_20099579_C_T | 272 | T>I | No | 1000Genomes | |
| tmp_1_20099597_C_T | 278 | T>M | No | 1000Genomes | |
| tmp_1_20099647_G_A | 295 | A>T | No | 1000Genomes | |
| ENSVATH13561892 | 296 | A>T | No | 1000Genomes | |
| ENSVATH14311538 | 297 | A>V | No | 1000Genomes | |
| ENSVATH04956878 | 312 | G>A | No | 1000Genomes | |
| ENSVATH04956879 | 321 | T>R | No | 1000Genomes | |
| tmp_1_20099788_A_C | 342 | S>R | No | 1000Genomes | |
| tmp_1_20099836_G_T | 358 | A>S | No | 1000Genomes | |
| tmp_1_20100111_C_A | 377 | P>Q | No | 1000Genomes | |
| ENSVATH04956893 | 399 | M>I | No | 1000Genomes | |
| ENSVATH13561896 | 433 | A>T | No | 1000Genomes | |
| tmp_1_20100432_A_G | 484 | K>R | No | 1000Genomes | |
| tmp_1_20100450_A_T | 490 | Y>F | No | 1000Genomes | |
| ENSVATH04956902 | 513 | R>G | No | 1000Genomes | |
| ENSVATH13561897 | 518 | H>Q | No | 1000Genomes | |
| tmp_1_20100549_G_T | 523 | S>I | No | 1000Genomes | |
| tmp_1_20100561_A_C | 527 | D>A | No | 1000Genomes | |
| ENSVATH04956903 | 530 | T>I | No | 1000Genomes | |
| ENSVATH04956905 | 532 | R>K | No | 1000Genomes | |
| ENSVATH04956905 | 532 | R>T | No | 1000Genomes | |
| ENSVATH13561899 | 551 | G>S | No | 1000Genomes | |
| tmp_1_20100641_G_A | 554 | V>I | No | 1000Genomes | |
| tmp_1_20100647_A_G | 556 | T>A | No | 1000Genomes | |
| ENSVATH04956908 | 557 | S>I | No | 1000Genomes | |
| ENSVATH00096760 | 563 | P>Q | No | 1000Genomes | |
| ENSVATH04956909 | 576 | L>V | No | 1000Genomes | |
| ENSVATH14311543 | 586 | S>G | No | 1000Genomes |
No associated diseases with Q42534
4 regional properties for Q42534
Functions
| Description | ||
|---|---|---|
| EC Number | 3.1.1.11 | Carboxylic ester hydrolases |
| Subcellular Localization |
|
|
| PANTHER Family | ||
| PANTHER Subfamily | ||
| PANTHER Protein Class | ||
| PANTHER Pathway Category | No pathway information available | |
2 GO annotations of cellular component
| Name | Definition |
|---|---|
| extracellular region | The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite. |
| plant-type cell wall | A more or less rigid stucture lying outside the cell membrane of a cell and composed of cellulose and pectin and other organic and inorganic substances. |
3 GO annotations of molecular function
| Name | Definition |
|---|---|
| aspartyl esterase activity | Catalysis of the hydrolysis of an ester bond by a mechanism involving a catalytically active aspartic acid residue. |
| pectinesterase activity | Catalysis of the reaction: pectin + n H2O = n methanol + pectate. |
| pectinesterase inhibitor activity | Binds to and stops, prevents or reduces the activity of pectinesterase. |
3 GO annotations of biological process
| Name | Definition |
|---|---|
| callus formation | The process by which a callus is formed at a wound site. A plant callus is a portion of plant tissue that consists of mass of undifferentiated plant cells. It consists primarily of parenchyma cells but possibly contains other cell types as the callus begins to differentiate. |
| cell wall modification | The series of events leading to chemical and structural alterations of an existing cell wall that can result in loosening, increased extensibility or disassembly. |
| pectin catabolic process | The chemical reactions and pathways resulting in the breakdown of pectin, a polymer containing a backbone of alpha-1,4-linked D-galacturonic acid residues. |
43 homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| O22149 | PME17 | Probable pectinesterase/pectinesterase inhibitor 17 | Arabidopsis thaliana (Mouse-ear cress) | SS |
| O49006 | PME3 | Pectinesterase/pectinesterase inhibitor 3 | Arabidopsis thaliana (Mouse-ear cress) | SS |
| O81320 | PME38 | Putative pectinesterase/pectinesterase inhibitor 38 | Arabidopsis thaliana (Mouse-ear cress) | SS |
| Q7Y201 | PME13 | Probable pectinesterase/pectinesterase inhibitor 13 | Arabidopsis thaliana (Mouse-ear cress) | SS |
| Q9SMY6 | PME45 | Putative pectinesterase/pectinesterase inhibitor 45 | Arabidopsis thaliana (Mouse-ear cress) | SS |
| Q9SRX4 | PME7 | Probable pectinesterase/pectinesterase inhibitor 7 | Arabidopsis thaliana (Mouse-ear cress) | SS |
| Q1JPL7 | PME18 | Pectinesterase/pectinesterase inhibitor 18 | Arabidopsis thaliana (Mouse-ear cress) | SS |
| Q84JX1 | PME19 | Probable pectinesterase/pectinesterase inhibitor 19 | Arabidopsis thaliana (Mouse-ear cress) | SS |
| O49298 | PME6 | Probable pectinesterase/pectinesterase inhibitor 6 | Arabidopsis thaliana (Mouse-ear cress) | SS |
| Q43867 | PME1 | Pectinesterase 1 | Arabidopsis thaliana (Mouse-ear cress) | SS |
| O48711 | PME12 | Probable pectinesterase/pectinesterase inhibitor 12 | Arabidopsis thaliana (Mouse-ear cress) | SS |
| Q9SKX2 | PME16 | Probable pectinesterase/pectinesterase inhibitor 16 | Arabidopsis thaliana (Mouse-ear cress) | SS |
| O80722 | PME4 | Pectinesterase 4 | Arabidopsis thaliana (Mouse-ear cress) | SS |
| Q5MFV8 | PME5 | Pectinesterase 5 | Arabidopsis thaliana (Mouse-ear cress) | SS |
| O22256 | PME20 | Probable pectinesterase/pectinesterase inhibitor 20 | Arabidopsis thaliana (Mouse-ear cress) | SS |
| Q8GX86 | PME21 | Probable pectinesterase/pectinesterase inhibitor 21 | Arabidopsis thaliana (Mouse-ear cress) | SS |
| Q9M9W7 | PME22 | Putative pectinesterase/pectinesterase inhibitor 22 | Arabidopsis thaliana (Mouse-ear cress) | SS |
| Q8GXA1 | PME23 | Probable pectinesterase/pectinesterase inhibitor 23 | Arabidopsis thaliana (Mouse-ear cress) | SS |
| Q9SG77 | PME24 | Putative pectinesterase/pectinesterase inhibitor 24 | Arabidopsis thaliana (Mouse-ear cress) | SS |
| Q9STY3 | PME33 | Probable pectinesterase/pectinesterase inhibitor 33 | Arabidopsis thaliana (Mouse-ear cress) | SS |
| Q9LYT5 | PME35 | Probable pectinesterase/pectinesterase inhibitor 35 | Arabidopsis thaliana (Mouse-ear cress) | SS |
| Q84R10 | PME36 | Probable pectinesterase/pectinesterase inhibitor 36 | Arabidopsis thaliana (Mouse-ear cress) | SS |
| Q5MFV6 | VGDH2 | Probable pectinesterase/pectinesterase inhibitor VGDH2 | Arabidopsis thaliana (Mouse-ear cress) | SS |
| O81415 | PME39 | Probable pectinesterase/pectinesterase inhibitor 39 | Arabidopsis thaliana (Mouse-ear cress) | SS |
| O81301 | PME40 | Probable pectinesterase/pectinesterase inhibitor 40 | Arabidopsis thaliana (Mouse-ear cress) | SS |
| Q8RXK7 | PME41 | Probable pectinesterase/pectinesterase inhibitor 41 | Arabidopsis thaliana (Mouse-ear cress) | SS |
| Q1PEC0 | PME42 | Probable pectinesterase/pectinesterase inhibitor 42 | Arabidopsis thaliana (Mouse-ear cress) | SS |
| O23447 | PME43 | Putative pectinesterase/pectinesterase inhibitor 43 | Arabidopsis thaliana (Mouse-ear cress) | SS |
| Q9SMY7 | PME44 | Probable pectinesterase/pectinesterase inhibitor 44 | Arabidopsis thaliana (Mouse-ear cress) | SS |
| Q9FF78 | PME46 | Probable pectinesterase/pectinesterase inhibitor 46 | Arabidopsis thaliana (Mouse-ear cress) | SS |
| Q9FF77 | PME47 | Probable pectinesterase/pectinesterase inhibitor 47 | Arabidopsis thaliana (Mouse-ear cress) | SS |
| Q9LXD9 | PME51 | Probable pectinesterase/pectinesterase inhibitor 51 | Arabidopsis thaliana (Mouse-ear cress) | SS |
| Q3E989 | PME54 | Probable pectinesterase/pectinesterase inhibitor 54 | Arabidopsis thaliana (Mouse-ear cress) | SS |
| Q3E8Z8 | PME28 | Putative pectinesterase/pectinesterase inhibitor 28 | Arabidopsis thaliana (Mouse-ear cress) | SS |
| Q9FJ21 | PME58 | Probable pectinesterase/pectinesterase inhibitor 58 | Arabidopsis thaliana (Mouse-ear cress) | SS |
| Q9FHN5 | PME59 | Probable pectinesterase/pectinesterase inhibitor 59 | Arabidopsis thaliana (Mouse-ear cress) | SS |
| Q9FHN4 | PME60 | Probable pectinesterase/pectinesterase inhibitor 60 | Arabidopsis thaliana (Mouse-ear cress) | SS |
| Q9FK05 | PME61 | Probable pectinesterase/pectinesterase inhibitor 61 | Arabidopsis thaliana (Mouse-ear cress) | SS |
| Q8L7Q7 | PME64 | Probable pectinesterase/pectinesterase inhibitor 64 | Arabidopsis thaliana (Mouse-ear cress) | SS |
| Q94CB1 | PME25 | Probable pectinesterase/pectinesterase inhibitor 25 | Arabidopsis thaliana (Mouse-ear cress) | SS |
| Q9LXK7 | PME32 | Probable pectinesterase/pectinesterase inhibitor 32 | Arabidopsis thaliana (Mouse-ear cress) | SS |
| Q9M3B0 | PME34 | Probable pectinesterase/pectinesterase inhibitor 34 | Arabidopsis thaliana (Mouse-ear cress) | SS |
| Q43143 | PMEU1 | Pectinesterase/pectinesterase inhibitor U1 | Solanum lycopersicum (Tomato) (Lycopersicon esculentum) | SS |
| 10 | 20 | 30 | 40 | 50 | 60 |
| MAPIKEFISK | FSDFKNNKKL | ILSSAAIALL | LLASIVGIAA | TTTNQNKNQK | ITTLSSTSHA |
| 70 | 80 | 90 | 100 | 110 | 120 |
| ILKSVCSSTL | YPELCFSAVA | ATGGKELTSQ | KEVIEASLNL | TTKAVKHNYF | AVKKLIAKRK |
| 130 | 140 | 150 | 160 | 170 | 180 |
| GLTPREVTAL | HDCLETIDET | LDELHVAVED | LHQYPKQKSL | RKHADDLKTL | ISSAITNQGT |
| 190 | 200 | 210 | 220 | 230 | 240 |
| CLDGFSYDDA | DRKVRKALLK | GQVHVEHMCS | NALAMIKNMT | ETDIANFELR | DKSSTFTNNN |
| 250 | 260 | 270 | 280 | 290 | 300 |
| NRKLKEVTGD | LDSDGWPKWL | SVGDRRLLQG | STIKADATVA | DDGSGDFTTV | AAAVAAAPEK |
| 310 | 320 | 330 | 340 | 350 | 360 |
| SNKRFVIHIK | AGVYRENVEV | TKKKTNIMFL | GDGRGKTIIT | GSRNVVDGST | TFHSATVAAV |
| 370 | 380 | 390 | 400 | 410 | 420 |
| GERFLARDIT | FQNTAGPSKH | QAVALRVGSD | FSAFYQCDMF | AYQDTLYVHS | NRQFFVKCHI |
| 430 | 440 | 450 | 460 | 470 | 480 |
| TGTVDFIFGN | AAAVLQDCDI | NARRPNSGQK | NMVTAQGRSD | PNQNTGIVIQ | NCRIGGTSDL |
| 490 | 500 | 510 | 520 | 530 | 540 |
| LAVKGTFPTY | LGRPWKEYSR | TVIMQSDISD | VIRPEGWHEW | SGSFALDTLT | YREYLNRGGG |
| 550 | 560 | 570 | 580 | ||
| AGTANRVKWK | GYKVITSDTE | AQPFTAGQFI | GGGGWLASTG | FPFSLSL |