Q41741
Gene name |
|
Protein name |
Eukaryotic initiation factor 4A |
Names |
eIF-4A, ATP-dependent RNA helicase eIF4A |
Species |
Zea mays (Maize) |
KEGG Pathway |
|
EC number |
3.6.4.13: Acting on ATP; involved in cellular and subcellular movement |
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for Q41741
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-Q41741-F1 | Predicted | AlphaFoldDB |
No variants for Q41741
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| No variants for Q41741 | |||||
No associated diseases with Q41741
5 regional properties for Q41741
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| conserved_site | ATP-dependent RNA helicase DEAD-box, conserved site | 184 - 192 | IPR000629 |
| domain | Helicase, C-terminal | 249 - 410 | IPR001650 |
| domain | DEAD/DEAH box helicase domain | 62 - 223 | IPR011545 |
| domain | Helicase superfamily 1/2, ATP-binding domain | 56 - 253 | IPR014001 |
| domain | RNA helicase, DEAD-box type, Q motif | 37 - 65 | IPR014014 |
Functions
| Description | ||
|---|---|---|
| EC Number | 3.6.4.13 | Acting on ATP; involved in cellular and subcellular movement |
| Subcellular Localization |
|
|
| PANTHER Family | ||
| PANTHER Subfamily | ||
| PANTHER Protein Class | ||
| PANTHER Pathway Category | No pathway information available | |
2 GO annotations of cellular component
| Name | Definition |
|---|---|
| cytoplasm | The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. |
| nucleus | A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. |
5 GO annotations of molecular function
| Name | Definition |
|---|---|
| ATP binding | Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. |
| ATP hydrolysis activity | Catalysis of the reaction: ATP + H2O = ADP + H+ phosphate. ATP hydrolysis is used in some reactions as an energy source, for example to catalyze a reaction or drive transport against a concentration gradient. |
| RNA binding | Binding to an RNA molecule or a portion thereof. |
| RNA helicase activity | Unwinding of an RNA helix, driven by ATP hydrolysis. |
| translation initiation factor activity | Functions in the initiation of ribosome-mediated translation of mRNA into a polypeptide. |
1 GO annotations of biological process
| Name | Definition |
|---|---|
| cytoplasmic translational initiation | The process preceding formation of the peptide bond between the first two amino acids of a protein in the cytoplasm. This includes the formation of a complex of the ribosome, mRNA or circRNA, and an initiation complex that contains the first aminoacyl-tRNA. |
18 homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| P41378 | Eukaryotic initiation factor 4A | Triticum aestivum (Wheat) | PR | |
| P10081 | TIF2 | ATP-dependent RNA helicase eIF4A | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) | PR |
| Q3SZ54 | EIF4A1 | Eukaryotic initiation factor 4A-I | Bos taurus (Bovine) | PR |
| Q3SZ65 | EIF4A2 | Eukaryotic initiation factor 4A-II | Bos taurus (Bovine) | PR |
| Q8JFP1 | EIF4A2 | Eukaryotic initiation factor 4A-II | Gallus gallus (Chicken) | PR |
| A5A6N4 | EIF4A1 | Eukaryotic initiation factor 4A-I | Pan troglodytes (Chimpanzee) | PR |
| Q14240 | EIF4A2 | Eukaryotic initiation factor 4A-II | Homo sapiens (Human) | PR |
| P60842 | EIF4A1 | Eukaryotic initiation factor 4A-I | Homo sapiens (Human) | PR |
| P60843 | Eif4a1 | Eukaryotic initiation factor 4A-I | Mus musculus (Mouse) | PR |
| P10630 | Eif4a2 | Eukaryotic initiation factor 4A-II | Mus musculus (Mouse) | PR |
| Q5RKI1 | Eif4a2 | Eukaryotic initiation factor 4A-II | Rattus norvegicus (Rat) | PR |
| P35683 | Os06g0701100 | Eukaryotic initiation factor 4A-1 | Oryza sativa subsp japonica (Rice) | PR |
| Q6Z2Z4 | Os02g0146600 | Eukaryotic initiation factor 4A-3 | Oryza sativa subsp japonica (Rice) | PR |
| P27639 | inf-1 | Eukaryotic initiation factor 4A | Caenorhabditis elegans | PR |
| Q9CAI7 | TIF4A-3 | Eukaryotic initiation factor 4A-3 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q3E9C3 | RH58 | DEAD-box ATP-dependent RNA helicase 58, chloroplastic | Arabidopsis thaliana (Mouse-ear cress) | PR |
| P41377 | TIF4A-2 | Eukaryotic initiation factor 4A-2 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| P41376 | EIF4A1 | Eukaryotic initiation factor 4A-1 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| 10 | 20 | 30 | 40 | 50 | 60 |
| MAGLAPEGSQ | FDDKQYDKKM | QEILTEDFFT | SYDDVCESFD | SMGLQENLLR | GIYAYGFEKP |
| 70 | 80 | 90 | 100 | 110 | 120 |
| SAIQQRGIVP | FCKGLDVIQQ | AQSGTGKTAT | FCSGILQQLD | YGLVECQALV | LAPTRELAQQ |
| 130 | 140 | 150 | 160 | 170 | 180 |
| IEKVMRALGD | YLGVKVHACV | GGTSVREDQR | ILASGVHVVV | GTPGRVFDML | RRQSLRPDNI |
| 190 | 200 | 210 | 220 | 230 | 240 |
| KMFVLDEADE | MLSRGFKDQI | YDIFQLLPSK | IQVGVFSATM | PPEALEITRK | FMNKPVRILV |
| 250 | 260 | 270 | 280 | 290 | 300 |
| KRDELTLEGI | KQFYVNIDKE | DWKLDTLCDL | YETLAITQSV | IFVNTRRKVD | WLTDKMRSRD |
| 310 | 320 | 330 | 340 | 350 | 360 |
| HTVSATHGDM | DQNTRDIIMR | EFRSGSSRVL | ITTDLLARGI | DVQQVSLVIN | YDLPTQPENY |
| 370 | 380 | 390 | 400 | ||
| LHRIGRSGRF | GRKGVAINFV | TRDDERIVFD | VQRFYNVTVE | ELPANVADLL |