Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

Autoinhibited structure

Activated structure

1 structures for Q40702

Entry ID Method Resolution Chain Position Source
AF-Q40702-F1 Predicted AlphaFoldDB

No variants for Q40702

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for Q40702

No associated diseases with Q40702

3 regional properties for Q40702

Type Name Position InterPro Accession
domain Transcription factor, MADS-box 1 - 61 IPR002100
domain Transcription factor, K-box 82 - 170 IPR002487
domain MADS MEF2-like 2 - 80 IPR033896

Functions

Description
EC Number
Subcellular Localization
  • Nucleus
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

1 GO annotations of cellular component

Name Definition
nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.

3 GO annotations of molecular function

Name Definition
DNA-binding transcription factor activity, RNA polymerase II-specific A DNA-binding transcription factor activity that modulates the transcription of specific gene sets transcribed by RNA polymerase II.
protein dimerization activity The formation of a protein dimer, a macromolecular structure consists of two noncovalently associated identical or nonidentical subunits.
RNA polymerase II cis-regulatory region sequence-specific DNA binding Binding to a specific upstream regulatory DNA sequence (transcription factor recognition sequence or binding site) located in cis relative to the transcription start site (i.e., on the same strand of DNA) of a gene transcribed by RNA polymerase II.

4 GO annotations of biological process

Name Definition
cell differentiation The process in which relatively unspecialized cells, e.g. embryonic or regenerative cells, acquire specialized structural and/or functional features that characterize the cells, tissues, or organs of the mature organism or some other relatively stable phase of the organism's life history. Differentiation includes the processes involved in commitment of a cell to a specific fate and its subsequent development to the mature state.
positive regulation of transcription by RNA polymerase II Any process that activates or increases the frequency, rate or extent of transcription from an RNA polymerase II promoter.
regulation of transcription by RNA polymerase II Any process that modulates the frequency, rate or extent of transcription mediated by RNA polymerase II.
specification of stamen identity The process in which a floral organ primordium acquires stamen or staminode identity. Identity is considered to be the aggregate of characteristics by which a structure is recognized.

17 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
A2VDZ3 MEF2A Myocyte-specific enhancer factor 2A Bos taurus (Bovine) SS
Q9W6U8 MEF2A Myocyte-specific enhancer factor 2A Gallus gallus (Chicken) SS
Q06413 MEF2C Myocyte-specific enhancer factor 2C Homo sapiens (Human) EV
Q02078 MEF2A Myocyte-specific enhancer factor 2A Homo sapiens (Human) SS
Q60929 Mef2a Myocyte-specific enhancer factor 2A Mus musculus (Mouse) SS
Q8CFN5 Mef2c Myocyte-specific enhancer factor 2C Mus musculus (Mouse) SS
A2ICN5 MEF2A Myocyte-specific enhancer factor 2A Sus scrofa (Pig) SS
A4UTP7 MEF2C Myocyte-specific enhancer factor 2C Sus scrofa (Pig) SS
Q2MJT0 Mef2a Myocyte-specific enhancer factor 2A Rattus norvegicus (Rat) SS
A0A096MJY4 Mef2c Myocyte-specific enhancer factor 2C Rattus norvegicus (Rat) SS
Q655V4 MADS30 MADS-box transcription factor 30 Oryza sativa subsp japonica (Rice) PR
Q5K4R0 MADS47 MADS-box transcription factor 47 Oryza sativa subsp japonica (Rice) PR
Q1PFA4 AGL30 Agamous-like MADS-box protein AGL30 Arabidopsis thaliana (Mouse-ear cress) PR
P29383 AGL3 Agamous-like MADS-box protein AGL3 Arabidopsis thaliana (Mouse-ear cress) PR
P35632 AP3 Floral homeotic protein APETALA 3 Arabidopsis thaliana (Mouse-ear cress) PR
Q683D7 MAF5 Protein MADS AFFECTING FLOWERING 5 Arabidopsis thaliana (Mouse-ear cress) PR
Q9FUY6 J MADS-box protein JOINTLESS Solanum lycopersicum (Tomato) (Lycopersicon esculentum) PR
10 20 30 40 50 60
MGRGKIEIKR IENSTNRQVT FSKRRSGILK KAREISVLCD AEVGVVIFSS AGKLYDYCSP
70 80 90 100 110 120
KTSLSRILEK YQTNSGKILW DEKHKSLSAE IDRIKKENDN MQIELRHLKG EDLNSLQPKE
130 140 150 160 170 180
LIMIEEALDN GIVNVNDKLM DHWERHVRTD KMLEDENKLL AFKLHQQDIA LSGSMRDLEL
190 200
GYHPDRDFAA QMPITFRVQP SHPNLQENN