Q3ZT31

PR
Gene name
Snx25
Protein name
Sorting nexin-25
Names
Species
Mus musculus (Mouse)
KEGG Pathway
mmu:102141
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

236-306 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

4 structures for Q3ZT31

Entry ID Method Resolution Chain Position Source
7WF8 X-ray 135 A A/B 280-402 PDB
7WF9 X-ray 255 A A/B 280-405 PDB
8HQL X-ray 240 A A/B/C/D/E 506-624 PDB
AF-Q3ZT31-F1 Predicted AlphaFoldDB

56 variants for Q3ZT31

Variant ID(s) Position Change Description Diseaes Association Provenance
rs3388980151 2 D>V No EVA
rs3398899274 3 R>P No EVA
rs233943806 23 N>S No EVA
rs3388969313 30 Q>L No EVA
rs3388983401 39 F>S No EVA
rs37038661 48 Q>H No EVA
rs3388980127 58 V>A No EVA
rs3388982026 64 V>I No EVA
rs38833681 142 V>I No EVA
rs256171361 158 R>K No EVA
rs247732377 177 A>S No EVA
rs3398795503 189 S>R No EVA
rs3399250244 190 N>K No EVA
rs3399051804 192 D>A No EVA
rs3388983396 205 V>L No EVA
rs3388953019 216 F>I No EVA
rs3412796751 244 I>V No EVA
rs3388983382 251 K>E No EVA
rs3388983432 264 P>L No EVA
rs3388981618 292 M>T No EVA
rs3388959476 310 K>M No EVA
rs235481496 315 G>D No EVA
rs3388981558 340 Q>R No EVA
rs3388952961 344 V>SDG* No EVA
rs3388987292 346 S>R No EVA
rs250502716 350 S>P No EVA
rs3388986429 357 K>Q No EVA
rs3388986435 370 E>K No EVA
rs3388976038 379 V>E No EVA
rs3388987254 399 K>M No EVA
rs228370686 402 R>H No EVA
rs38914837 411 A>T No EVA
rs3388962849 499 R>I No EVA
rs1132540315 566 C>Y No EVA
rs3388987320 570 L>F No EVA
rs3388980051 571 K>R No EVA
rs3388980017 583 F>V No EVA
rs3388933787 586 I>L No EVA
rs3388959478 609 E>G No EVA
rs3388975991 626 D>E No EVA
rs3388983389 664 D>V No EVA
rs3388933828 665 S>R No EVA
rs39023302 680 S>A No EVA
rs3388986432 699 F>C No EVA
rs3388933811 699 F>L No EVA
rs3388981814 711 Q>E No EVA
rs3388975663 720 K>E No EVA
rs3399111299 724 D>G No EVA
rs3388979969 731 S>N No EVA
rs3388975677 732 E>D No EVA
rs36445664 740 S>T No EVA
rs3388981600 743 R>L No EVA
rs3388980154 781 D>N No EVA
rs3388952988 791 N>K No EVA
rs3388962867 841 V>C No EVA
rs3388962866 841 V>S No EVA

No associated diseases with Q3ZT31

3 regional properties for Q3ZT31

Type Name Position InterPro Accession
domain Protein kinase domain 23 - 279 IPR000719
active_site Serine/threonine-protein kinase, active site 138 - 150 IPR008271
binding_site Protein kinase, ATP binding site 29 - 52 IPR017441

Functions

Description
EC Number
Subcellular Localization
  • Endosome membrane ; Peripheral membrane protein
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

3 GO annotations of cellular component

Name Definition
endosome A vacuole to which materials ingested by endocytosis are delivered.
endosome membrane The lipid bilayer surrounding an endosome.
intracellular membrane-bounded organelle Organized structure of distinctive morphology and function, bounded by a single or double lipid bilayer membrane and occurring within the cell. Includes the nucleus, mitochondria, plastids, vacuoles, and vesicles. Excludes the plasma membrane.

2 GO annotations of molecular function

Name Definition
phosphatidylinositol binding Binding to an inositol-containing glycerophospholipid, i.e. phosphatidylinositol (PtdIns) and its phosphorylated derivatives.
type I transforming growth factor beta receptor binding Binding to a type I transforming growth factor beta receptor.

4 GO annotations of biological process

Name Definition
negative regulation of pathway-restricted SMAD protein phosphorylation Any process that decreases the rate, frequency or extent of pathway-restricted SMAD protein phosphorylation. Pathway-restricted SMAD proteins and common-partner SMAD proteins are involved in the transforming growth factor beta receptor signaling pathways.
negative regulation of transforming growth factor beta receptor signaling pathway Any process that stops, prevents, or reduces the frequency, rate or extent of any TGF-beta receptor signaling pathway.
protein transport The directed movement of proteins into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.
receptor catabolic process The chemical reactions and pathways resulting in the breakdown of a receptor molecule, a macromolecule that undergoes combination with a hormone, neurotransmitter, drug or intracellular messenger to initiate a change in cell function.

8 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
Q9Y5W7 SNX14 Sorting nexin-14 Homo sapiens (Human) PR
Q96S38 RPS6KC1 Ribosomal protein S6 kinase delta-1 Homo sapiens (Human) PR
Q9Y5W8 SNX13 Sorting nexin-13 Homo sapiens (Human) PR
Q96BR1 SGK3 Serine/threonine-protein kinase Sgk3 Homo sapiens (Human) SS
Q8BLK9 Rps6kc1 Ribosomal protein S6 kinase delta-1 Mus musculus (Mouse) PR
Q9ERE3 Sgk3 Serine/threonine-protein kinase Sgk3 Mus musculus (Mouse) PR
Q8BHY8 Snx14 Sorting nexin-14 Mus musculus (Mouse) PR
Q6PHS6 Snx13 Sorting nexin-13 Mus musculus (Mouse) PR
10 20 30 40 50 60
MDRVLRDVFD YSYRDYILSW YGNLSRDDGQ LYHLLLDDFW EIVKQIRQRL SHVDVVKVVC
70 80 90 100 110 120
NDIVKALLTH FCDLKAATAR HEEQPRPFVL HACLKDSHDE VRFLQTCSQV LVLCLLPSKD
130 140 150 160 170 180
IQSLSLRTML AEILTTKVLK PVVELLSNPD YINQMLLRQL EYREQMSEHH KRAYTYAPSY
190 200 210 220 230 240
EDFIKLINSN SDVDFLKQLR YQIVVEIIQA TTISSFPQLK RHKGKESAAM KTDLLRARNM
250 260 270 280 290 300
KRYINQLTVA KKQCEKRIRI LGGPAYDQQE DGASDEGEGP QSQKILQFED IMTNPFYRER
310 320 330 340 350 360
FGTYMERIDK RALVGFWESA EHLKNANKSE IPQLVSEMYQ NFFVESKEIS VEKSLYKEIQ
370 380 390 400 410 420
QCLVGNRGIE VFSKIQADVS EVLRERYYPS FLVSDLYEKL MREEEEEEPD AQLASEKDEL
430 440 450 460 470 480
GSGGEAGEEA VEGTSGVSDP ASFAVIKLRE LNEKLEYKRQ ALSSIQNAPK PDKKIISKLK
490 500 510 520 530 540
DEILLIEKEC TALQLHMART DWWCENLGLW RASITSAEVT EENGEQMPCY FVRVNLQEVG
550 560 570 580 590 600
GVETKNWTVP RRLSEFQNLH RKLSECVPSL KKVQLPSLSK LPFKSIDHKF LGKSRNQLNA
610 620 630 640 650 660
FLQNLLSDER LFQSEALYAF LSPSPDYLKV IDVQGKKTSF SLSSFLEKLP RDFFSHQEEE
670 680 690 700 710 720
IEEDSDLSDY GDDVDGKKDS LAEPCFMLIG EIFELRGMFK WVRRTLIALV QVTFGRTINK
730 740 750 760 770 780
QIRDTVSWIS SEQMLVYYIS AFRDAFWPNG KLAPPTRIRS VAQSQETKQR AQQKLLENIP
790 800 810 820 830
DTLQSLVGQQ NARHGIIKIF KALQETKANK HLLYVLMELL LTELCPELRA HLDQFKAGQV