Q3ZCC3
SS
Gene name |
TRAF6 |
Protein name |
TNF receptor-associated factor 6 |
Names |
EC 2.3.2.27 , E3 ubiquitin-protein ligase TRAF6 , RING-type E3 ubiquitin transferase TRAF6 |
Species |
Bos taurus (Bovine) |
KEGG Pathway |
bta:539124 |
EC number |
2.3.2.27: Aminoacyltransferases |
Protein Class |
|
Descriptions
The Tumor Necrosis Factor (TNF) Receptor Associated Factor (TRAF) class of intracellular signal transducers is responsible for mediating many of the activation events initiated by TNF receptor (TNFR) and Toll-like/Interleukin-1, 17 and 18 receptor (TIR) families. These receptors can, both directly and indirectly, activate TRAF6 via specific binding of proteins containing TRAF Interacting Motif (TIM) peptides to a groove on the carboxyl-terminal MATH domain. <br>TRAF6 is autoinhibited by an intramolecular interaction between the RING-Zinc (RZ) region and MATH domain. The interaction renders TRAF6 inactive and structurally closed, as well as incapable of auto-ubiquitination. RING-Zinc fingers region and the MATH domain are targets for ubiquitination. TRAF autoubiquitination in trans is a means of sustaining an open conformation active in downstream signaling.
Autoinhibitory domains (AIDs)
Target domain |
71-274 (RZ domain) |
Relief mechanism |
Partner binding |
Assay |
|
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for Q3ZCC3
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-Q3ZCC3-F1 | Predicted | AlphaFoldDB |
39 variants for Q3ZCC3
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| rs450666715 | 15 | S>A | No | EVA | |
| rs797202753 | 22 | A>T | No | EVA | |
| rs481849195 | 37 | V>L | No | EVA | |
| rs714085251 | 177 | I>V | No | EVA | |
| rs449042201 | 191 | E>A | No | EVA | |
| rs475619383 | 228 | M>K | No | EVA | |
| rs455761504 | 229 | P>T | No | EVA | |
| rs435580843 | 233 | D>E | No | EVA | |
| rs473757745 | 234 | L>Q | No | EVA | |
| rs433370766 | 235 | D>G | No | EVA | |
| rs444950964 | 236 | C>W | No | EVA | |
| rs464729530 | 236 | C>Y | No | EVA | |
| rs437655031 | 237 | P>A | No | EVA | |
| rs437655031 | 237 | P>T | No | EVA | |
| rs469042115 | 239 | A>T | No | EVA | |
| rs448912518 | 245 | F>C | No | EVA | |
| rs480251824 | 246 | S>R | No | EVA | |
| rs460470261 | 247 | A>S | No | EVA | |
| rs446671696 | 249 | G>C | No | EVA | |
| rs472477144 | 312 | V>G | No | EVA | |
| rs441102825 | 312 | V>I | No | EVA | |
| rs432124030 | 313 | H>Y | No | EVA | |
| rs470311466 | 351 | K>T | No | EVA | |
| rs456580594 | 367 | Q>R | No | EVA | |
| rs436405181 | 370 | N>I | No | EVA | |
| rs467742599 | 372 | I>L | No | EVA | |
| rs447898717 | 382 | M>I | No | EVA | |
| rs479156712 | 383 | H>Q | No | EVA | |
| rs465497378 | 395 | I>M | No | EVA | |
| rs445432793 | 404 | K>N | No | EVA | |
| rs483012570 | 406 | G>S | No | EVA | |
| rs463436669 | 415 | L>R | No | EVA | |
| rs443285381 | 417 | L>P | No | EVA | |
| rs464297017 | 423 | C>* | No | EVA | |
| rs460990566 | 426 | Y>C | No | EVA | |
| rs720553055 | 472 | A>T | No | EVA | |
| rs723263863 | 483 | T>P | No | EVA | |
| rs1115416753 | 496 | F>L | No | EVA | |
| rs723863593 | 526 | G>V | No | EVA |
No associated diseases with Q3ZCC3
9 regional properties for Q3ZCC3
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| domain | Zinc finger, TRAF-type | 152 - 193 | IPR001293-1 |
| domain | Zinc finger, TRAF-type | 205 - 262 | IPR001293-2 |
| domain | Zinc finger, RING-type | 71 - 110 | IPR001841 |
| domain | MATH/TRAF domain | 370 - 519 | IPR002083 |
| conserved_site | Zinc finger, RING-type, conserved site | 86 - 95 | IPR017907 |
| domain | TNF receptor-associated factor 6, C3HC3D-type RING zinc finger | 68 - 125 | IPR027139 |
| domain | TNF receptor-associated factor 6, MATH domain | 371 - 520 | IPR037309 |
| domain | TNF receptor-associated factor 6, zinc finger 2 | 158 - 184 | IPR041310 |
| domain | TRAF1-6, MATH domain | 393 - 516 | IPR049342 |
Functions
| Description | ||
|---|---|---|
| EC Number | 2.3.2.27 | Aminoacyltransferases |
| Subcellular Localization |
|
|
| PANTHER Family | ||
| PANTHER Subfamily | ||
| PANTHER Protein Class | ||
| PANTHER Pathway Category | No pathway information available | |
4 GO annotations of cellular component
| Name | Definition |
|---|---|
| cell cortex | The region of a cell that lies just beneath the plasma membrane and often, but not always, contains a network of actin filaments and associated proteins. |
| cytoplasm | The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. |
| lipid droplet | An intracellular non-membrane-bounded organelle comprising a matrix of coalesced lipids surrounded by a phospholipid monolayer. May include associated proteins. |
| nucleus | A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. |
4 GO annotations of molecular function
| Name | Definition |
|---|---|
| tumor necrosis factor receptor binding | Binding to a tumor necrosis factor receptor. |
| ubiquitin protein ligase activity | Catalysis of the transfer of ubiquitin to a substrate protein via the reaction X-ubiquitin + S -> X + S-ubiquitin, where X is either an E2 or E3 enzyme, the X-ubiquitin linkage is a thioester bond, and the S-ubiquitin linkage is an amide bond |
| ubiquitin-protein transferase activity | Catalysis of the transfer of ubiquitin from one protein to another via the reaction X-Ub + Y --> Y-Ub + X, where both X-Ub and Y-Ub are covalent linkages. |
| zinc ion binding | Binding to a zinc ion (Zn). |
10 GO annotations of biological process
| Name | Definition |
|---|---|
| DNA damage response | Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating damage to its DNA from environmental insults or errors during metabolism. |
| innate immune response | Innate immune responses are defense responses mediated by germline encoded components that directly recognize components of potential pathogens. |
| intracellular signal transduction | The process in which a signal is passed on to downstream components within the cell, which become activated themselves to further propagate the signal and finally trigger a change in the function or state of the cell. |
| lipopolysaccharide-mediated signaling pathway | The series of molecular signals initiated by the binding of a lipopolysaccharide (LPS) to a receptor on the surface of a target cell, and ending with the regulation of a downstream cellular process, e.g. transcription. Lipopolysaccharides are major components of the outer membrane of Gram-negative bacteria, making them prime targets for recognition by the immune system. |
| positive regulation of canonical NF-kappaB signal transduction | Any process that activates or increases the frequency, rate or extent of I-kappaB kinase/NF-kappaB signaling. |
| positive regulation of NF-kappaB transcription factor activity | Any process that activates or increases the frequency, rate or extent of activity of the transcription factor NF-kappaB. |
| protein K63-linked ubiquitination | A protein ubiquitination process in which a polymer of ubiquitin, formed by linkages between lysine residues at position 63 of the ubiquitin monomers, is added to a protein. K63-linked ubiquitination does not target the substrate protein for degradation, but is involved in several pathways, notably as a signal to promote error-free DNA postreplication repair. |
| regulation of apoptotic process | Any process that modulates the occurrence or rate of cell death by apoptotic process. |
| regulation of canonical NF-kappaB signal transduction | Any process that modulates I-kappaB kinase/NF-kappaB signaling. |
| tumor necrosis factor-mediated signaling pathway | The series of molecular signals initiated by tumor necrosis factor binding to its receptor on the surface of a cell, and ending with the regulation of a downstream cellular process, e.g. transcription. |
7 homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| Q9Y4K3 | TRAF6 | TNF receptor-associated factor 6 | Homo sapiens (Human) | EV |
| P70196 | Traf6 | TNF receptor-associated factor 6 | Mus musculus (Mouse) | SS |
| A7XUJ6 | TRAF6 | TNF receptor-associated factor 6 | Sus scrofa (Pig) | SS |
| B5DF45 | Traf6 | TNF receptor-associated factor 6 | Rattus norvegicus (Rat) | SS |
| B6CJY5 | TRAF6 | TNF receptor-associated factor 6 | Macaca mulatta (Rhesus macaque) | SS |
| Q28DL4 | traf6 | TNF receptor-associated factor 6 | Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) | SS |
| Q6IWL4 | traf6 | TNF receptor-associated factor 6 | Danio rerio (Zebrafish) (Brachydanio rerio) | SS |
| 10 | 20 | 30 | 40 | 50 | 60 |
| MSLLHCENSC | GSSQSESDCC | AAMAASSCGT | AAKDDSVSGT | ASTVTLSSSF | MEEIQGYDVE |
| 70 | 80 | 90 | 100 | 110 | 120 |
| FDPPLESKYE | CPICLMALRE | AVQTPCGHRF | CKACIIKSIR | DAGHKCPVDN | EILLENQLFP |
| 130 | 140 | 150 | 160 | 170 | 180 |
| DNFAKREILS | LMVKCPNEGC | LHKMELRHLE | EHQAHCEFAL | MSCPQCQRPF | QKCHLNIHIL |
| 190 | 200 | 210 | 220 | 230 | 240 |
| KECPRRQVPC | ENCAVSMAFE | DKEIHEQNCP | LANVICEYCN | TMLIREQMPN | HYDLDCPTAP |
| 250 | 260 | 270 | 280 | 290 | 300 |
| VPCTFSAFGC | HEKMQRNHLA | RHLQENTQSH | MRMMAQAVQT | LSLAVAPVPQ | CTMPLYDSVP |
| 310 | 320 | 330 | 340 | 350 | 360 |
| PTRPSSGRHS | EVHNFQETIQ | QLEGRLVRQD | HQIRELTAKM | ETQSMYVNEL | KRTIRTLEDK |
| 370 | 380 | 390 | 400 | 410 | 420 |
| VAEIEAQQCN | GIYIWKIGNF | GMHLKSQEEE | KPVVIHSPGF | YTGKPGYKLC | MRLHLQLPSA |
| 430 | 440 | 450 | 460 | 470 | 480 |
| QRCANYISLF | VHTMQGEYDS | HLPWPFQGTI | RLTILDQSEA | AVRQNHEEIM | DAKPELLAFQ |
| 490 | 500 | 510 | 520 | 530 | 540 |
| RPTIPRNPKG | FGYVTFMHLE | ALRQRTFIKD | DTLLVRCEVS | TRFDMGSLRR | EGFQPRSTDS |
| GI |