Q3ZBV2

SS
Gene name
DDX19A
Protein name
ATP-dependent RNA helicase DDX19A
Names
DEAD box protein 19A
Species
Bos taurus (Bovine)
KEGG Pathway
bta:529929
EC number
3.6.4.13: Acting on ATP; involved in cellular and subcellular movement
Protein Class

Descriptions

(Annotation from UniProt)
The N-terminal extension helix acts as an autoinhibitory domain, preventing ATP hydrolysis, unless the N-terminus of the protein is displaced by RNA binding, allowing cleft closure to bring key side chains into position for catalysis.

Autoinhibitory domains (AIDs)

54-67 (N-terminal extension helix) SS

Target domain

124-294 (Helicase ATP-binding domain)

Relief mechanism

Ligand binding

Assay

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for Q3ZBV2

Entry ID Method Resolution Chain Position Source
AF-Q3ZBV2-F1 Predicted AlphaFoldDB

68 variants for Q3ZBV2

Variant ID(s) Position Change Description Diseaes Association Provenance
rs442565598 2 A>P No Ensembl
rs472213928 5 S>* No Ensembl
rs453634207 6 W>* No Ensembl
rs432074329 8 L>R No Ensembl
rs456052820 9 A>G No Ensembl
rs437622494 10 V>G No Ensembl
rs470472051 11 D>A No Ensembl
rs455268278 12 E>D No Ensembl
rs436547653 13 Q>E No Ensembl
rs466373624 13 Q>R No Ensembl
rs477571741 14 E>D No Ensembl
rs447757400 14 E>G No Ensembl
rs449997848 18 K>N No Ensembl
rs483104845 19 S>L No Ensembl
rs483104845 19 S>W No Ensembl
rs457572155 22 N>K No Ensembl
rs516944365 32 P>S No Ensembl
rs452292775 76 V>M No Ensembl
rs473392897 134 I>M No Ensembl
rs433095123 135 A>D No Ensembl
rs451556246 135 A>P No Ensembl
rs469298103 136 Q>* No Ensembl
rs435417876 141 T>P No Ensembl
rs446507307 146 A>P No Ensembl
rs434346760 152 L>V No Ensembl
rs464137636 155 V>G No Ensembl
rs445658580 157 P>L No Ensembl
rs463132949 159 E>G No Ensembl
rs450990553 161 Y>D No Ensembl
rs480632964 161 Y>S No Ensembl
rs440519509 163 Q>E No Ensembl
rs473397968 163 Q>R No Ensembl
rs460250031 210 E>D No Ensembl
rs478746356 210 E>Q No Ensembl
rs438336862 211 H>Y No Ensembl
rs477806311 213 V>G No Ensembl
rs459205726 215 G>C No Ensembl
rs459205726 215 G>S No Ensembl
rs443965421 216 T>P No Ensembl
rs455101262 222 D>E No Ensembl
rs443034851 224 C>* No Ensembl
rs472733097 225 S>P No Ensembl
rs454143280 236 K>E No Ensembl
rs432320623 239 V>A No Ensembl
rs449068115 246 M>I No Ensembl
rs437842600 246 M>L No Ensembl
rs467685757 246 M>R No Ensembl
rs478851397 250 Q>H No Ensembl
rs478851397 250 Q>H No Ensembl
rs466643293 251 G>V No Ensembl
rs444963548 260 Q>E No Ensembl
rs455593688 287 V>L No Ensembl
rs433848697 289 P>L No Ensembl
rs473363264 293 I>L No Ensembl
rs432993244 293 I>M No Ensembl
rs451508633 293 I>T No Ensembl
rs469022039 299 E>G No Ensembl
rs450624912 300 E>D No Ensembl
rs435149053 305 T>P No Ensembl
rs446471243 321 Q>R No Ensembl
rs460730213 324 C>F No Ensembl
rs435266231 372 A>D No Ensembl
rs446404652 388 T>S No Ensembl
rs434379668 392 C>R No Ensembl
rs439675444 409 L>H No Ensembl
rs441753327 436 G>R No Ensembl
rs446178803 471 D>A No Ensembl
rs437152750 474 E>K No Ensembl

No associated diseases with Q3ZBV2

3 regional properties for Q3ZBV2

Type Name Position InterPro Accession
domain Helicase, C-terminal 305 - 473 IPR001650
domain Helicase superfamily 1/2, ATP-binding domain 110 - 309 IPR014001
domain RNA helicase, DEAD-box type, Q motif 91 - 119 IPR014014

Functions

Description
EC Number 3.6.4.13 Acting on ATP; involved in cellular and subcellular movement
Subcellular Localization
  • Cytoplasm
  • Nucleus, nucleoplasm
  • Associates with the nuclear pore complex cytoplasmic fibrils
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

3 GO annotations of cellular component

Name Definition
cytoplasmic stress granule A dense aggregation in the cytosol composed of proteins and RNAs that appear when the cell is under stress.
nucleoplasm That part of the nuclear content other than the chromosomes or the nucleolus.
nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.

4 GO annotations of molecular function

Name Definition
ATP binding Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
ATP hydrolysis activity Catalysis of the reaction: ATP + H2O = ADP + H+ phosphate. ATP hydrolysis is used in some reactions as an energy source, for example to catalyze a reaction or drive transport against a concentration gradient.
RNA binding Binding to an RNA molecule or a portion thereof.
RNA helicase activity Unwinding of an RNA helix, driven by ATP hydrolysis.

1 GO annotations of biological process

Name Definition
poly(A)+ mRNA export from nucleus The directed movement of poly(A)+ mRNA out of the nucleus into the cytoplasm.

13 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
Q2NL22 EIF4A3 Eukaryotic initiation factor 4A-III Bos taurus (Bovine) PR
Q5W5U4 DDX4 Probable ATP-dependent RNA helicase DDX4 Bos taurus (Bovine) SS
Q2TBP1 DDX25 ATP-dependent RNA helicase DDX25 Bos taurus (Bovine) PR
Q3SZ65 EIF4A2 Eukaryotic initiation factor 4A-II Bos taurus (Bovine) PR
Q3T147 DDX39B Spliceosome RNA helicase DDX39B Bos taurus (Bovine) PR
Q0IIK5 DDX1 ATP-dependent RNA helicase DDX1 Bos taurus (Bovine) PR
Q9UHL0 DDX25 ATP-dependent RNA helicase DDX25 Homo sapiens (Human) PR
Q9UMR2 DDX19B ATP-dependent RNA helicase DDX19B Homo sapiens (Human) PR
Q9NUU7 DDX19A ATP-dependent RNA helicase DDX19A Homo sapiens (Human) PR
Q9QY15 Ddx25 ATP-dependent RNA helicase DDX25 Mus musculus (Mouse) PR
Q61655 Ddx19a ATP-dependent RNA helicase DDX19A Mus musculus (Mouse) SS
Q10RI7 Os03g0158200 DEAD-box ATP-dependent RNA helicase 38 Oryza sativa subsp japonica (Rice) PR
Q93ZG7 RH38 DEAD-box ATP-dependent RNA helicase 38 Arabidopsis thaliana (Mouse-ear cress) PR
10 20 30 40 50 60
MATDSWALAV DEQEAAVKSM SNLQIKEEKV KPDTNGVIKT NATPEKTDEE EKEDRAAQSL
70 80 90 100 110 120
LNKLIRSNLV DNTNQVEVLQ RDPNSPLYSV KSFEELRLKP QLLQGVYAMG FNRPSKIQEN
130 140 150 160 170 180
ALPMMLAEPP QNLIAQSQSG TGKTAAFVLA MLSRVEPAER YPQCLCLSPT YELALQTGKV
190 200 210 220 230 240
IEQMGKFHPE LKLAYAVRGN KLERGQKISE HIVIGTPGTV LDWCSKLKFI DPKKIKVFVL
250 260 270 280 290 300
DEADVMIATQ GHQDQSIRIQ RMLPRNCQML LFSATFEDSV WKFAQKVVPD PNIIKLKREE
310 320 330 340 350 360
ETLDTIKQYY VLCNSRDEKF QALCNIYGAI TIAQAMIFCH TRKTASWLAA ELSKEGHQVA
370 380 390 400 410 420
LLSGEMVVEQ RAAVIERFRE GKEKVLVTTN VCARGIDVEQ VSVVINFDLP VDKDGNPDNE
430 440 450 460 470
TYLHRIGRTG RFGKRGLAVN MVDSKHSMNI LNRIQEHFNK KIERLDTDDL DEIEKIAN