Q3ZBL9
Gene name |
CCNH |
Protein name |
Cyclin-H |
Names |
|
Species |
Bos taurus (Bovine) |
KEGG Pathway |
bta:615512 |
EC number |
|
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for Q3ZBL9
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-Q3ZBL9-F1 | Predicted | AlphaFoldDB |
No variants for Q3ZBL9
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| No variants for Q3ZBL9 | |||||
No associated diseases with Q3ZBL9
3 GO annotations of cellular component
| Name | Definition |
|---|---|
| nucleus | A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. |
| transcription factor TFIIH holo complex | A complex that is capable of kinase activity directed towards the C-terminal Domain (CTD) of the largest subunit of RNA polymerase II and is essential for initiation at RNA polymerase II promoters in vitro. It is composed of the core TFIIH complex and the TFIIK complex. |
| transcription factor TFIIK complex | A transcription factor complex that forms part of the holo TFIIH complex. In Saccharomyces/human, TFIIK contains Ccl1p/Cyclin H, Tfb3p/MAT1 and Kin28p/CDK7. |
1 GO annotations of molecular function
| Name | Definition |
|---|---|
| cyclin-dependent protein serine/threonine kinase regulator activity | Modulates the activity of a cyclin-dependent protein serine/threonine kinase, enzymes of the protein kinase family that are regulated through association with cyclins and other proteins. |
5 GO annotations of biological process
| Name | Definition |
|---|---|
| cell cycle | The progression of biochemical and morphological phases and events that occur in a cell during successive cell replication or nuclear replication events. Canonically, the cell cycle comprises the replication and segregation of genetic material followed by the division of the cell, but in endocycles or syncytial cells nuclear replication or nuclear division may not be followed by cell division. |
| phosphorylation of RNA polymerase II C-terminal domain | The process of introducing a phosphate group on to an amino acid residue in the C-terminal domain of RNA polymerase II. Typically, this occurs during the transcription cycle and results in production of an RNA polymerase II enzyme where the carboxy-terminal domain (CTD) of the largest subunit is extensively phosphorylated, often referred to as hyperphosphorylated or the II(0) form. Specific types of phosphorylation within the CTD are usually associated with specific regions of genes, though there are exceptions. The phosphorylation state regulates the association of specific complexes such as the capping enzyme or 3'-RNA processing machinery to the elongating RNA polymerase complex. |
| regulation of cyclin-dependent protein serine/threonine kinase activity | Any process that modulates the frequency, rate or extent of cyclin-dependent protein serine/threonine kinase activity. |
| regulation of transcription by RNA polymerase II | Any process that modulates the frequency, rate or extent of transcription mediated by RNA polymerase II. |
| transcription by RNA polymerase II | The synthesis of RNA from a DNA template by RNA polymerase II (RNAP II), originating at an RNA polymerase II promoter. Includes transcription of messenger RNA (mRNA) and certain small nuclear RNAs (snRNAs). |
5 homologous proteins in AiPD
| 10 | 20 | 30 | 40 | 50 | 60 |
| MYHNSSQKRH | WTFASEEQLA | RLRADANRKF | KCKAVANGKV | LPNDPVFLEP | HEEITLCKYY |
| 70 | 80 | 90 | 100 | 110 | 120 |
| EKRLLEFCSV | FKPAMPRSVV | GTACMYFKRF | YLNNSVMEYH | PRIIMLTCAF | LACKVDEFNV |
| 130 | 140 | 150 | 160 | 170 | 180 |
| SSPQFVGNLR | ESPLGQEKTL | EQILEYELLL | IQQLNFHLIV | HNPYRPFEGF | LIDLKTRYPL |
| 190 | 200 | 210 | 220 | 230 | 240 |
| LENPEILRKT | ADDFLNRVAL | TDAHLLYTPS | QIALTAILSS | ASRAGITMES | YLSESLMLKE |
| 250 | 260 | 270 | 280 | 290 | 300 |
| NRTSLSQLLD | IMKSMRNLVK | KYEPPRPEEV | AALKQKLERC | HSAELALNVV | TKKRKGYEDD |
| 310 | |||||
| DYVSKKSKHE | EVCSPKGSFM |