Q3ZBH9

PR
Gene name
MCM7
Protein name
DNA replication licensing factor MCM7
Names
Species
Bos taurus (Bovine)
KEGG Pathway
bta:539924
EC number
3.6.4.12: Acting on ATP; involved in cellular and subcellular movement
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

82-162 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for Q3ZBH9

Entry ID Method Resolution Chain Position Source
AF-Q3ZBH9-F1 Predicted AlphaFoldDB

166 variants for Q3ZBH9

Variant ID(s) Position Change Description Diseaes Association Provenance
rs467435352 3 L>F No EVA
rs462966939 7 V>E No EVA
rs459479527 20 F>L No EVA
rs479453521 31 F>L No EVA
rs444985200 34 G>R No EVA
rs465327709 35 N>S No EVA
rs476671667 94 V>I No EVA
rs442000295 95 N>S No EVA
rs472686884 102 Y>* No EVA
rs441441552 105 H>L No EVA
rs452632826 106 R>L No EVA
rs458185494 109 M>I No EVA
rs478403522 115 D>A No EVA
rs445736204 123 Q>H No EVA
rs462639109 124 N>I No EVA
rs472360988 174 K>N No EVA
rs441468221 182 Y>S No EVA
rs458269742 183 T>P No EVA
rs472012673 185 D>A No EVA
rs443801265 186 Q>K No EVA
rs462652430 187 C>G No EVA
rs482790650 187 C>W No EVA
rs448149539 189 A>P No EVA
rs461750022 191 T>P No EVA
rs478557742 192 Y>H No EVA
rs447630711 192 Y>S No EVA
rs443558447 195 I>M No EVA
rs463608047 199 T>A No EVA
rs463608047 199 T>P No EVA
rs480253043 201 M>L No EVA
rs448972982 203 L>Q No EVA
rs465771162 230 I>L No EVA
rs479731206 235 M>I No EVA
rs445251083 237 M>R No EVA
rs465373905 239 E>Q No EVA
rs477770107 242 D>E No EVA
rs467286454 309 S>R No EVA
rs452812905 329 E>G No EVA
rs432284705 345 Y>F No EVA
rs475657675 346 G>A No EVA
rs452335826 346 G>R No EVA
rs455054470 356 L>I No EVA
rs475120048 356 L>R No EVA
rs460509642 359 V>G No EVA
rs440498750 359 V>M No EVA
rs439939094 362 V>G No EVA
rs448572899 363 D>E No EVA
rs483061623 363 D>V No EVA
rs468579482 365 S>F No EVA
rs480939374 366 P>T No EVA
rs446460781 367 R>L No EVA
rs469278511 369 M>I No EVA
rs445936920 369 M>K No EVA
rs437867486 371 I>N No EVA
rs474758161 372 R>M No EVA
rs470058584 374 N>D No EVA
rs435548658 374 N>I No EVA
rs455913327 376 N>K No EVA
rs472688716 377 I>S No EVA
rs471928239 382 D>E No EVA
rs451887411 382 D>V No EVA
rs439331142 384 G>C No EVA
rs482648948 390 L>P No EVA
rs461713275 394 I>T No EVA
rs478971354 395 D>H No EVA
rs447450577 396 R>S No EVA
rs450137971 397 L>P No EVA
rs470097241 398 A>P No EVA
rs470097241 398 A>S No EVA
rs479889429 412 V>G No EVA
rs445208326 414 L>R No EVA
rs465343089 416 A>G No EVA
rs437494559 420 R>T No EVA
rs468009661 424 S>G No EVA
rs436580648 424 S>R No EVA
rs472257727 427 L>R No EVA
rs455448787 427 L>V No EVA
rs434438828 428 T>A No EVA
rs471172377 429 L>F No EVA
rs457072926 432 G>W No EVA
rs473833701 433 A>G No EVA
rs442563454 435 V>L No EVA
rs459515442 438 D>G No EVA
rs479985983 441 V>E No EVA
rs479985983 441 V>G No EVA
rs438840837 448 D>E No EVA
rs458889876 459 H>P No EVA
rs482205278 459 H>Q No EVA
rs451262011 462 M>I No EVA
rs468044882 463 E>D No EVA
rs447015363 465 Q>H No EVA
rs481647686 465 Q>K No EVA
rs467158210 466 T>P No EVA
rs434490901 469 I>M No EVA
rs451376298 474 I>L No EVA
rs517117070 476 T>A No EVA
rs464845434 477 T>P No EVA
rs436738433 482 C>S No EVA
rs457109737 487 A>P No EVA
rs434991383 489 N>T No EVA
rs442683874 491 A>S No EVA
rs453035635 502 E>D No EVA
rs473189624 503 Q>L No EVA
rs438923952 504 N>H No EVA
rs482242087 510 A>P No EVA
rs461308912 517 L>P No EVA
rs481735581 518 L>P No EVA
rs447089543 519 W>G No EVA
rs444923691 521 I>T No EVA
rs436826037 523 D>A No EVA
rs464882372 523 D>Y No EVA
rs456795610 525 P>T No EVA
rs436294930 526 D>G No EVA
rs467155366 526 D>N No EVA
rs453172535 528 D>N No EVA
rs432132063 530 D>V No EVA
rs452660801 531 L>V No EVA
rs468299356 534 A>D No EVA
rs464611456 539 Y>* No EVA
rs454133354 539 Y>S No EVA
rs433124827 542 Q>H No EVA
rs456705735 555 D>H No EVA
rs456705735 555 D>Y No EVA
rs476722324 557 K>N No EVA
rs480781494 577 L>R No EVA
rs459730223 578 A>S No EVA
rs1114324868 580 Y>C No EVA
rs445591853 587 E>G No EVA
rs465649405 591 E>V No EVA
rs451139094 601 T>P No EVA
rs451528482 612 L>P No EVA
rs471532961 613 S>Y No EVA
rs443440282 615 A>D No EVA
rs109008195 616 L>V No EVA
rs471131735 625 V>M No EVA
rs439816807 626 E>G No EVA
rs476825738 629 D>A No EVA
rs460981666 630 V>G No EVA
rs444165298 630 V>L No EVA
rs474654858 631 N>I No EVA
rs460104191 632 E>* No EVA
rs477301218 635 R>W No EVA
rs445954243 636 L>V No EVA
rs462800798 637 M>R No EVA
rs482869067 638 E>G No EVA
rs468666137 639 M>K No EVA
rs468666137 639 M>R No EVA
rs434023363 640 S>A No EVA
rs447602510 641 K>E No EVA
rs464353454 642 D>A No EVA
rs439166343 642 D>E No EVA
rs464353454 642 D>G No EVA
rs476866227 645 L>R No EVA
rs435766829 646 G>C No EVA
rs474729330 647 D>E No EVA
rs440083641 648 K>E No EVA
rs439562993 650 Q>E No EVA
rs482933948 650 Q>H No EVA
rs439562993 650 Q>K No EVA
rs462812098 650 Q>L No EVA
rs462812098 650 Q>R No EVA
rs448208037 651 T>K No EVA
rs461909380 652 A>T No EVA
rs447686439 653 R>M No EVA
rs455597817 691 P>T No EVA
rs440980711 708 Q>* No EVA

No associated diseases with Q3ZBH9

6 regional properties for Q3ZBH9

Type Name Position InterPro Accession
domain MCM domain 322 - 541 IPR001208
domain AAA+ ATPase domain 373 - 526 IPR003593
conserved_site Mini-chromosome maintenance, conserved site 440 - 448 IPR018525
domain MCM N-terminal domain 11 - 139 IPR027925
domain MCM OB domain 149 - 278 IPR033762
domain MCM, AAA-lid domain 558 - 640 IPR041562

Functions

Description
EC Number 3.6.4.12 Acting on ATP; involved in cellular and subcellular movement
Subcellular Localization
  • Nucleus
  • Chromosome
  • Associated with chromatin before the formation of nuclei and detaches from it as DNA replication progresses
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

5 GO annotations of cellular component

Name Definition
CMG complex A protein complex that contains the GINS complex, Cdc45p, and the heterohexameric MCM complex, and that is involved in unwinding DNA during replication.
cytosol The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
MCM complex A hexameric protein complex required for the initiation and regulation of DNA replication.
nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
organelle membrane A membrane that is one of the two lipid bilayers of an organelle envelope or the outermost membrane of single membrane bound organelle.

4 GO annotations of molecular function

Name Definition
ATP binding Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
ATP hydrolysis activity Catalysis of the reaction: ATP + H2O = ADP + H+ phosphate. ATP hydrolysis is used in some reactions as an energy source, for example to catalyze a reaction or drive transport against a concentration gradient.
DNA helicase activity Unwinding of a DNA helix, driven by ATP hydrolysis.
single-stranded DNA binding Binding to single-stranded DNA.

9 GO annotations of biological process

Name Definition
cell cycle The progression of biochemical and morphological phases and events that occur in a cell during successive cell replication or nuclear replication events. Canonically, the cell cycle comprises the replication and segregation of genetic material followed by the division of the cell, but in endocycles or syncytial cells nuclear replication or nuclear division may not be followed by cell division.
cell population proliferation The multiplication or reproduction of cells, resulting in the expansion of a cell population.
cellular response to DNA damage stimulus Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating damage to its DNA from environmental insults or errors during metabolism.
cellular response to xenobiotic stimulus Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus from a xenobiotic, a compound foreign to the organism exposed to it. It may be synthesized by another organism (like ampicilin) or it can be a synthetic chemical.
DNA replication initiation The process in which DNA-dependent DNA replication is started; this begins with the ATP dependent loading of an initiator complex onto the DNA, this is followed by DNA melting and helicase activity. In bacteria, the gene products that enable the helicase activity are loaded after the initial melting and in archaea and eukaryotes, the gene products that enable the helicase activity are inactive when they are loaded and subsequently activate.
DNA strand elongation involved in DNA replication The process in which an existing DNA strand is extended by activities including the addition of nucleotides to the 3' end of the strand, complementary to an existing template, as part of DNA replication.
DNA unwinding involved in DNA replication The process in which interchain hydrogen bonds between two strands of DNA are broken or 'melted', generating unpaired template strands for DNA replication.
double-strand break repair via break-induced replication The error-free repair of a double-strand break in DNA in which the centromere-proximal end of a broken chromosome searches for a homologous region in an intact chromosome. DNA synthesis initiates from the 3' end of the invading DNA strand, using the intact chromosome as the template, and progresses to the end of the chromosome.
regulation of phosphorylation Any process that modulates the frequency, rate or extent of addition of phosphate groups into a molecule.

5 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
Q2KIZ8 MCM6 DNA replication licensing factor MCM6 Bos taurus (Bovine) PR
Q9XYU0 Mcm7 DNA replication licensing factor Mcm7 Drosophila melanogaster (Fruit fly) PR
P33993 MCM7 DNA replication licensing factor MCM7 Homo sapiens (Human) PR
Q61881 Mcm7 DNA replication licensing factor MCM7 Mus musculus (Mouse) PR
Q6NX31 mcm7 DNA replication licensing factor mcm7 Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) PR
10 20 30 40 50 60
MALKDYVLEK DKVKKFLQEF YQDDESGKKQ FKYGNQLVQL AHREQVAMYV DLDDIAEDDP
70 80 90 100 110 120
ELVDSICENT KRYARLFADA VQELLPQYKE REVVNKDVLD VYIEHRLMME QRSRDPGAAR
130 140 150 160 170 180
SPQNQYPPEL MRRFELYFQG PSSNKPRVIR EVRADSVGKL VTVRGIVTRV SEVKPRMVVA
190 200 210 220 230 240
TYTCDQCGAE TYQPIQSPTF MPLIMCPSQE CQTNRSGGRL YLQTRGSKFI KFQEMKMQEH
250 260 270 280 290 300
SDQVPVGNIP RSITVLVEGE NTRIAQPGDH VSVTGIFLPI LRTGFRQMVQ GLLSETYLEA
310 320 330 340 350 360
HRIVKMSKSE EDESGAGELT REELRQITEE DFYEKLAASI APEIYGHEDV KKALLLLLVG
370 380 390 400 410 420
GVDQSPRGMK IRGNINICLM GDPGVAKSQL LSYIDRLAPR SQYTTGRGSS GVGLTAAVLR
430 440 450 460 470 480
DSVSGELTLE GGALVLADQG VCCIDEFDKM AEADRTAIHE VMEQQTISIA KAGILTTLNA
490 500 510 520 530 540
RCSILAAANP AYGRYNPRRS LEQNIQLPAA LLSRFDLLWL IQDRPDRDND LRLAQHITYV
550 560 570 580 590 600
HQHSRQPPAQ FEPLDMKLMR RYIAMCREKQ PAVPESLADY ITAAYVEMRR EAWASKDATY
610 620 630 640 650 660
TSARTLLAIL RLSTALARLR MVDTVEKEDV NEAIRLMEMS KDSLLGDKGQ TARTQRPADV
670 680 690 700 710
IFATVRELVS EGQSVRFSEA EQRCISRGFT PAQFQAALDE YEELNVWQVN TARTRITFV