AiPD: Autoinhibited Protein Database

Gene name	Hipk4 (Gm162)
Protein name	Homeodomain-interacting protein kinase 4
Names
Species	Mus musculus (Mouse)
KEGG Pathway	mmu:233020
EC number	2.7.11.1: Protein-serine/threonine kinases
Protein Class

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

313-616 (Predicted disordered autoinhibitory region) PR

313-616 (Predicted disordered autoinhibitory region)

cis-regPred

No accessory elements

Entry ID	Method	Resolution	Chain	Position	Source
AF-Q3V016-F1	Predicted				AlphaFoldDB

Variant ID(s)	Position	Change	Diseaes Association	Provenance
rs3388865803	14	I>M	No	EVA
rs3388884762	32	S>R	No	EVA
rs3388865841	57	K>R	No	EVA
rs3388892299	94	Q>P	No	EVA
rs3388874997	105	F>I	No	EVA
rs3388884025	106	A>V	No	EVA
rs3388893853	129	E>Q	No	EVA
rs3388872397	147	Q>*	No	EVA
rs3397749971	155	K>R	No	EVA
rs3388865845	175	Y>*	No	EVA
rs3388884796	175	Y>F	No	EVA
rs3388893845	193	C>Y	No	EVA
rs3388883984	222	D>N	No	EVA
rs3388887449	238	L>W	No	EVA
rs3397762503	240	H>Y	No	EVA
rs3388872387	242	A>T	No	EVA
rs3388875054	249	F>I	No	EVA
rs3388893883	258	T>I	No	EVA
rs248677002	270	L>I	No	EVA
rs3388884044	315	A>T	No	EVA
rs3388884770	324	I>M	No	EVA
rs3388851377	355	A>T	No	EVA
rs3388893833	451	V>I	No	EVA
rs234697230	480	G>S	No	EVA
rs238942938	483	L>V	No	EVA
rs3388880933	486	R>L	No	EVA
rs3388872389	494	A>V	No	EVA
rs3388851284	513	P>S	No	EVA
rs1131814675	518	P>S	No	EVA
rs3397296915	548	G>V	No	EVA
rs3388892752	549	I>F	No	EVA
rs3388884054	562	E>D	No	EVA
rs3388874989	587	S>T	No	EVA
rs3388895109	587	S>Y	No	EVA

Type	Name	Position	InterPro Accession
repeat	Leucine-rich repeat	121 - 140	IPR001611-1
repeat	Leucine-rich repeat	146 - 162	IPR001611-2
repeat	Leucine-rich repeat	229 - 250	IPR001611-3
repeat	Leucine-rich repeat	300 - 322	IPR001611-4
repeat	Leucine-rich repeat	324 - 346	IPR001611-5
repeat	Leucine-rich repeat	500 - 521	IPR001611-6
repeat	Leucine-rich repeat	591 - 657	IPR001611-7
repeat	Leucine-rich repeat, typical subtype	119 - 143	IPR003591-1
repeat	Leucine-rich repeat, typical subtype	144 - 169	IPR003591-2
repeat	Leucine-rich repeat, typical subtype	298 - 322	IPR003591-3
repeat	Leucine-rich repeat, typical subtype	419 - 444	IPR003591-4
repeat	Leucine-rich repeat, typical subtype	498 - 521	IPR003591-5
repeat	Leucine-rich repeat, typical subtype	522 - 546	IPR003591-6
repeat	Leucine-rich repeat, typical subtype	608 - 631	IPR003591-7
repeat	Leucine-rich repeat, typical subtype	632 - 657	IPR003591-8
domain	Leucine-rich repeat-containing N-terminal, plant-type	54 - 91	IPR013210

		Description
EC Number	2.7.11.1	Protein-serine/threonine kinases
Subcellular Localization	Cytoplasm
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category	No pathway information available

Name	Definition
cytoplasm	The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
nucleus	A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.

Name	Definition
ATP binding	Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
histone kinase activity	Catalysis of the transfer of a phosphate group to a histone.
protein kinase activity	Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP.
protein serine kinase activity	Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate.
protein serine/threonine kinase activity	Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate, and ATP + protein threonine = ADP + protein threonine phosphate.
protein tyrosine kinase activity	Catalysis of the reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate.

Name	Definition
histone modification	The covalent alteration of one or more amino acid residues within a histone protein.
peptidyl-serine phosphorylation	The phosphorylation of peptidyl-serine to form peptidyl-O-phospho-L-serine.
peptidyl-threonine phosphorylation	The phosphorylation of peptidyl-threonine to form peptidyl-O-phospho-L-threonine.
protein autophosphorylation	The phosphorylation by a protein of one or more of its own amino acid residues (cis-autophosphorylation), or residues on an identical protein (trans-autophosphorylation).
protein phosphorylation	The process of introducing a phosphate group on to a protein.
regulation of signal transduction by p53 class mediator	Any process that modulates the frequency, rate or extent of signal transduction by p53 class mediator.

UniProt AC	Gene Name	Protein Name	Species	Evidence Code
Q92630	DYRK2	Dual specificity tyrosine-phosphorylation-regulated kinase 2	Homo sapiens (Human)	PR
Q13627	DYRK1A	Dual specificity tyrosine-phosphorylation-regulated kinase 1A	Homo sapiens (Human)	PR
Q9NR20	DYRK4	Dual specificity tyrosine-phosphorylation-regulated kinase 4	Homo sapiens (Human)	PR
Q9H2X6	HIPK2	Homeodomain-interacting protein kinase 2	Homo sapiens (Human)	EV
Q9H422	HIPK3	Homeodomain-interacting protein kinase 3	Homo sapiens (Human)	SS
Q8NE63	HIPK4	Homeodomain-interacting protein kinase 4	Homo sapiens (Human)	PR
Q61214	Dyrk1a	Dual specificity tyrosine-phosphorylation-regulated kinase 1A	Mus musculus (Mouse)	PR
Q9QZR5	Hipk2	Homeodomain-interacting protein kinase 2	Mus musculus (Mouse)	SS
Q8BI55	Dyrk4	Dual specificity tyrosine-phosphorylation-regulated kinase 4	Mus musculus (Mouse)	PR
Q4V793	Hipk4	Homeodomain-interacting protein kinase 4	Rattus norvegicus (Rat)	PR