AiPD: Autoinhibited Protein Database

Gene name	Ubtfl1
Protein name	Upstream-binding factor 1-like protein 1
Names	HMG-box preimplantation embryo-specific protein, HMGPI
Species	Mus musculus (Mouse)
KEGG Pathway	mmu:546118
EC number
Protein Class

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

1-394 (Predicted disordered autoinhibitory region) PR

1-394 (Predicted disordered autoinhibitory region)

cis-regPred

No accessory elements

Entry ID	Method	Resolution	Chain	Position	Source
AF-Q3USZ2-F1	Predicted				AlphaFoldDB

Variant ID(s)	Position	Change	Diseaes Association	Provenance
rs3388974578	18	L>F	No	EVA
rs257706876	23	E>K	No	EVA
rs45941702	71	R>C	No	EVA
rs215218690	87	K>N	No	EVA
rs217731160	137	E>K	No	EVA
rs234955480	140	R>H	No	EVA
rs260084645	171	R>K	No	EVA
rs580123867	173	P>S	No	EVA
rs48062114	178	P>L	No	EVA
rs224767171	193	T>M	No	EVA
rs244824557	238	E>D	No	EVA
rs3399324881	250	F>L	No	EVA
rs3399904749	250	F>Y	No	EVA
rs3389012745	284	R>G	No	EVA
rs46115002	311	K>N	No	EVA
rs255917127	329	E>Q	No	EVA
rs248970436	365	A>S	No	EVA
rs264126176	370	Q>K	No	EVA
rs233165269	373	T>M	No	EVA
rs252360499	379	D>E	No	EVA
rs225711245	395	D>E	No	EVA

Type	Name	Position	InterPro Accession
domain	High mobility group box domain	100 - 170	IPR009071-1
domain	High mobility group box domain	224 - 292	IPR009071-2

		Description
EC Number
Subcellular Localization	Cytoplasm Nucleus	Mainly cytoplasmic from the 4-cell stage to the morula stage Becomes nuclear at the blastocyst stage In ES cells, found in both the nucleus and the cytoplasm
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category	No pathway information available

Name	Definition
cytoplasm	The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
nucleus	A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.

Name	Definition
RNA polymerase I core promoter sequence-specific DNA binding	Binding to a regulatory region composed of the transcription start site and binding sites for transcription factors of the RNA polymerase I transcription machinery. This site is often referred to as the CORE element. In mammalian cells, the CORE element functions in conjunction with the Upstream Control Element (UCE), while in fungi, protozoa, and plants, the CORE element functions without a UCE.
RNA polymerase I general transcription initiation factor activity	A general transcription initiation factor activity that contributes to transcription start site selection and transcription initiation of genes transcribed by RNA polymerase I. Factors required for RNA polymerase I transcription initiation include upstream activation factor (UAF), core factor (CF), TATA binding protein (TBP) and RRN3. In all species characterized, RNA polymerase I transcribes a large polycistronic transcript that is processed into several mature rRNAs (3 or 4 depending on the species), including the large subunit rRNA (28S in humans), the small subunit rRNA (18S in humans), as well as one or two additional smaller rRNAs (the 5.8S rRNA in humans). In most species, this large rRNA transcript is the sole product of RNA polymerase I. However there are rare exceptions, such as Trypanosoma brucei, where RNA polymerase I also transcribes certain mRNAs.

Name	Definition
blastocyst growth	An increase in size of a blastocyst due to expansion of the blastocoelic cavity cell shape changes and cell proliferation.
embryo implantation	Attachment of the blastocyst to the uterine lining.
positive regulation of transcription by RNA polymerase I	Any process that activates or increases the frequency, rate or extent of transcription mediated by RNA polymerase I.
regulation of gene expression	Any process that modulates the frequency, rate or extent of gene expression. Gene expression is the process in which a gene's coding sequence is converted into a mature gene product (protein or RNA).
transcription by RNA polymerase I	The synthesis of RNA from a DNA template by RNA polymerase I (RNAP I), originating at an RNAP I promoter.

UniProt AC	Gene Name	Protein Name	Species	Evidence Code
Q32L34	HMGB4	High mobility group protein B4	Bos taurus (Bovine)	PR
Q0II87	TFAM	Transcription factor A, mitochondrial	Bos taurus (Bovine)	PR
Q00059	TFAM	Transcription factor A, mitochondrial	Homo sapiens (Human)	PR
P17480	UBTF	Nucleolar transcription factor 1	Homo sapiens (Human)	EV
P0CB48	UBTFL6	Putative upstream-binding factor 1-like protein 6	Homo sapiens (Human)	PR
P40630	Tfam	Transcription factor A, mitochondrial	Mus musculus (Mouse)	PR
P25976	Ubtf	Nucleolar transcription factor 1	Mus musculus (Mouse)	PR
Q5D144	TFAM	Transcription factor A, mitochondrial	Sus scrofa (Pig)	PR
P25977	Ubtf	Nucleolar transcription factor 1	Rattus norvegicus (Rat)	PR
Q9T012	HMGB13	High mobility group B protein 13	Arabidopsis thaliana (Mouse-ear cress)	PR
Q9SUP7	HMGB6	High mobility group B protein 6	Arabidopsis thaliana (Mouse-ear cress)	PR