Q3UQ44
SS
Gene name |
Iqgap2 |
Protein name |
Ras GTPase-activating-like protein IQGAP2 |
Names |
|
Species |
Mus musculus (Mouse) |
KEGG Pathway |
mmu:544963 |
EC number |
|
Protein Class |
|
Descriptions
Ras GTPase-activating-like protein IQGAP1 plays a crucial role in regulating the dynamics and assembly of the actin cytoskeleton. IQGAP1 binds directly nucleotide-depleted Cdc42 (Cdc42-ND) and may serve as a negative effector or sequester nucleotide-free Cdc42 to prevent signaling. The regions C1 (956-1274) and C2 (1276-1657) of IQGAP1 can either interact with nucleotide-free Cdc42, or interact together, depending on the phosphorylation state of Ser-1443. When Ser-1443 is not phosphorylated, C1 and C2 interact, which prevents binding of nucleotide-free Cdc42 and promotes binding of GTP-bound Cdc42. The phosphorylation of Ser-1443 prevents interaction between C1 and C2, which opens the structure of the C-terminus and allows binding and sequestration of nucleotide-free Cdc42 on both C1 and C2.
Autoinhibitory domains (AIDs)
Target domain |
869-1187 (C1 fragments) |
Relief mechanism |
PTM |
Assay |
|
Accessory elements
No accessory elements
References
Autoinhibited structure
Activated structure
1 structures for Q3UQ44
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-Q3UQ44-F1 | Predicted | AlphaFoldDB |
80 variants for Q3UQ44
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| rs3403824891 | 25 | A>S | No | EVA | |
| rs3403762906 | 38 | Y>S | No | EVA | |
| rs3389290580 | 70 | R>L | No | EVA | |
| rs3389309637 | 79 | A>T | No | EVA | |
| rs3389226695 | 141 | N>T | No | EVA | |
| rs3389226648 | 146 | I>V | No | EVA | |
| rs3389226709 | 147 | Y>* | No | EVA | |
| rs3389294672 | 155 | Y>F | No | EVA | |
| rs3389313511 | 166 | Q>E | No | EVA | |
| rs3389290588 | 180 | S>I | No | EVA | |
| rs3389309629 | 184 | K>T | No | EVA | |
| rs3389272531 | 215 | H>Y | No | EVA | |
| rs3389298771 | 228 | G>R | No | EVA | |
| rs3389265128 | 285 | Y>* | No | EVA | |
| rs3389294625 | 294 | I>N | No | EVA | |
| rs3389290591 | 350 | N>S | No | EVA | |
| rs3389293505 | 354 | Q>R | No | EVA | |
| rs3389299357 | 356 | T>I | No | EVA | |
| rs234561023 | 443 | I>V | No | EVA | |
| rs50650803 | 485 | D>N | No | EVA | |
| rs3389298801 | 501 | T>S | No | EVA | |
| rs3389293537 | 508 | D>V | No | EVA | |
| rs3389280938 | 510 | K>N | No | EVA | |
| rs29724564 | 513 | S>F | No | EVA | |
| rs3389272519 | 523 | Q>* | No | EVA | |
| rs29727558 | 526 | N>D | No | EVA | |
| rs1133124710 | 530 | V>G | No | EVA | |
| rs241095509 | 543 | V>I | No | EVA | |
| rs261510652 | 544 | D>N | No | EVA | |
| rs47890647 | 565 | P>S | No | EVA | |
| rs3389272480 | 643 | I>T | No | EVA | |
| rs3389280934 | 644 | V>M | No | EVA | |
| rs51782746 | 666 | R>C | No | EVA | |
| rs48301116 | 671 | T>A | No | EVA | |
| rs48735573 | 672 | L>S | No | EVA | |
| rs3389299381 | 693 | S>I | No | EVA | |
| rs3389298781 | 696 | K>Q | No | EVA | |
| rs3389294608 | 769 | D>Y | No | EVA | |
| rs3389296319 | 770 | Y>N | No | EVA | |
| rs3404533839 | 797 | D>E | No | EVA | |
| rs3404520987 | 798 | F>I | No | EVA | |
| rs3389290630 | 831 | K>T | No | EVA | |
| rs3404819253 | 950 | K>M | No | EVA | |
| rs3404520989 | 957 | I>L | No | EVA | |
| rs258829184 | 980 | T>S | No | EVA | |
| rs3389272530 | 997 | A>V | No | EVA | |
| rs3389313487 | 1000 | I>N | No | EVA | |
| rs3389265172 | 1013 | N>I | No | EVA | |
| rs49091994 | 1056 | D>G | No | EVA | |
| rs3389313527 | 1100 | V>A | No | EVA | |
| rs3389296340 | 1104 | L>V | No | EVA | |
| rs3389306198 | 1116 | P>H | No | EVA | |
| rs3389309672 | 1119 | F>L | No | EVA | |
| rs3389298772 | 1145 | L>M | No | EVA | |
| rs3508038489 | 1148 | A>T | No | EVA | |
| rs3389293546 | 1160 | H>R | No | EVA | |
| rs246182125 | 1186 | P>L | No | EVA | |
| rs3389306173 | 1198 | T>M | No | EVA | |
| rs3389306196 | 1231 | T>S | No | EVA | |
| rs3389290585 | 1233 | K>R | No | EVA | |
| rs3389290602 | 1265 | N>I | No | EVA | |
| rs3389299420 | 1281 | S>P | No | EVA | |
| rs51999239 | 1329 | G>E | No | EVA | |
| rs251313128 | 1344 | V>I | No | EVA | |
| rs47476195 | 1349 | T>A | No | EVA | |
| rs3389290593 | 1367 | L>F | No | EVA | |
| rs3389290577 | 1413 | L>P | No | EVA | |
| rs3389309655 | 1427 | A>T | No | EVA | |
| rs3389298824 | 1434 | F>S | No | EVA | |
| rs3389290639 | 1465 | D>N | No | EVA | |
| rs29248733 | 1468 | A>T | No | EVA | |
| rs3389306194 | 1489 | K>N | No | EVA | |
| rs1133153746 | 1492 | L>P | No | EVA | |
| rs255731848 | 1511 | I>M | No | EVA | |
| rs864280553 | 1515 | D>N | No | EVA | |
| rs3389280944 | 1521 | V>I | No | EVA | |
| rs3389299612 | 1523 | S>T | No | EVA | |
| rs3389299604 | 1524 | K>N | No | EVA | |
| rs3389296297 | 1527 | G>D | No | EVA | |
| rs3389270709 | 1545 | Y>* | No | EVA |
No associated diseases with Q3UQ44
1 regional properties for Q3UQ44
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| domain | Small GTP-binding protein domain | 12 - 139 | IPR005225 |
5 GO annotations of cellular component
| Name | Definition |
|---|---|
| cell cortex | The region of a cell that lies just beneath the plasma membrane and often, but not always, contains a network of actin filaments and associated proteins. |
| cell surface | The external part of the cell wall and/or plasma membrane. |
| filopodium | Thin, stiff, actin-based protrusion extended by the leading edge of a motile cell such as a crawling fibroblast or amoeba, or an axonal or dendritic growth cone, or a dendritic shaft. |
| lamellipodium | A thin sheetlike process extended by the leading edge of a migrating cell or extending cell process; contains a dense meshwork of actin filaments. |
| microvillus | Thin cylindrical membrane-covered projections on the surface of an animal cell containing a core bundle of actin filaments. Present in especially large numbers on the absorptive surface of intestinal cells. |
6 GO annotations of molecular function
| Name | Definition |
|---|---|
| actin filament binding | Binding to an actin filament, also known as F-actin, a helical filamentous polymer of globular G-actin subunits. |
| Arp2/3 complex binding | Binding to an Arp2/3 complex, a protein complex that contains two actin-related proteins, Arp2 and Arp3, and five novel proteins (ARPC1-5). |
| calmodulin binding | Binding to calmodulin, a calcium-binding protein with many roles, both in the calcium-bound and calcium-free states. |
| GTPase activator activity | Binds to and increases the activity of a GTPase, an enzyme that catalyzes the hydrolysis of GTP. |
| phosphatidylinositol-3,4,5-trisphosphate binding | Binding to phosphatidylinositol-3,4,5-trisphosphate, a derivative of phosphatidylinositol in which the inositol ring is phosphorylated at the 3', 4' and 5' positions. |
| small GTPase binding | Binding to a small monomeric GTPase. |
4 GO annotations of biological process
| Name | Definition |
|---|---|
| Arp2/3 complex-mediated actin nucleation | The actin nucleation process in which actin monomers combine to form a new branch on the side of an existing actin filament; mediated by the Arp2/3 protein complex and its interaction with other proteins. |
| mitotic actomyosin contractile ring assembly actin filament organization | Any actin filament organization that is involved in mitotic actomyosin contractile ring assembly. |
| regulation of actin cytoskeleton organization | Any process that modulates the frequency, rate or extent of the formation, arrangement of constituent parts, or disassembly of cytoskeletal structures comprising actin filaments and their associated proteins. |
| thrombin-activated receptor signaling pathway | A G protein-coupled receptor signaling pathway initiated by thrombin binding to its receptor on the surface of a target cell, and ending with the regulation of a downstream cellular process. |
4 homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| P46940 | IQGAP1 | Ras GTPase-activating-like protein IQGAP1 | Homo sapiens (Human) | EV |
| Q86VI3 | IQGAP3 | Ras GTPase-activating-like protein IQGAP3 | Homo sapiens (Human) | SS |
| Q13576 | IQGAP2 | Ras GTPase-activating-like protein IQGAP2 | Homo sapiens (Human) | SS |
| Q9JKF1 | Iqgap1 | Ras GTPase-activating-like protein IQGAP1 | Mus musculus (Mouse) | SS |
| 10 | 20 | 30 | 40 | 50 | 60 |
| MPHEELPSLQ | RPRYGSIVDD | ERLSAEEMDE | RRRQNIAYEY | LCHLEEAKRW | MEVCLVEELP |
| 70 | 80 | 90 | 100 | 110 | 120 |
| PTTELEEGLR | NGVYLAKLAK | FFAPKMVSEK | KIYDVEQTRY | KKSGLHFRHT | DNTVQWLRAM |
| 130 | 140 | 150 | 160 | 170 | 180 |
| EAIGLPKIFY | PETTDVYDRK | NIPRMIYCIH | ALSLYLFKLG | IAPQIQDLLG | KVDFTEEEIS |
| 190 | 200 | 210 | 220 | 230 | 240 |
| NMRKELEKYG | IQMPAFSKIG | GILANELSVD | EAALHAAVIA | INEAIEKGVA | KQTIITLRNP |
| 250 | 260 | 270 | 280 | 290 | 300 |
| NAVLTCVDDS | LSQEYQKELW | EAKKKKEESA | KLKNSCISEE | ERDAYEELLT | QAEIQSNIST |
| 310 | 320 | 330 | 340 | 350 | 360 |
| VNRMAAVDHI | NAVLQEGDPE | NTLLALKKPE | AQLPAVYPFA | AVMYQNELFN | LQKQNTSNYL |
| 370 | 380 | 390 | 400 | 410 | 420 |
| AHEELLIAVE | MLSAVALLNQ | ALESSDLVAV | QNQLRSPTIG | FNNLDEAHVD | RYADALLSVK |
| 430 | 440 | 450 | 460 | 470 | 480 |
| QEALSQGQDT | LSWNEIQNCI | DMINNQIQEE | NDRMVVLGYI | NEAIDAGNPL | KTLDTLLLPT |
| 490 | 500 | 510 | 520 | 530 | 540 |
| ANIRDVDPDC | AQHYQDVLFY | TKSQKLGDPK | NVSKVLWLDE | IQQAINEANV | DENRAKQWVT |
| 550 | 560 | 570 | 580 | 590 | 600 |
| LVVDVNECLD | RKQSDHILTA | LKSSPSNIHN | ILPECANKYY | DTLVKAKESK | TDNESSEGSW |
| 610 | 620 | 630 | 640 | 650 | 660 |
| VTLNVQEKYN | YYYNTDSKEG | SWVPPELCLS | KESWLTGEEI | EDIVEEVTSD | YIREKLWSAS |
| 670 | 680 | 690 | 700 | 710 | 720 |
| EDLLVRFEAT | TLGPALREEF | EARKAFLYEQ | TESVVKIQAF | WKGFKQRQEY | LHRQQVFAGN |
| 730 | 740 | 750 | 760 | 770 | 780 |
| VDSVVKIQSW | FRMVTARKSY | LSRLRYFEDH | KNEIVKIQSL | LRASKARDDY | KALVGSENPP |
| 790 | 800 | 810 | 820 | 830 | 840 |
| LTVIRKFVYL | LDQSDLDFQE | ELEVARLREE | VVTKIRANQQ | LEKDLNLMDI | KIGLLVKNRI |
| 850 | 860 | 870 | 880 | 890 | 900 |
| TLEDVISHRK | KLNKKKGGEI | EILNNTDNKG | IKSLSKERRK | TLETYQQLFY | LLQTKPSYLA |
| 910 | 920 | 930 | 940 | 950 | 960 |
| KLIFQMPQNK | STKFMDTVIF | TLYNYASNQR | EEYLLLKLFK | TALEEEIKSK | VDQVQDIVTG |
| 970 | 980 | 990 | 1000 | 1010 | 1020 |
| NPTVIKMVVS | FNRGARGQNT | LRQLLAPVVK | EIIEDKALVI | NTNPVEVYKA | WVNQLETQTG |
| 1030 | 1040 | 1050 | 1060 | 1070 | 1080 |
| EASKLPYDVT | TEQALTYPEV | KNKLEASIEN | LRKVTDKVLG | SIISSLDLLP | YGLRYIAKVL |
| 1090 | 1100 | 1110 | 1120 | 1130 | 1140 |
| KNSIREKFPD | ATEEELLKIV | GNLLYYRYMN | PAIVAPDGFD | IIDMTAGGQI | NSNQRRNLGS |
| 1150 | 1160 | 1170 | 1180 | 1190 | 1200 |
| VAKVLQHAAS | NKLFEGENEH | LSSMNNYLSE | TYQEFRKYFQ | EACDVPEPEE | KFNMDKYTDL |
| 1210 | 1220 | 1230 | 1240 | 1250 | 1260 |
| VTVSKPVIYI | SIEEIINTHL | LLLEHQDAIA | TEKSDLLNEL | LESLGEVPTV | ESFLGEGAVD |
| 1270 | 1280 | 1290 | 1300 | 1310 | 1320 |
| PNDPNKENTL | NQLSKTEISL | SLTSKYDVKD | GEAVDGRSLM | IKTKKLIIDV | TRNQPGSTLT |
| 1330 | 1340 | 1350 | 1360 | 1370 | 1380 |
| EILETPATGQ | QELEHAKDME | SRAVVDSRTP | EEGKQSQAVI | EDARLPLEQK | KRKIQRNLRT |
| 1390 | 1400 | 1410 | 1420 | 1430 | 1440 |
| LEQTGHVSSK | NKYQDILNEI | AKDIRNQRIH | RKLRKAELSK | LQQTLNALNK | KAAFYEDQIN |
| 1450 | 1460 | 1470 | 1480 | 1490 | 1500 |
| YYDTYIKTCV | DNLKRKNSRR | SIKLDGKAEP | KGTKRVKPVR | YTAAKLHDKG | VLLGIDDLQT |
| 1510 | 1520 | 1530 | 1540 | 1550 | 1560 |
| NQFKNVMFDI | IATEDMGIFD | VRSKFLGVEM | EKVQLNIQDL | LQMQYEGVAV | MKMFDKVKVN |
| 1570 | |||||
| VNLLIYLLNK | KFYGK |