Q3UMM4

PR
Gene name
Cdk10
Protein name
Cyclin-dependent kinase 10
Names
Cell division protein kinase 10
Species
Mus musculus (Mouse)
KEGG Pathway
mmu:234854
EC number
2.7.11.22: Protein-serine/threonine kinases
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

1-63 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

180-203 (Activation loop from InterPro)

Target domain

31-339 (Catalytic domain of the Serine/Threonine Kinase, Cyclin-Dependent protein Kinase 10)

Relief mechanism

Assay

References

Autoinhibited structure

Activated structure

1 structures for Q3UMM4

Entry ID Method Resolution Chain Position Source
AF-Q3UMM4-F1 Predicted AlphaFoldDB

13 variants for Q3UMM4

Variant ID(s) Position Change Description Diseaes Association Provenance
rs3388993564 58 D>Y No EVA
rs3389015864 125 A>T No EVA
rs3388987520 133 T>I No EVA
rs3388999099 142 C>Y No EVA
rs3389016449 176 C>S No EVA
rs3388968567 181 D>E No EVA
rs3389018104 225 V>A No EVA
rs3389024212 225 V>I No EVA
rs3389025110 268 K>R No EVA
rs3389005674 298 R>H No EVA
rs3389016633 312 A>T No EVA
rs3389019410 314 S>L No EVA
rs1135000304 341 H>R No EVA

No associated diseases with Q3UMM4

4 regional properties for Q3UMM4

Type Name Position InterPro Accession
domain Protein kinase domain 39 - 323 IPR000719
active_site Serine/threonine-protein kinase, active site 159 - 171 IPR008271
binding_site Protein kinase, ATP binding site 45 - 68 IPR017441
domain Cyclin-dependent kinase 10, catalytic domain 31 - 339 IPR044093

Functions

Description
EC Number 2.7.11.22 Protein-serine/threonine kinases
Subcellular Localization
  • Cytoplasm, cytoskeleton, cilium basal body
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

4 GO annotations of cellular component

Name Definition
ciliary basal body A membrane-tethered, short cylindrical array of microtubules and associated proteins found at the base of a eukaryotic cilium (also called flagellum) that is similar in structure to a centriole and derives from it. The cilium basal body is the site of assembly and remodelling of the cilium and serves as a nucleation site for axoneme growth. As well as anchoring the cilium, it is thought to provide a selective gateway regulating the entry of ciliary proteins and vesicles by intraflagellar transport.
cyclin-dependent protein kinase holoenzyme complex Cyclin-dependent protein kinases (CDKs) are enzyme complexes that contain a kinase catalytic subunit associated with a regulatory cyclin partner.
cytoplasm The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.

5 GO annotations of molecular function

Name Definition
ATP binding Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
cyclin-dependent protein kinase activity Cyclin-dependent catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP.
cyclin-dependent protein serine/threonine kinase activity Cyclin-dependent catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate, and ATP + protein threonine = ADP + protein threonine phosphate.
protein serine kinase activity Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate.
protein serine/threonine kinase activity Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate, and ATP + protein threonine = ADP + protein threonine phosphate.

8 GO annotations of biological process

Name Definition
cell projection organization A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a prolongation or process extending from a cell, e.g. a flagellum or axon.
negative regulation of cilium assembly Any process that stops, prevents or reduces the frequency, rate or extent of cilium assembly.
peptidyl-threonine phosphorylation The phosphorylation of peptidyl-threonine to form peptidyl-O-phospho-L-threonine.
positive regulation of MAPK cascade Any process that activates or increases the frequency, rate or extent of signal transduction mediated by the MAPK cascade.
protein phosphorylation The process of introducing a phosphate group on to a protein.
regulation of actin cytoskeleton organization Any process that modulates the frequency, rate or extent of the formation, arrangement of constituent parts, or disassembly of cytoskeletal structures comprising actin filaments and their associated proteins.
regulation of cell cycle G2/M phase transition Any signalling pathway that modulates the activity of a cell cycle cyclin-dependent protein kinase to modulate the switch from G2 phase to M phase of the cell cycle.
regulation of mitotic cell cycle Any process that modulates the rate or extent of progress through the mitotic cell cycle.

17 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
Q2TBL8 CDK10 Cyclin-dependent kinase 10 Bos taurus (Bovine) PR
P21127 CDK11B Cyclin-dependent kinase 11B Homo sapiens (Human) PR
Q15131 CDK10 Cyclin-dependent kinase 10 Homo sapiens (Human) PR
O35495 Cdk14 Cyclin-dependent kinase 14 Mus musculus (Mouse) PR
Q8K0D0 Cdk17 Cyclin-dependent kinase 17 Mus musculus (Mouse) PR
Q8R3L8 Cdk8 Cyclin-dependent kinase 8 Mus musculus (Mouse) PR
Q8BWD8 Cdk19 Cyclin-dependent kinase 19 Mus musculus (Mouse) PR
Q99J95 Cdk9 Cyclin-dependent kinase 9 Mus musculus (Mouse) PR
Q3TZA2 Cdkl4 Cyclin-dependent kinase-like 4 Mus musculus (Mouse) PR
Q8CEQ0 Cdkl1 Cyclin-dependent kinase-like 1 Mus musculus (Mouse) PR
Q8BLF2 Cdkl3 Cyclin-dependent kinase-like 3 Mus musculus (Mouse) PR
Q9QUK0 Cdkl2 Cyclin-dependent kinase-like 2 Mus musculus (Mouse) PR
Q9JHU3 Cdk20 Cyclin-dependent kinase 20 Mus musculus (Mouse) PR
Q4KM47 Cdk10 Cyclin-dependent kinase 10 Rattus norvegicus (Rat) PR
Q09437 cdk-11.1 Cyclin-dependent kinase 11.1 Caenorhabditis elegans PR
Q9FGW5 CDKG1 Cyclin-dependent kinase G1 Arabidopsis thaliana (Mouse-ear cress) PR
F4I114 At1g09600 Probable serine/threonine-protein kinase At1g09600 Arabidopsis thaliana (Mouse-ear cress) PR
10 20 30 40 50 60
MAEVDLESDQ IRLKCIRKEG FFTVPPEHRL GRCRSVKEFE KLNRIGEGTY GIVYRARDTQ
70 80 90 100 110 120
TDEIVALKKV RMDKEKDGIP ISSLREITLL LRLRHPNIVE LKEVVVGNHL ESIFLVMGYC
130 140 150 160 170 180
EQDLASLLEN MPTPFSEAQV KCIMLQVLRG LQYLHRNFII HRDLKVSNLL MTDKGCVKTA
190 200 210 220 230 240
DFGLARAYGV PVKPMTPKVV TLWYRAPELL LGTTTQTTSI DMWAVGCILA ELLAHKPLLP
250 260 270 280 290 300
GTSEIHQIDL IVQLLGTPSE NIWPGFSKLP LAGQYSLRKQ PYNNLKHKFP WLSEAGLRLL
310 320 330 340 350
NFLFMYDPKK RATSGDCLES SYFKEKPLPC EPELMPTFPH HRNKRAAPAA AEGQSKRCRP