Q3ULB5
Gene name |
Pak6 |
Protein name |
Serine/threonine-protein kinase PAK 6 |
Names |
p21-activated kinase 6, PAK-6 |
Species |
Mus musculus (Mouse) |
KEGG Pathway |
mmu:214230 |
EC number |
2.7.11.1: Protein-serine/threonine kinases |
Protein Class |
|
Descriptions
(Annotation based on sequence homology with Q9NQU5)
The p21-activated protein kinases5 (PAK5) belongs to group II PAK family and is involved in actin cytoskeleton regulation, cell growth, migration and survival, and so on. Group II PAKs (PAK4, 5, and 6) harbor well-conserved pseudosubstrate sequences. For PAK4, the N-terminal inhibitory segment contains two pseudopeptide sequences (FTGLPR at 32th and RPKPLV at 49th) that bind to the active site of the kinase domain as a pseudosubstrate. Like PAK4, PAK6 catalytic activity is inhibited by a peptide corresponding to its N-terminal pseudosubstrate (RRPKPVVDP at 49th).
PAKs are activated by the binding of GTP-loaded Cdc42 (or Rac) to the CRIB domain, which disrupts the dimer and unfolds autoinhibitory region. After releasing autoinhibitory region, kinase domain is then autophosphorylated for full activation.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
544-567 (Activation loop from InterPro)
Target domain |
386-682 (Catalytic domain of the Serine/Threonine Kinase, p21-activated kinase 6) |
Relief mechanism |
|
Assay |
|
Autoinhibited structure
Activated structure
1 structures for Q3ULB5
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-Q3ULB5-F1 | Predicted | AlphaFoldDB |
17 variants for Q3ULB5
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| rs3388581689 | 32 | K>Q | No | EVA | |
| rs3388578574 | 47 | L>M | No | EVA | |
| rs3388577488 | 55 | D>E | No | EVA | |
| rs246681260 | 174 | A>T | No | EVA | |
| rs212825324 | 202 | S>N | No | EVA | |
| rs260949806 | 209 | P>L | No | EVA | |
| rs3388577515 | 293 | R>L | No | EVA | |
| rs3149830 | 337 | A>V | No | EVA | |
| rs3388577542 | 422 | V>M | No | EVA | |
| rs27458116 | 426 | R>Q | No | EVA | |
| rs3388578546 | 466 | V>M | No | EVA | |
| rs3392098299 | 495 | S>P | No | EVA | |
| rs3388575433 | 510 | A>T | No | EVA | |
| rs3388581681 | 600 | P>H | No | EVA | |
| rs3388583021 | 654 | L>R | No | EVA | |
| rs3392013865 | 662 | T>P | No | EVA | |
| rs3392112346 | 663 | G>R | No | EVA |
No associated diseases with Q3ULB5
Functions
| Description | ||
|---|---|---|
| EC Number | 2.7.11.1 | Protein-serine/threonine kinases |
| Subcellular Localization |
|
|
| PANTHER Family | ||
| PANTHER Subfamily | ||
| PANTHER Protein Class | ||
| PANTHER Pathway Category | No pathway information available | |
4 GO annotations of cellular component
| Name | Definition |
|---|---|
| cell junction | A cellular component that forms a specialized region of connection between two or more cells, or between a cell and the extracellular matrix, or between two membrane-bound components of a cell, such as flagella. |
| cytoplasm | The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. |
| fibrillar center | A structure found most metazoan nucleoli, but not usually found in lower eukaryotes; surrounded by the dense fibrillar component; the zone of transcription from multiple copies of the pre-rRNA genes is in the border region between these two structures. |
| nucleoplasm | That part of the nuclear content other than the chromosomes or the nucleolus. |
3 GO annotations of molecular function
| Name | Definition |
|---|---|
| ATP binding | Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. |
| protein serine kinase activity | Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate. |
| protein serine/threonine kinase activity | Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate, and ATP + protein threonine = ADP + protein threonine phosphate. |
8 GO annotations of biological process
| Name | Definition |
|---|---|
| intracellular signal transduction | The process in which a signal is passed on to downstream components within the cell, which become activated themselves to further propagate the signal and finally trigger a change in the function or state of the cell. |
| learning | Any process in an organism in which a relatively long-lasting adaptive behavioral change occurs as the result of experience. |
| locomotory behavior | The specific movement from place to place of an organism in response to external or internal stimuli. Locomotion of a whole organism in a manner dependent upon some combination of that organism's internal state and external conditions. |
| memory | The activities involved in the mental information processing system that receives (registers), modifies, stores, and retrieves informational stimuli. The main stages involved in the formation and retrieval of memory are encoding (processing of received information by acquisition), storage (building a permanent record of received information as a result of consolidation) and retrieval (calling back the stored information and use it in a suitable way to execute a given task). |
| neuron projection arborization | The process in which the anatomical structures of a neuron projection are generated and organized into branches. A neuron projection is any process extending from a neural cell, such as axons or dendrites. |
| neuron projection extension | Long distance growth of a single neuron projection involved in cellular development. A neuron projection is a prolongation or process extending from a nerve cell, e.g. an axon or dendrite. |
| protein phosphorylation | The process of introducing a phosphate group on to a protein. |
| regulation of MAPK cascade | Any process that modulates the frequency, rate or extent of signal transduction mediated by the MAP kinase (MAPK) cascade. |
27 homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| Q12469 | SKM1 | Serine/threonine-protein kinase SKM1 | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) | PR |
| Q08E52 | PAK1 | Serine/threonine-protein kinase PAK 1 | Bos taurus (Bovine) | SS |
| Q7YQL4 | PAK3 | Serine/threonine-protein kinase PAK 3 | Pan troglodytes (Chimpanzee) | SS |
| Q9VXE5 | mbt | Serine/threonine-protein kinase PAK mbt | Drosophila melanogaster (Fruit fly) | PR |
| Q13153 | PAK1 | Serine/threonine-protein kinase PAK 1 | Homo sapiens (Human) | EV |
| Q13177 | PAK2 | Serine/threonine-protein kinase PAK 2 | Homo sapiens (Human) | EV |
| O75914 | PAK3 | Serine/threonine-protein kinase PAK 3 | Homo sapiens (Human) | SS |
| O96013 | PAK4 | Serine/threonine-protein kinase PAK 4 | Homo sapiens (Human) | EV |
| Q9P286 | PAK5 | Serine/threonine-protein kinase PAK 5 | Homo sapiens (Human) | EV |
| Q9NQU5 | PAK6 | Serine/threonine-protein kinase PAK 6 | Homo sapiens (Human) | EV |
| Q8C015 | Pak5 | Serine/threonine-protein kinase PAK 5 | Mus musculus (Mouse) | SS |
| Q8CIN4 | Pak2 | Serine/threonine-protein kinase PAK 2 | Mus musculus (Mouse) | SS |
| Q9JI11 | Stk4 | Serine/threonine-protein kinase 4 | Mus musculus (Mouse) | PR |
| Q9JI10 | Stk3 | Serine/threonine-protein kinase 3 | Mus musculus (Mouse) | SS |
| Q8BTW9 | Pak4 | Serine/threonine-protein kinase PAK 4 | Mus musculus (Mouse) | PR |
| Q61036 | Pak3 | Serine/threonine-protein kinase PAK 3 | Mus musculus (Mouse) | SS |
| Q9JM52 | Mink1 | Misshapen-like kinase 1 | Mus musculus (Mouse) | PR |
| P83510 | Tnik | Traf2 and NCK-interacting protein kinase | Mus musculus (Mouse) | PR |
| P97820 | Map4k4 | Mitogen-activated protein kinase kinase kinase kinase 4 | Mus musculus (Mouse) | PR |
| O88643 | Pak1 | Serine/threonine-protein kinase PAK 1 | Mus musculus (Mouse) | SS |
| Q62829 | Pak3 | Serine/threonine-protein kinase PAK 3 | Rattus norvegicus (Rat) | SS |
| Q64303 | Pak2 | Serine/threonine-protein kinase PAK 2 | Rattus norvegicus (Rat) | SS |
| P35465 | Pak1 | Serine/threonine-protein kinase PAK 1 | Rattus norvegicus (Rat) | SS |
| D4A280 | Pak5 | Serine/threonine-protein kinase PAK 5 | Rattus norvegicus (Rat) | SS |
| Q17850 | pak-1 | Serine/threonine-protein kinase pak-1 | Caenorhabditis elegans | PR |
| G5EGQ3 | max-2 | Serine/threonine-protein kinase max-2 | Caenorhabditis elegans | SS |
| G5EFU0 | pak-2 | Serine/threonine-protein kinase pak-2 | Caenorhabditis elegans | PR |
| 10 | 20 | 30 | 40 | 50 | 60 |
| MFRKKKKKRP | EISAPQNFQH | RVHTSFDPKE | GKFVGLPPQW | QNILDTLRRP | KPVVDPSRIT |
| 70 | 80 | 90 | 100 | 110 | 120 |
| RVQLQPMKTV | VRGSSVPTEG | YISGLLNDIQ | KLSVISSNTL | RGRSPTSRRR | AQSLGLLGDD |
| 130 | 140 | 150 | 160 | 170 | 180 |
| QWAADPDMYL | QSPQSEHTDP | HGLYLSCNGG | TPAGHRQVPW | PEPQSPQALP | NGMAAKAQSL |
| 190 | 200 | 210 | 220 | 230 | 240 |
| GPAEFQGASQ | RCLQQLGACL | QSSPPGTSPP | MATGRRGVKV | AKHSSEEARP | QSCLVGSAIG |
| 250 | 260 | 270 | 280 | 290 | 300 |
| RPGGEGSPSP | KNQESSLKHR | LFRSMFLSTP | ATGAASSSKP | VPLPQNKPNS | AFRPPQKDSS |
| 310 | 320 | 330 | 340 | 350 | 360 |
| SNLVAKAQSL | PSEQPMGTFS | PLTTSDTSSP | QKSLRTAPAA | GPLPGRSSPA | GSPRTRHAQI |
| 370 | 380 | 390 | 400 | 410 | 420 |
| STSNLYLPQD | PTVAKGALGG | EDTGIVTHEQ | FKAALRMVVD | QGDPRLLLDS | YVKIGEGSTG |
| 430 | 440 | 450 | 460 | 470 | 480 |
| IVCLAREKHS | GRQVAVKMMD | LRKQQRRELL | FNEVVIMRDY | QHLNVVEMYK | SYLVGEELWV |
| 490 | 500 | 510 | 520 | 530 | 540 |
| LMEFLQGGAL | TDIISQVRLN | EEQIATVCEA | VLQALAYLHA | QGVIHRDIKS | DSILLTLDGR |
| 550 | 560 | 570 | 580 | 590 | 600 |
| VKLSDFGFCA | QISKDVPKRK | SLVGTPYWMA | PEVISRSLYA | TEVDIWSLGI | MVIEMVDGEP |
| 610 | 620 | 630 | 640 | 650 | 660 |
| PYFSDSPVQA | MKRLRDSAPP | KLKNSYKVSP | VLRDFLDRML | VREPQERATA | QELLDHPFLL |
| 670 | 680 | ||||
| QTGLPECLVP | LIQLYRKQTS | TC |