Q3UH93

SS
Gene name
Plxnd1
Protein name
Plexin-D1
Names
Species
Mus musculus (Mouse)
KEGG Pathway
mmu:67784
EC number
Protein Class

Descriptions

Plexin cell surface receptors bind to semaphorin ligands and transduce signals for regulating neuronal axon guidance. In mouse Plexin-A3 (P70208), the autoinhibitory regions including an Rho GTPase-binding domain (RBD) and a segment preceding C1 domain make extensive interactions with the GAP domain (C1 and C2 domains), which may enable it to regulate the GAP conformation in response to semaphorin binding. According to human Plexin-A1 (Q9UIW2) study, the Sema domain in Plexin-A3 may be also involved in autoinhibition.

Autoinhibitory domains (AIDs)

63-528 (Sema domain) SS

Target domain

1345-1888 (Plexin, RasGAP domain)

Relief mechanism

Partner binding

Assay

1294-1403 (Segment preceding C1 domain) SS

Target domain

1345-1888 (Plexin, RasGAP domain)

Relief mechanism

Assay

1527-1698 (RBD domain) SS

Target domain

1345-1888 (Plexin, RasGAP domain)

Relief mechanism

Partner binding

Assay

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

3 structures for Q3UH93

Entry ID Method Resolution Chain Position Source
5V6R X-ray 270 A A/B 1339-1925 PDB
5V6T X-ray 319 A A 1339-1925 PDB
AF-Q3UH93-F1 Predicted AlphaFoldDB

10 variants for Q3UH93

Variant ID(s) Position Change Description Diseaes Association Provenance
rs251020982 14 R>W No Ensembl
rs261642626 25 P>L No Ensembl
rs221983981 47 G>S No Ensembl
rs220047323 253 K>R No Ensembl
rs234356730 392 A>T No Ensembl
rs248103966 797 S>N No Ensembl
rs239469789 1028 T>A No Ensembl
rs864258413 1110 G>D No Ensembl
rs229028313 1410 I>L No Ensembl
rs239772195 1834 T>I No Ensembl

No associated diseases with Q3UH93

8 regional properties for Q3UH93

Type Name Position InterPro Accession
domain BRCT domain 386 - 467 IPR001357
domain Zinc finger, PARP-type 9 - 93 IPR001510-1
domain Zinc finger, PARP-type 113 - 203 IPR001510-2
domain Poly(ADP-ribose) polymerase, regulatory domain 662 - 794 IPR004102
domain WGR domain 542 - 638 IPR008893
domain Poly(ADP-ribose) polymerase, catalytic domain 788 - 1014 IPR012317
domain PARP1-like, PADR1 domain, zinc ribbon fold 292 - 332 IPR012982
domain PARP1-like, PADR1 domain, N-terminal helical subdomain 233 - 291 IPR049296

Functions

Description
EC Number
Subcellular Localization
  • Cell membrane ; Single-pass membrane protein
  • Cell projection, lamellipodium membrane
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

5 GO annotations of cellular component

Name Definition
integral component of plasma membrane The component of the plasma membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.
lamellipodium A thin sheetlike process extended by the leading edge of a migrating cell or extending cell process; contains a dense meshwork of actin filaments.
lamellipodium membrane The portion of the plasma membrane surrounding a lamellipodium.
plasma membrane The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
semaphorin receptor complex A stable binary complex of a neurophilin and a plexin, together forming a functional semaphorin receptor.

2 GO annotations of molecular function

Name Definition
protein domain specific binding Binding to a specific domain of a protein.
semaphorin receptor activity Combining with a semaphorin, and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity.

19 GO annotations of biological process

Name Definition
angiogenesis Blood vessel formation when new vessels emerge from the proliferation of pre-existing blood vessels.
aorta development The progression of the aorta over time, from its initial formation to the mature structure. An aorta is an artery that carries blood from the heart to other parts of the body.
branching involved in blood vessel morphogenesis The process of coordinated growth and sprouting of blood vessels giving rise to the organized vascular system.
cardiac septum development The progression of a cardiac septum over time, from its initial formation to the mature structure.
coronary vasculature development The process whose specific outcome is the progression of the blood vessels of the heart over time, from its formation to the mature structure.
dichotomous subdivision of terminal units involved in salivary gland branching The process in which a salivary epithelial cord bifurcates at its end.
endothelial cell migration The orderly movement of an endothelial cell into the extracellular matrix to form an endothelium.
kidney development The process whose specific outcome is the progression of the kidney over time, from its formation to the mature structure. The kidney is an organ that filters the blood and/or excretes the end products of body metabolism in the form of urine.
negative regulation of cell adhesion Any process that stops, prevents, or reduces the frequency, rate or extent of cell adhesion.
outflow tract morphogenesis The process in which the anatomical structures of the outflow tract are generated and organized. The outflow tract is the portion of the heart through which blood flows into the arteries.
positive regulation of axonogenesis Any process that activates or increases the frequency, rate or extent of axonogenesis.
positive regulation of protein binding Any process that activates or increases the frequency, rate or extent of protein binding.
regulation of angiogenesis Any process that modulates the frequency, rate or extent of angiogenesis.
regulation of cell migration Any process that modulates the frequency, rate or extent of cell migration.
regulation of cell shape Any process that modulates the surface configuration of a cell.
regulation of GTPase activity Any process that modulates the rate of GTP hydrolysis by a GTPase.
semaphorin-plexin signaling pathway The series of molecular signals generated as a consequence of a semaphorin receptor (composed of a plexin and a neurophilin) binding to a semaphorin ligand.
semaphorin-plexin signaling pathway involved in axon guidance Any semaphorin-plexin signaling pathway that is involved in axon guidance.
synapse assembly The aggregation, arrangement and bonding together of a set of components to form a synapse. This process ends when the synapse is mature (functional).

27 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
Q769I5 MET Hepatocyte growth factor receptor Bos taurus (Bovine) PR
A0M8S8 MET Hepatocyte growth factor receptor Felis catus (Cat) (Felis silvestris catus) PR
Q04912 MST1R Macrophage-stimulating protein receptor Homo sapiens (Human) EV
P08581 MET Hepatocyte growth factor receptor Homo sapiens (Human) EV
O43157 PLXNB1 Plexin-B1 Homo sapiens (Human) EV SS
Q9HCM2 PLXNA4 Plexin-A4 Homo sapiens (Human) SS
O75051 PLXNA2 Plexin-A2 Homo sapiens (Human) SS
P51805 PLXNA3 Plexin-A3 Homo sapiens (Human) SS
Q9UIW2 PLXNA1 Plexin-A1 Homo sapiens (Human) EV SS
O15031 PLXNB2 Plexin-B2 Homo sapiens (Human) SS
Q9ULL4 PLXNB3 Plexin-B3 Homo sapiens (Human) SS
Q62190 Mst1r Macrophage-stimulating protein receptor Mus musculus (Mouse) SS
P16056 Met Hepatocyte growth factor receptor Mus musculus (Mouse) PR
B2RXS4 Plxnb2 Plexin-B2 Mus musculus (Mouse) SS
P70206 Plxna1 Plexin-A1 Mus musculus (Mouse) EV SS
P70207 Plxna2 Plexin-A2 Mus musculus (Mouse) SS
Q80UG2 Plxna4 Plexin-A4 Mus musculus (Mouse) SS
Q8CJH3 Plxnb1 Plexin-B1 Mus musculus (Mouse) SS
Q9QY40 Plxnb3 Plexin-B3 Mus musculus (Mouse) SS
Q9QZC2 Plxnc1 Plexin-C1 Mus musculus (Mouse) SS
P70208 Plxna3 Plexin-A3 Mus musculus (Mouse) EV SS
Q2QLE0 MET Hepatocyte growth factor receptor Sus scrofa (Pig) PR
P97523 Met Hepatocyte growth factor receptor Rattus norvegicus (Rat) PR
D3ZPX4 Plxna3 Plexin-A3 Rattus norvegicus (Rat) SS
D3ZLH5 Plxnb3 Plexin-B3 Rattus norvegicus (Rat) SS
Q6BEA0 plxna4 Plexin-A4 Danio rerio (Zebrafish) (Brachydanio rerio) SS
B0S5N4 plxna3 Plexin A3 Danio rerio (Zebrafish) (Brachydanio rerio) SS
10 20 30 40 50 60
MARRAAGGAP PSARAAAAVP LRPRPHSRGP GLLPLPLLLL LGAARAGALE IQRRFPSPTP
70 80 90 100 110 120
TNNFALDGTA GTVYLAAVNR LYQLSSANLS LEAEATVGPV PDSPLCHAPQ LPQASCEHPR
130 140 150 160 170 180
RLTDNYNKIL QLDPGQGLVV ACGSIYQGLC QLRRRGNISA LAVSFPPAAP TAEPVTVFPS
190 200 210 220 230 240
MLNVAANHPN ASTVGLVLPP TSGTGGSRLL VGATYTGFGS AFFPRNRSLE DHRFENTPEI
250 260 270 280 290 300
AIRSLDARGD LAKLFTFDLN PSDDNILKIK QGAKEQHKLG FVRAFLHPAV PPHSAQPYAY
310 320 330 340 350 360
LALNSEARAG DKDSQARSLL ARICLPRGAG GDAKKLTESY IQLGLQCAGG AGRGDLYSRL
370 380 390 400 410 420
VSVFPAREQF FAVFERPQGA PGARNAPAAL CAFRFDDVQA AIRAARTACF VEPAPDVVAV
430 440 450 460 470 480
LDSVVQGTGP ACESKRNIQL QPEQLDCGAA HLQHPLTILQ PLRASPVFRA PGLTAVAVAS
490 500 510 520 530 540
ANNYTAVFLG TATGRLLKIS LNESMQVVSR RVLTVAYGEP VHHVMQFDPM DPGYLYLMTS
550 560 570 580 590 600
HQMARVKVAA CEVHSTCGDC VGAADAYCGW CTLETRCTLQ QDCTNSSQPH FWTSASEGPS
610 620 630 640 650 660
RCPAMTVLPS EIDVHRDYTG MILQISGSLP SLSGMEMACD YGNGVRTVAR VPGPAYDHQI
670 680 690 700 710 720
AYCNLLPRAQ FPSFPAGQDH VTVEMSVRVK GHNIVSANFT IYDCSRIGQV YPHTACTSCL
730 740 750 760 770 780
STQWPCSWCI QLHSCVSNQS QCQDSPNPTS PQDCPQILPS PLAPVPTGGS QDILVPLTKA
790 800 810 820 830 840
TFFHGSSLEC SFGLEESFEA VWANNSLVRC NQVVLHTTQK SQVFPLSLKL KGPPDRFLDS
850 860 870 880 890 900
PNPMTVVVYN CAMGSPDCSQ CLGREDLGHL CVWNDGCRLR GPLQPLPGTC PAPEIRAIEP
910 920 930 940 950 960
LSGPLDGGTL LTIRGRNLGR RLSDVAHGVW IGSVACEPLA DRYTVSEEIV CATGPAAGAF
970 980 990 1000 1010 1020
SDVVTVNVSK EGRSREQFSY VLPTVHSLEP SMGPKAGGTR ITIHGSDLNV GSMLQVLVND
1030 1040 1050 1060 1070 1080
TDPCTDLTRT ATSITCTVPG GTLPSPVPVC VRFESRGCVH GNLTFWYMQN PVITAISPGR
1090 1100 1110 1120 1130 1140
SPVSGGRTIT VAGERFHMVQ NVSMAVHHIG REPTFCKVLN STLITCPSPG ALSNASAPVD
1150 1160 1170 1180 1190 1200
FFINGRAYAD EAAEELLDPA EAQRGSRFRL DYLPNPQFST AKREKWIKHH PGEPLTLVIH
1210 1220 1230 1240 1250 1260
KEQDSLGLES HEYHIKIGQV SCDIQIISDR VIHCSVNESL GTAEGQLPIT IQVGNFNQTI
1270 1280 1290 1300 1310 1320
ATLQLGGSET AIVVSIVICS VLLLLSVVAL FVFCTKSRRA ERYWQKTLLQ MEEMESQIRE
1330 1340 1350 1360 1370 1380
EIRKGFAELQ TDMTDLTKEL NRSQGIPFLE YKHFVTRTFF PKCSSLYEER YVLPSKTLNS
1390 1400 1410 1420 1430 1440
QGGSPPQETH PLLGEWNIPE HCRPSMEEGI SLFSSLLNNK HFLIVFVHAL EQQKDFAVRD
1450 1460 1470 1480 1490 1500
RCSLASLLTI ALHGKLEYYT SIMKELLVDL IDASAAKNPK LMLRRTESVV EKMLTNWMSI
1510 1520 1530 1540 1550 1560
CMYGCLRETV GEPFFLLLCA IKQQINKGSI DAITGKARYT LNEEWLLREN IEAKPRNLNV
1570 1580 1590 1600 1610 1620
SFQGCGMDSL SVRAMDTDTL TQVKEKILEA FCKNVPYSQW PRAEDVDLEW FASSTQSYVL
1630 1640 1650 1660 1670 1680
RDLDDTSVVE DGRKKLNTLA HYKIPEGASL AMSLTDKKDS TLGRVKDLDT EKYFHLVLPT
1690 1700 1710 1720 1730 1740
DELVEPKKSH RQSHRKKVLP EIYLTRLLST KGTLQKFLDD LFKAILSIRE DKPPLAVKYF
1750 1760 1770 1780 1790 1800
FDFLEEQAEK RGISDPDTLH IWKTNSLPLR FWVNILKNPQ FVFDIEKTDH IDACLSVIAQ
1810 1820 1830 1840 1850 1860
AFIDACSISD LQLGKDSPTN KLLYAKEIPE YRKTVQRYYK QIQDMTPLSE QEMNAHLAEE
1870 1880 1890 1900 1910 1920
SRKYQNEFNT NVAMAEIYKY AKRYRPQIMA ALEANPTARR TQLQHKFEQV VALMENNIYE
CYSEA