Q3U5C8

PR
Gene name
Arhgef16
Protein name
Rho guanine nucleotide exchange factor 16
Names
Ephexin-4
Species
Mus musculus (Mouse)
KEGG Pathway
mmu:230972
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

29-102 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

5 structures for Q3U5C8

Entry ID Method Resolution Chain Position Source
7CSO X-ray 239 A A/B/C/D 261-713 PDB
7CSP X-ray 300 A A/B 209-713 PDB
7CSR X-ray 300 A A/B/C 261-713 PDB
7YKF X-ray 228 A B/D 152-163 PDB
AF-Q3U5C8-F1 Predicted AlphaFoldDB

29 variants for Q3U5C8

Variant ID(s) Position Change Description Diseaes Association Provenance
rs3388731446 8 S>R No EVA
rs3388741627 30 N>K No EVA
rs3388738794 40 S>R No EVA
rs221647573 54 A>V No EVA
rs3388712147 66 D>G No EVA
rs3388745329 141 M>I No EVA
rs3388724687 149 L>M No EVA
rs3410573622 204 G>S No EVA
rs3394959564 222 E>DS* No EVA
rs3395185405 223 I>S* No EVA
rs3388722390 230 T>I No EVA
rs3388731539 253 T>A No EVA
rs3388738549 308 S>I No EVA
rs3388728576 319 E>* No EVA
rs3388737585 380 A>P No EVA
rs3388734095 389 Q>* No EVA
rs3388733978 391 T>I No EVA
rs222928447 513 F>L No EVA
rs3388734071 523 K>* No EVA
rs3388734102 541 V>A No EVA
rs3394959605 543 K>* No EVA
rs3388731148 551 L>M No EVA
rs3388722330 562 Q>H No EVA
rs253833495 564 R>K No EVA
rs3394851476 571 P>A No EVA
rs254698719 572 L>S No EVA
rs3388743249 610 S>R No EVA
rs3388737614 673 E>G No EVA
rs3388722329 681 G>A No EVA

No associated diseases with Q3U5C8

5 regional properties for Q3U5C8

Type Name Position InterPro Accession
domain Dbl homology (DH) domain 288 - 472 IPR000219
domain SH3 domain 633 - 693 IPR001452
domain Pleckstrin homology domain 505 - 626 IPR001849
domain ARHGEF16/ARHGEF26, SH3 domain 637 - 688 IPR035797
domain Ephexin-like, PH domain 493 - 626 IPR047270

Functions

Description
EC Number
Subcellular Localization
  • Cytoplasm
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

1 GO annotations of cellular component

Name Definition
cytoplasm The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.

4 GO annotations of molecular function

Name Definition
guanyl-nucleotide exchange factor activity Stimulates the exchange of GDP to GTP on a signaling GTPase, changing its conformation to its active form. Guanine nucleotide exchange factors (GEFs) act by stimulating the release of guanosine diphosphate (GDP) to allow binding of guanosine triphosphate (GTP), which is more abundant in the cell under normal cellular physiological conditions.
PDZ domain binding Binding to a PDZ domain of a protein, a domain found in diverse signaling proteins.
receptor tyrosine kinase binding Binding to a receptor that possesses protein tyrosine kinase activity.
small GTPase binding Binding to a small monomeric GTPase.

3 GO annotations of biological process

Name Definition
activation of GTPase activity Any process that initiates the activity of an inactive GTPase through the replacement of GDP by GTP.
cell chemotaxis The directed movement of a motile cell guided by a specific chemical concentration gradient. Movement may be towards a higher concentration (positive chemotaxis) or towards a lower concentration (negative chemotaxis).
positive regulation of protein localization to plasma membrane Any process that activates or increases the frequency, rate or extent of protein localization to plasma membrane.

12 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
Q12774 ARHGEF5 Rho guanine nucleotide exchange factor 5 Homo sapiens (Human) EV
A5YM69 ARHGEF35 Rho guanine nucleotide exchange factor 35 Homo sapiens (Human) PR
O94989 ARHGEF15 Rho guanine nucleotide exchange factor 15 Homo sapiens (Human) SS
Q8IW93 ARHGEF19 Rho guanine nucleotide exchange factor 19 Homo sapiens (Human) SS
Q8N5V2 NGEF Ephexin-1 Homo sapiens (Human) EV
Q96DR7 ARHGEF26 Rho guanine nucleotide exchange factor 26 Homo sapiens (Human) SS
Q5VV41 ARHGEF16 Rho guanine nucleotide exchange factor 16 Homo sapiens (Human) PR
E9Q7D5 Arhgef5 Rho guanine nucleotide exchange factor 5 Mus musculus (Mouse) SS
Q8BWA8 Arhgef19 Rho guanine nucleotide exchange factor 19 Mus musculus (Mouse) PR
Q5FWH6 Arhgef15 Rho guanine nucleotide exchange factor 15 Mus musculus (Mouse) SS
Q8CHT1 Ngef Ephexin-1 Mus musculus (Mouse) SS
Q5BKC9 Ngef Ephexin-1 Rattus norvegicus (Rat) SS
10 20 30 40 50 60
MSQRHSDSSL DEKLLEYRFH AELRLDANGN PIPGLPMVRS SLKARANAAF EPDASEPLPP
70 80 90 100 110 120
PPSPEDEEPP RPIVLSTQSP AALKMGTQQL IPKSLAVASK AKTKSPARHQ SFGAAVLSKE
130 140 150 160 170 180
AARRNPQLFS APSFSLDDMD MDMVTTGNLR RNLRNQSYRA AMKGPGPPSS KGDSVQLGPK
190 200 210 220 230 240
LQALAEEAAQ PPSRYPAKNK KTLGRKRAHK GSFKDDPQLY QEIRERGLNT SHESDDDILD
250 260 270 280 290 300
EPSGPVGTQR ADTTIVVKSY RPAQLTWSQL PEVLESGVLD TLSTEERKRQ EAIFEILTSE
310 320 330 340 350 360
FSYLHSLSIL VTEFLQSREL RATMTQTEHH HLFSNILDVM SASQKFFEAL EQRHKAQVCV
370 380 390 400 410 420
EDISDILEDH AQHHFHPYIA YCSNEVYQQR TLQKLSNSNA AFRDVLKEIE KRPACGGLPM
430 440 450 460 470 480
ISFLILPMQR VTRLPLLTDT LCLKTQGHPE RYKAASQALK AISKLVKQCN EGAHKMERTE
490 500 510 520 530 540
QIYTLNMQLD FGKVKSLPLI SASRWLLKRG ELFLLEESSI FRKIASRPTC YLFLFNDVLV
550 560 570 580 590 600
VTKKKSEESY LVQDYAQLDH VQVRKLEPSE PLLPGGSSRS SSVPYPFQVN LLHNSEGRQE
610 620 630 640 650 660
QILLSSDSAS DRARWITALT YKERQWQGIT NKGELPQVEV TKAYFAKQAD EITLQQADIV
670 680 690 700 710
LVLQEEDGWL HGERLRDGET GWFPESFAHS ITSRVAVEGN VRRMERLRVE TDV