AiPD: Autoinhibited Protein Database

Gene name	Dennd1b
Protein name	DENN domain-containing protein 1B
Names	Connecdenn 2
Species	Mus musculus (Mouse)
KEGG Pathway	mmu:329260
EC number
Protein Class

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

96-174 (Predicted disordered autoinhibitory region) PR

96-174 (Predicted disordered autoinhibitory region)

cis-regPred

No accessory elements

Entry ID	Method	Resolution	Chain	Position	Source
AF-Q3U1T9-F1	Predicted				AlphaFoldDB

Variant ID(s)	Position	Change	Diseaes Association	Provenance
rs254637010	31	V>I	No	EVA
rs3388502581	108	Y>H	No	EVA
rs3388502812	165	P>A	No	EVA
rs3388502347	226	I>N	No	EVA
rs3388505059	229	L>F	No	EVA
rs3388503381	232	H>Y	No	EVA
rs3390727098	264	V>F	No	EVA
rs3390727093	266	L>S	No	EVA
rs3390702854	269	D>N	No	EVA
rs3390727011	272	T>M	No	EVA
rs3413128289	307	A>V	No	EVA
rs3388505125	323	D>A	No	EVA
rs3390721526	328	K>R	No	EVA
rs3388501680	346	S>G	No	EVA
rs3388502895	348	M>I	No	EVA
rs3388500572	349	K>T	No	EVA
rs3388502889	351	F>L	No	EVA
rs3388505132	353	E>D	No	EVA
rs13473665	388	S>L	No	EVA
rs3388502862	438	G>R	No	EVA
rs241809741	480	K>R	No	EVA
rs30934663	486	T>A	No	EVA
rs3388506016	487	H>Q	No	EVA
rs3388502913	494	S>R	No	EVA
rs3412974129	495	L>I	No	EVA
rs3388501724	507	D>V	No	EVA
rs3388505879	514	K>E	No	EVA
rs214684051	567	A>V	No	EVA
rs864305276	601	C>S	No	EVA
rs265096456	608	E>D	No	EVA
rs3388505969	663	V>M	No	EVA
rs247884112	668	P>S	No	EVA
rs257508405	692	K>T	No	EVA
rs3388500543	710	P>S	No	EVA
rs3388504714	725	K>N	No	EVA
rs3390713046	747	S>T	No	EVA

Type	Name	Position	InterPro Accession
conserved_site	Heat shock protein 70, conserved site	12 - 19	IPR018181-1
conserved_site	Heat shock protein 70, conserved site	200 - 213	IPR018181-2
conserved_site	Heat shock protein 70, conserved site	337 - 351	IPR018181-3

		Description
EC Number
Subcellular Localization	Cytoplasm, cytosol Cytoplasmic vesicle, clathrin-coated vesicle
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category	No pathway information available

Name	Definition
clathrin-coated vesicle	A vesicle with a coat formed of clathrin connected to the membrane via one of the clathrin adaptor complexes.
cytosol	The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
intracellular membrane-bounded organelle	Organized structure of distinctive morphology and function, bounded by a single or double lipid bilayer membrane and occurring within the cell. Includes the nucleus, mitochondria, plastids, vacuoles, and vesicles. Excludes the plasma membrane.
nuclear speck	A discrete extra-nucleolar subnuclear domain, 20-50 in number, in which splicing factors are seen to be localized by immunofluorescence microscopy.

Name	Definition
guanyl-nucleotide exchange factor activity	Stimulates the exchange of GDP to GTP on a signaling GTPase, changing its conformation to its active form. Guanine nucleotide exchange factors (GEFs) act by stimulating the release of guanosine diphosphate (GDP) to allow binding of guanosine triphosphate (GTP), which is more abundant in the cell under normal cellular physiological conditions.
phosphatidylinositol phosphate binding	Binding to phosphatidylinositol phosphate.
small GTPase binding	Binding to a small monomeric GTPase.

Name	Definition
endocytic recycling	The directed movement of membrane-bounded vesicles from endosomes back to the plasma membrane, a trafficking pathway that promotes the recycling of internalized transmembrane proteins.
endocytosis	A vesicle-mediated transport process in which cells take up external materials or membrane constituents by the invagination of a small region of the plasma membrane to form a new membrane-bounded vesicle.
positive regulation of GTPase activity	Any process that activates or increases the activity of a GTPase.
positive regulation of T-helper 2 cell cytokine production	Any process that activates or increases the frequency, rate or extent of T-helper 2 cell cytokine production.
protein transport	The directed movement of proteins into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.
regulation of immune response	Any process that modulates the frequency, rate or extent of the immune response, the immunological reaction of an organism to an immunogenic stimulus.
T cell receptor signaling pathway	The series of molecular signals initiated by the cross-linking of an antigen receptor on a T cell.

UniProt AC	Gene Name	Protein Name	Species	Evidence Code
Q8TEH3	DENND1A	DENN domain-containing protein 1A	Homo sapiens (Human)	SS
Q6P3S1	DENND1B	DENN domain-containing protein 1B	Homo sapiens (Human)	SS
Q8C4S8	Dennd2a	DENN domain-containing protein 2A	Mus musculus (Mouse)	PR
Q8K382	Dennd1a	DENN domain-containing protein 1A	Mus musculus (Mouse)	EV