Q3U0S6
PR
Gene name |
Rasip1 |
Protein name |
Ras-interacting protein 1 |
Names |
Rain |
Species |
Mus musculus (Mouse) |
KEGG Pathway |
mmu:69903 |
EC number |
|
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for Q3U0S6
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-Q3U0S6-F1 | Predicted | AlphaFoldDB |
49 variants for Q3U0S6
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| rs3397460511 | 36 | G>R | No | EVA | |
| rs3397922187 | 37 | R>Q | No | EVA | |
| rs3397450570 | 40 | P>A | No | EVA | |
| rs3397087987 | 44 | S>F | No | EVA | |
| rs3397860813 | 60 | L>P | No | EVA | |
| rs31514716 | 129 | A>S | No | EVA | |
| rs3388888302 | 336 | R>H | No | EVA | |
| rs3388912701 | 354 | P>L | No | EVA | |
| rs3388907420 | 400 | V>G | No | EVA | |
| rs3388900551 | 413 | S>F | No | EVA | |
| rs3388911383 | 442 | A>G | No | EVA | |
| rs3388913319 | 458 | L>P | No | EVA | |
| rs3388907382 | 487 | G>E | No | EVA | |
| rs3388909594 | 488 | G>A | No | EVA | |
| rs3388911379 | 496 | W>R | No | EVA | |
| rs3397911368 | 566 | P>L | No | EVA | |
| rs3388883219 | 569 | P>S | No | EVA | |
| rs3388907892 | 582 | R>S | No | EVA | |
| rs49200743 | 626 | V>A | No | EVA | |
| rs3388892443 | 626 | V>M | No | EVA | |
| rs3388911394 | 635 | V>M | No | EVA | |
| rs3388892402 | 654 | V>I | No | EVA | |
| rs3388900476 | 658 | V>L | No | EVA | |
| rs3388896642 | 659 | L>R | No | EVA | |
| rs3388913284 | 680 | L>M | No | EVA | |
| rs3388907932 | 681 | E>G | No | EVA | |
| rs3388909028 | 684 | D>N | No | EVA | |
| rs3388889766 | 702 | V>I | No | EVA | |
| rs3388889827 | 705 | L>F | No | EVA | |
| rs3397911386 | 708 | T>A | No | EVA | |
| rs3388909048 | 721 | P>S | No | EVA | |
| rs3388907924 | 722 | F>L | No | EVA | |
| rs3388903597 | 724 | A>S | No | EVA | |
| rs3388903581 | 725 | G>R | No | EVA | |
| rs3397795439 | 750 | Q>H | No | EVA | |
| rs3397616447 | 752 | A>G | No | EVA | |
| rs3397860816 | 757 | S>G | No | EVA | |
| rs32519373 | 757 | S>N | No | EVA | |
| rs3388911414 | 785 | L>M | No | EVA | |
| rs3388911382 | 804 | R>G | No | EVA | |
| rs227340750 | 804 | R>K | No | EVA | |
| rs3388900511 | 806 | N>K | No | EVA | |
| rs3388892394 | 829 | K>N | No | EVA | |
| rs3388907884 | 838 | C>Y | No | EVA | |
| rs3388911577 | 855 | D>E | No | EVA | |
| rs3388907870 | 857 | P>H | No | EVA | |
| rs3397795526 | 877 | R>G | No | EVA | |
| rs3388906200 | 880 | P>Q | No | EVA | |
| rs3388911589 | 890 | R>W | No | EVA |
No associated diseases with Q3U0S6
Functions
5 GO annotations of cellular component
| Name | Definition |
|---|---|
| cell-cell junction | A cell junction that forms a connection between two or more cells of an organism; excludes direct cytoplasmic intercellular bridges, such as ring canals in insects. |
| Golgi apparatus | A membrane-bound cytoplasmic organelle of the endomembrane system that further processes the core oligosaccharides (e.g. N-glycans) added to proteins in the endoplasmic reticulum and packages them into membrane-bound vesicles. The Golgi apparatus operates at the intersection of the secretory, lysosomal, and endocytic pathways. |
| Golgi stack | The set of thin, flattened membrane-bounded compartments, called cisternae, that form the central portion of the Golgi complex. The stack usually comprises cis, medial, and trans cisternae; the cis- and trans-Golgi networks are not considered part of the stack. |
| perinuclear region of cytoplasm | Cytoplasm situated near, or occurring around, the nucleus. |
| protein-containing complex | A stable assembly of two or more macromolecules, i.e. proteins, nucleic acids, carbohydrates or lipids, in which at least one component is a protein and the constituent parts function together. |
3 GO annotations of molecular function
| Name | Definition |
|---|---|
| GTPase binding | Binding to a GTPase, any enzyme that catalyzes the hydrolysis of GTP. |
| protein homodimerization activity | Binding to an identical protein to form a homodimer. |
| small GTPase binding | Binding to a small monomeric GTPase. |
11 GO annotations of biological process
| Name | Definition |
|---|---|
| angiogenesis | Blood vessel formation when new vessels emerge from the proliferation of pre-existing blood vessels. |
| branching morphogenesis of an epithelial tube | The process in which the anatomical structures of branches in an epithelial tube are generated and organized. A tube is a long hollow cylinder. |
| negative regulation of autophagy | Any process that stops, prevents, or reduces the frequency, rate or extent of autophagy. Autophagy is the process in which cells digest parts of their own cytoplasm. |
| negative regulation of membrane permeability | Any process that stops, prevents or reduces the frequency, rate or extent of the passage or uptake of molecules by a membrane. |
| negative regulation of Rho protein signal transduction | Any process that stops, prevents, or reduces the frequency, rate or extent of Rho protein signal transduction. |
| negative regulation of Rho-dependent protein serine/threonine kinase activity | Any process that stops, prevents or reduces the frequency, rate or extent of Rho-dependent protein serine/threonine kinase activity. |
| positive regulation of cell population proliferation | Any process that activates or increases the rate or extent of cell proliferation. |
| positive regulation of integrin activation | Any process that activates or increases the frequency, rate, or extent of integrin activation. |
| regulation of GTPase activity | Any process that modulates the rate of GTP hydrolysis by a GTPase. |
| signal transduction | The cellular process in which a signal is conveyed to trigger a change in the activity or state of a cell. Signal transduction begins with reception of a signal (e.g. a ligand binding to a receptor or receptor activation by a stimulus such as light), or for signal transduction in the absence of ligand, signal-withdrawal or the activity of a constitutively active receptor. Signal transduction ends with regulation of a downstream cellular process, e.g. regulation of transcription or regulation of a metabolic process. Signal transduction covers signaling from receptors located on the surface of the cell and signaling via molecules located within the cell. For signaling between cells, signal transduction is restricted to events at and within the receiving cell. |
| vasculogenesis | The differentiation of endothelial cells from progenitor cells during blood vessel development, and the de novo formation of blood vessels and tubes. |
14 homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| Q27991 | MYH10 | Myosin-10 | Bos taurus (Bovine) | SS |
| Q02440 | MYO5A | Unconventional myosin-Va | Gallus gallus (Chicken) | SS |
| B0I1T2 | MYO1G | Unconventional myosin-Ig | Homo sapiens (Human) | PR |
| Q9NQX4 | MYO5C | Unconventional myosin-Vc | Homo sapiens (Human) | SS |
| Q9ULV0 | MYO5B | Unconventional myosin-Vb | Homo sapiens (Human) | SS |
| P35580 | MYH10 | Myosin-10 | Homo sapiens (Human) | SS |
| Q9Y4I1 | MYO5A | Unconventional myosin-Va | Homo sapiens (Human) | SS |
| Q5U651 | RASIP1 | Ras-interacting protein 1 | Homo sapiens (Human) | PR |
| P21271 | Myo5b | Unconventional myosin-Vb | Mus musculus (Mouse) | SS |
| Q61879 | Myh10 | Myosin-10 | Mus musculus (Mouse) | SS |
| Q99104 | Myo5a | Unconventional myosin-Va | Mus musculus (Mouse) | EV |
| P70569 | Myo5b | Unconventional myosin-Vb | Rattus norvegicus (Rat) | SS |
| Q9JLT0 | Myh10 | Myosin-10 | Rattus norvegicus (Rat) | SS |
| Q9M2K0 | XI-J | Myosin-16 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| 10 | 20 | 30 | 40 | 50 | 60 |
| MLSGERKEGG | SPRFGKLHLP | VGLWINSPRK | QLAKLGRRWP | SAASVKSSSS | DTGSRSSEPL |
| 70 | 80 | 90 | 100 | 110 | 120 |
| PPPPPPPHVE | LRRVGAVKAA | GGASGSRAKR | ISQLFRGSGA | GGAGGPGTPG | GAQRWASEKK |
| 130 | 140 | 150 | 160 | 170 | 180 |
| LPELAAGVAP | EPPLPTRAAV | PPGVLKIFAS | GLASGANYKS | VLATERSTAR | ELVAEALERY |
| 190 | 200 | 210 | 220 | 230 | 240 |
| GLTGGRGAGD | SGCVDAYALC | DALGRPAVGV | GGGEWRAEHL | RVLADAERPL | LVQDLWRARP |
| 250 | 260 | 270 | 280 | 290 | 300 |
| GWARRFELRG | REEARRLEQE | AFGAADADGT | NAPSWRTQKN | RSRAASGGAA | LASPGPGSGS |
| 310 | 320 | 330 | 340 | 350 | 360 |
| GTPTGSGGKE | RSENLSLRRS | VSELSLQGRR | RRQQERRQQA | LSMAPGAADA | QMVPTDPGDF |
| 370 | 380 | 390 | 400 | 410 | 420 |
| DQLTQCLIQA | PSNRPYFLLL | QGYQDAQDFV | VYVMTREQHV | FGRGGPSSSR | GGSPAPYVDT |
| 430 | 440 | 450 | 460 | 470 | 480 |
| FLNAPDILPR | HCTVRAGPEP | PAMVRPSRGA | PVTHNGCLLL | REAELHPGDL | LGLGEHFLFM |
| 490 | 500 | 510 | 520 | 530 | 540 |
| YKDPRSGGSG | PARPSWLPAR | PGAAPPGPGW | AFSCRLCGRG | LQERGEALAA | YLDGREPVLR |
| 550 | 560 | 570 | 580 | 590 | 600 |
| FRPREEEALL | GEIVRAAASG | AGDLPPLGPA | TLLALCVQHS | ARELELGHLP | RLLGRLARLI |
| 610 | 620 | 630 | 640 | 650 | 660 |
| KEAVWEKIKE | IGDRQPENHP | EGVPEVPLTP | EAVSVELRPL | ILWMANTTEL | LSFVQEKVLE |
| 670 | 680 | 690 | 700 | 710 | 720 |
| MEKEADQEGL | SSDPQLCNDL | ELCDEALALL | DEVIMCTFQQ | SVYYLTKTLY | STLPALLDSN |
| 730 | 740 | 750 | 760 | 770 | 780 |
| PFTAGAELPG | PGAELEAMPP | GLRPTLGVFQ | AALELTSQCE | LHPDLVSQTF | GYLFFFSNAS |
| 790 | 800 | 810 | 820 | 830 | 840 |
| LLNSLMERGQ | GRPFYQWSRA | VQIRTNLDLV | LDWLQGAGLG | DIATEFFRKL | SIAVNLLCVP |
| 850 | 860 | 870 | 880 | 890 | 900 |
| RTSLLKASWS | SLRTDYPTLT | PAQLHHLLSH | YQLGPGRGPP | PAWDPPPAER | DAVDTGDIFE |
| 910 | 920 | 930 | 940 | 950 | 960 |
| SFSSHPPLIL | PLGSSRLRLT | GPVTDDALHR | ELRRLRRLLW | DLEQQELPAN | HRHGPPVAST |
| P |