Q3TZA2

PR
Gene name
Cdkl4 (Gm942)
Protein name
Cyclin-dependent kinase-like 4
Names
Species
Mus musculus (Mouse)
KEGG Pathway
mmu:381113
EC number
2.7.11.22: Protein-serine/threonine kinases
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

211-342 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

143-165 (Activation loop from InterPro)

Target domain

4-286 (Protein kinase domain)

Relief mechanism

Assay

References

Autoinhibited structure

Activated structure

1 structures for Q3TZA2

Entry ID Method Resolution Chain Position Source
AF-Q3TZA2-F1 Predicted AlphaFoldDB

17 variants for Q3TZA2

Variant ID(s) Position Change Description Diseaes Association Provenance
rs3389475451 15 Y>* No EVA
rs3389440033 39 E>V No EVA
rs215416155 42 R>P No EVA
rs3389489693 70 F>I No EVA
rs3389498883 95 P>S No EVA
rs3389462102 222 P>L No EVA
rs264944954 263 M>I No EVA
rs3389440045 264 K>* No EVA
rs258879392 276 T>A No EVA
rs246235054 287 E>D No EVA
rs3389392358 295 K>R No EVA
rs3407952829 300 S>L No EVA
rs3389462124 307 R>H No EVA
rs3389477333 312 L>Q No EVA
rs108278294 316 I>L No EVA
rs259750724 318 G>R No EVA
rs3389462119 340 P>T No EVA

No associated diseases with Q3TZA2

3 regional properties for Q3TZA2

Type Name Position InterPro Accession
domain Protein kinase domain 4 - 286 IPR000719
active_site Serine/threonine-protein kinase, active site 122 - 134 IPR008271
binding_site Protein kinase, ATP binding site 10 - 34 IPR017441

Functions

Description
EC Number 2.7.11.22 Protein-serine/threonine kinases
Subcellular Localization
  • Cytoplasm
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

2 GO annotations of cellular component

Name Definition
cytoplasm The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.

3 GO annotations of molecular function

Name Definition
ATP binding Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
cyclin-dependent protein serine/threonine kinase activity Cyclin-dependent catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate, and ATP + protein threonine = ADP + protein threonine phosphate.
protein serine kinase activity Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate.

1 GO annotations of biological process

Name Definition
protein phosphorylation The process of introducing a phosphate group on to a protein.

17 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
Q00532 CDKL1 Cyclin-dependent kinase-like 1 Homo sapiens (Human) PR
Q92772 CDKL2 Cyclin-dependent kinase-like 2 Homo sapiens (Human) PR
Q5MAI5 CDKL4 Cyclin-dependent kinase-like 4 Homo sapiens (Human) PR
Q8CEQ0 Cdkl1 Cyclin-dependent kinase-like 1 Mus musculus (Mouse) PR
Q3UMM4 Cdk10 Cyclin-dependent kinase 10 Mus musculus (Mouse) PR
O35495 Cdk14 Cyclin-dependent kinase 14 Mus musculus (Mouse) PR
Q8K0D0 Cdk17 Cyclin-dependent kinase 17 Mus musculus (Mouse) PR
Q8R3L8 Cdk8 Cyclin-dependent kinase 8 Mus musculus (Mouse) PR
Q8BWD8 Cdk19 Cyclin-dependent kinase 19 Mus musculus (Mouse) PR
Q99J95 Cdk9 Cyclin-dependent kinase 9 Mus musculus (Mouse) PR
Q8BLF2 Cdkl3 Cyclin-dependent kinase-like 3 Mus musculus (Mouse) PR
Q9QUK0 Cdkl2 Cyclin-dependent kinase-like 2 Mus musculus (Mouse) PR
Q9JHU3 Cdk20 Cyclin-dependent kinase 20 Mus musculus (Mouse) PR
Q5XIT0 Cdkl2 Cyclin-dependent kinase-like 2 Rattus norvegicus (Rat) PR
Q9JM01 Cdkl3 Cyclin-dependent kinase-like 3 Rattus norvegicus (Rat) PR
Q66HE7 Cdkl1 Cyclin-dependent kinase-like 1 Rattus norvegicus (Rat) PR
Q6AXJ9 cdkl1 Cyclin-dependent kinase-like 1 Danio rerio (Zebrafish) (Brachydanio rerio) PR
10 20 30 40 50 60
MEKYEKLAKI GEGSYGVVFK CRNKSSGQVV AIKKFVESED DRVVRKIALR EIRMLKQLKH
70 80 90 100 110 120
PNLVNLIEVF RRKRKMHLVF EYCDHTLLNE LERNPNGVSD GVIKSVLWQT LQALNFCHKH
130 140 150 160 170 180
NCIHRDVKPE NILITKQGMI KICDFGFARI LIPGDAYTDY VATRWYRAPE LLVGDTKYGS
190 200 210 220 230 240
SVDVWAVGCV FAELLTGQPL WPGKSDVDQL YLIIRTLGKL IPRHQSIFRS NQFFRGISIP
250 260 270 280 290 300
EPEDMETLEE KFSNVQPVAL SFMKGCLKMN PDERLTCAQL LDSAYFESFQ EDQMKRKARS
310 320 330 340
EGRSRRRQQN QLLPLIPGSH ISPTPDGRKQ VVQLKFDHLP NI