Q3TYX3
Gene name |
Smyd5 (Rai15) |
Protein name |
Histone-lysine N-trimethyltransferase SMYD5 |
Names |
Protein NN8-4AG, Retinoic acid-induced protein 15, SET and MYND domain-containing protein 5, [histone H4]-lysine20 N-trimethyltransferase SMYD5 |
Species |
Mus musculus (Mouse) |
KEGG Pathway |
mmu:232187 |
EC number |
2.1.1.372: Methyltransferases |
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for Q3TYX3
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-Q3TYX3-F1 | Predicted | AlphaFoldDB |
27 variants for Q3TYX3
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| rs3388842660 | 17 | D>Y | No | EVA | |
| rs3388847964 | 45 | G>V | No | EVA | |
| rs3388844513 | 68 | R>M | No | EVA | |
| rs3397013880 | 72 | H>L | No | EVA | |
| rs3396583619 | 77 | L>V | No | EVA | |
| rs3396838835 | 78 | E>D | No | EVA | |
| rs3396576373 | 81 | E>V | No | EVA | |
| rs3397167525 | 120 | S>C* | No | EVA | |
| rs3397059983 | 120 | S>T | No | EVA | |
| rs49923319 | 199 | Q>E | No | EVA | |
| rs49923319 | 199 | Q>K | No | EVA | |
| rs242168930 | 201 | Q>H | No | EVA | |
| rs45875302 | 202 | A>E | No | EVA | |
| rs240040012 | 214 | D>G | No | EVA | |
| rs3388807099 | 272 | L>V | No | EVA | |
| rs3388836343 | 304 | S>T | No | EVA | |
| rs3388838080 | 306 | L>I | No | EVA | |
| rs3388823046 | 323 | T>N | No | EVA | |
| rs3388847884 | 334 | V>A | No | EVA | |
| rs3388807118 | 340 | I>T | No | EVA | |
| rs3388834343 | 352 | D>E | No | EVA | |
| rs3388842707 | 358 | R>C | No | EVA | |
| rs3388841983 | 377 | C>S | No | EVA | |
| rs3388822940 | 395 | E>G | No | EVA | |
| rs3388836319 | 409 | L>I | No | EVA | |
| rs3388807094 | 412 | E>G | No | EVA | |
| rs3388836577 | 414 | T>I | No | EVA |
No associated diseases with Q3TYX3
Functions
| Description | ||
|---|---|---|
| EC Number | 2.1.1.372 | Methyltransferases |
| Subcellular Localization |
|
|
| PANTHER Family | ||
| PANTHER Subfamily | ||
| PANTHER Protein Class | ||
| PANTHER Pathway Category | No pathway information available | |
No GO annotations of cellular component
| Name | Definition |
|---|---|
| No GO annotations for cellular component |
2 GO annotations of molecular function
| Name | Definition |
|---|---|
| histone methyltransferase activity (H4-K20 specific) | Catalysis of the reaction: S-adenosyl-L-methionine + histone H4 L-lysine (position 20) = S-adenosyl-L-homocysteine + histone H4 N6-methyl-L-lysine (position 20). This reaction is the addition of a methyl group onto lysine at position 20 of the histone H4 protein. |
| metal ion binding | Binding to a metal ion. |
5 GO annotations of biological process
| Name | Definition |
|---|---|
| histone H4-K20 trimethylation | The modification of histone H4 by addition of three methyl groups to lysine at position 20 of the histone. |
| negative regulation of gene expression, epigenetic | An epigenetic process that silences gene expression at specific genomic regions through chromatin remodelling either by modifying higher order chromatin fiber structure, nucleosomal histones, or the DNA. |
| negative regulation of transposition | Any process that decreases the frequency, rate or extent of transposition. Transposition results in the movement of discrete segments of DNA between nonhomologous sites. |
| regulation of stem cell differentiation | Any process that modulates the frequency, rate or extent of stem cell differentiation. |
| regulation of stem cell division | Any process that modulates the frequency, rate or extent of stem cell division. |
13 homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| Q0P585 | SMYD2 | N-lysine methyltransferase SMYD2 | Bos taurus (Bovine) | SS |
| E1C5V0 | SMYD2 | N-lysine methyltransferase SMYD2 | Gallus gallus (Chicken) | SS |
| Q5ZIZ2 | SMYD5 | Histone-lysine N-trimethyltransferase SMYD5 | Gallus gallus (Chicken) | PR |
| Q9NRG4 | SMYD2 | N-lysine methyltransferase SMYD2 | Homo sapiens (Human) | SS |
| Q9H7B4 | SMYD3 | Histone-lysine N-methyltransferase SMYD3 | Homo sapiens (Human) | EV |
| Q6GMV2 | SMYD5 | Histone-lysine N-trimethyltransferase SMYD5 | Homo sapiens (Human) | PR |
| Q8R5A0 | Smyd2 | N-lysine methyltransferase SMYD2 | Mus musculus (Mouse) | EV |
| Q9CWR2 | Smyd3 | Histone-lysine N-methyltransferase SMYD3 | Mus musculus (Mouse) | SS |
| C3RZA1 | SMYD2 | N-lysine methyltransferase SMYD2 | Sus scrofa (Pig) | SS |
| Q7M6Z3 | Smyd2 | N-lysine methyltransferase SMYD2 | Rattus norvegicus (Rat) | SS |
| P34318 | set-3 | SET domain-containing protein 3 | Caenorhabditis elegans | PR |
| Q5RGL7 | smyd2b | N-lysine methyltransferase SMYD2-B | Danio rerio (Zebrafish) (Brachydanio rerio) | SS |
| Q5BJI7 | smyd2a | N-lysine methyltransferase SMYD2-A | Danio rerio (Zebrafish) (Brachydanio rerio) | SS |
| 10 | 20 | 30 | 40 | 50 | 60 |
| MAASMCDVFS | FCVGVADRAR | GSVEVRYVDS | IKGKGLFATQ | LIRKGETIFI | ERPLVAAQFL |
| 70 | 80 | 90 | 100 | 110 | 120 |
| WNALYQYRAC | DHCLRALEKA | EENAQRLTGK | PSQILPHPEL | CSVRKDLHQN | CPHCQVMYCS |
| 130 | 140 | 150 | 160 | 170 | 180 |
| AECRLAAAEQ | YHQILCPGPS | HDPRHPLNKL | QEAWRSVHYP | PETASIMLMA | RMVATVKQAK |
| 190 | 200 | 210 | 220 | 230 | 240 |
| DKDHWVRLFN | HFCSRTANQE | QAIVHKLLKG | KFKDQLELLL | GLFKEALYEE | ALSLWFTPEG |
| 250 | 260 | 270 | 280 | 290 | 300 |
| FRSLFALVGT | NGQGIGTSSL | SQWVHACDAL | ELTPQDREQL | DTFIDQLYKD | IEAATGEFLN |
| 310 | 320 | 330 | 340 | 350 | 360 |
| CEGSGLFVLQ | SCCNHSCVPN | AETSFPENNF | VLHVTALEDI | KPGEEICISY | LDCCQRERSR |
| 370 | 380 | 390 | 400 | 410 | |
| HSRHKILREN | YLFNCSCPKC | LAEADDPNVT | SEEEEEEDEE | EGEPEDAELG | DEMTDV |