Q3TVC7

SS
Gene name
Ccndbp1 (Dip1, Gcip, Maid)
Protein name
Cyclin-D1-binding protein 1
Names
Grap2 and cyclin-D-interacting protein , Maternal Id-like protein , Stage specific embryonic cDNA-8 protein , SSEC-8
Species
Mus musculus (Mouse)
KEGG Pathway
mmu:17151
EC number
Protein Class

Descriptions

CCNDBP1 (Cyclin-D1-binding protein 1) is a dominant-negative helix-loop-helix (dnHLH) protein, which lacks DNA-binding ability and captures basic HLH transcription factors to inhibit cellular differentiation and enhance cell proliferation and motility. In the structure of a free-standing human CCNDBP1, CCNDBP1 adopts a V-shaped conformation, with N-terminal and C-terminal five-helix bundles connected by the HLH region. The HLH region is extended, with its hydrophobic dimerization interfaces embedded in the N- and C-terminal helix bundles. CCNDBP1 exists in slow equilibrium between the V-shaped form and the partially unfolded, relaxed form. The latter form is readily available for interactions with its target bHLH transcription factors. Mutations disrupting the interactions in the V-shaped form compromise the target transcription factor specificity.

Autoinhibitory domains (AIDs)

0-135 (N-bundle) SS

Target domain

148-197 (HLH region)

Relief mechanism

Partner binding

Assay

225-356 (C-bundle) SS

Target domain

148-197 (HLH region)

Relief mechanism

Partner binding

Assay

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for Q3TVC7

Entry ID Method Resolution Chain Position Source
AF-Q3TVC7-F1 Predicted AlphaFoldDB

12 variants for Q3TVC7

Variant ID(s) Position Change Description Diseaes Association Provenance
rs214324513 26 R>Q No EVA
rs229780594 66 V>I No EVA
rs250262943 76 W>S No EVA
rs230237545 119 A>T No EVA
rs3388585508 124 D>Y No EVA
rs3388587685 139 Q>H No EVA
rs3388584246 139 Q>L No EVA
rs3388585288 174 L>P No EVA
rs3388582384 187 E>V No EVA
rs3388582344 251 L>P No EVA
rs3392137078 282 P>A No EVA
rs3388587047 321 S>N No EVA

No associated diseases with Q3TVC7

2 regional properties for Q3TVC7

Type Name Position InterPro Accession
domain Cyclin-D1-binding protein 1-like, N-terminal 53 - 194 IPR049317
domain Cyclin-D1-binding protein 1-like, C-terminal 213 - 316 IPR049318

Functions

Description
EC Number
Subcellular Localization
  • Cytoplasm
  • Nucleus
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

2 GO annotations of cellular component

Name Definition
cytoplasm The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.

No GO annotations of molecular function

Name Definition
No GO annotations for molecular function

2 GO annotations of biological process

Name Definition
cell cycle The progression of biochemical and morphological phases and events that occur in a cell during successive cell replication or nuclear replication events. Canonically, the cell cycle comprises the replication and segregation of genetic material followed by the division of the cell, but in endocycles or syncytial cells nuclear replication or nuclear division may not be followed by cell division.
regulation of cell cycle Any process that modulates the rate or extent of progression through the cell cycle.

4 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
Q2KIZ9 CCNDBP1 Cyclin-D1-binding protein 1 Bos taurus (Bovine) SS
O95273 CCNDBP1 Cyclin-D1-binding protein 1 Homo sapiens (Human) EV
Q5BK06 Ccndbp1 Cyclin-D1-binding protein 1 Rattus norvegicus (Rat) SS
A3KNI7 ccndbp1 Cyclin-D1-binding protein 1 homolog Danio rerio (Zebrafish) (Brachydanio rerio) SS
10 20 30 40 50 60
MASSTAAVPF LAPPLEQLRH LAEELRSLLP RVRVGEAQET AEEFNREMFW RRLNEAAVKV
70 80 90 100 110 120
NGEATVLTTH FSKLPWPSPQ ETQRICEQVR IAIEEIIIVY YSLPKDQGIT LRKLVRNAAL
130 140 150 160 170 180
DIVDGMAQLL EVLLTAPSQS TENGDLISCN SVSVACQQVP EIPKDNKAAA LLMLTKSVDF
190 200 210 220 230 240
VKDAHEEMEQ AVEECDPYSG LLNDSEDNSD SHSDEDGVLG LPSNRDSYWS EEDQELIIPC
250 260 270 280 290 300
LALVRASRAS LKKIRILVAE NGKKDEVAQL DDIVDISDEI SPSVDDLVLS IYPPVCHLTV
310 320 330 340 350
RISSAKLVSV LIKALEITKA SHVSPHPGDS WIPLLINAVD HCMNRIKALT QRAAEL