Q3TR54

SS
Gene name
Gsdmc4
Protein name
Gasdermin-C4
Names
Species
Mus musculus (Mouse)
KEGG Pathway
mmu:74548
EC number
Protein Class

Descriptions

Gasdermin proteins are a pore-forming protein causing membrane permeabilization and pyroptosis, and functions downstream of the inflammatory caspases. The C-terminal gasdermin domain may adopt an intramolecular complex with the N-terminal domain, which may inhibit the activation of the N-terminal gasdermin domain as observed in GSDMD.

Autoinhibitory domains (AIDs)

272-441 (C-terminal gasdermin domain) SS

Target domain

5-233 (N-terminal gasdermin domain)

Relief mechanism

Cleavage

Assay

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for Q3TR54

Entry ID Method Resolution Chain Position Source
AF-Q3TR54-F1 Predicted AlphaFoldDB

11 variants for Q3TR54

Variant ID(s) Position Change Description Diseaes Association Provenance
rs579312519 266 T>R No Ensembl
rs580841058 268 E>Q No Ensembl
rs584740128 272 N>H No Ensembl
rs581321019 274 N>D No Ensembl
rs31087685 375 Q>L No Ensembl
rs579857664 395 T>P No Ensembl
rs587160045 400 S>P No Ensembl
rs583777902 401 S>* No Ensembl
rs586573043 403 T>I No Ensembl
rs31086869 465 Q>R No Ensembl
rs579640317 476 S>R No Ensembl

No associated diseases with Q3TR54

40 regional properties for Q3TR54

Type Name Position InterPro Accession
domain Protein kinase domain 1606 - 1859 IPR000719-1
domain Protein kinase domain 2961 - 3213 IPR000719-2
domain Immunoglobulin subtype 2 57 - 117 IPR003598-1
domain Immunoglobulin subtype 2 739 - 806 IPR003598-2
domain Immunoglobulin subtype 2 886 - 954 IPR003598-3
domain Immunoglobulin subtype 2 985 - 1053 IPR003598-4
domain Immunoglobulin subtype 2 1081 - 1148 IPR003598-5
domain Immunoglobulin subtype 2 1205 - 1272 IPR003598-6
domain Immunoglobulin subtype 2 1502 - 1569 IPR003598-7
domain Immunoglobulin subtype 2 2599 - 2667 IPR003598-8
domain Immunoglobulin subtype 51 - 128 IPR003599-1
domain Immunoglobulin subtype 733 - 817 IPR003599-2
domain Immunoglobulin subtype 880 - 965 IPR003599-3
domain Immunoglobulin subtype 979 - 1064 IPR003599-4
domain Immunoglobulin subtype 1075 - 1159 IPR003599-5
domain Immunoglobulin subtype 1199 - 1283 IPR003599-6
domain Immunoglobulin subtype 1401 - 1487 IPR003599-7
domain Immunoglobulin subtype 1496 - 1580 IPR003599-8
domain Immunoglobulin subtype 2593 - 2678 IPR003599-9
domain Fibronectin type III 1287 - 1387 IPR003961-1
domain Fibronectin type III 2681 - 2777 IPR003961-2
domain Immunoglobulin-like domain 45 - 126 IPR007110-1
domain Immunoglobulin-like domain 727 - 815 IPR007110-2
domain Immunoglobulin-like domain 874 - 963 IPR007110-3
domain Immunoglobulin-like domain 968 - 1062 IPR007110-4
domain Immunoglobulin-like domain 1069 - 1157 IPR007110-5
domain Immunoglobulin-like domain 1193 - 1283 IPR007110-6
domain Immunoglobulin-like domain 1490 - 1578 IPR007110-7
domain Immunoglobulin-like domain 2586 - 2676 IPR007110-8
active_site Serine/threonine-protein kinase, active site 1720 - 1732 IPR008271-1
active_site Serine/threonine-protein kinase, active site 3076 - 3088 IPR008271-2
domain Immunoglobulin I-set 45 - 127 IPR013098-1
domain Immunoglobulin I-set 727 - 816 IPR013098-2
domain Immunoglobulin I-set 874 - 964 IPR013098-3
domain Immunoglobulin I-set 976 - 1063 IPR013098-4
domain Immunoglobulin I-set 1070 - 1158 IPR013098-5
domain Immunoglobulin I-set 1193 - 1282 IPR013098-6
domain Immunoglobulin I-set 1490 - 1579 IPR013098-7
domain Immunoglobulin I-set 2587 - 2677 IPR013098-8
binding_site Protein kinase, ATP binding site 1612 - 1635 IPR017441

Functions

Description
EC Number
Subcellular Localization
  • [Gasdermin-C4]: Cytoplasm, cytosol
  • ;
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

4 GO annotations of cellular component

Name Definition
cytoplasm The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
cytosol The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
integral component of membrane The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.
plasma membrane The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.

3 GO annotations of molecular function

Name Definition
phosphatidylinositol-4,5-bisphosphate binding Binding to phosphatidylinositol-4,5-bisphosphate, a derivative of phosphatidylinositol in which the inositol ring is phosphorylated at the 4' and 5' positions.
phosphatidylinositol-4-phosphate binding Binding to phosphatidylinositol-4-phosphate, a derivative of phosphatidylinositol in which the inositol ring is phosphorylated at the 4' position.
phosphatidylserine binding Binding to phosphatidylserine, a class of glycophospholipids in which a phosphatidyl group is esterified to the hydroxyl group of L-serine.

2 GO annotations of biological process

Name Definition
defense response to bacterium Reactions triggered in response to the presence of a bacterium that act to protect the cell or organism.
pyroptosis A caspase-1-dependent cell death subroutine that is associated with the generation of pyrogenic mediators such as IL-1beta and IL-18.

12 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
P57764 GSDMD Gasdermin-D Homo sapiens (Human) EV
Q96QA5 GSDMA Gasdermin-A Homo sapiens (Human) SS
Q9BYG8 GSDMC Gasdermin-C Homo sapiens (Human) SS
Q8TAX9 GSDMB Gasdermin-B Homo sapiens (Human) EV
Q8CB12 Gsdmc3 Gasdermin-C3 Mus musculus (Mouse) SS
Q2KHK6 Gsdmc2 Gasdermin-C2 Mus musculus (Mouse) SS
Q5Y4Y6 Gsdma3 Gasdermin-A3 Mus musculus (Mouse) EV
Q99NB5 Gsdmc Gasdermin-C Mus musculus (Mouse) SS
Q9D8T2 Gsdmd Gasdermin-D Mus musculus (Mouse) SS
Q9EST1 Gsdma Gasdermin-A Mus musculus (Mouse) SS
Q32M21 Gsdma2 Gasdermin-A2 Mus musculus (Mouse) SS
P85967 Gsdmc Gasdermin-C Rattus norvegicus (Rat) SS
10 20 30 40 50 60
MGYSFDRASK DVVKKLQGRD LRPVECLSDA TKFRLFHILQ ETPRSGWETE DIPVGFTLLD
70 80 90 100 110 120
LLEPNFPVPE PEVSAPKPFI HVQSTDLEAN LNVADIARGG VGYVGYGGYN IEVQSTSIPN
130 140 150 160 170 180
PKLEILQNRK LLDKLPTFMK FCRMERKNLY VVTEAYEVSK DTMLTGLSSV NLLVKGFFKQ
190 200 210 220 230 240
LFKVRGKAGR SEKYSIPIPK GSVLAYKKQQ LVIENNTCVI LPSATKKKMT FPDRPLKLYD
250 260 270 280 290 300
LPVTLRYQEE VIETGSWIDD IDPIGTIEEP ANLNFMCLQH EVSEQTQLLA ELSKDVQEVV
310 320 330 340 350 360
FSSFLHMLSD RDVLYDLMKM LELNQLGHMD GPGGKILDEL RKDSSTPHDV LKDLNLYLLQ
370 380 390 400 410 420
ALLVLSDTQL CLLAQSVKMG LLPHQVELVK SILQTNFKYS SNTPFTLQPQ LLAPLQGEGL
430 440 450 460 470
AITYELLEEC GLKMELNNPR STWDLEAKMP LSALYGSLSF LQQLQKANSS SKPSLSPGYI