Q3TR54
Gene name |
Gsdmc4 |
Protein name |
Gasdermin-C4 |
Names |
|
Species |
Mus musculus (Mouse) |
KEGG Pathway |
mmu:74548 |
EC number |
|
Protein Class |
|
Descriptions
Autoinhibitory domains (AIDs)
Target domain |
5-233 (N-terminal gasdermin domain) |
Relief mechanism |
Cleavage |
Assay |
|
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for Q3TR54
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-Q3TR54-F1 | Predicted | AlphaFoldDB |
11 variants for Q3TR54
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| rs579312519 | 266 | T>R | No | Ensembl | |
| rs580841058 | 268 | E>Q | No | Ensembl | |
| rs584740128 | 272 | N>H | No | Ensembl | |
| rs581321019 | 274 | N>D | No | Ensembl | |
| rs31087685 | 375 | Q>L | No | Ensembl | |
| rs579857664 | 395 | T>P | No | Ensembl | |
| rs587160045 | 400 | S>P | No | Ensembl | |
| rs583777902 | 401 | S>* | No | Ensembl | |
| rs586573043 | 403 | T>I | No | Ensembl | |
| rs31086869 | 465 | Q>R | No | Ensembl | |
| rs579640317 | 476 | S>R | No | Ensembl |
No associated diseases with Q3TR54
10 regional properties for Q3TR54
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| domain | CRIB domain | 1546 - 1583 | IPR000095 |
| domain | Protein kinase domain | 100 - 369 | IPR000719 |
| domain | AGC-kinase, C-terminal | 370 - 440 | IPR000961 |
| domain | Citron homology (CNH) domain | 1203 - 1504 | IPR001180 |
| domain | Pleckstrin homology domain | 1059 - 1179 | IPR001849 |
| domain | Protein kinase C-like, phorbol ester/diacylglycerol-binding domain | 989 - 1040 | IPR002219 |
| active_site | Serine/threonine-protein kinase, active site | 220 - 232 | IPR008271 |
| binding_site | Protein kinase, ATP binding site | 106 - 129 | IPR017441 |
| domain | Protein kinase, C-terminal | 388 - 430 | IPR017892 |
| domain | KELK-motif containing domain | 477 - 556 | IPR031597 |
4 GO annotations of cellular component
| Name | Definition |
|---|---|
| cytoplasm | The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. |
| cytosol | The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. |
| integral component of membrane | The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane. |
| plasma membrane | The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. |
3 GO annotations of molecular function
| Name | Definition |
|---|---|
| phosphatidylinositol-4,5-bisphosphate binding | Binding to phosphatidylinositol-4,5-bisphosphate, a derivative of phosphatidylinositol in which the inositol ring is phosphorylated at the 4' and 5' positions. |
| phosphatidylinositol-4-phosphate binding | Binding to phosphatidylinositol-4-phosphate, a derivative of phosphatidylinositol in which the inositol ring is phosphorylated at the 4' position. |
| phosphatidylserine binding | Binding to phosphatidylserine, a class of glycophospholipids in which a phosphatidyl group is esterified to the hydroxyl group of L-serine. |
2 GO annotations of biological process
| Name | Definition |
|---|---|
| defense response to bacterium | Reactions triggered in response to the presence of a bacterium that act to protect the cell or organism. |
| pyroptosis | A caspase-1-dependent cell death subroutine that is associated with the generation of pyrogenic mediators such as IL-1beta and IL-18. |
12 homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| P57764 | GSDMD | Gasdermin-D | Homo sapiens (Human) | EV |
| Q96QA5 | GSDMA | Gasdermin-A | Homo sapiens (Human) | SS |
| Q9BYG8 | GSDMC | Gasdermin-C | Homo sapiens (Human) | SS |
| Q8TAX9 | GSDMB | Gasdermin-B | Homo sapiens (Human) | EV |
| Q8CB12 | Gsdmc3 | Gasdermin-C3 | Mus musculus (Mouse) | SS |
| Q2KHK6 | Gsdmc2 | Gasdermin-C2 | Mus musculus (Mouse) | SS |
| Q5Y4Y6 | Gsdma3 | Gasdermin-A3 | Mus musculus (Mouse) | EV |
| Q99NB5 | Gsdmc | Gasdermin-C | Mus musculus (Mouse) | SS |
| Q9D8T2 | Gsdmd | Gasdermin-D | Mus musculus (Mouse) | SS |
| Q9EST1 | Gsdma | Gasdermin-A | Mus musculus (Mouse) | SS |
| Q32M21 | Gsdma2 | Gasdermin-A2 | Mus musculus (Mouse) | SS |
| P85967 | Gsdmc | Gasdermin-C | Rattus norvegicus (Rat) | SS |
| 10 | 20 | 30 | 40 | 50 | 60 |
| MGYSFDRASK | DVVKKLQGRD | LRPVECLSDA | TKFRLFHILQ | ETPRSGWETE | DIPVGFTLLD |
| 70 | 80 | 90 | 100 | 110 | 120 |
| LLEPNFPVPE | PEVSAPKPFI | HVQSTDLEAN | LNVADIARGG | VGYVGYGGYN | IEVQSTSIPN |
| 130 | 140 | 150 | 160 | 170 | 180 |
| PKLEILQNRK | LLDKLPTFMK | FCRMERKNLY | VVTEAYEVSK | DTMLTGLSSV | NLLVKGFFKQ |
| 190 | 200 | 210 | 220 | 230 | 240 |
| LFKVRGKAGR | SEKYSIPIPK | GSVLAYKKQQ | LVIENNTCVI | LPSATKKKMT | FPDRPLKLYD |
| 250 | 260 | 270 | 280 | 290 | 300 |
| LPVTLRYQEE | VIETGSWIDD | IDPIGTIEEP | ANLNFMCLQH | EVSEQTQLLA | ELSKDVQEVV |
| 310 | 320 | 330 | 340 | 350 | 360 |
| FSSFLHMLSD | RDVLYDLMKM | LELNQLGHMD | GPGGKILDEL | RKDSSTPHDV | LKDLNLYLLQ |
| 370 | 380 | 390 | 400 | 410 | 420 |
| ALLVLSDTQL | CLLAQSVKMG | LLPHQVELVK | SILQTNFKYS | SNTPFTLQPQ | LLAPLQGEGL |
| 430 | 440 | 450 | 460 | 470 | |
| AITYELLEEC | GLKMELNNPR | STWDLEAKMP | LSALYGSLSF | LQQLQKANSS | SKPSLSPGYI |