Q3TL54
PR
Gene name |
Trim43a |
Protein name |
Tripartite motif-containing protein 43A |
Names |
|
Species |
Mus musculus (Mouse) |
KEGG Pathway |
mmu:547109 |
EC number |
|
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for Q3TL54
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-Q3TL54-F1 | Predicted | AlphaFoldDB |
33 variants for Q3TL54
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| rs3389070836 | 4 | D>G | No | EVA | |
| rs3389050883 | 14 | L>F | No | EVA | |
| rs579501329 | 21 | S>G | No | EVA | |
| rs3389061933 | 23 | F>Y | No | EVA | |
| rs583021535 | 43 | S>F | No | EVA | |
| rs3389060071 | 52 | Y>H | No | EVA | |
| rs47058755 | 55 | M>T | No | EVA | |
| rs586695504 | 60 | F>C | No | EVA | |
| rs585153486 | 66 | N>K | No | EVA | |
| rs3389066987 | 87 | N>I | No | EVA | |
| rs587241900 | 91 | H>N | No | EVA | |
| rs3389056170 | 131 | V>I | No | EVA | |
| rs108785685 | 160 | I>K | No | EVA | |
| rs108086330 | 164 | T>M | No | EVA | |
| rs578370554 | 183 | G>E | No | EVA | |
| rs238611563 | 190 | C>R | No | EVA | |
| rs238611563 | 190 | C>S | No | EVA | |
| rs258136925 | 226 | I>T | No | EVA | |
| rs585137393 | 240 | Y>C | No | EVA | |
| rs3389060223 | 247 | D>N | No | EVA | |
| rs3389064182 | 254 | R>S | No | EVA | |
| rs3389042111 | 268 | I>L | No | EVA | |
| rs3389061936 | 269 | P>S | No | EVA | |
| rs581039277 | 314 | S>T | No | EVA | |
| rs3389070843 | 335 | G>* | No | EVA | |
| rs3389029784 | 340 | E>A | No | EVA | |
| rs3389058222 | 342 | D>G | No | EVA | |
| rs107747673 | 354 | R>C | No | EVA | |
| rs47840476 | 365 | A>V | No | EVA | |
| rs583451874 | 366 | A>V | No | EVA | |
| rs225858260 | 371 | L>I | No | EVA | |
| rs3389060278 | 379 | K>Q | No | EVA | |
| rs107999570 | 380 | E>D | No | EVA |
No associated diseases with Q3TL54
9 regional properties for Q3TL54
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| domain | B-box-type zinc finger | 88 - 129 | IPR000315 |
| domain | Zinc finger, RING-type | 16 - 56 | IPR001841 |
| domain | B30.2/SPRY domain | 270 - 445 | IPR001870 |
| domain | Butyrophylin-like, SPRY domain | 319 - 343 | IPR003879-1 |
| domain | Butyrophylin-like, SPRY domain | 349 - 362 | IPR003879-2 |
| domain | Butyrophylin-like, SPRY domain | 393 - 417 | IPR003879-3 |
| domain | Butyrophylin-like, SPRY domain | 424 - 442 | IPR003879-4 |
| conserved_site | Zinc finger, RING-type, conserved site | 31 - 40 | IPR017907 |
| domain | Zinc finger, C3HC4 RING-type | 16 - 56 | IPR018957 |
1 GO annotations of cellular component
| Name | Definition |
|---|---|
| cytoplasm | The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. |
3 GO annotations of molecular function
| Name | Definition |
|---|---|
| protein kinase binding | Binding to a protein kinase, any enzyme that catalyzes the transfer of a phosphate group, usually from ATP, to a protein substrate. |
| ubiquitin protein ligase activity | Catalysis of the transfer of ubiquitin to a substrate protein via the reaction X-ubiquitin + S -> X + S-ubiquitin, where X is either an E2 or E3 enzyme, the X-ubiquitin linkage is a thioester bond, and the S-ubiquitin linkage is an amide bond: an isopeptide bond between the C-terminal glycine of ubiquitin and the epsilon-amino group of lysine residues in the substrate or, in the linear extension of ubiquitin chains, a peptide bond the between the C-terminal glycine and N-terminal methionine of ubiquitin residues. |
| zinc ion binding | Binding to a zinc ion (Zn). |
3 GO annotations of biological process
| Name | Definition |
|---|---|
| innate immune response | Innate immune responses are defense responses mediated by germline encoded components that directly recognize components of potential pathogens. |
| protein ubiquitination | The process in which one or more ubiquitin groups are added to a protein. |
| regulation of gene expression | Any process that modulates the frequency, rate or extent of gene expression. Gene expression is the process in which a gene's coding sequence is converted into a mature gene product (protein or RNA). |
47 homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| Q5E9G4 | TRIM10 | Tripartite motif-containing protein 10 | Bos taurus (Bovine) | PR |
| Q2T9Z0 | TRIM17 | E3 ubiquitin-protein ligase TRIM17 | Bos taurus (Bovine) | PR |
| E1BJS7 | TRIM71 | E3 ubiquitin-protein ligase TRIM71 | Bos taurus (Bovine) | PR |
| Q7YRV4 | TRIM21 | E3 ubiquitin-protein ligase TRIM21 | Bos taurus (Bovine) | PR |
| Q1PRL4 | TRIM71 | E3 ubiquitin-protein ligase TRIM71 | Gallus gallus (Chicken) | PR |
| Q7YR32 | TRIM10 | Tripartite motif-containing protein 10 | Pan troglodytes (Chimpanzee) | PR |
| O15553 | MEFV | Pyrin | Homo sapiens (Human) | SS |
| Q9BTV5 | FSD1 | Fibronectin type III and SPRY domain-containing protein 1 | Homo sapiens (Human) | PR |
| Q9H2S5 | RNF39 | RING finger protein 39 | Homo sapiens (Human) | PR |
| P19474 | TRIM21 | E3 ubiquitin-protein ligase TRIM21 | Homo sapiens (Human) | PR |
| Q9UJV3 | MID2 | Probable E3 ubiquitin-protein ligase MID2 | Homo sapiens (Human) | PR |
| P29590 | PML | Protein PML | Homo sapiens (Human) | PR |
| Q9C029 | TRIM7 | E3 ubiquitin-protein ligase TRIM7 | Homo sapiens (Human) | PR |
| Q9NQ86 | TRIM36 | E3 ubiquitin-protein ligase TRIM36 | Homo sapiens (Human) | PR |
| Q86UV6 | TRIM74 | Tripartite motif-containing protein 74 | Homo sapiens (Human) | PR |
| Q9UPQ4 | TRIM35 | E3 ubiquitin-protein ligase TRIM35 | Homo sapiens (Human) | PR |
| Q6ZMU5 | TRIM72 | Tripartite motif-containing protein 72 | Homo sapiens (Human) | PR |
| Q86UV7 | TRIM73 | Tripartite motif-containing protein 73 | Homo sapiens (Human) | PR |
| Q8N9V2 | TRIML1 | Probable E3 ubiquitin-protein ligase TRIML1 | Homo sapiens (Human) | PR |
| Q86XT4 | TRIM50 | E3 ubiquitin-protein ligase TRIM50 | Homo sapiens (Human) | PR |
| Q5EBN2 | TRIM61 | Putative tripartite motif-containing protein 61 | Homo sapiens (Human) | PR |
| Q9BZY9 | TRIM31 | E3 ubiquitin-protein ligase TRIM31 | Homo sapiens (Human) | PR |
| Q2Q1W2 | TRIM71 | E3 ubiquitin-protein ligase TRIM71 | Homo sapiens (Human) | PR |
| Q9BXM9 | FSD1L | FSD1-like protein | Homo sapiens (Human) | PR |
| A6NCK2 | TRIM43B | Tripartite motif-containing protein 43B | Homo sapiens (Human) | PR |
| Q8BZT2 | Sh3rf2 | E3 ubiquitin-protein ligase SH3RF2 | Mus musculus (Mouse) | PR |
| Q60953 | Pml | Protein PML | Mus musculus (Mouse) | PR |
| Q99PQ1 | Trim12a | Tripartite motif-containing protein 12A | Mus musculus (Mouse) | PR |
| Q61510 | Trim25 | E3 ubiquitin/ISG15 ligase TRIM25 | Mus musculus (Mouse) | PR |
| Q1PSW8 | Trim71 | E3 ubiquitin-protein ligase TRIM71 | Mus musculus (Mouse) | PR |
| P86449 | Trim43c | Tripartite motif-containing protein 43C | Mus musculus (Mouse) | PR |
| Q1XH17 | Trim72 | Tripartite motif-containing protein 72 | Mus musculus (Mouse) | PR |
| Q7TPM3 | Trim17 | E3 ubiquitin-protein ligase TRIM17 | Mus musculus (Mouse) | PR |
| Q810I2 | Trim50 | E3 ubiquitin-protein ligase TRIM50 | Mus musculus (Mouse) | PR |
| Q9JJ26 | Mefv | Pyrin | Mus musculus (Mouse) | SS |
| Q9WUH5 | Trim10 | Tripartite motif-containing protein 10 | Mus musculus (Mouse) | PR |
| O77666 | TRIM26 | Tripartite motif-containing protein 26 | Sus scrofa (Pig) | PR |
| O19085 | TRIM10 | Tripartite motif-containing protein 10 | Sus scrofa (Pig) | PR |
| Q865W2 | TRIM50 | E3 ubiquitin-protein ligase TRIM50 | Sus scrofa (Pig) | PR |
| Q920M2 | Rnf39 | RING finger protein 39 | Rattus norvegicus (Rat) | PR |
| Q9JJ25 | Mefv | Pyrin | Rattus norvegicus (Rat) | SS |
| A0JPQ4 | Trim72 | Tripartite motif-containing protein 72 | Rattus norvegicus (Rat) | PR |
| Q810I1 | Trim50 | E3 ubiquitin-protein ligase TRIM50 | Rattus norvegicus (Rat) | PR |
| D3ZVM4 | Trim71 | E3 ubiquitin-protein ligase TRIM71 | Rattus norvegicus (Rat) | PR |
| F6QEU4 | trim71 | E3 ubiquitin-protein ligase TRIM71 | Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) | PR |
| Q640S6 | trim72 | Tripartite motif-containing protein 72 | Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) | PR |
| E7FAM5 | trim71 | E3 ubiquitin-protein ligase TRIM71 | Danio rerio (Zebrafish) (Brachydanio rerio) | PR |
| 10 | 20 | 30 | 40 | 50 | 60 |
| MESDNLQDPQ | EETLTCSICQ | SIFMNPVYLR | CGHKFCEACL | LLSQEDIKFP | AYCPMCMQPF |
| 70 | 80 | 90 | 100 | 110 | 120 |
| NQEYINDISL | KKQVSIVRKK | RLMKYLNSKE | HKCVTHKAKK | MIFCDKSKIL | LCHLCSDSQE |
| 130 | 140 | 150 | 160 | 170 | 180 |
| HSGHTHCSID | VAVQEKMEEL | LKHMDSLWRR | LKIQQNYVEI | ERRTTLWWLS | VKLREEVIKR |
| 190 | 200 | 210 | 220 | 230 | 240 |
| VYGKQCPPLC | EERDQHIECL | RHQSNTTLEE | LRKSEATIVH | ERNQLIEVYR | ELMTMSQRPY |
| 250 | 260 | 270 | 280 | 290 | 300 |
| QELLVQDLDD | LFRRSKLAAK | LDMPQGMIPR | LHAHSIPGLT | ARLNSFRVKI | SFKHSIMFGY |
| 310 | 320 | 330 | 340 | 350 | 360 |
| TSVRPFDIRL | LHESTSLDSA | ETHRVSWGKK | SFSRGKYYWE | VDLKDHEQWT | VGVRKDPWLR |
| 370 | 380 | 390 | 400 | 410 | 420 |
| GRSYAATPTD | LFLLECLRKE | DHYILITRIG | GEHYIEKPVG | QVGVFLDCEG | GYVSFVDVAK |
| 430 | 440 | ||||
| SSLILSYSPG | TFHCAVRPFF | SAVYT |