Q3TBD2

SS
Gene name
Arhgap45
Protein name
Rho GTPase-activating protein 45
Names
Minor histocompatibility protein HA-1
Species
Mus musculus (Mouse)
KEGG Pathway
mmu:70719
EC number
Protein Class

Descriptions

ARHGAP45 contains a GTPase activator for the Rho-type GTPase (RhoGAP) domain that would be able to negatively regulate the actin cytoskeleton as well as cell spreading. The N-terminal BAR domain of human ARHGAP45(Q92619) is autoinhibitory as ARHGAP45 mutants lacking this region, but not full-length ARHGAP45, show GAP activity towards RhoGTPases.

Autoinhibitory domains (AIDs)

268-538 (N-terminal BAR domain) SS

Target domain

698-1107 (C1-GAP-tail domains)

Relief mechanism

Assay

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for Q3TBD2

Entry ID Method Resolution Chain Position Source
AF-Q3TBD2-F1 Predicted AlphaFoldDB

No variants for Q3TBD2

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for Q3TBD2

No associated diseases with Q3TBD2

15 regional properties for Q3TBD2

Type Name Position InterPro Accession
domain PB1 domain 15 - 98 IPR000270
domain Protein kinase domain 252 - 518 IPR000719
domain AGC-kinase, C-terminal 519 - 590 IPR000961
domain Protein kinase C-like, phorbol ester/diacylglycerol-binding domain 130 - 182 IPR002219
active_site Serine/threonine-protein kinase, active site 372 - 384 IPR008271
binding_site Protein kinase, ATP binding site 258 - 285 IPR017441
domain Protein kinase, C-terminal 540 - 580 IPR017892
domain Diacylglycerol/phorbol-ester binding 128 - 142 IPR020454-1
domain Diacylglycerol/phorbol-ester binding 144 - 153 IPR020454-2
domain Diacylglycerol/phorbol-ester binding 157 - 168 IPR020454-3
domain Diacylglycerol/phorbol-ester binding 169 - 181 IPR020454-4
domain Atypical Protein Kinase C zeta, catalytic domain 236 - 592 IPR034662
domain Protein kinase C, PB1 domain 16 - 98 IPR034877
domain Protein kinase C zeta type, conserved region 1 129 - 183 IPR047314
domain PB1-like domain 15 - 98 IPR053793

Functions

Description
EC Number
Subcellular Localization
  • Cytoplasm
  • Cell projection, ruffle membrane
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

2 GO annotations of cellular component

Name Definition
cytoplasm The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
ruffle membrane The portion of the plasma membrane surrounding a ruffle.

2 GO annotations of molecular function

Name Definition
GTPase activator activity Binds to and increases the activity of a GTPase, an enzyme that catalyzes the hydrolysis of GTP.
metal ion binding Binding to a metal ion.

2 GO annotations of biological process

Name Definition
activation of GTPase activity Any process that initiates the activity of an inactive GTPase through the replacement of GDP by GTP.
intracellular signal transduction The process in which a signal is passed on to downstream components within the cell, which become activated themselves to further propagate the signal and finally trigger a change in the function or state of the cell.

3 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
Q14CB8 ARHGAP19 Rho GTPase-activating protein 19 Homo sapiens (Human) PR
Q92619 ARHGAP45 Rho GTPase-activating protein 45 Homo sapiens (Human) EV
Q8BYW1 Arhgap25 Rho GTPase-activating protein 25 Mus musculus (Mouse) PR
10 20 30 40 50 60
MFSRKKRELM KTPSISKKNR AGSPNPQSSS GELPRKDWTE APGLEPPATS LSTVAKGTGT
70 80 90 100 110 120
LKRPTSLSRH ASAAGFPLSG TATWTLVRGY RSPLSAASPA ELPTEGAFPD GVEDISTLLA
130 140 150 160 170 180
DVARFAEGLE KLKECVLQDD LLEARRPLAH ECLGEALRVM RQVISRYPLL NTVETLTAAG
190 200 210 220 230 240
TLIAKVKAFH YECNNESDKR EFEKALETIA VSFSCTVSEF LLGEVDSSTL LAVPPGDPSQ
250 260 270 280 290 300
SMENLYGAGT EGPPHNVEEC EEGCLPPEEV DMLLQRCEGG VDAALQYAKD MARYMKDLIS
310 320 330 340 350 360
YLEKRTTLEM EFAKGLQKVV HNCRQSVTHE PHMPLLSIYS LALEQDLEFG HGMVQAAGTL
370 380 390 400 410 420
QTQTFMQPLT LRRLEHERRR KEIKESWHRA QRKLQEAEAN LRKAKQGYKQ RCEDHDKARL
430 440 450 460 470 480
QVAKAEEEQQ GTGPGAGTAA SKALDKRRRL EEEAKNKAEE AMATYRTCVA DAKTQKQELE
490 500 510 520 530 540
DTKVTALRQI QEVIRQSDQT IKSATISYYQ LMHMQTAPLP VNFQMLCESS KLYDPGQQYA
550 560 570 580 590 600
SHVRQLQRGE EPDVRYDFEP YVSNNSWSPI MRTRKGSFNP GDASGPEAAG SPPEEGGTSE
610 620 630 640 650 660
AAPNKDHRGG RGHQVHKSWP ISISDTEVGL DTSSGDLKKF DRTSSSGTMS SSEELGDQEA
670 680 690 700 710 720
GLVASAFDSA DLNGMDPELP VAMPSGPFRH VGLSKAARTH RLRKLRTPAK CRECNSYVYF
730 740 750 760 770 780
QGAECEECCL ACHKKCLETL AIQCGHKKLQ GRLQLFGQDF SQAALSTPDG VPFIVKKCVC
790 800 810 820 830 840
EIERRALHTK GIYRVNGVKT RVEKLCQAFE NGKELVELSQ ASPHDISNVL KLYLRQLPEP
850 860 870 880 890 900
LISFRFYHEL VGLAKDSLKA EAEAKAASRG RQGGSESEAA TLAMVGRLRE LMQDLPAENR
910 920 930 940 950 960
ATLLYLLKHL RRIVEMEQDN KMTPGNLGIV FGPTLLRPRP TDATVSLSSL VDYPHQARVI
970 980 990 1000 1010 1020
ETLIVHYGLV FEEEPEEAPG SQEGASTQCG QLESAEGIVF PLQEEAEDGS RESHAASNDS
1030 1040 1050 1060 1070 1080
DSELEDASDP LSSSDASALH RLSFLEQTEA GLEEGPQSHS GSEEQLEGED GAPGPWLCHF
1090 1100 1110
NTNQSNNTSR APLPTMRLRG GQITGGTSQE RQPQFV