Q3T1J9
Gene name |
Mob1a (Mobk1b, Mobkl1b) |
Protein name |
MOB kinase activator 1A |
Names |
Mob1 homolog 1B , Mps one binder kinase activator-like 1B |
Species |
Rattus norvegicus (Rat) |
KEGG Pathway |
rno:297387 |
EC number |
|
Protein Class |
|
Descriptions
Autoinhibitory domains (AIDs)
Target domain |
41-204 (MH domain) |
Relief mechanism |
PTM |
Assay |
|
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for Q3T1J9
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-Q3T1J9-F1 | Predicted | AlphaFoldDB |
No variants for Q3T1J9
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| No variants for Q3T1J9 | |||||
No associated diseases with Q3T1J9
No regional properties for Q3T1J9
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| No domain, repeats, and functional sites for Q3T1J9 | |||
2 GO annotations of cellular component
| Name | Definition |
|---|---|
| cytoplasm | The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. |
| nucleus | A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. |
2 GO annotations of molecular function
| Name | Definition |
|---|---|
| metal ion binding | Binding to a metal ion. |
| protein kinase activator activity | Binds to and increases the activity of a protein kinase, an enzyme which phosphorylates a protein. |
2 GO annotations of biological process
| Name | Definition |
|---|---|
| hippo signaling | The series of molecular signals mediated by the serine/threonine kinase Hippo or one of its orthologs. In Drosophila, Hippo in complex with the scaffold protein Salvador (Sav), phosphorylates and activates Warts (Wts), which in turn phosphorylates and inactivates the Yorkie (Yki) transcriptional activator. The core fly components hippo, sav, wts and mats are conserved in mammals as STK4/3 (MST1/2), SAV1/WW45, LATS1/2 and MOB1. |
| positive regulation of protein phosphorylation | Any process that activates or increases the frequency, rate or extent of addition of phosphate groups to amino acids within a protein. |
10 homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| P43563 | MOB2 | CBK1 kinase activator protein MOB2 | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) | PR |
| P40484 | MOB1 | DBF2 kinase activator protein MOB1 | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) | SS |
| Q95RA8 | mats | MOB kinase activator-like 1 | Drosophila melanogaster (Fruit fly) | SS |
| Q7L9L4 | MOB1B | MOB kinase activator 1B | Homo sapiens (Human) | SS |
| Q9H8S9 | MOB1A | MOB kinase activator 1A | Homo sapiens (Human) | EV |
| Q8BPB0 | Mob1b | MOB kinase activator 1B | Mus musculus (Mouse) | EV |
| Q8VI63 | Mob2 | MOB kinase activator 2 | Mus musculus (Mouse) | EV |
| Q921Y0 | Mob1a | MOB kinase activator 1A | Mus musculus (Mouse) | SS |
| Q8GYX0 | MOB1B | MOB kinase activator-like 1B | Arabidopsis thaliana (Mouse-ear cress) | SS |
| Q9FHI1 | MOB1A | MOB kinase activator-like 1A | Arabidopsis thaliana (Mouse-ear cress) | SS |
| 10 | 20 | 30 | 40 | 50 | 60 |
| MSFLFSSRSS | KTFKPKKNIP | EGSHQYELLK | HAEATLGSGN | LRQAVMLPEG | EDLNEWIAVN |
| 70 | 80 | 90 | 100 | 110 | 120 |
| TVDFFNQINM | LYGTITEFCT | EASCPVMSAG | PRYEYHWADG | TNIKKPIKCS | APKYIDYLMT |
| 130 | 140 | 150 | 160 | 170 | 180 |
| WVQDQLDDET | LFPSKIGVPF | PKNFMSVAKT | ILKRLFRVYA | HIYHQHFDSV | MQLQEEAHLN |
| 190 | 200 | 210 | |||
| TSFKHFIFFV | QEFNLIDRRE | LAPLQELIEK | LGSKDR |