Q3SZ65
PR
Gene name |
EIF4A2 |
Protein name |
Eukaryotic initiation factor 4A-II |
Names |
eIF-4A-II, eIF4A-II, ATP-dependent RNA helicase eIF4A-2 |
Species |
Bos taurus (Bovine) |
KEGG Pathway |
bta:286819 |
EC number |
3.6.4.13: Acting on ATP; involved in cellular and subcellular movement |
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for Q3SZ65
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-Q3SZ65-F1 | Predicted | AlphaFoldDB |
57 variants for Q3SZ65
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| rs475147459 | 4 | G>S | No | EVA | |
| rs461806908 | 11 | E>* | No | EVA | |
| rs449595160 | 13 | G>V | No | EVA | |
| rs482623038 | 14 | G>V | No | EVA | |
| rs472419687 | 22 | G>C | No | EVA | |
| rs441386673 | 23 | V>G | No | EVA | |
| rs468761342 | 26 | S>G | No | EVA | |
| rs456199934 | 27 | N>S | No | EVA | |
| rs437667963 | 28 | W>S | No | EVA | |
| rs464201633 | 33 | D>Y | No | EVA | |
| rs445651343 | 34 | N>K | No | EVA | |
| rs478563588 | 35 | F>L | No | EVA | |
| rs448342411 | 36 | D>E | No | EVA | |
| rs466870586 | 36 | D>N | No | EVA | |
| rs481292272 | 54 | E>V | No | EVA | |
| rs462737360 | 55 | K>M | No | EVA | |
| rs443723760 | 55 | K>N | No | EVA | |
| rs483164241 | 56 | P>S | No | EVA | |
| rs458021860 | 60 | Q>* | No | EVA | |
| rs475234195 | 71 | Y>D | No | EVA | |
| rs456713458 | 74 | I>F | No | EVA | |
| rs464264980 | 92 | L>R | No | EVA | |
| rs452179701 | 93 | Q>R | No | EVA | |
| rs433583801 | 102 | T>P | No | EVA | |
| rs469450513 | 119 | K>R | No | EVA | |
| rs876054071 | 120 | V>A | No | EVA | |
| rs450912295 | 126 | D>G | No | EVA | |
| rs465669671 | 145 | M>L | No | EVA | |
| rs480069320 | 154 | H>N | No | EVA | |
| rs461483016 | 163 | V>E | No | EVA | |
| rs481964730 | 167 | L>* | No | EVA | |
| rs469467838 | 179 | M>V | No | EVA | |
| rs457382774 | 189 | L>R | No | EVA | |
| rs480166134 | 219 | T>P | No | EVA | |
| rs468032751 | 222 | L>F | No | EVA | |
| rs482422327 | 228 | F>V | No | EVA | |
| rs463306751 | 230 | R>T | No | EVA | |
| rs438425646 | 234 | R>L | No | EVA | |
| rs459161478 | 235 | I>L | No | EVA | |
| rs441143234 | 236 | L>V | No | EVA | |
| rs443405018 | 255 | E>D | No | EVA | |
| rs433301321 | 272 | T>K | No | EVA | |
| rs465707784 | 274 | T>R | No | EVA | |
| rs447300519 | 275 | Q>* | No | EVA | |
| rs480292932 | 275 | Q>P | No | EVA | |
| rs461732569 | 276 | A>D | No | EVA | |
| rs440410150 | 277 | V>G | No | EVA | |
| rs449934582 | 278 | I>T | No | EVA | |
| rs482915012 | 283 | R>G | No | EVA | |
| rs457987644 | 288 | W>C | No | EVA | |
| rs439439763 | 293 | M>I | No | EVA | |
| rs478773937 | 295 | A>S | No | EVA | |
| rs455712105 | 308 | D>A | No | EVA | |
| rs468306938 | 335 | R>G | No | EVA | |
| rs444656158 | 390 | T>I | No | EVA | |
| rs444656158 | 390 | T>N | No | EVA | |
| rs446789129 | 401 | M>I | No | EVA |
No associated diseases with Q3SZ65
6 regional properties for Q3SZ65
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| conserved_site | ATP-dependent RNA helicase DEAD-box, conserved site | 181 - 189 | IPR000629 |
| domain | Helicase, C-terminal | 246 - 407 | IPR001650 |
| domain | DEAD/DEAH box helicase domain | 58 - 222 | IPR011545 |
| domain | Helicase superfamily 1/2, ATP-binding domain | 52 - 250 | IPR014001 |
| domain | RNA helicase, DEAD-box type, Q motif | 33 - 61 | IPR014014 |
| domain | ATP-dependent RNA helicase eIF4A, DEAD-box helicase domain | 35 - 236 | IPR044728 |
Functions
| Description | ||
|---|---|---|
| EC Number | 3.6.4.13 | Acting on ATP; involved in cellular and subcellular movement |
| Subcellular Localization |
|
|
| PANTHER Family | ||
| PANTHER Subfamily | ||
| PANTHER Protein Class | ||
| PANTHER Pathway Category | No pathway information available | |
2 GO annotations of cellular component
| Name | Definition |
|---|---|
| catalytic step 2 spliceosome | A spliceosomal complex that contains three snRNPs, including U5, bound to a splicing intermediate in which the first catalytic cleavage of the 5' splice site has occurred. The precise subunit composition differs significantly from that of the catalytic step 1, or activated, spliceosome, and includes many proteins in addition to those found in the associated snRNPs. |
| nucleolus | A small, dense body one or more of which are present in the nucleus of eukaryotic cells. It is rich in RNA and protein, is not bounded by a limiting membrane, and is not seen during mitosis. Its prime function is the transcription of the nucleolar DNA into 45S ribosomal-precursor RNA, the processing of this RNA into 5.8S, 18S, and 28S components of ribosomal RNA, and the association of these components with 5S RNA and proteins synthesized outside the nucleolus. This association results in the formation of ribonucleoprotein precursors; these pass into the cytoplasm and mature into the 40S and 60S subunits of the ribosome. |
6 GO annotations of molecular function
| Name | Definition |
|---|---|
| ATP binding | Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. |
| ATP hydrolysis activity | Catalysis of the reaction: ATP + H2O = ADP + H+ phosphate. ATP hydrolysis is used in some reactions as an energy source, for example to catalyze a reaction or drive transport against a concentration gradient. |
| mRNA binding | Binding to messenger RNA (mRNA), an intermediate molecule between DNA and protein. mRNA includes UTR and coding sequences, but does not contain introns. |
| RNA binding | Binding to an RNA molecule or a portion thereof. |
| RNA helicase activity | Unwinding of an RNA helix, driven by ATP hydrolysis. |
| translation initiation factor activity | Functions in the initiation of ribosome-mediated translation of mRNA into a polypeptide. |
No GO annotations of biological process
| Name | Definition |
|---|---|
| No GO annotations for biological process |
30 homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| P41378 | Eukaryotic initiation factor 4A | Triticum aestivum (Wheat) | PR | |
| Q12099 | FAL1 | ATP-dependent RNA helicase FAL1 | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) | PR |
| Q3SZ54 | EIF4A1 | Eukaryotic initiation factor 4A-I | Bos taurus (Bovine) | PR |
| Q0IIK5 | DDX1 | ATP-dependent RNA helicase DDX1 | Bos taurus (Bovine) | PR |
| Q2NL22 | EIF4A3 | Eukaryotic initiation factor 4A-III | Bos taurus (Bovine) | PR |
| Q3T147 | DDX39B | Spliceosome RNA helicase DDX39B | Bos taurus (Bovine) | PR |
| Q5W5U4 | DDX4 | Probable ATP-dependent RNA helicase DDX4 | Bos taurus (Bovine) | SS |
| Q2TBP1 | DDX25 | ATP-dependent RNA helicase DDX25 | Bos taurus (Bovine) | PR |
| Q3ZBV2 | DDX19A | ATP-dependent RNA helicase DDX19A | Bos taurus (Bovine) | SS |
| Q8JFP1 | EIF4A2 | Eukaryotic initiation factor 4A-II | Gallus gallus (Chicken) | PR |
| A5A6N4 | EIF4A1 | Eukaryotic initiation factor 4A-I | Pan troglodytes (Chimpanzee) | PR |
| Q9VHS8 | CG7483 | Eukaryotic initiation factor 4A-III | Drosophila melanogaster (Fruit fly) | PR |
| P60842 | EIF4A1 | Eukaryotic initiation factor 4A-I | Homo sapiens (Human) | PR |
| Q14240 | EIF4A2 | Eukaryotic initiation factor 4A-II | Homo sapiens (Human) | PR |
| Q41741 | Eukaryotic initiation factor 4A | Zea mays (Maize) | PR | |
| P10630 | Eif4a2 | Eukaryotic initiation factor 4A-II | Mus musculus (Mouse) | PR |
| P60843 | Eif4a1 | Eukaryotic initiation factor 4A-I | Mus musculus (Mouse) | PR |
| Q5RKI1 | Eif4a2 | Eukaryotic initiation factor 4A-II | Rattus norvegicus (Rat) | PR |
| P35683 | Os06g0701100 | Eukaryotic initiation factor 4A-1 | Oryza sativa subsp japonica (Rice) | PR |
| Q6Z2Z4 | Os02g0146600 | Eukaryotic initiation factor 4A-3 | Oryza sativa subsp japonica (Rice) | PR |
| Q5VNM3 | EIF4A3A | Eukaryotic initiation factor 4A-III homolog A | Oryza sativa subsp japonica (Rice) | PR |
| Q10I26 | EIF4A3B | Eukaryotic initiation factor 4A-III homolog B | Oryza sativa subsp japonica (Rice) | PR |
| P27639 | inf-1 | Eukaryotic initiation factor 4A | Caenorhabditis elegans | PR |
| Q3E9C3 | RH58 | DEAD-box ATP-dependent RNA helicase 58, chloroplastic | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q9CAI7 | TIF4A-3 | Eukaryotic initiation factor 4A-3 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q94A52 | EIF4A3 | Eukaryotic initiation factor 4A-III homolog | Arabidopsis thaliana (Mouse-ear cress) | PR |
| P41377 | TIF4A-2 | Eukaryotic initiation factor 4A-2 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| P41376 | EIF4A1 | Eukaryotic initiation factor 4A-1 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| B7ZTW1 | eif4a3 | Eukaryotic initiation factor 4A-III | Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) | PR |
| Q7ZVA6 | eif4a3 | Eukaryotic initiation factor 4A-III | Danio rerio (Zebrafish) (Brachydanio rerio) | PR |
| 10 | 20 | 30 | 40 | 50 | 60 |
| MSGGSADYNR | EHGGPEGMDP | DGVIESNWNE | IVDNFDDMNL | KESLLRGIYA | YGFEKPSAIQ |
| 70 | 80 | 90 | 100 | 110 | 120 |
| QRAIIPCIKG | YDVIAQAQSG | TGKTATFAIS | ILQQLEIEFK | ETQALVLAPT | RELAQQIQKV |
| 130 | 140 | 150 | 160 | 170 | 180 |
| ILALGDYMGA | TCHACIGGTN | VRNEMQKLQA | EAPHIVVGTP | GRVFDMLNRR | YLSPKWIKMF |
| 190 | 200 | 210 | 220 | 230 | 240 |
| VLDEADEMLS | RGFKDQIYEI | FQKLNTSIQV | VLLSATMPTD | VLEVTKKFMR | DPIRILVKKE |
| 250 | 260 | 270 | 280 | 290 | 300 |
| ELTLEGIKQF | YINVEREEWK | LDTLCDLYET | LTITQAVIFL | NTRRKVDWLT | EKMHARDFTV |
| 310 | 320 | 330 | 340 | 350 | 360 |
| SALHGDMDQK | ERDVIMREFR | SGSSRVLITT | DLLARGIDVQ | QVSLVINYDL | PTNRENYIHR |
| 370 | 380 | 390 | 400 | ||
| IGRGGRFGRK | GVAINFVTEE | DKRILRDIET | FYNTTVEEMP | MNVADLI |