Q3SZ40

PR
Gene name
DDX56
Protein name
Probable ATP-dependent RNA helicase DDX56
Names
DEAD box protein 56
Species
Bos taurus (Bovine)
KEGG Pathway
bta:508728
EC number
3.6.4.13: Acting on ATP; involved in cellular and subcellular movement
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

471-546 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for Q3SZ40

Entry ID Method Resolution Chain Position Source
AF-Q3SZ40-F1 Predicted AlphaFoldDB

119 variants for Q3SZ40

Variant ID(s) Position Change Description Diseaes Association Provenance
rs451494328 3 D>E No EVA
rs465191338 5 E>* No EVA
rs433855542 6 S>P No EVA
rs453985989 9 F>C No EVA
rs720964818 11 H>N No EVA
rs442343772 16 H>Q No EVA
rs467602022 23 T>P No EVA
rs436267468 27 W>C No EVA
rs455948171 29 R>* No EVA
rs432035387 31 T>P No EVA
rs452129885 31 T>R No EVA
rs472018247 36 K>E No EVA
rs460771527 40 L>V No EVA
rs443175224 42 L>P No EVA
rs462938170 43 E>A No EVA
rs483060303 45 K>E No EVA
rs445356592 46 D>A No EVA
rs458934529 47 L>P No EVA
rs479165659 48 L>P No EVA
rs447358862 49 A>G No EVA
rs436227394 50 R>L No EVA
rs436227394 50 R>P No EVA
rs469598540 51 A>G No EVA
rs449925128 51 A>P No EVA
rs431998738 52 R>L No EVA
rs472243472 53 T>P No EVA
rs434504874 54 G>R No EVA
rs474456834 56 G>A No EVA
rs474456834 56 G>V No EVA
rs463297963 57 K>E No EVA
rs463297963 57 K>Q No EVA
rs438782645 60 A>P No EVA
rs479121291 62 A>G No EVA
rs447783117 63 I>V No EVA
rs481057017 65 M>I No EVA
rs461085774 65 M>T No EVA
rs449888185 67 Q>K No EVA
rs469860347 67 Q>P No EVA
rs432269360 68 L>R No EVA
rs445564186 69 L>P No EVA
rs434467825 70 L>H No EVA
rs465809201 70 L>I No EVA
rs467970933 71 H>P No EVA
rs436539481 72 R>K No EVA
rs436539481 72 R>T No EVA
rs457679401 78 V>G No EVA
rs477923722 80 E>D No EVA
rs446541416 81 Q>H No EVA
rs459940418 82 A>S No EVA
rs468667654 93 E>D No EVA
rs450773016 120 A>D No EVA
rs464550547 121 A>G No EVA
rs433251667 123 D>G No EVA
rs134246539 139 V>G No EVA
rs135507908 141 T>A No EVA
rs444366180 149 L>F No EVA
rs442144003 207 L>H No EVA
rs462206992 213 H>Y No EVA
rs719286321 215 P>L No EVA
rs467196628 231 L>F No EVA
rs455982496 267 T>P No EVA
rs476270898 268 L>R No EVA
rs432079922 271 S>I No EVA
rs472057306 272 Y>S No EVA
rs440691180 275 R>P No EVA
rs474506495 277 F>S No EVA
rs442811489 278 L>R No EVA
rs462977146 279 E>D No EVA
rs483175313 280 Q>K No EVA
rs458672950 281 F>L No EVA
rs438923060 281 F>Y No EVA
rs478899713 282 S>T No EVA
rs447400346 283 I>L No EVA
rs467459902 283 I>T No EVA
rs459309971 298 C>G No EVA
rs479493712 301 I>L No EVA
rs1116117036 345 V>M No EVA
rs480083785 367 E>K No EVA
rs479904857 385 V>D No EVA
rs448740472 388 F>L No EVA
rs482232750 391 P>A No EVA
rs450882667 393 E>Q No EVA
rs433288517 395 S>A No EVA
rs453104619 403 L>V No EVA
rs465606071 408 S>G No EVA
rs434264190 409 G>A No EVA
rs876123378 412 V>A No EVA
rs876531841 416 Y>S No EVA
rs454377304 420 M>I No EVA
rs474523027 427 R>H No EVA
rs463362478 449 E>* No EVA
rs476997367 451 K>N No EVA
rs439236923 455 L>V No EVA
rs459408701 456 H>P No EVA
rs479530548 457 S>P No EVA
rs467980211 458 E>D No EVA
rs447868772 458 E>G No EVA
rs481755532 460 L>P No EVA
rs449217227 465 E>D No EVA
rs469256845 466 D>H No EVA
rs437559143 466 D>V No EVA
rs383606647 472 Q>H No EVA
rs451219685 486 K>R No EVA
rs433685545 491 N>T No EVA
rs453372328 492 V>D No EVA
rs455977816 495 Y>* No EVA
rs442192552 495 Y>C No EVA
rs473672043 495 Y>H No EVA
rs442192552 495 Y>S No EVA
rs476124003 496 L>R No EVA
rs444419270 497 V>L No EVA
rs481980007 501 L>P No EVA
rs450739011 503 G>V No EVA
rs464434811 514 P>T No EVA
rs1117043351 516 A>V No EVA
rs481145034 523 A>E No EVA
rs449484791 524 K>T No EVA
rs483284446 541 P>H No EVA
rs445445508 542 T>I No EVA

No associated diseases with Q3SZ40

4 regional properties for Q3SZ40

Type Name Position InterPro Accession
domain Helicase, C-terminal 230 - 424 IPR001650
domain DEAD/DEAH box helicase domain 31 - 206 IPR011545
domain Helicase superfamily 1/2, ATP-binding domain 26 - 234 IPR014001
domain RNA helicase, DEAD-box type, Q motif 7 - 35 IPR014014

Functions

Description
EC Number 3.6.4.13 Acting on ATP; involved in cellular and subcellular movement
Subcellular Localization
  • Nucleus, nucleolus
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

1 GO annotations of cellular component

Name Definition
nucleolus A small, dense body one or more of which are present in the nucleus of eukaryotic cells. It is rich in RNA and protein, is not bounded by a limiting membrane, and is not seen during mitosis. Its prime function is the transcription of the nucleolar DNA into 45S ribosomal-precursor RNA, the processing of this RNA into 5.8S, 18S, and 28S components of ribosomal RNA, and the association of these components with 5S RNA and proteins synthesized outside the nucleolus. This association results in the formation of ribonucleoprotein precursors; these pass into the cytoplasm and mature into the 40S and 60S subunits of the ribosome.

4 GO annotations of molecular function

Name Definition
ATP binding Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
ATP hydrolysis activity Catalysis of the reaction: ATP + H2O = ADP + H+ phosphate. ATP hydrolysis is used in some reactions as an energy source, for example to catalyze a reaction or drive transport against a concentration gradient.
RNA binding Binding to an RNA molecule or a portion thereof.
RNA helicase activity Unwinding of an RNA helix, driven by ATP hydrolysis.

1 GO annotations of biological process

Name Definition
rRNA processing Any process involved in the conversion of a primary ribosomal RNA (rRNA) transcript into one or more mature rRNA molecules.

5 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
Q06218 DBP9 ATP-dependent RNA helicase DBP9 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) PR
Q3SZ54 EIF4A1 Eukaryotic initiation factor 4A-I Bos taurus (Bovine) PR
Q29S22 DDX47 Probable ATP-dependent RNA helicase DDX47 Bos taurus (Bovine) PR
Q2NL08 DDX55 ATP-dependent RNA helicase DDX55 Bos taurus (Bovine) PR
Q9NY93 DDX56 Probable ATP-dependent RNA helicase DDX56 Homo sapiens (Human) PR
10 20 30 40 50 60
MEDPESLGFE HMGLDHRLLQ AVTDLGWSRP TLIQEKAIPL ALEGKDLLAR ARTGSGKTAA
70 80 90 100 110 120
YAIPMLQLLL HRKATGPVVE QAVRALVLVP TKELARQAQS MIQQLAAYCA RDIRVANVSA
130 140 150 160 170 180
AEDSASQRAV LMEKPDVVVG TPSRILNHLQ QDNLKLRDSM ELLVVDEADL LFSFGFEEEL
190 200 210 220 230 240
KSLLCHLPRI YQAFLMSATF NEDVQALKEL VLHNPVTLKL QESQLPGPDQ LQQFQVVCET
250 260 270 280 290 300
EEDKFLLLYA LLKLSLIRGK SLLFVNTLER SYRLRLFLEQ FSIPACVLNG ELPLRSRCHI
310 320 330 340 350 360
ISQFNQGFYD CVIATDAEVL GPPVKGKHRG KGPKRDKASD PEAGVARGID FHHVCAVLNF
370 380 390 400 410 420
DLPPTPEAYI HRAGRTARAN NPGIVLTFVL PTEQSQLGKI EELLSGDSGA PVLLPYQFHM
430 440 450 460 470 480
EEIEGFRYRC RDAMRSVTKQ AIREARLKEI KEELLHSEKL KTYFEDNPRD LQLLRHDLPL
490 500 510 520 530 540
HPAVVKPHLG NVPDYLVPPA LRGLVHPHKK RKKPLASKKA KKAKTQNPLR SFKHRGEKCR
PTAAPS