Q3SWY6

PR
Gene name
STK25
Protein name
Serine/threonine-protein kinase 25
Names
Species
Bos taurus (Bovine)
KEGG Pathway
bta:373543
EC number
2.7.11.1: Protein-serine/threonine kinases
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

1-93 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

157-180 (Activation loop from InterPro)

Target domain

15-291 (Catalytic domain of Serine/Threonine Kinase 25, also called Yeast Sps1/Ste20-related kinase 1)

Relief mechanism

Assay

References

Autoinhibited structure

Activated structure

1 structures for Q3SWY6

Entry ID Method Resolution Chain Position Source
AF-Q3SWY6-F1 Predicted AlphaFoldDB

163 variants for Q3SWY6

Variant ID(s) Position Change Description Diseaes Association Provenance
rs457724611 2 A>P No EVA
rs475426643 3 H>L No EVA
rs444136835 3 H>Y No EVA
rs441954729 8 A>D No EVA
rs475043782 34 V>G No EVA
rs454884384 57 E>G No EVA
rs435102668 73 C>Y No EVA
rs134522657 74 D>A No EVA
rs383226473 80 R>H No EVA
rs41818709 83 G>S No EVA
rs432589147 84 S>P No EVA
rs470354479 85 Y>S No EVA
rs450651113 86 L>R No EVA
rs447139716 94 I>M No EVA
rs478280136 97 Y>S No EVA
rs482459242 106 L>R No EVA
rs463505923 130 Y>* No EVA
rs477268973 130 Y>S No EVA
rs450181904 131 L>P No EVA
rs482470001 144 A>T No EVA
rs448977793 146 V>A No EVA
rs478101681 150 E>A No EVA
rs457876061 152 G>C No EVA
rs475607911 157 A>S No EVA
rs466989278 160 G>W No EVA
rs442031338 164 Q>* No EVA
rs453138663 178 T>P No EVA
rs464905483 189 Q>* No EVA
rs437419812 189 Q>H No EVA
rs457560991 189 Q>R No EVA
rs480285108 191 A>D No EVA
rs449016460 191 A>P No EVA
rs459895539 198 I>F No EVA
rs439680592 200 S>* No EVA
rs443938212 201 L>R No EVA
rs475263361 202 G>A No EVA
rs475263361 202 G>V No EVA
rs435002694 203 I>N No EVA
rs472782732 204 T>P No EVA
rs432834481 207 E>A No EVA
rs450368555 212 E>K No EVA
rs436746245 212 E>V No EVA
rs468338324 213 P>T No EVA
rs479455539 215 N>T No EVA
rs448290246 215 N>Y No EVA
rs459438947 217 D>A No EVA
rs477524934 219 H>P No EVA
rs446129527 219 H>Y No EVA
rs463782372 222 R>G No EVA
rs443676664 222 R>L No EVA
rs474977078 223 V>A No EVA
rs461686609 226 L>R No EVA
rs472843646 227 I>L No EVA
rs452596274 227 I>T No EVA
rs432887715 228 P>T No EVA
rs457003338 230 N>H No EVA
rs436807809 230 N>T No EVA
rs454688577 231 S>R No EVA
rs467998803 231 S>T No EVA
rs434600407 232 P>A No EVA
rs477223708 234 T>K No EVA
rs445758351 234 T>P No EVA
rs470298918 235 L>I No EVA
rs481451437 236 E>* No EVA
rs461302614 237 G>A No EVA
rs461302614 237 G>D No EVA
rs479321307 238 H>P No EVA
rs479321307 238 H>R No EVA
rs459231495 239 H>N No EVA
rs439013864 239 H>R No EVA
rs476837558 241 K>R No EVA
rs443244071 243 F>L No EVA
rs456916074 243 F>S No EVA
rs474414771 244 K>N No EVA
rs454349496 245 E>A No EVA
rs434663014 245 E>D No EVA
rs454349496 245 E>G No EVA
rs466057688 246 F>L No EVA
rs452356621 248 E>* No EVA
rs432219373 248 E>A No EVA
rs469987556 249 A>P No EVA
rs450219894 250 C>G No EVA
rs467788824 254 D>G No EVA
rs467788824 254 D>V No EVA
rs440511333 258 R>G No EVA
rs471950516 259 P>A No EVA
rs451684236 259 P>H No EVA
rs471950516 259 P>T No EVA
rs109170488 260 T>N No EVA
rs469198827 262 K>Q No EVA
rs455883059 264 L>I No EVA
rs435802144 270 I>M No EVA
rs447003638 284 I>F No EVA
rs478429895 290 W>R No EVA
rs465118306 291 R>M No EVA
rs444884834 299 S>A No EVA
rs462500888 300 S>R No EVA
rs442768447 302 E>Q No EVA
rs480478920 305 D>E No EVA
rs460387029 306 I>L No EVA
rs471227432 311 E>D No EVA
rs457495347 315 Q>R No EVA
rs437378060 316 G>V No EVA
rs469099792 321 F>L No EVA
rs448996268 323 P>Q No EVA
rs466482731 334 H>D No EVA
rs446737315 338 A>D No EVA
rs446737315 338 A>G No EVA
rs478123811 339 L>R No EVA
rs210682111 345 S>L No EVA
rs434621545 346 A>G No EVA
rs446100519 347 E>D No EVA
rs465938046 347 E>V No EVA
rs432417470 348 P>S No EVA
rs470193107 351 R>T No EVA
rs450139068 354 R>G No EVA
rs481387910 355 S>A No EVA
rs447949235 363 R>P No EVA
rs479256228 368 E>G No EVA
rs469423389 376 S>R No EVA
rs480854833 380 V>A No EVA
rs480854833 380 V>G No EVA
rs467536020 381 G>E No EVA
rs137351125 382 A>G No EVA
rs458480618 383 L>R No EVA
rs478661416 383 L>V No EVA
rs133648039 384 E>G No EVA
rs137767589 385 E>G No EVA
rs442661354 386 L>P No EVA
rs442661354 386 L>Q No EVA
rs442661354 386 L>R No EVA
rs462833934 386 L>V No EVA
rs474000236 388 N>D No EVA
rs440448220 388 N>K No EVA
rs454217039 388 N>T No EVA
rs451559562 389 A>D No EVA
rs471632297 389 A>S No EVA
rs437940733 390 F>L No EVA
rs475940760 391 S>G No EVA
rs455962130 391 S>R No EVA
rs435823300 392 L>P No EVA
rs433631109 394 E>G No EVA
rs465048371 395 E>G No EVA
rs444879471 396 S>A No EVA
rs482614302 397 C>R No EVA
rs462897277 400 I>L No EVA
rs449044334 401 S>W No EVA
rs480453763 402 D>G No EVA
rs460276351 404 L>R No EVA
rs440504274 407 H>P No EVA
rs471740964 411 R>G No EVA
rs458056610 413 Q>E No EVA
rs466875958 414 R>S No EVA
rs446689940 415 F>L No EVA
rs477813769 418 S>G No EVA
rs464142711 420 N>T No EVA
rs450919105 421 H>P No EVA
rs462234041 424 S>P No EVA
rs462234041 424 S>T No EVA
rs479848391 425 T>N No EVA
rs442043430 425 T>P No EVA
rs1117171782 426 R>C No EVA
rs460011097 427 R>R No EVA

No associated diseases with Q3SWY6

3 regional properties for Q3SWY6

Type Name Position InterPro Accession
domain Protein kinase domain 20 - 270 IPR000719
binding_site Protein kinase, ATP binding site 26 - 49 IPR017441
domain Serine/threonine kinase 25, catalytic domain 15 - 291 IPR035060

Functions

Description
EC Number 2.7.11.1 Protein-serine/threonine kinases
Subcellular Localization
  • Cytoplasm
  • Golgi apparatus
  • Localizes to the Golgi apparatus
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

2 GO annotations of cellular component

Name Definition
cytoplasm The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
Golgi apparatus A membrane-bound cytoplasmic organelle of the endomembrane system that further processes the core oligosaccharides (e.g. N-glycans) added to proteins in the endoplasmic reticulum and packages them into membrane-bound vesicles. The Golgi apparatus operates at the intersection of the secretory, lysosomal, and endocytic pathways.

5 GO annotations of molecular function

Name Definition
ATP binding Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
metal ion binding Binding to a metal ion.
protein homodimerization activity Binding to an identical protein to form a homodimer.
protein serine kinase activity Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate.
protein serine/threonine kinase activity Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate, and ATP + protein threonine = ADP + protein threonine phosphate.

9 GO annotations of biological process

Name Definition
axonogenesis De novo generation of a long process of a neuron, including the terminal branched region. Refers to the morphogenesis or creation of shape or form of the developing axon, which carries efferent (outgoing) action potentials from the cell body towards target cells.
establishment of Golgi localization The directed movement of the Golgi to a specific location.
establishment or maintenance of cell polarity Any cellular process that results in the specification, formation or maintenance of anisotropic intracellular organization or cell growth patterns.
Golgi reassembly The reformation of the Golgi following its breakdown and partitioning contributing to Golgi inheritance.
intrinsic apoptotic signaling pathway in response to hydrogen peroxide The series of molecular signals in which an intracellular signal is conveyed to trigger the apoptotic death of a cell. The pathway is induced in response to hydrogen peroxide (H2O2).
positive regulation of axonogenesis Any process that activates or increases the frequency, rate or extent of axonogenesis.
positive regulation of stress-activated MAPK cascade Any process that activates or increases the frequency, rate or extent of signal transduction mediated by the stress-activated MAPK cascade.
protein autophosphorylation The phosphorylation by a protein of one or more of its own amino acid residues (cis-autophosphorylation), or residues on an identical protein (trans-autophosphorylation).
protein phosphorylation The process of introducing a phosphate group on to a protein.

19 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
Q5E9L6 STK4 Serine/threonine-protein kinase 4 Bos taurus (Bovine) SS
P41279 MAP3K8 Mitogen-activated protein kinase kinase kinase 8 Homo sapiens (Human) EV
Q9P289 STK26 Serine/threonine-protein kinase 26 Homo sapiens (Human) PR
Q9Y6E0 STK24 Serine/threonine-protein kinase 24 Homo sapiens (Human) PR
O00506 STK25 Serine/threonine-protein kinase 25 Homo sapiens (Human) PR
Q13188 STK3 Serine/threonine-protein kinase 3 Homo sapiens (Human) SS
Q13043 STK4 Serine/threonine-protein kinase 4 Homo sapiens (Human) EV
Q07174 Map3k8 Mitogen-activated protein kinase kinase kinase 8 Mus musculus (Mouse) SS
Q99JT2 Stk26 Serine/threonine-protein kinase 26 Mus musculus (Mouse) PR
Q99KH8 Stk24 Serine/threonine-protein kinase 24 Mus musculus (Mouse) PR
Q9Z2W1 Stk25 Serine/threonine-protein kinase 25 Mus musculus (Mouse) PR
Q9JI10 Stk3 Serine/threonine-protein kinase 3 Mus musculus (Mouse) SS
Q9JI11 Stk4 Serine/threonine-protein kinase 4 Mus musculus (Mouse) PR
Q63562 Map3k8 Mitogen-activated protein kinase kinase kinase 8 Rattus norvegicus (Rat) SS
B0LT89 Stk24 Serine/threonine-protein kinase 24 Rattus norvegicus (Rat) PR
H2L099 gck-1 Germinal center kinase 1 Caenorhabditis elegans PR
Q9NB31 cst-1 Serine/threonine-protein kinase cst-1 Caenorhabditis elegans PR
Q6P3Q4 stk4 Serine/threonine-protein kinase 4 Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) SS
Q7ZUQ3 stk3 Serine/threonine-protein kinase 3 Danio rerio (Zebrafish) (Brachydanio rerio) SS
10 20 30 40 50 60
MAHLRGFANQ HSRVDPEELF TKLDRIGKGS FGEVYKGIDN RTKEVVAIKI IDLEEAEDEI
70 80 90 100 110 120
EDIQQEITVL SQCDSPYITR YFGSYLKSTK LWIIMEYLGG GSALDLLKPG PLEETYIATI
130 140 150 160 170 180
LREILKGLDY LHSERKIHRD IKAANVLLSE QGDVKLADFG VAGQLTDTQI KRNTFVGTPF
190 200 210 220 230 240
WMAPEVIKQS AYDFKADIWS LGITAIELAK GEPPNSDLHP MRVLFLIPKN SPPTLEGHHS
250 260 270 280 290 300
KPFKEFVEAC LNKDPRFRPT AKELLKHKFI TRYTKKTSFL TELIDRYKRW RSEGHGEESS
310 320 330 340 350 360
SEDSDIDGDP EDGEQGPIWT FPPTIRPSPH GKLHKGTALH GPQKSAEPVK RQPRSQCLST
370 380 390 400 410 420
LVRPVFGELK EKHKQSGGGV GALEELENAF SLAEESCPGI SDKLMAHLVE RVQRFSHSRN
HLTSTR