Q3MHP2

PR
Gene name
RAB11B
Protein name
Ras-related protein Rab-11B
Names
Species
Bos taurus (Bovine)
KEGG Pathway
bta:532723
EC number
3.6.5.2: Acting on GTP; involved in cellular and subcellular movement
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

155-218 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for Q3MHP2

Entry ID Method Resolution Chain Position Source
AF-Q3MHP2-F1 Predicted AlphaFoldDB

116 variants for Q3MHP2

Variant ID(s) Position Change Description Diseaes Association Provenance
rs434225351 6 D>N No EVA
rs454424445 12 F>S No EVA
rs453065720 14 V>E No EVA
rs438529334 15 V>A No EVA
rs438529334 15 V>G No EVA
rs473122270 15 V>L No EVA
rs458501755 17 I>M No EVA
rs475414047 18 G>V No EVA
rs443860010 19 D>A No EVA
rs480759240 21 G>A No EVA
rs459945985 22 V>E No EVA
rs459945985 22 V>G No EVA
rs445302405 23 G>A No EVA
rs465338730 24 K>* No EVA
rs465338730 24 K>E No EVA
rs437216651 24 K>T No EVA
rs450947387 26 N>D No EVA
rs467653823 26 N>I No EVA
rs436316467 26 N>K No EVA
rs467653823 26 N>S No EVA
rs453078445 32 T>P No EVA
rs473186363 33 R>P No EVA
rs432014688 35 E>D No EVA
rs452125235 41 K>N No EVA
rs443984841 46 V>A No EVA
rs460823448 47 E>D No EVA
rs474308445 48 F>L No EVA
rs443102393 50 T>P No EVA
rs480088263 57 G>C No EVA
rs482350103 66 D>A No EVA
rs458961226 66 D>N No EVA
rs450910386 69 G>S No EVA
rs467815536 70 Q>K No EVA
rs446713507 72 R>P No EVA
rs481265733 72 R>S No EVA
rs466749354 74 R>P No EVA
rs452305583 77 T>A No EVA
rs468898851 78 S>P No EVA
rs433205995 80 Y>D No EVA
rs456488507 80 Y>S No EVA
rs469981038 83 G>A No EVA
rs435553878 85 V>L No EVA
rs455686535 86 G>S No EVA
rs472517640 90 V>L No EVA
rs434724361 91 Y>F No EVA
rs451433809 124 N>K No EVA
rs471611272 126 S>G No EVA
rs443318415 127 D>A No EVA
rs463429601 130 H>P No EVA
rs459999679 152 E>G No EVA
rs479863443 154 S>P No EVA
rs449730644 171 E>A No EVA
rs463245993 171 E>D No EVA
rs449730644 171 E>V No EVA
rs483351645 172 I>F No EVA
rs483351645 172 I>L No EVA
rs468760135 172 I>M No EVA
rs448621029 172 I>S No EVA
rs448621029 172 I>T No EVA
rs483351645 172 I>V No EVA
rs434017064 173 Y>H No EVA
rs434017064 173 Y>N No EVA
rs447721275 173 Y>S No EVA
rs433133092 174 R>C No EVA
rs456416911 174 R>H No EVA
rs456416911 174 R>L No EVA
rs456416911 174 R>P No EVA
rs433133092 174 R>S No EVA
rs476539121 175 I>F No EVA
rs476539121 175 I>L No EVA
rs435480860 175 I>T No EVA
rs476539121 175 I>V No EVA
rs440914665 176 V>A No EVA
rs440914665 176 V>E No EVA
rs472396479 176 V>L No EVA
rs472396479 176 V>M No EVA
rs471525616 177 S>A No EVA
rs443242750 177 S>L No EVA
rs471525616 177 S>P No EVA
rs462326594 178 Q>H No EVA
rs483285883 178 Q>K No EVA
rs448697490 178 Q>P No EVA
rs478993533 179 K>Q No EVA
rs447831366 179 K>T No EVA
rs464485644 180 Q>K No EVA
rs433294957 180 Q>L No EVA
rs433294957 180 Q>R No EVA
rs470176351 181 I>L No EVA
rs455574162 181 I>M No EVA
rs435437488 181 I>N No EVA
rs435437488 181 I>S No EVA
rs435437488 181 I>T No EVA
rs472515715 182 A>P No EVA
rs472515715 182 A>T No EVA
rs471445980 183 D>G No EVA
rs451557965 183 D>H No EVA
rs463331656 184 R>P No EVA
rs473824228 185 A>E No EVA
rs442437714 186 A>E No EVA
rs442437714 186 A>G No EVA
rs479155108 187 H>Q No EVA
rs441366035 188 D>A No EVA
rs478065562 189 E>G No EVA
rs458179445 189 E>Q No EVA
rs450114381 190 S>T No EVA
rs480652456 191 P>L No EVA
rs470169448 191 P>T No EVA
rs449301333 198 I>T No EVA
rs466054683 199 S>N No EVA
rs451480013 202 P>T No EVA
rs465179114 204 T>P No EVA
rs436860073 205 D>A No EVA
rs456958104 210 N>I No EVA
rs473962703 212 L>Q No EVA
rs133469651 214 C>S No EVA
rs442384947 216 Q>K No EVA

No associated diseases with Q3MHP2

1 regional properties for Q3MHP2

Type Name Position InterPro Accession
domain Small GTP-binding protein domain 10 - 168 IPR005225

Functions

Description
EC Number 3.6.5.2 Acting on GTP; involved in cellular and subcellular movement
Subcellular Localization
  • Recycling endosome membrane ; Lipid-anchor ; Cytoplasmic side
  • Cytoplasmic vesicle, secretory vesicle, synaptic vesicle membrane ; Lipid-anchor ; Cytoplasmic side
  • Cytoplasmic vesicle, phagosome membrane ; Lipid-anchor ; Cytoplasmic side
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

9 GO annotations of cellular component

Name Definition
anchoring junction A cell junction that mechanically attaches a cell (and its cytoskeleton) to neighboring cells or to the extracellular matrix.
endosome A vacuole to which materials ingested by endocytosis are delivered.
Golgi apparatus A membrane-bound cytoplasmic organelle of the endomembrane system that further processes the core oligosaccharides (e.g. N-glycans) added to proteins in the endoplasmic reticulum and packages them into membrane-bound vesicles. The Golgi apparatus operates at the intersection of the secretory, lysosomal, and endocytic pathways.
phagocytic vesicle A membrane-bounded intracellular vesicle that arises from the ingestion of particulate material by phagocytosis.
phagocytic vesicle membrane The lipid bilayer surrounding a phagocytic vesicle.
recycling endosome An organelle consisting of a network of tubules that functions in targeting molecules, such as receptors transporters and lipids, to the plasma membrane.
recycling endosome membrane The lipid bilayer surrounding a recycling endosome.
synaptic vesicle A secretory organelle, typically 50 nm in diameter, of presynaptic nerve terminals; accumulates in high concentrations of neurotransmitters and secretes these into the synaptic cleft by fusion with the 'active zone' of the presynaptic plasma membrane.
synaptic vesicle membrane The lipid bilayer surrounding a synaptic vesicle.

4 GO annotations of molecular function

Name Definition
G protein activity A molecular function regulator that cycles between active GTP-bound and inactive GDP-bound states. In its active state, binds to a variety of effector proteins to regulate cellular processes. Intrinsic GTPase activity returns the G protein to its GDP-bound state. The return to the GDP-bound state can be accelerated by the action of a GTPase-activating protein (GAP).
GDP binding Binding to GDP, guanosine 5'-diphosphate.
GTP binding Binding to GTP, guanosine triphosphate.
GTPase activity Catalysis of the reaction: GTP + H2O = GDP + H+ + phosphate.

13 GO annotations of biological process

Name Definition
cellular response to acidic pH Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a pH stimulus with pH < 7. pH is a measure of the acidity or basicity of an aqueous solution.
constitutive secretory pathway A process of exocytosis found in all eukaryotic cells, in which transport vesicles destined for the plasma membrane leave the trans-Golgi network in a steady stream. Upon exocytosis, the membrane proteins and lipids in these vesicles provide new components for the plasma membrane, and the soluble proteins inside the vesicles are released into the extracellular space.
endocytic recycling The directed movement of membrane-bounded vesicles from endosomes back to the plasma membrane, a trafficking pathway that promotes the recycling of internalized transmembrane proteins.
exocytosis A process of secretion by a cell that results in the release of intracellular molecules (e.g. hormones, matrix proteins) contained within a membrane-bounded vesicle. Exocytosis can occur either by full fusion, when the vesicle collapses into the plasma membrane, or by a kiss-and-run mechanism that involves the formation of a transient contact, a pore, between a granule (for exemple of chromaffin cells) and the plasma membrane. The latter process most of the time leads to only partial secretion of the granule content. Exocytosis begins with steps that prepare vesicles for fusion with the membrane (tethering and docking) and ends when molecules are secreted from the cell.
insulin secretion involved in cellular response to glucose stimulus The regulated release of proinsulin from secretory granules (B granules) in the B cells of the pancreas; accompanied by cleavage of proinsulin to form mature insulin, in response to a glucose stimulus.
melanosome transport The directed movement of melanosomes into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.
receptor recycling The process that results in the return of receptor molecules to an active state and an active cellular location after they have been stimulated by a ligand. An active state is when the receptor is ready to receive a signal.
regulated exocytosis A process of exocytosis in which soluble proteins and other substances are initially stored in secretory vesicles for later release. It is found mainly in cells that are specialized for secreting products such as hormones, neurotransmitters, or digestive enzymes rapidly on demand.
regulation of anion transport Any process that modulates the frequency, rate or extent of the directed movement of anions, atoms or small molecules with a net negative charge into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.
regulation of endocytic recycling Any process that modulates the frequency, rate or extent of endocytic recycling.
regulation of protein localization to cell surface Any process that modulates the frequency, rate or extent of protein localization to the cell surface.
transferrin transport The directed movement of transferrin into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.
vesicle-mediated transport A cellular transport process in which transported substances are moved in membrane-bounded vesicles; transported substances are enclosed in the vesicle lumen or located in the vesicle membrane. The process begins with a step that directs a substance to the forming vesicle, and includes vesicle budding and coating. Vesicles are then targeted to, and fuse with, an acceptor membrane.

16 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
Q2TBH7 RAB4A Ras-related protein Rab-4A Bos taurus (Bovine) PR
Q2TA29 RAB11A Ras-related protein Rab-11A Bos taurus (Bovine) PR
Q5ZJN2 RAB11A Ras-related protein Rab-11A Gallus gallus (Chicken) PR
P62491 RAB11A Ras-related protein Rab-11A Homo sapiens (Human) PR
Q15907 RAB11B Ras-related protein Rab-11B Homo sapiens (Human) PR
P62492 Rab11a Ras-related protein Rab-11A Mus musculus (Mouse) PR
P46638 Rab11b Ras-related protein Rab-11B Mus musculus (Mouse) PR
Q52NJ1 RAB11A Ras-related protein Rab-11A Sus scrofa (Pig) PR
P62494 Rab11a Ras-related protein Rab-11A Rattus norvegicus (Rat) PR
O35509 Rab11b Ras-related protein Rab-11B Rattus norvegicus (Rat) PR
Q9LNK1 RABA3 Ras-related protein RABA3 Arabidopsis thaliana (Mouse-ear cress) PR
Q9LH50 RABA4D Ras-related protein RABA4d Arabidopsis thaliana (Mouse-ear cress) PR
Q9FE79 RABA4C Ras-related protein RABA4c Arabidopsis thaliana (Mouse-ear cress) PR
O04486 RABA2A Ras-related protein RABA2a Arabidopsis thaliana (Mouse-ear cress) PR
O49513 RABA1E Ras-related protein RABA1e Arabidopsis thaliana (Mouse-ear cress) PR
Q9LNW1 RABA2B Ras-related protein RABA2b Arabidopsis thaliana (Mouse-ear cress) PR
10 20 30 40 50 60
MGTRDDEYDY LFKVVLIGDS GVGKSNLLSR FTRNEFNLES KSTIGVEFAT RSIQVDGKTI
70 80 90 100 110 120
KAQIWDTAGQ ERYRAITSAY YRGAVGALLV YDIAKHLTYE NVERWLKELR DHADSNIVIM
130 140 150 160 170 180
LVGNKSDLRH LRAVPTDEAR AFAEKNNLSF IETSALDSTN VEEAFKNILT EIYRIVSQKQ
190 200 210
IADRAAHDES PGNNVVDISV PPTTDGQKPN KLQCCQNL