Q3LAC4
SS
Gene name |
Prex2 (Depdc2) |
Protein name |
Phosphatidylinositol 3,4,5-trisphosphate-dependent Rac exchanger 2 protein |
Names |
P-Rex2 , PtdIns, 3,4,5-dependent Rac exchanger 2 , DEP domain-containing protein 2 |
Species |
Mus musculus (Mouse) |
KEGG Pathway |
mmu:109294 |
EC number |
|
Protein Class |
|
Descriptions
Phosphatidylinositol (3,4,5)-trisphosphate (PIP3)-dependent Rac exchanger 1 (P-Rex1) catalyzes the exchange of GDP for GTP on Rac GTPases, thereby triggering changes in the actin cytoskeleton and in transcription. P-Rex1 contains a DH domain, a PH domain, two DEP domains, and two PDZ domains. The DEP1 domain alone can autoinhibit the activity of P-Rex1 by interacting with the DH/PH domains.
Autoinhibitory domains (AIDs)
Target domain |
4-369 (DH/PH domains) |
Relief mechanism |
Ligand binding, Partner binding |
Assay |
|
Accessory elements
No accessory elements
References
- Ravala SK et al. (2020) "The first DEP domain of the RhoGEF P-Rex1 autoinhibits activity and contributes to membrane binding", The Journal of biological chemistry, 295, 12635-12647
- Chang YG et al. (2022) "Structure of the metastatic factor P-Rex1 reveals a two-layered autoinhibitory mechanism", Nature structural & molecular biology, 29, 767-773
Autoinhibited structure
Activated structure
1 structures for Q3LAC4
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-Q3LAC4-F1 | Predicted | AlphaFoldDB |
65 variants for Q3LAC4
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| rs6242335 | 3 | D>E | No | EVA | |
| rs3388458118 | 62 | V>M | No | EVA | |
| rs3388458605 | 104 | F>V | No | EVA | |
| rs3388458126 | 141 | C>Y | No | EVA | |
| rs3388457868 | 162 | I>F | No | EVA | |
| rs3388458284 | 162 | I>N | No | EVA | |
| rs3388458431 | 165 | I>M | No | EVA | |
| rs3389622188 | 172 | L>LKVF*LCIANSIHN*NTFK | No | EVA | |
| rs221732171 | 182 | R>K | No | EVA | |
| rs233770539 | 187 | T>A | No | EVA | |
| rs3388457873 | 188 | A>T | No | EVA | |
| rs3388458440 | 191 | E>G | No | EVA | |
| rs3388457718 | 212 | K>N | No | EVA | |
| rs3538950479 | 282 | D>G | No | EVA | |
| rs31928826 | 284 | Y>H | No | EVA | |
| rs3388458492 | 321 | K>R | No | EVA | |
| rs3388457875 | 329 | K>R | No | EVA | |
| rs3388458139 | 350 | K>* | No | EVA | |
| rs3388458064 | 503 | V>I | No | EVA | |
| rs3388458682 | 513 | I>F | No | EVA | |
| rs3388458259 | 520 | T>A | No | EVA | |
| rs3388457902 | 556 | F>L | No | EVA | |
| rs3388458461 | 585 | S>* | No | EVA | |
| rs3388458565 | 619 | M>L | No | EVA | |
| rs3388458192 | 645 | D>E | No | EVA | |
| rs1132225941 | 658 | L>P | No | EVA | |
| rs3388458450 | 664 | T>I | No | EVA | |
| rs3388458439 | 727 | V>I | No | EVA | |
| rs3389658714 | 806 | N>D | No | EVA | |
| rs3389644921 | 806 | N>I | No | EVA | |
| rs244312473 | 861 | S>N | No | EVA | |
| rs3388458857 | 882 | S>C | No | EVA | |
| rs3388458418 | 884 | R>S | No | EVA | |
| rs3388458307 | 892 | I>M | No | EVA | |
| rs3388458533 | 914 | K>E | No | EVA | |
| rs3388458090 | 917 | I>T | No | EVA | |
| rs3388458609 | 919 | P>T | No | EVA | |
| rs3388458639 | 940 | P>Q | No | EVA | |
| rs31934669 | 1004 | Q>R | No | EVA | |
| rs3388458400 | 1006 | L>W | No | EVA | |
| rs31934672 | 1009 | E>K | No | EVA | |
| rs3388458837 | 1011 | D>Y | No | EVA | |
| rs217801887 | 1019 | H>L | No | EVA | |
| rs3389633100 | 1024 | K>R | No | EVA | |
| rs3389661153 | 1027 | T>S | No | EVA | |
| rs3538951311 | 1035 | S>N | No | EVA | |
| rs3388458600 | 1081 | V>I | No | EVA | |
| rs3388458355 | 1152 | T>I | No | EVA | |
| rs223792129 | 1220 | S>G | No | EVA | |
| rs250668691 | 1231 | H>Y | No | EVA | |
| rs262071634 | 1232 | A>V | No | EVA | |
| rs256557330 | 1247 | S>L | No | EVA | |
| rs3388457542 | 1337 | L>S | No | EVA | |
| rs3388457894 | 1408 | E>G | No | EVA | |
| rs3388458025 | 1439 | K>* | No | EVA | |
| rs47084439 | 1459 | A>V | No | EVA | |
| rs50516245 | 1460 | Y>D | No | EVA | |
| rs51258138 | 1461 | I>M | No | EVA | |
| rs3388458888 | 1493 | T>I | No | EVA | |
| rs3388458168 | 1497 | A>T | No | EVA | |
| rs3389662120 | 1521 | C>* | No | EVA | |
| rs32108454 | 1537 | T>A | No | EVA | |
| rs3389652538 | 1594 | P>T | No | EVA | |
| rs3388457586 | 1595 | V>A | No | EVA | |
| rs3388458276 | 1596 | G>* | No | EVA |
No associated diseases with Q3LAC4
8 regional properties for Q3LAC4
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| domain | Dbl homology (DH) domain | 15 - 206 | IPR000219 |
| domain | DEP domain | 382 - 456 | IPR000591-1 |
| domain | DEP domain | 484 - 558 | IPR000591-2 |
| conserved_site | Guanine-nucleotide dissociation stimulator, CDC24, conserved site | 154 - 179 | IPR001331 |
| domain | PDZ domain | 584 - 666 | IPR001478-1 |
| domain | PDZ domain | 669 - 744 | IPR001478-2 |
| domain | Pleckstrin homology domain | 237 - 355 | IPR001849 |
| domain | PREX2, DEP domain 1 | 374 - 454 | IPR037367 |
1 GO annotations of cellular component
| Name | Definition |
|---|---|
| plasma membrane | The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. |
2 GO annotations of molecular function
| Name | Definition |
|---|---|
| GTPase activator activity | Binds to and increases the activity of a GTPase, an enzyme that catalyzes the hydrolysis of GTP. |
| guanyl-nucleotide exchange factor activity | Stimulates the exchange of GDP to GTP on a signaling GTPase, changing its conformation to its active form. Guanine nucleotide exchange factors (GEFs) act by stimulating the release of guanosine diphosphate (GDP) to allow binding of guanosine triphosphate (GTP), which is more abundant in the cell under normal cellular physiological conditions. |
5 GO annotations of biological process
| Name | Definition |
|---|---|
| adult locomotory behavior | Locomotory behavior in a fully developed and mature organism. |
| dendrite morphogenesis | The process in which the anatomical structures of a dendrite are generated and organized. |
| G protein-coupled receptor signaling pathway | The series of molecular signals initiated by a ligand binding to its receptor, in which the activated receptor promotes the exchange of GDP for GTP on the alpha-subunit of an associated heterotrimeric G-protein complex. The GTP-bound activated alpha-G-protein then dissociates from the beta- and gamma-subunits to further transmit the signal within the cell. The pathway begins with receptor-ligand interaction, and ends with regulation of a downstream cellular process. The pathway can start from the plasma membrane, Golgi or nuclear membrane. |
| phosphatidylinositol 3-kinase/protein kinase B signal transduction | A series of reactions, mediated by the intracellular serine/threonine kinase protein kinase B (also called AKT), which occurs as a result of a single trigger reaction or compound. |
| regulation of signaling | Any process that modulates the frequency, rate or extent of a signaling process. |
13 homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| Q58DL7 | ARHGEF9 | Rho guanine nucleotide exchange factor 9 | Bos taurus (Bovine) | SS |
| O43307 | ARHGEF9 | Rho guanine nucleotide exchange factor 9 | Homo sapiens (Human) | SS |
| Q6XZF7 | DNMBP | Dynamin-binding protein | Homo sapiens (Human) | PR |
| Q9NR80 | ARHGEF4 | Rho guanine nucleotide exchange factor 4 | Homo sapiens (Human) | EV |
| A1IGU5 | ARHGEF37 | Rho guanine nucleotide exchange factor 37 | Homo sapiens (Human) | PR |
| Q96N96 | SPATA13 | Spermatogenesis-associated protein 13 | Homo sapiens (Human) | EV |
| Q8TCU6 | PREX1 | Phosphatidylinositol 3,4,5-trisphosphate-dependent Rac exchanger 1 protein | Homo sapiens (Human) | EV |
| Q70Z35 | PREX2 | Phosphatidylinositol 3,4,5-trisphosphate-dependent Rac exchanger 2 protein | Homo sapiens (Human) | SS |
| Q5DU57 | Spata13 | Spermatogenesis-associated protein 13 | Mus musculus (Mouse) | SS |
| Q7TNR9 | Arhgef4 | Rho guanine nucleotide exchange factor 4 | Mus musculus (Mouse) | EV |
| Q3UTH8 | Arhgef9 | Rho guanine nucleotide exchange factor 9 | Mus musculus (Mouse) | SS |
| Q570Y9 | Deptor | DEP domain-containing mTOR-interacting protein | Mus musculus (Mouse) | PR |
| Q69ZK0 | Prex1 | Phosphatidylinositol 3,4,5-trisphosphate-dependent Rac exchanger 1 protein | Mus musculus (Mouse) | SS |
| 10 | 20 | 30 | 40 | 50 | 60 |
| MSDESAREVD | KQLRLRVCVL | SELQKTERDY | VGTLEFLVSA | FLHRMNQCAA | AKVDKNVTEE |
| 70 | 80 | 90 | 100 | 110 | 120 |
| TVKMLFSNIE | EILIVHKEFL | KVVEECLYPE | PSAQQEVGAC | FLHFKDKFRI | YDEYCSNHEK |
| 130 | 140 | 150 | 160 | 170 | 180 |
| AQKLLLELNK | IRTIRTFLLN | CMLLGGRKNT | DVPLEGYLVT | PIQRICKYPL | LLKELLKRTP |
| 190 | 200 | 210 | 220 | 230 | 240 |
| RRHSDYTAVM | EALQAMKAVC | SNINEAKRQM | EKLEVLEEWQ | AHIEGWEGSN | ITDTCTEMLM |
| 250 | 260 | 270 | 280 | 290 | 300 |
| CGVLMKISSG | NIQERVFFLF | DNLLVYCKRK | HRRLKNSKAS | TDGYRYVFRG | RINTEVMEVE |
| 310 | 320 | 330 | 340 | 350 | 360 |
| NVDDGTADFH | SSGHIVVNGW | KIHNTAKNKW | FVCMAKSPEE | KHEWFEAILK | ERERRKGLKL |
| 370 | 380 | 390 | 400 | 410 | 420 |
| GMEQDTWVMI | SEQGEKLYKM | MCKQGNLIKD | RKRKLTTFPK | CFLGSEFVSW | LLEIGEIHRP |
| 430 | 440 | 450 | 460 | 470 | 480 |
| EEGVHLGQAL | LENGIIHHVT | DKHQFKPEQM | LYRFRYDDGT | FYPRSEMQDV | ISKGVRLYCR |
| 490 | 500 | 510 | 520 | 530 | 540 |
| LHSLFTPVVR | DKDYHLRTYK | SVVMANKLID | WLIAQGDCRT | REEAMIFAVG | LCDNGFMHHV |
| 550 | 560 | 570 | 580 | 590 | 600 |
| LEKSEFKDEP | LLFRFFADEE | MEGSNMKHRL | MKHDLKVVEN | VIAKSLLIKS | NEGSYGFGLE |
| 610 | 620 | 630 | 640 | 650 | 660 |
| DKNKVPIIKL | VEKGSNAEMA | GMEVGKKIFA | INGDLVFLRP | FPEVDCFLKS | CLNSRKPLRV |
| 670 | 680 | 690 | 700 | 710 | 720 |
| LVSTKPRETV | KIPDSADGLG | FQIRGFGPSV | VHAVGRGTVA | AAAGLHPGQC | IIKVNGINVS |
| 730 | 740 | 750 | 760 | 770 | 780 |
| KETHASVIAH | VTACRKYKRP | MKQDSIQWVY | DSLESAQEDI | QKSHSKPPGD | GAGDAFECKV |
| 790 | 800 | 810 | 820 | 830 | 840 |
| EDVIDKFNTM | AIIDGKKEHV | SLTVDNVHLE | YGVVYEYDST | AGTKCNVVEK | MVEPKGFFSL |
| 850 | 860 | 870 | 880 | 890 | 900 |
| TAKILEALAK | SDEHFVQNCT | SLNSLNEVIA | TDLQSKFTSM | CSERIEHVCH | RISSYGRFSR |
| 910 | 920 | 930 | 940 | 950 | 960 |
| VLKNRAWPTF | KQAKPKISPL | HSSDFCPTNC | HVNVMEVSYP | KTSTSLGSAF | GVQLDSRKHN |
| 970 | 980 | 990 | 1000 | 1010 | 1020 |
| SHDKENKSVE | PGKLSPMVYI | QHTITTMAAP | SGLSLGHKDG | HGLQYLLKEE | DLETQDIYHK |
| 1030 | 1040 | 1050 | 1060 | 1070 | 1080 |
| LLGKLQTALK | EVEMSVCQID | DLLSSITYSP | KLERKTTECV | TPMDSDNEKG | ERNSKRVCFN |
| 1090 | 1100 | 1110 | 1120 | 1130 | 1140 |
| VAGDEQEDSG | HDTVSNRDSY | SDCNSNRNSI | ASFTSICSSQ | CSSYFHSDEM | DSGDELPISV |
| 1150 | 1160 | 1170 | 1180 | 1190 | 1200 |
| RISHDKQDKI | HTCLEQLFSQ | IDSIINLLKG | QAVIRAFEQT | KYLTPGRGLQ | EFQQEMEAKL |
| 1210 | 1220 | 1230 | 1240 | 1250 | 1260 |
| SCPRRLRLHL | KQDPWNLPSS | IQALAQSIRK | HAEEVKCRIL | LALLEYSDSE | TQLRRDMVFC |
| 1270 | 1280 | 1290 | 1300 | 1310 | 1320 |
| QSLVATVCAF | SEQLMAALNQ | MFDNSKENEM | ETCEASRRWL | DQIANAGVLF | HFQSLLSPNL |
| 1330 | 1340 | 1350 | 1360 | 1370 | 1380 |
| KDEQAMLEDT | LVALFDLEKV | SFFFKPSEED | PLVANVPLTY | QVEGSRQALK | VYFYMDSYHF |
| 1390 | 1400 | 1410 | 1420 | 1430 | 1440 |
| EQLPQRLKNG | GGFKIHPVLF | SQALESMEGY | CYRDNISVEE | FQAQINTASL | EKVKQYNQKL |
| 1450 | 1460 | 1470 | 1480 | 1490 | 1500 |
| RAFYLDKSNS | PPNTTSKAAY | IDKLMKPLNA | LDELYRLITS | FIRSKRIAAC | VNTPCSASGV |
| 1510 | 1520 | 1530 | 1540 | 1550 | 1560 |
| GLLSVSSELC | DRLGACHIIM | CSSGVHRCTL | SVTLEQTITL | ARSHGLPPRY | IMQAMDVMRK |
| 1570 | 1580 | 1590 | |||
| QGARVQNTAK | NLGVRDRTPQ | SAPRLYKLCE | PPPPVGEE |