Q3KP66

PR
Gene name
INAVA
Protein name
Innate immunity activator protein
Names
Species
Homo sapiens (Human)
KEGG Pathway
hsa:55765
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

298-407 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for Q3KP66

Entry ID Method Resolution Chain Position Source
AF-Q3KP66-F1 Predicted AlphaFoldDB

2 variants for Q3KP66

Variant ID(s) Position Change Description Diseaes Association Provenance
VAR_080249
rs41313912
 333 Y>F IBD29; decreases protein stability [UniProt] Yes UniProt
dbSNP
rs296520
VAR_030835
 538 R>C No UniProt
dbSNP

1 associated diseases with Q3KP66

[MIM: 618077]: Inflammatory bowel disease 29 (IBD29)

A chronic, relapsing inflammation of the gastrointestinal tract with a complex etiology. It is subdivided into Crohn disease and ulcerative colitis phenotypes. Crohn disease may affect any part of the gastrointestinal tract from the mouth to the anus, but most frequently it involves the terminal ileum and colon. Bowel inflammation is transmural and discontinuous; it may contain granulomas or be associated with intestinal or perianal fistulas. In contrast, in ulcerative colitis, the inflammation is continuous and limited to rectal and colonic mucosal layers; fistulas and granulomas are not observed. Both diseases include extraintestinal inflammation of the skin, eyes, or joints. {ECO:0000269|PubMed:21983784, ECO:0000269|PubMed:28436939, ECO:0000269|PubMed:29420262}. Note=Disease susceptibility is associated with variants affecting the gene represented in this entry.

Without disease ID
  • A chronic, relapsing inflammation of the gastrointestinal tract with a complex etiology. It is subdivided into Crohn disease and ulcerative colitis phenotypes. Crohn disease may affect any part of the gastrointestinal tract from the mouth to the anus, but most frequently it involves the terminal ileum and colon. Bowel inflammation is transmural and discontinuous; it may contain granulomas or be associated with intestinal or perianal fistulas. In contrast, in ulcerative colitis, the inflammation is continuous and limited to rectal and colonic mucosal layers; fistulas and granulomas are not observed. Both diseases include extraintestinal inflammation of the skin, eyes, or joints. {ECO:0000269|PubMed:21983784, ECO:0000269|PubMed:28436939, ECO:0000269|PubMed:29420262}. Note=Disease susceptibility is associated with variants affecting the gene represented in this entry.

11 regional properties for Q3KP66

Type Name Position InterPro Accession
domain FERM domain 39 - 359 IPR000299
domain Protein kinase domain 425 - 683 IPR000719
domain Serine-threonine/tyrosine-protein kinase, catalytic domain 426 - 678 IPR001245
domain Focal adhesion kinase, targeting (FAT) domain 870 - 1000 IPR005189
active_site Tyrosine-protein kinase, active site 545 - 557 IPR008266
binding_site Protein kinase, ATP binding site 431 - 457 IPR017441
domain FERM central domain 145 - 254 IPR019748
domain Band 4.1 domain 35 - 265 IPR019749
domain Tyrosine-protein kinase, catalytic domain 425 - 679 IPR020635
domain Focal adhesion kinase, N-terminal 39 - 137 IPR041390
domain FAK1/PYK2, FERM domain C-lobe 261 - 368 IPR041784

Functions

Description
EC Number
Subcellular Localization
  • Nucleus
  • Cytoplasm
  • Translocates to the nucleus upon NOD2 stimulation
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

4 GO annotations of cellular component

Name Definition
cytoplasm The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
nuclear body Extra-nucleolar nuclear domains usually visualized by confocal microscopy and fluorescent antibodies to specific proteins.
nucleoplasm That part of the nuclear content other than the chromosomes or the nucleolus.
nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.

No GO annotations of molecular function

Name Definition
No GO annotations for molecular function

16 GO annotations of biological process

Name Definition
adherens junction maintenance The maintenance of an adherens junction. An adherens junction is a cell-cell junction composed of the epithelial cadherin-catenin complex at which the cytoplasmic face of the plasma membrane is attached to actin filaments.
innate immune response Innate immune responses are defense responses mediated by germline encoded components that directly recognize components of potential pathogens.
intestinal epithelial structure maintenance A tissue homeostatic process required for the maintenance of the structure of the intestinal epithelium.
nucleotide-binding oligomerization domain containing 2 signaling pathway The series of molecular signals initiated by the binding of a ligand (such as a bacterial peptidoglycan) to a cytoplasmic nucleotide-binding oligomerization domain containing 2 (NOD2) protein receptor, and ending with regulation of a downstream cellular process.
pattern recognition receptor signaling pathway The series of molecular signals initiated by a ligand binding to a pattern recognition receptor (PRR), and ending with the regulation of a downstream cellular process, e.g. transcription. PRRs bind pathogen-associated molecular pattern (PAMPs), structures conserved among microbial species, or damage-associated molecular pattern (DAMPs), endogenous molecules released from damaged cells.
positive regulation of cytokine production involved in immune response Any process that activates or increases the frequency, rate, or extent of cytokine production that contributes to an immune response.
positive regulation of I-kappaB kinase/NF-kappaB signaling Any process that activates or increases the frequency, rate or extent of I-kappaB kinase/NF-kappaB signaling.
positive regulation of interleukin-1 beta production Any process that activates or increases the frequency, rate, or extent of interleukin-1 beta production.
positive regulation of interleukin-10 production Any process that activates or increases the frequency, rate, or extent of interleukin-10 production.
positive regulation of interleukin-6 production Any process that activates or increases the frequency, rate, or extent of interleukin-6 production.
positive regulation of MAPK cascade Any process that activates or increases the frequency, rate or extent of signal transduction mediated by the MAPK cascade.
positive regulation of protein ubiquitination Any process that activates or increases the frequency, rate or extent of the addition of ubiquitin groups to a protein.
positive regulation of stress-activated MAPK cascade Any process that activates or increases the frequency, rate or extent of signal transduction mediated by the stress-activated MAPK cascade.
reactive oxygen species biosynthetic process The chemical reactions and pathways resulting in the formation of reactive oxygen species, any molecules or ions formed by the incomplete one-electron reduction of oxygen.
response to muramyl dipeptide Any process that results in a change in state or activity of an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a muramyl dipeptide stimulus. Muramyl dipeptide is derived from peptidoglycan.
response to peptidoglycan Any process that results in a change in state or activity of an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a peptidoglycan stimulus. Peptidoglycan is a bacterial cell wall macromolecule.

21 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
Q32LP2 RDX Radixin Bos taurus (Bovine) SS
P31976 EZR Ezrin Bos taurus (Bovine) PR
Q2HJ49 MSN Moesin Bos taurus (Bovine) PR
Q9PU45 RDX Radixin Gallus gallus (Chicken) PR
P46150 Moe Moesin/ezrin/radixin homolog 1 Drosophila melanogaster (Fruit fly) SS
Q24564 Mer Moesin/ezrin/radixin homolog 2 Drosophila melanogaster (Fruit fly) SS
P35240 NF2 Merlin Homo sapiens (Human) EV
P26038 MSN Moesin Homo sapiens (Human) EV
P15311 EZR Ezrin Homo sapiens (Human) EV
P35241 RDX Radixin Homo sapiens (Human) SS
P26043 Rdx Radixin Mus musculus (Mouse) SS
A2AD83 Frmd7 FERM domain-containing protein 7 Mus musculus (Mouse) PR
P26040 Ezr Ezrin Mus musculus (Mouse) SS
P46662 Nf2 Merlin Mus musculus (Mouse) SS
P26041 Msn Moesin Mus musculus (Mouse) SS
P26042 MSN Moesin Sus scrofa (Pig) PR
P26044 RDX Radixin Sus scrofa (Pig) SS
Q63648 Nf2 Merlin Rattus norvegicus (Rat) SS
P31977 Ezr Ezrin Rattus norvegicus (Rat) SS
O35763 Msn Moesin Rattus norvegicus (Rat) SS
Q6Q413 nf2b NF2, moesin-ezrin-radixin-like Danio rerio (Zebrafish) (Brachydanio rerio) SS
10 20 30 40 50 60
MLQMPKLNEI PPGRAGRREA RGEGRWPGQT GPEAARLEWR AQGQAGGARA PWDSWGSSRL
70 80 90 100 110 120
PTQPGPGWSR CPPSLLCALS FQKSTMESKD EVSDTDSGII LQSGPDSPVS PMKELTHAVH
130 140 150 160 170 180
KQQRALEARL EACLEELRRL CLREAELTGT LPAEYPLKPG EKAPKVRRRI GAAYKLDDWA
190 200 210 220 230 240
LHREDPLSSL ERQLALQLQI TEAARRLCLE ENLSRQARRQ RKHSMLQEEK KLQELQRCLV
250 260 270 280 290 300
ERRRNSEPPP AAALPLGREL SASDDSSLSD GLLLEEEESQ VPKPPPESPA PPSRPLPPQT
310 320 330 340 350 360
LEGLQPTGPE AGSPERAPVQ NSPWKETSLD HPYEKPRKSS EPWSESSSPA TTPQDGPSAS
370 380 390 400 410 420
SLWLLEPASY HVVPIRGVPG QWQGRTSAPA TPEIQGRRGQ SQSLRVDSFR AGPEGRGRSA
430 440 450 460 470 480
FPRRRPTHYT VTVPDSCFPA TKPPLPHAAC HSCSEDSGSD VSSISHPTSP GSSSPDISFL
490 500 510 520 530 540
QPLSPPKTHR HRGAWVPAGS RELVAHHPKL LLPPGYFPAG RYVVVAESPL PPGEWELRRA
550 560 570 580 590 600
APGPAYEEEG TPLRYQRLVP SRSRIVRTPS LKDSPAGRGL SKAAVSEELK WWHERARLRS
610 620 630 640 650 660
TRPHSLDRQG AFRVRSLPLG REGFGRALGP RAQVPTVCVL RRSPDGAPVQ VFVPEKGEII
SQV