Q3KP66
PR
Gene name |
INAVA |
Protein name |
Innate immunity activator protein |
Names |
|
Species |
Homo sapiens (Human) |
KEGG Pathway |
hsa:55765 |
EC number |
|
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for Q3KP66
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-Q3KP66-F1 | Predicted | AlphaFoldDB |
2 variants for Q3KP66
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
|
VAR_080249 rs41313912 |
333 | Y>F | IBD29; decreases protein stability [UniProt] | Yes |
UniProt dbSNP |
|
rs296520 VAR_030835 |
538 | R>C | No |
UniProt dbSNP |
No associated diseases with Q3KP66
4 regional properties for Q3KP66
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| domain | Protein kinase domain | 43 - 329 | IPR000719 |
| conserved_site | Mitogen-activated protein (MAP) kinase, conserved site | 78 - 181 | IPR003527 |
| active_site | Serine/threonine-protein kinase, active site | 165 - 177 | IPR008271 |
| binding_site | Protein kinase, ATP binding site | 49 - 73 | IPR017441 |
4 GO annotations of cellular component
| Name | Definition |
|---|---|
| cytoplasm | The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. |
| nuclear body | Extra-nucleolar nuclear domains usually visualized by confocal microscopy and fluorescent antibodies to specific proteins. |
| nucleoplasm | That part of the nuclear content other than the chromosomes or the nucleolus. |
| nucleus | A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. |
No GO annotations of molecular function
| Name | Definition |
|---|---|
| No GO annotations for molecular function |
16 GO annotations of biological process
| Name | Definition |
|---|---|
| adherens junction maintenance | The maintenance of an adherens junction. An adherens junction is a cell-cell junction composed of the epithelial cadherin-catenin complex at which the cytoplasmic face of the plasma membrane is attached to actin filaments. |
| innate immune response | Innate immune responses are defense responses mediated by germline encoded components that directly recognize components of potential pathogens. |
| intestinal epithelial structure maintenance | A tissue homeostatic process required for the maintenance of the structure of the intestinal epithelium. |
| nucleotide-binding oligomerization domain containing 2 signaling pathway | The series of molecular signals initiated by the binding of a ligand (such as a bacterial peptidoglycan) to a cytoplasmic nucleotide-binding oligomerization domain containing 2 (NOD2) protein receptor, and ending with regulation of a downstream cellular process. |
| pattern recognition receptor signaling pathway | The series of molecular signals initiated by a ligand binding to a pattern recognition receptor (PRR), and ending with the regulation of a downstream cellular process, e.g. transcription. PRRs bind pathogen-associated molecular pattern (PAMPs), structures conserved among microbial species, or damage-associated molecular pattern (DAMPs), endogenous molecules released from damaged cells. |
| positive regulation of cytokine production involved in immune response | Any process that activates or increases the frequency, rate, or extent of cytokine production that contributes to an immune response. |
| positive regulation of I-kappaB kinase/NF-kappaB signaling | Any process that activates or increases the frequency, rate or extent of I-kappaB kinase/NF-kappaB signaling. |
| positive regulation of interleukin-1 beta production | Any process that activates or increases the frequency, rate, or extent of interleukin-1 beta production. |
| positive regulation of interleukin-10 production | Any process that activates or increases the frequency, rate, or extent of interleukin-10 production. |
| positive regulation of interleukin-6 production | Any process that activates or increases the frequency, rate, or extent of interleukin-6 production. |
| positive regulation of MAPK cascade | Any process that activates or increases the frequency, rate or extent of signal transduction mediated by the MAPK cascade. |
| positive regulation of protein ubiquitination | Any process that activates or increases the frequency, rate or extent of the addition of ubiquitin groups to a protein. |
| positive regulation of stress-activated MAPK cascade | Any process that activates or increases the frequency, rate or extent of signal transduction mediated by the stress-activated MAPK cascade. |
| reactive oxygen species biosynthetic process | The chemical reactions and pathways resulting in the formation of reactive oxygen species, any molecules or ions formed by the incomplete one-electron reduction of oxygen. |
| response to muramyl dipeptide | Any process that results in a change in state or activity of an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a muramyl dipeptide stimulus. Muramyl dipeptide is derived from peptidoglycan. |
| response to peptidoglycan | Any process that results in a change in state or activity of an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a peptidoglycan stimulus. Peptidoglycan is a bacterial cell wall macromolecule. |
21 homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| Q32LP2 | RDX | Radixin | Bos taurus (Bovine) | SS |
| P31976 | EZR | Ezrin | Bos taurus (Bovine) | PR |
| Q2HJ49 | MSN | Moesin | Bos taurus (Bovine) | PR |
| Q9PU45 | RDX | Radixin | Gallus gallus (Chicken) | PR |
| P46150 | Moe | Moesin/ezrin/radixin homolog 1 | Drosophila melanogaster (Fruit fly) | SS |
| Q24564 | Mer | Moesin/ezrin/radixin homolog 2 | Drosophila melanogaster (Fruit fly) | SS |
| P35240 | NF2 | Merlin | Homo sapiens (Human) | EV |
| P26038 | MSN | Moesin | Homo sapiens (Human) | EV |
| P15311 | EZR | Ezrin | Homo sapiens (Human) | EV |
| P35241 | RDX | Radixin | Homo sapiens (Human) | SS |
| P26043 | Rdx | Radixin | Mus musculus (Mouse) | SS |
| A2AD83 | Frmd7 | FERM domain-containing protein 7 | Mus musculus (Mouse) | PR |
| P26040 | Ezr | Ezrin | Mus musculus (Mouse) | SS |
| P46662 | Nf2 | Merlin | Mus musculus (Mouse) | SS |
| P26041 | Msn | Moesin | Mus musculus (Mouse) | SS |
| P26042 | MSN | Moesin | Sus scrofa (Pig) | PR |
| P26044 | RDX | Radixin | Sus scrofa (Pig) | SS |
| Q63648 | Nf2 | Merlin | Rattus norvegicus (Rat) | SS |
| P31977 | Ezr | Ezrin | Rattus norvegicus (Rat) | SS |
| O35763 | Msn | Moesin | Rattus norvegicus (Rat) | SS |
| Q6Q413 | nf2b | NF2, moesin-ezrin-radixin-like | Danio rerio (Zebrafish) (Brachydanio rerio) | SS |
| 10 | 20 | 30 | 40 | 50 | 60 |
| MLQMPKLNEI | PPGRAGRREA | RGEGRWPGQT | GPEAARLEWR | AQGQAGGARA | PWDSWGSSRL |
| 70 | 80 | 90 | 100 | 110 | 120 |
| PTQPGPGWSR | CPPSLLCALS | FQKSTMESKD | EVSDTDSGII | LQSGPDSPVS | PMKELTHAVH |
| 130 | 140 | 150 | 160 | 170 | 180 |
| KQQRALEARL | EACLEELRRL | CLREAELTGT | LPAEYPLKPG | EKAPKVRRRI | GAAYKLDDWA |
| 190 | 200 | 210 | 220 | 230 | 240 |
| LHREDPLSSL | ERQLALQLQI | TEAARRLCLE | ENLSRQARRQ | RKHSMLQEEK | KLQELQRCLV |
| 250 | 260 | 270 | 280 | 290 | 300 |
| ERRRNSEPPP | AAALPLGREL | SASDDSSLSD | GLLLEEEESQ | VPKPPPESPA | PPSRPLPPQT |
| 310 | 320 | 330 | 340 | 350 | 360 |
| LEGLQPTGPE | AGSPERAPVQ | NSPWKETSLD | HPYEKPRKSS | EPWSESSSPA | TTPQDGPSAS |
| 370 | 380 | 390 | 400 | 410 | 420 |
| SLWLLEPASY | HVVPIRGVPG | QWQGRTSAPA | TPEIQGRRGQ | SQSLRVDSFR | AGPEGRGRSA |
| 430 | 440 | 450 | 460 | 470 | 480 |
| FPRRRPTHYT | VTVPDSCFPA | TKPPLPHAAC | HSCSEDSGSD | VSSISHPTSP | GSSSPDISFL |
| 490 | 500 | 510 | 520 | 530 | 540 |
| QPLSPPKTHR | HRGAWVPAGS | RELVAHHPKL | LLPPGYFPAG | RYVVVAESPL | PPGEWELRRA |
| 550 | 560 | 570 | 580 | 590 | 600 |
| APGPAYEEEG | TPLRYQRLVP | SRSRIVRTPS | LKDSPAGRGL | SKAAVSEELK | WWHERARLRS |
| 610 | 620 | 630 | 640 | 650 | 660 |
| TRPHSLDRQG | AFRVRSLPLG | REGFGRALGP | RAQVPTVCVL | RRSPDGAPVQ | VFVPEKGEII |
| SQV |