Q3E9C3
PR
Gene name |
RH58 (At5g19210, T24G5.110) |
Protein name |
DEAD-box ATP-dependent RNA helicase 58, chloroplastic |
Names |
|
Species |
Arabidopsis thaliana (Mouse-ear cress) |
KEGG Pathway |
ath:AT5G19210 |
EC number |
3.6.4.13: Acting on ATP; involved in cellular and subcellular movement |
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for Q3E9C3
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-Q3E9C3-F1 | Predicted | AlphaFoldDB |
35 variants for Q3E9C3
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| ENSVATH00631674 | 13 | F>C | No | 1000Genomes | |
| ENSVATH03080117 | 22 | V>L | No | 1000Genomes | |
| ENSVATH03080119 | 26 | L>P | No | 1000Genomes | |
| ENSVATH03080120 | 27 | K>N | No | 1000Genomes | |
| ENSVATH03080121 | 30 | F>V | No | 1000Genomes | |
| ENSVATH03080124 | 44 | P>S | No | 1000Genomes | |
| ENSVATH03080125 | 45 | S>N | No | 1000Genomes | |
| ENSVATH00631676 | 50 | N>K | No | 1000Genomes | |
| ENSVATH00631677 | 64 | N>S | No | 1000Genomes | |
| ENSVATH03080127 | 68 | E>D | No | 1000Genomes | |
| ENSVATH03080128 | 69 | T>P | No | 1000Genomes | |
| tmp_5_6461682_A_T | 80 | Q>L | No | 1000Genomes | |
| ENSVATH00631678 | 82 | F>Y | No | 1000Genomes | |
| ENSVATH03080132 | 92 | E>K | No | 1000Genomes | |
| tmp_5_6461837_A_T | 101 | D>V | No | 1000Genomes | |
| ENSVATH14092741 | 132 | L>F | No | 1000Genomes | |
| ENSVATH06994498 | 151 | V>L | No | 1000Genomes | |
| ENSVATH14092742 | 172 | E>D | No | 1000Genomes | |
| ENSVATH06994500 | 174 | D>N | No | 1000Genomes | |
| tmp_5_6462400_G_T | 206 | A>S | No | 1000Genomes | |
| tmp_5_6462473_T_C | 230 | V>A | No | 1000Genomes | |
| tmp_5_6462648_G_A | 243 | V>I | No | 1000Genomes | |
| tmp_5_6462690_G_A | 257 | D>N | No | 1000Genomes | |
| tmp_5_6462750_G_C | 277 | D>H | No | 1000Genomes | |
| tmp_5_6462944_T_C | 301 | L>S | No | 1000Genomes | |
| ENSVATH10857544 | 313 | T>A | No | 1000Genomes | |
| ENSVATH10857615 | 313 | T>I | No | 1000Genomes | |
| ENSVATH03080148 | 356 | E>K | No | 1000Genomes | |
| tmp_5_6463261_T_A | 357 | F>I | No | 1000Genomes | |
| ENSVATH10857619 | 367 | E>G | No | 1000Genomes | |
| tmp_5_6463538_G_A | 424 | D>N | No | 1000Genomes | |
| ENSVATH06994512 | 428 | R>Q | No | 1000Genomes | |
| ENSVATH00631693 | 445 | A>T | No | 1000Genomes | |
| ENSVATH03080149 | 464 | M>L | No | 1000Genomes | |
| ENSVATH06994514 | 473 | L>L | No | 1000Genomes |
No associated diseases with Q3E9C3
Functions
| Description | ||
|---|---|---|
| EC Number | 3.6.4.13 | Acting on ATP; involved in cellular and subcellular movement |
| Subcellular Localization |
|
|
| PANTHER Family | ||
| PANTHER Subfamily | ||
| PANTHER Protein Class | ||
| PANTHER Pathway Category | No pathway information available | |
2 GO annotations of cellular component
| Name | Definition |
|---|---|
| chloroplast | A chlorophyll-containing plastid with thylakoids organized into grana and frets, or stroma thylakoids, and embedded in a stroma. |
| spliceosomal complex | Any of a series of ribonucleoprotein complexes that contain snRNA(s) and small nuclear ribonucleoproteins (snRNPs), and are formed sequentially during the spliceosomal splicing of one or more substrate RNAs, and which also contain the RNA substrate(s) from the initial target RNAs of splicing, the splicing intermediate RNA(s), to the final RNA products. During cis-splicing, the initial target RNA is a single, contiguous RNA transcript, whether mRNA, snoRNA, etc., and the released products are a spliced RNA and an excised intron, generally as a lariat structure. During trans-splicing, there are two initial substrate RNAs, the spliced leader RNA and a pre-mRNA. |
4 GO annotations of molecular function
| Name | Definition |
|---|---|
| ATP binding | Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. |
| ATP hydrolysis activity | Catalysis of the reaction: ATP + H2O = ADP + H+ phosphate. ATP hydrolysis is used in some reactions as an energy source, for example to catalyze a reaction or drive transport against a concentration gradient. |
| RNA binding | Binding to an RNA molecule or a portion thereof. |
| RNA helicase activity | Unwinding of an RNA helix, driven by ATP hydrolysis. |
1 GO annotations of biological process
| Name | Definition |
|---|---|
| mRNA splicing, via spliceosome | The joining together of exons from one or more primary transcripts of messenger RNA (mRNA) and the excision of intron sequences, via a spliceosomal mechanism, so that mRNA consisting only of the joined exons is produced. |
30 homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| P41378 | Eukaryotic initiation factor 4A | Triticum aestivum (Wheat) | PR | |
| Q3SZ54 | EIF4A1 | Eukaryotic initiation factor 4A-I | Bos taurus (Bovine) | PR |
| Q3SZ65 | EIF4A2 | Eukaryotic initiation factor 4A-II | Bos taurus (Bovine) | PR |
| Q0IIK5 | DDX1 | ATP-dependent RNA helicase DDX1 | Bos taurus (Bovine) | PR |
| Q8JFP1 | EIF4A2 | Eukaryotic initiation factor 4A-II | Gallus gallus (Chicken) | PR |
| A5A6N4 | EIF4A1 | Eukaryotic initiation factor 4A-I | Pan troglodytes (Chimpanzee) | PR |
| P60842 | EIF4A1 | Eukaryotic initiation factor 4A-I | Homo sapiens (Human) | PR |
| Q14240 | EIF4A2 | Eukaryotic initiation factor 4A-II | Homo sapiens (Human) | PR |
| Q41741 | Eukaryotic initiation factor 4A | Zea mays (Maize) | PR | |
| P10630 | Eif4a2 | Eukaryotic initiation factor 4A-II | Mus musculus (Mouse) | PR |
| P60843 | Eif4a1 | Eukaryotic initiation factor 4A-I | Mus musculus (Mouse) | PR |
| Q5RKI1 | Eif4a2 | Eukaryotic initiation factor 4A-II | Rattus norvegicus (Rat) | PR |
| Q6Z2Z4 | Os02g0146600 | Eukaryotic initiation factor 4A-3 | Oryza sativa subsp japonica (Rice) | PR |
| P35683 | Os06g0701100 | Eukaryotic initiation factor 4A-1 | Oryza sativa subsp japonica (Rice) | PR |
| P27639 | inf-1 | Eukaryotic initiation factor 4A | Caenorhabditis elegans | PR |
| P41377 | TIF4A-2 | Eukaryotic initiation factor 4A-2 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q9CAI7 | TIF4A-3 | Eukaryotic initiation factor 4A-3 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q9C718 | RH20 | DEAD-box ATP-dependent RNA helicase 20 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q84W89 | RH37 | DEAD-box ATP-dependent RNA helicase 37 | Arabidopsis thaliana (Mouse-ear cress) | SS |
| Q94A52 | EIF4A3 | Eukaryotic initiation factor 4A-III homolog | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q8LA13 | RH11 | DEAD-box ATP-dependent RNA helicase 11 | Arabidopsis thaliana (Mouse-ear cress) | SS |
| Q9M2F9 | RH52 | DEAD-box ATP-dependent RNA helicase 52 | Arabidopsis thaliana (Mouse-ear cress) | SS |
| Q56XG6 | RH15 | DEAD-box ATP-dependent RNA helicase 15 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q8W4R3 | RH30 | DEAD-box ATP-dependent RNA helicase 30 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q93ZG7 | RH38 | DEAD-box ATP-dependent RNA helicase 38 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q9LFN6 | RH56 | DEAD-box ATP-dependent RNA helicase 56 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q9SZB4 | RH43 | Putative DEAD-box ATP-dependent RNA helicase 43 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q9LU46 | RH35 | DEAD-box ATP-dependent RNA helicase 35 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q9FZ92 | RH44 | Putative DEAD-box ATP-dependent RNA helicase 44 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q8H136 | RH14 | DEAD-box ATP-dependent RNA helicase 14 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| 10 | 20 | 30 | 40 | 50 | 60 |
| MASQLLNVPH | LAFFPKISYA | SVFSTLKPSF | FHSTSTRRAL | KSSPSSRIIN | LQAVAETSSE |
| 70 | 80 | 90 | 100 | 110 | 120 |
| IESNSVTETT | VPLTLRQICQ | GFVPEHILHR | MEEIGFVFPT | DIQREALPTL | FTGRDCILHA |
| 130 | 140 | 150 | 160 | 170 | 180 |
| QTGSGKTLTY | LLLIFSLINP | QRSSVQAVIV | VPTRELGMQV | TKVARMLAAK | SEIDVKGCTV |
| 190 | 200 | 210 | 220 | 230 | 240 |
| MALLDGGTLR | RHKSWLKAEP | PAILVATVAS | LCHMLEKHIF | RIDSVRVLVV | DEVDFLFYSS |
| 250 | 260 | 270 | 280 | 290 | 300 |
| KQVGSVRKLL | TSFSSCDKRQ | TVFASASIPQ | HKHFVHDCIQ | QKWTKRDVVH | VHVSAIMPMP |
| 310 | 320 | 330 | 340 | 350 | 360 |
| LCLLHRFVMC | EKTNKHQVLL | ALLESDAPES | AIIFVGEQSE | KSKKAGNDPS | TTLLMEFLKT |
| 370 | 380 | 390 | 400 | 410 | 420 |
| SYKGSLEILL | LEGDMNFNSR | AASLTEIRQG | GGFLLVSTDI | AARGIDLPET | THIFNFDLPQ |
| 430 | 440 | 450 | 460 | 470 | |
| TVTDYLHRAG | RAGRKPFSDR | KCIVANLITS | EERFVLQRYE | NELMFSCEEM | ML |