Q3E991
PR
Gene name |
PRK6 |
Protein name |
Pollen receptor-like kinase 6 |
Names |
AtPRK6 |
Species |
Arabidopsis thaliana (Mouse-ear cress) |
KEGG Pathway |
ath:AT5G20690 |
EC number |
|
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
3 structures for Q3E991
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| 5Y9W | X-ray | 185 A | A/B | 27-262 | PDB |
| 5YAH | X-ray | 210 A | B | 27-262 | PDB |
| AF-Q3E991-F1 | Predicted | AlphaFoldDB |
41 variants for Q3E991
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| ENSVATH07002697 | 10 | F>C | No | 1000Genomes | |
| tmp_5_7002520_C_T | 23 | P>L | No | 1000Genomes | |
| tmp_5_7002519_C_A | 23 | P>T | No | 1000Genomes | |
| tmp_5_7002573_G_A | 41 | V>M | No | 1000Genomes | |
| ENSVATH10886577 | 96 | P>S | No | 1000Genomes | |
| tmp_5_7002786_C_G | 112 | L>V | No | 1000Genomes | |
| tmp_5_7002792_C_A | 114 | H>N | No | 1000Genomes | |
| tmp_5_7002798_T_C | 116 | F>L | No | 1000Genomes | |
| tmp_5_7002807_C_T | 119 | R>C | No | 1000Genomes | |
| tmp_5_7002853_A_C | 134 | E>A | No | 1000Genomes | |
| ENSVATH07002698 | 236 | G>A | No | 1000Genomes | |
| ENSVATH07002699 | 250 | P>A | No | 1000Genomes | |
| ENSVATH14109240 | 251 | P>T | No | 1000Genomes | |
| ENSVATH07002700 | 256 | S>F | No | 1000Genomes | |
| ENSVATH10886580 | 302 | A>T | No | 1000Genomes | |
| tmp_5_7003395_T_G | 315 | S>A | No | 1000Genomes | |
| ENSVATH07002702 | 316 | E>Q | No | 1000Genomes | |
| ENSVATH14109241 | 321 | T>N | No | 1000Genomes | |
| ENSVATH07002703 | 323 | K>E | No | 1000Genomes | |
| tmp_5_7003459_C_G | 336 | S>W | No | 1000Genomes | |
| tmp_5_7003515_G_A | 355 | G>R | No | 1000Genomes | |
| tmp_5_7003530_C_G | 360 | L>V | No | 1000Genomes | |
| ENSVATH07002704 | 372 | T>A | No | 1000Genomes | |
| tmp_5_7003608_G_T | 386 | A>S | No | 1000Genomes | |
| tmp_5_7003831_T_A | 460 | M>K | No | 1000Genomes | |
| tmp_5_7004094_T_C | 508 | L>P | No | 1000Genomes | |
| ENSVATH07002710 | 518 | V>I | No | 1000Genomes | |
| ENSVATH10886598 | 522 | E>K | No | 1000Genomes | |
| ENSVATH07002712 | 536 | L>F | No | 1000Genomes | |
| tmp_5_7004225_C_T | 552 | P>S | No | 1000Genomes | |
| ENSVATH07002713 | 562 | H>Q | No | 1000Genomes | |
| ENSVATH14109243 | 591 | G>A | No | 1000Genomes | |
| tmp_5_7004376_C_T | 602 | S>L | No | 1000Genomes | |
| ENSVATH10886600 | 611 | L>I | No | 1000Genomes | |
| ENSVATH07002714 | 620 | T>I | No | 1000Genomes | |
| ENSVATH14109244 | 623 | M>I | No | 1000Genomes | |
| ENSVATH00635132 | 628 | E>D | No | 1000Genomes | |
| ENSVATH14109275 | 636 | C>G | No | 1000Genomes | |
| ENSVATH10886601 | 642 | D>N | No | 1000Genomes | |
| tmp_5_7004507_G_A | 646 | D>N | No | 1000Genomes | |
| tmp_5_7004520_C_G | 650 | A>G | No | 1000Genomes |
No associated diseases with Q3E991
8 regional properties for Q3E991
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| domain | Protein kinase domain | 384 - 659 | IPR000719 |
| repeat | Leucine-rich repeat | 119 - 180 | IPR001611-1 |
| repeat | Leucine-rich repeat | 193 - 212 | IPR001611-2 |
| repeat | Leucine-rich repeat, typical subtype | 118 - 142 | IPR003591-1 |
| repeat | Leucine-rich repeat, typical subtype | 143 - 166 | IPR003591-2 |
| repeat | Leucine-rich repeat, typical subtype | 167 - 190 | IPR003591-3 |
| repeat | Leucine-rich repeat, typical subtype | 191 - 214 | IPR003591-4 |
| domain | Leucine-rich repeat-containing N-terminal, plant-type | 33 - 67 | IPR013210 |
Functions
4 GO annotations of cellular component
| Name | Definition |
|---|---|
| cytoplasm | The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. |
| integral component of membrane | The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane. |
| plasma membrane | The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. |
| pollen tube tip | The region at growing end of the pollen tube cell, where polarized growth occurs. |
3 GO annotations of molecular function
| Name | Definition |
|---|---|
| ATP binding | Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. |
| identical protein binding | Binding to an identical protein or proteins. |
| protein serine/threonine kinase activity | Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate, and ATP + protein threonine = ADP + protein threonine phosphate. |
2 GO annotations of biological process
| Name | Definition |
|---|---|
| pollen tube guidance | The process in which the growth of pollen tube is directed towards the female gametophyte. |
| protein phosphorylation | The process of introducing a phosphate group on to a protein. |
32 homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| P0C0K6 | EPHB6 | Ephrin type-B receptor 6 | Pan troglodytes (Chimpanzee) | SS |
| P54756 | EPHA5 | Ephrin type-A receptor 5 | Homo sapiens (Human) | SS |
| P54764 | EPHA4 | Ephrin type-A receptor 4 | Homo sapiens (Human) | SS |
| P29322 | EPHA8 | Ephrin type-A receptor 8 | Homo sapiens (Human) | SS |
| P29320 | EPHA3 | Ephrin type-A receptor 3 | Homo sapiens (Human) | PR |
| Q15375 | EPHA7 | Ephrin type-A receptor 7 | Homo sapiens (Human) | SS |
| Q9UF33 | EPHA6 | Ephrin type-A receptor 6 | Homo sapiens (Human) | SS |
| P29323 | EPHB2 | Ephrin type-B receptor 2 | Homo sapiens (Human) | EV |
| P54762 | EPHB1 | Ephrin type-B receptor 1 | Homo sapiens (Human) | SS |
| P54753 | EPHB3 | Ephrin type-B receptor 3 | Homo sapiens (Human) | SS |
| P29317 | EPHA2 | Ephrin type-A receptor 2 | Homo sapiens (Human) | SS |
| P54760 | EPHB4 | Ephrin type-B receptor 4 | Homo sapiens (Human) | SS |
| Q5JZY3 | EPHA10 | Ephrin type-A receptor 10 | Homo sapiens (Human) | SS |
| P21709 | EPHA1 | Ephrin type-A receptor 1 | Homo sapiens (Human) | SS |
| O15197 | EPHB6 | Ephrin type-B receptor 6 | Homo sapiens (Human) | SS |
| Q02763 | TEK | Angiopoietin-1 receptor | Homo sapiens (Human) | SS |
| P09581 | Csf1r | Macrophage colony-stimulating factor 1 receptor | Mus musculus (Mouse) | SS |
| P21803 | Fgfr2 | Fibroblast growth factor receptor 2 | Mus musculus (Mouse) | SS |
| P16092 | Fgfr1 | Fibroblast growth factor receptor 1 | Mus musculus (Mouse) | SS |
| Q03142 | Fgfr4 | Fibroblast growth factor receptor 4 | Mus musculus (Mouse) | PR |
| P05622 | Pdgfrb | Platelet-derived growth factor receptor beta | Mus musculus (Mouse) | SS |
| Q00342 | Flt3 | Receptor-type tyrosine-protein kinase FLT3 | Mus musculus (Mouse) | SS |
| Q61006 | Musk | Muscle, skeletal receptor tyrosine-protein kinase | Mus musculus (Mouse) | SS |
| P55144 | Tyro3 | Tyrosine-protein kinase receptor TYRO3 | Mus musculus (Mouse) | SS |
| Q00993 | Axl | Tyrosine-protein kinase receptor UFO | Mus musculus (Mouse) | PR |
| Q60805 | Mertk | Tyrosine-protein kinase Mer | Mus musculus (Mouse) | SS |
| Q3UFB7 | Ntrk1 | High affinity nerve growth factor receptor | Mus musculus (Mouse) | SS |
| Q61851 | Fgfr3 | Fibroblast growth factor receptor 3 | Mus musculus (Mouse) | PR |
| Q84JQ4 | PRK2 | Pollen receptor-like kinase 2 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q9FG33 | LECRKS5 | Probable L-type lectin-domain containing receptor kinase S.5 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| C0LGQ4 | MDIS2 | Protein MALE DISCOVERER 2 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| O12990 | jak1 | Tyrosine-protein kinase JAK1 | Danio rerio (Zebrafish) (Brachydanio rerio) | PR |
| 10 | 20 | 30 | 40 | 50 | 60 |
| MAAAVLNPGF | FLLILLLSFS | ISPSLQYVSE | SEPLVRFKNS | VKITKGDLNS | WREGTDPCSG |
| 70 | 80 | 90 | 100 | 110 | 120 |
| KWFGIYCQKG | LTVSGIHVTR | LGLSGTITVD | DLKDLPNLKT | IRLDNNLLSG | PLPHFFKLRG |
| 130 | 140 | 150 | 160 | 170 | 180 |
| LKSLMLSNNS | FSGEIRDDFF | KDMSKLKRLF | LDHNKFEGSI | PSSITQLPQL | EELHMQSNNL |
| 190 | 200 | 210 | 220 | 230 | 240 |
| TGEIPPEFGS | MKNLKVLDLS | TNSLDGIVPQ | SIADKKNLAV | NLTENEYLCG | PVVDVGCENI |
| 250 | 260 | 270 | 280 | 290 | 300 |
| ELNDPQEGQP | PSKPSSSVPE | TSNKAAINAI | MVSISLLLLF | FIIVGVIKRR | NKKKNPDFRM |
| 310 | 320 | 330 | 340 | 350 | 360 |
| LANNRENDVV | EVRISESSST | TAKRSTDSSR | KRGGHSDDGS | TKKGVSNIGK | GGNGGGGGAL |
| 370 | 380 | 390 | 400 | 410 | 420 |
| GGGMGDIIMV | NTDKGSFGLP | DLMKAAAEVL | GNGSLGSAYK | AVMTTGLSVV | VKRIRDMNQL |
| 430 | 440 | 450 | 460 | 470 | 480 |
| AREPFDVEMR | RFGKLRHPNI | LTPLAYHYRR | EEKLVVSEYM | PKSSLLYVLH | GDRGIYHSEL |
| 490 | 500 | 510 | 520 | 530 | 540 |
| TWATRLKIIQ | GVAHGMKFLH | EEFASYDLPH | GNLKSSNVLL | SETYEPLISD | YAFLPLLQPS |
| 550 | 560 | 570 | 580 | 590 | 600 |
| NASQALFAFK | TPEFAQTQQV | SHKSDVYCLG | IIILEILTGK | FPSQYLNNGK | GGTDIVQWVQ |
| 610 | 620 | 630 | 640 | 650 | |
| SSVAEQKEEE | LIDPEIVNNT | ESMRQMVELL | RVGAACIASN | PDERLDMREA | VRRIEQVKT |